Category: 5098-14-6

Taylor, Edward C.; Berrier, John V. published an article in 1977, the title of the article was Pteridines. Part XLII. Synthesis of some benzo[g]pteridines. A novel aromatization reaction.Name: 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

The benzopteridine I (R = NH2, R1 = R2 = H) was prepared by condensing 6-chloro-2-oximinocyclohexanone-HCl with H2NCH(CN)2.4-MeC6H4SO3H, aromatizing the quinoxaline oxide II by heating with HOAc, and condensing 2-amino-3-cyanoquinoxaline (III) with guanidine-HCl. Condensation of III with HC(OEt)3 gave I (R-R2 = H). I (R = NH2, R1 = R2 = H) was treated with HCl to give benzo[g]pterin. I [R = NH2, R1R2 = (CH)4] was obtained from 2-oximino-1-tetralone. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Name: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to benzopteridine, naphthopterdine, benzopterin, pterin condensed, aromatization tetrahydroquinoxaline oxide, guanidine aminocyanoquinoxaline condensation, Heterocyclic Compounds (More Than One Hetero Atom): Purines and Pteridines and other aspects.Name: 2-Aminomalononitrile 4-methylbenzenesulfonate

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Taylor, Edward C.; Portnoy, Robert C.; Hochstetler, Douglass C.; Kobayashi, T. published an article in 1975, the title of the article was Pteridines. XXXVIII. Synthesis of some 2,4-diamino-6-substituted methylpteridines. New route to pteroic acid.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

6-Substituted 2,4-diaminopteridines I and 6-substituted pterins II (R = Cl, OH, H, p-ClC6H4, p-EtO2CC6H4NH, PhCH2, etc.) were prepared by reaction of 2-amino-3-cyano-5-chloromethylpyrazine with nucleophiles, followed by ring closure with guanidine to give I, and final acid hydrolysis to II. The pyrazine oxides III (R = PhCH2S, p-O2NC6H4NMe, p-O2NC6H4NH) were prepared by treating XCH2COCH:NOH (X = Cl, Br) with H2NCH(CN)2.p-MeC6H4SO3H and nucleophiles. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to pteridine diamino, pterin, cyclization cyanoaminopyrazine guanidine, pyrazine cyclization guanidine, pyruvaldehyde oxime cyclization aminomalononitrile, Heterocyclic Compounds (More Than One Hetero Atom): Purines and Pteridines and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

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On December 31, 1980, Kadir, Kamaliah; Shaw, Gordon; Wright, David published an article.Application of 5098-14-6 The title of the article was Purines, pyrimidines, and imidazoles. Part 56. Some aminoimidazolecarboxamidines and derived adenines. And the article contained the following:

Cyclohexylimidazole I, prepared (37%) from H2NCH(CN)2, CH(OEt)3, and cyclohexylamine, gave 66% carboximidate II (R = OMe) on treatment with MeOH/HCl, which with NH3 gave 64% carboxamidine II (R = NH2) (III). Formylation of III gave N6-formyladenine IV (R = cyclohexyl), which was also prepared by formylation of 9-cyclohexyladenine. IV [R = CH2CH(OH)CH2OH] was similarly prepared The reaction of II (R = H) with HCO2H/Ac2O gave N6-formyladenine (IV; R = H), which was also prepared by formylation of adenine, whereas adenosine was not N-formylated under the same conditions. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Application of 5098-14-6

The Article related to aminomalononitrile cyclocondensation, aminoimidazole, imidazole amino, carboxamidine formylation, cyclohexylimidazole, nucleoside analog adenine, Heterocyclic Compounds (More Than One Hetero Atom): Purines and Pteridines and other aspects.Application of 5098-14-6

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On May 31, 2020, Vitkovska, Viktorija; Zogota, Rimants; Kalnins, Toms; Zelencova, Diana; Suna, Edgars published an article.Computed Properties of 5098-14-6 The title of the article was Aliphatic chain-containing macrocycles as diazonamide A analogs. And the article contained the following:

Aliphatic alkyl chain-containing 12-14-membered macrocycles were designed as structural analogs of antimitotic natural product diazonamide A. Macrocycles were synthesized from 5-bromooxazole in 7 to 9 linear steps using Ru-catalyzed ring-closing metathesis as the key transformation. Heat effect of binding to α,β-tubulin tetramer (T4-RB3 complex) has been measured for the synthesized macrocycles by isothermal titration calorimetry method. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Computed Properties of 5098-14-6

The Article related to diazonamide a analog aliphatic chain macrocycle preparation dissociation constant, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Computed Properties of 5098-14-6

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On February 25, 2018, Tuo, Wei; Bollier, Melanie; Leleu-Chavain, Natascha; Lemaire, Lucas; Barczyk, Amelie; Dezitter, Xavier; Klupsch, Frederique; Szczepanski, Fabien; Spencer, John; Chavatte, Philippe; Millet, Regis published an article.Electric Literature of 5098-14-6 The title of the article was Development of novel oxazolo[5,4-d]pyrimidines as competitive CB2 neutral antagonists based on scaffold hopping. And the article contained the following:

