Category: 5098-14-6

Taylor, Edward C.; Perlman, Katherine L.; Kim, Young-Ho; Sword, Ian P.; Jacobi, Peter A. published an article in 1973, the title of the article was Pteridines. XXIX. Unequivocal route to 2,4-diamino-6-substituted pteridines.Synthetic Route of 5098-14-6 And the article contains the following content:

2,4-Diamino-6-substituted pteridines (I) are prepared Reaction of an α-keto-aldoxime with aminomalononitrile gives 2-amino-3-cyano-5-substituted pyrazine 1-oxides which yield 2,4-diamino-6-substituted pteridine 8-oxides upon cyclization with guanidine. 2,4-Diaminopteridines are then obtained by deoxygenation of the corresponding 8-oxides, or alternately by prior deoxygenation of these pyrazine 1-oxides, followed by cyclization with guanidine. The conversion of 2-amino-3-cyano-5-methylpyrazine 1-oxide to the corresponding 1,4-dioxide, and a number of chem. transformations of this latter intermediate, are also described. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Synthetic Route of 5098-14-6

The Article related to pteridine diamino preparation, aminopteridine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Purines and Pteridines and other aspects.Synthetic Route of 5098-14-6

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Taylor, Edward C.; Jacobi, Peter A. published an article in 1973, the title of the article was Pteridines. XXX. Facile synthesis of xanthopterin.Reference of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Pterin 8-oxide (I) rearranges quant. to xanthopterin (II) upon dissolution in a mixture of CF3CO2H/(CF3CO)2O at 50°. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Reference of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to pterin oxide rearrangement xanthopterin, Heterocyclic Compounds (More Than One Hetero Atom): Purines and Pteridines and other aspects.Reference of 2-Aminomalononitrile 4-methylbenzenesulfonate

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On September 30, 1989, Freeman, Fillmore; Kim, Darrick S. H. L. published an article.Recommanded Product: 5098-14-6 The title of the article was Preparation of (E,E)-4-amino-1-aryl-3-cyano-4-methoxy-2-azabutadienes. And the article contained the following:

Treatment of (NC)2CHN+H3 4-MeC6H4SO3- with NaOAc and RCHO (R = Ph, 2-BrC6H4, 2-ClC6H4, 2-O2NC6H4, 4-O2NC6H4, 4-HOC6H4, 2-naphthyl) in MeOH gave 23-99% (E,E)-RCH:NC(CN):C(OMe)NH2. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 5098-14-6

The Article related to ammoniomalononitrile tosylate condensation aromatic aldehyde, aminoarylcyanomethoxyazabutadiene, azabutadiene aminoarylcyanomethoxy, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Naphthalenes and other aspects.Recommanded Product: 5098-14-6

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On March 28, 2012, Spencer, John; Patel, Hiren; Amin, Jahangir; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.; Furman, Christophe; Mansouri, Roxane; Chavatte, Philippe; Millet, Regis published an article.Category: nitriles-buliding-blocks The title of the article was Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. And the article contained the following:

A 2-substituted 5-aminooxazole-4-carbonitrile library has been synthesized and modified via microwave-mediated and flow chemistries. One synthesized compound, 5-(1H-pyrrol-1-yl)-4-(1H-tetrazol-5-yl)-2-(thien-2-yl)oxazole, contains three distinct heterocycles attached to the central oxazole core, highlighting the structural diversity of this approach. Three oxazoles had micromolar ki values against cannabinoid (CB1/CB2) receptors. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to aminooxazolecarbonitrile library preparation reaction, oxazolecarbonitrile amino library preparation reaction, cannabinoid receptor affinity aminooxazolecarbonitrile, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Category: nitriles-buliding-blocks

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On August 31, 1997, Freeman, Fillmore; Chen, Tao; Van der Linden, Johannes B. published an article.Computed Properties of 5098-14-6 The title of the article was Synthesis of highly functionalized 1,3-oxazoles. And the article contained the following:

A convenient 1-pot method for the preparation of 2-substituted 5-amino-4-cyano-1,3-oxazoles from carboxylic acids and aminomalononitrile tosylate is reported. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Computed Properties of 5098-14-6

The Article related to cyanooxazolamine preparation, aminooxazolenitrile preparation, oxazole amino cyano preparation, carboxylic acid aminomalononitrile tosylate cyclocondensation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Computed Properties of 5098-14-6

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Freeman, Fillmore; Kim, Darrick S. H. L. published an article in 1989, the title of the article was Preparation of 2-alkyl- and 2-aryl-5-amino-4-cyano-1,3-oxazoles.Application In Synthesis of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Aminopropanedinitrile p-toluenesulfonate reacts with acid chlorides to give 5-amino-4-cyano-1,3-oxazoles I (R = Me, Et, CHMe2, Ph, 4-MeOC6H4, 4-O2NC6H4, 2-furyl) in 51-95% yields. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Application In Synthesis of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to acid chloride cyclocondensation aminomalonitrile tosylate, oxazole amino cyano aryl alkyl, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Application In Synthesis of 2-Aminomalononitrile 4-methylbenzenesulfonate

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On September 1, 2018, Nikseresht, Ahmad; Ghasemi, Saba; Parak, Soraya published an article.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was [Cu3(BTC)2]: A metal-organic framework as an environment-friendly and economically catalyst for the synthesis of tacrine analogues by Friedlaender reaction under conventional and ultrasound irradiation. And the article contained the following:

Using a green and simple route with ultrasound illumination, atm. pressure and room temperature, for synthesizing tacrine analogs in the presence of [Cu3(BTC)2] as an environment-friendly and economically catalyst was considered. [Cu3(BTC)2] is one of the heterogeneous catalysts on hand capable of being employed, in the Friedlaender reaction, whenever 5-amino-4-cyano-2-phenyl-1,3-oxazole and appropriately substituted carbonyl derivatives under conventional and ultrasonic irradiation The results of this study indicate that the active sites in the [Cu3(BTC)2] for synthesis of cyclohepta[b]oxazolo[4,5-e]pyridine are mainly copper atoms and the role of Bronsted acid organic ligand in the MOF is negligible. These procedures were properly arranged to provide the utmost yields in a short while. The crystal stability in the process of catalysis was studied by various techniques such as XRD, BET and ICP that demonstrate excellent stability in reaction conditions. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to tacrine analog green preparation friedlaender copper benzenetricarboxylate mof catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

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On February 28, 1979, Junek, Hans; Mittelbach, Martin published an article.Synthetic Route of 5098-14-6 The title of the article was Syntheses with nitriles, LIV. Reduction of oximinomalonitrile to aminomalonitrile using Raney catalysts. And the article contained the following:

An improved synthesis of aminomalononitrile H2NCH(CN)2 (I) by using Raney-catalyst for the reduction of HON:C(CN)2 (II) at H2-pressure of 4 atm and 20° was given. Due to the reactivity of II some new derivatives of oximinocyanoacetamide are obtained by O- and N-acylation. Condensation of III with benzilmonoxime gave 2-amino-5,6-diphenylpyrazinecarbonitrile; with N-phenylformamidate 2-amino-2,2-dicyano-1-(N-phenylimino)-acetaldehyde was obtained. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Synthetic Route of 5098-14-6

The Article related to reduction oximinomalonitrile, malononitrile oximino, aminomalononitrile, acetamide oximinocyano, pyrazinecarbonitrile, cyclocondensation aminomalodinitrile benzil oxime, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Synthetic Route of 5098-14-6

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On June 6, 1980, Taylor, Edward C.; Dumas, Donald J. published an article.HPLC of Formula: 5098-14-6 The title of the article was Pteridines. 47. Preparation and chemistry of 2-amino-6-carbalkoxy-3-cyano-5-substituted pyrazine 1-oxides: synthesis of pterin-6-carboxaldehyde. And the article contained the following:

A new procedure for the synthesis of 2-amino-3-cyano-5-substituted pyrazines I [R = CH(OMe)2, Me], useful intermediates for the synthesis of pteridines, is described. Oximation of β-oxo esters followed by reaction with aminomalononitrile provides 2-amino-6-carbalkoxy-3-cyano-5-substituted pyrazine 1-oxides II. Protection of the amino group as its (dimethylamino)methylenamino derivative I followed by SN2 decarbalkoxylation provides pyrazines, which on removal of the protecting group and deoxygenation give pyrazines III. This method is designed to be of use in cases where the β-oxo ester cannot be converted directly to the corresponding α-oxo aldoxime. The procedure is applied to the synthesis of III [R = CH(OMe)2], an intermediate in the synthesis of pterin-6-carboxaldehyde. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).HPLC of Formula: 5098-14-6

The Article related to pyrazine oxide amino cyano carbalkoxy, pterincarboxaldehyde, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.HPLC of Formula: 5098-14-6

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Armarego, Wilfred L. F. published an article in 1977, the title of the article was Pterins. Part 2. Stereochemistry of catalytic reduction of 6-methyl- and 6,7-dimethyl-pterin and of 2,4-diamino-6-methylpteridine.Category: nitriles-buliding-blocks And the article contains the following content:

Catalytic addition of 2 mols. of H to 7-deuterio-6-trideuteriomethylpterin gave a 0.8:1 mixture of cis- and trans-7-deuterio-6-trideuteriomethyl-5,6,7,8-tetrahydropterin. Similar reduction of 2,4-diamino-7-deuterio-6-(partial)trideuteriomethylpteridine gave a 1:1 mixture of cis- and trans-2,4-diamino-7-deuterio-6-(partial)trideuteriomethyl-5,6,7,8-tetrahydropteridine. However, catalytic reduction of 6,7-dimethyl- and 6,7-bis(trideuteriomethyl)pterin is stereospecific and gave only the cis 5,6,7,8-tetrahydro derivatives Reduction of 6,7-dimethylpterin with Na in EtOH gave a 1:1 mixture of cis- and trans-6,7-dimethyl-5,6,7,8-tetrahydropterin. The stereochem. of the products was deduced from 1H NMR spectroscopy. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to catalyst reduction stereochem pterin, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Category: nitriles-buliding-blocks

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