A series of novel oxazolo[5,4-d]pyrimidines I [R1 = H, Cl, F, CF3; R2 = H, Me; R3 = n-Bu, cyclohexylmethyl, 1-methylpiperazinyl, etc.] was designed via a scaffold hopping strategy and synthesized through a newly developed approach. All these compounds I were evaluated for their biol. activity toward CB1/CB2 cannabinoid receptors, their metabolic stability in mice liver microsomes and their cytotoxicity against several cell lines. Eight compounds I [R1 = Cl, CF3; R2 = H, Me; R3 = 1-methylpiperazinyl, 1-ethylpiperazinyl, 1-acetylpiperazinyl] were identified as CB2 ligands with Ki values less than 1 ΜM. It was noteworthy that compounds I [R1 = Cl; R2 = Me; R3 = 1-methylpiperazinyl, 1-ethylpiperazinyl] showed CB2 binding affinity in the nanomolar range and significant selectivity over CB1 receptors. Interestingly, functionality studies imply that they behaved as competitive neutral antagonists. Moreover, all tested compounds I were devoid of cytotoxicity toward several cell lines, including Chinese hamster ovary cells (CHO) and human colorectal adenocarcinoma cells HT29. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Electric Literature of 5098-14-6

The Article related to oxazolopyrimidine preparation cytotoxicity sar cannabinoid receptor antagonist, cb(2) receptor, cannabinoid, neutral antagonist, oxazolo[5,4-d]pyrimidine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 5098-14-6

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On June 30, 1984, Pastor, Stephen D.; Nelson, Aaron L. published an article.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Substituted 5-(D,L-erythro-1′,2′-dihydroxypropyl)pyrazines. Potential precursors for the synthesis of biopterin derivatives. And the article contained the following:

Substituted 5-(D,L-erythro-1′,2′-dihydroxypropyl)pyrazines I (R = cyano, CO2CH2Ph) were prepared from crotonic acid. Functionalized 2-oximino-3-oxoesters II (R1 = Me, CMe3) showed anomalous behavior during decarboxylation. The structures of prepared compounds were determined by spectroscopic methods. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to dihydroxypropylpyrazinecarboxylate lactone, pyrazinecarboxylate dihydroxypropyl lactone, dihydroxydioxohexanoate monoxime decarboxylation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

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On December 31, 1988, Sato, Nobuhiro; Saito, Noriko published an article.Category: nitriles-buliding-blocks The title of the article was Studies on pyrazines. 17. An efficient synthesis of pteridine-6-carboxylic acids. And the article contained the following:

2,4-Diaminopteridine-6-carboxylic acid (I) and pterin-6-carboxylic acid (II) were prepared by permanganate oxidation of the corresponding 6-(2-furyl)-substituted pteridines under mild conditions. Several attempts to cleave the furan ring with other oxidizing agents are also described. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to aminopterincarboxylic acid, pteridinecarboxylic acid diamino, furan synthon carboxylic acid group, oxidation furan permanganate, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: nitriles-buliding-blocks

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Shey, Chun Feng; Chen, Chao Tung; Horng, Jhy Ming; Wang, Cheng Hsia published an article in 1984, the title of the article was Synthesis of 2,4-diamino-6-substituted pteridine.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Title compounds I (R = Cl, OH), intermediates for methotrexate, were prepared Thus, cyclocondensation of 2,4,5,6-tetraaminopyrimidine with CO(CH2OH)2 gave I (R = OH) whereas cyclocondensation of 2-amino-3-cyano-5-chloromethylpyrazine with guanidine gave I (R = Cl). The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to aminopteridine, pteridine diamino, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

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On December 31, 2004, Haight, Anthony R.; Bailey, Anne E.; Baker, William S.; Cain, Michael H.; Copp, Richard R.; DeMattei, John A.; Ford, Kelley L.; Henry, Rodger F.; Hsu, Margaret C.; Keyes, Robert F.; King, Steven A.; McLaughlin, Maureen A.; Melcher, Laura M.; Nadler, William R.; Oliver, Patricia A.; Parekh, Shyamal I.; Patel, Hemant H.; Seif, Louis S.; Staeger, Mike A.; Wayne, Gregory S.; Wittenberger, Steven J.; Zhang, Weijiang published an article.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was A Scaleable Synthesis of Fiduxosin. And the article contained the following:

Fiduxosin (I) is under development for the treatment of benign prostatic hyperplasia. A convergent strategy required methodologies for preparation of an enantiomerically pure 3,4-cis-disubstituted pyrrolidine and a 2,3,5-trisubstituted thienopyrazine in a regiospecific manner. A [3+2] cycloaddition of an enantiopure azomethine ylide followed by a diastereoselective crystallization was employed to prepare the benzopyranopyrrolidine in high diastereomeric and enantiomeric purity. Conditions for reduction of an O-aryl lactone susceptible to epimerization were developed, and cyclization of the alc./phenol to the ether was accomplished in high yield. The thienopyrazine was prepared by condensation of Me thioglycolate and a regiospecifically prepared 2-bromo-3-cyano-5-phenylpyrazine. Conditions for effective halogen substitutive deamination to prepare regiospecific trisubstituted pyrazines is described. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to fiduxosin scalable synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

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On January 1, 1982, Taylor, Edward C.; Dumas, Donald J. published an article.Related Products of 5098-14-6 The title of the article was Pteridines. 49. Synthesis of 2,4-diamino-6,8-dihydro-7-aryl-8-oxopyrrolo[3,4-g]pteridines. And the article contained the following:

Reaction of Et 4-chloro-2-oximino-3-oxobutyrate with aminomalononitrile tosylate followed by deoxygenation of the resulting pyrazine 1-oxide provides the cyanopyrazine (I). Treatment of I with arylamines gives the (arylaminomethyl)cyanopyrazines II (R = H, Me) which are readily cyclized to the oxopyrrolopyrazines III. Condensation of III with guanidine acetate in DMF then provides the title compounds IV (R = H, Me). The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Related Products of 5098-14-6

The Article related to pyrrolopteridinone diamino, pyrrolopyrazine cyano amino cyclization guanidine, pyrazinecarboxylate arylaminomethyl cyclization, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Related Products of 5098-14-6

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