Category: 5098-14-6

On December 31, 2004, Haight, Anthony R.; Bailey, Anne E.; Baker, William S.; Cain, Michael H.; Copp, Richard R.; DeMattei, John A.; Ford, Kelley L.; Henry, Rodger F.; Hsu, Margaret C.; Keyes, Robert F.; King, Steven A.; McLaughlin, Maureen A.; Melcher, Laura M.; Nadler, William R.; Oliver, Patricia A.; Parekh, Shyamal I.; Patel, Hemant H.; Seif, Louis S.; Staeger, Mike A.; Wayne, Gregory S.; Wittenberger, Steven J.; Zhang, Weijiang published an article.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was A Scaleable Synthesis of Fiduxosin. And the article contained the following:

Fiduxosin (I) is under development for the treatment of benign prostatic hyperplasia. A convergent strategy required methodologies for preparation of an enantiomerically pure 3,4-cis-disubstituted pyrrolidine and a 2,3,5-trisubstituted thienopyrazine in a regiospecific manner. A [3+2] cycloaddition of an enantiopure azomethine ylide followed by a diastereoselective crystallization was employed to prepare the benzopyranopyrrolidine in high diastereomeric and enantiomeric purity. Conditions for reduction of an O-aryl lactone susceptible to epimerization were developed, and cyclization of the alc./phenol to the ether was accomplished in high yield. The thienopyrazine was prepared by condensation of Me thioglycolate and a regiospecifically prepared 2-bromo-3-cyano-5-phenylpyrazine. Conditions for effective halogen substitutive deamination to prepare regiospecific trisubstituted pyrazines is described. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to fiduxosin scalable synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 1, 1982, Taylor, Edward C.; Dumas, Donald J. published an article.Related Products of 5098-14-6 The title of the article was Pteridines. 49. Synthesis of 2,4-diamino-6,8-dihydro-7-aryl-8-oxopyrrolo[3,4-g]pteridines. And the article contained the following:

Reaction of Et 4-chloro-2-oximino-3-oxobutyrate with aminomalononitrile tosylate followed by deoxygenation of the resulting pyrazine 1-oxide provides the cyanopyrazine (I). Treatment of I with arylamines gives the (arylaminomethyl)cyanopyrazines II (R = H, Me) which are readily cyclized to the oxopyrrolopyrazines III. Condensation of III with guanidine acetate in DMF then provides the title compounds IV (R = H, Me). The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Related Products of 5098-14-6

The Article related to pyrrolopteridinone diamino, pyrrolopyrazine cyano amino cyclization guanidine, pyrazinecarboxylate arylaminomethyl cyclization, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Related Products of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 1, 2001, Hirota, Kosaku; Kazaoka, Kazunori; Niimoto, Itaru; Sajiki, Hironao published an article.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Novel and efficient synthesis of 8-oxoadenine derivatives. And the article contained the following:

A novel synthetic method for the preparation of 8-oxoadenine derivatives was reported. This widely applicable synthetic method was realized through the use of 5-amino-2,3-dihydro-2-oxo-1-(phenylmethyl)-1H-imidazole-4-carbonitrile as the key intermediates. A variety of substituents were successfully introduced to the 2- and 9-position of the 8-oxoadenine nucleus. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to oxoadenine aminopurinone preparation, amino oxo imidazolecarbonitrile preparation cyclocondensation amidine, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 16, 1997, Peinador, Carlos; Quintela, Jose Ma.; Moreira, Maria J. published an article.Reference of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was A short and facile synthesis for heteromine A. And the article contained the following:

The first and efficient synthesis of the new purinium natural product, heteromine A, involving 5-amino-4-cyano-1-methylimidazole and N,N-dimethyldichlomethyleniminium chloride was reported. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Reference of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to heteromine a synthesis, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Reference of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 10, 1982, Colvin, Ernest W.; Kirby, Gordon W.; Wilson, Arthur C. published an article.Category: nitriles-buliding-blocks The title of the article was O-(Diphenylphosphinyl)hydroxylamine: a new reagent for electrophilic C-amination. And the article contained the following:

Ph2P(O)ONH2 (I) efficiently aminated (EtO)2P(O)CH-CO2CH2Ph, (EtO2C)2CH-, (NC)2CH-, PhMgBr, and Me(CH2)5MgBr in THF at -78掳 under Ar. E.g., treatment of (EtO)2P(O)CH2CO2CH2Ph with NaH at room temperature under Ar, then I at -78掳 gave 60% (EtO)2P(O)CH(NH2)CO2CH2Ph. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to phosphinylhydroxylamine amination phosphonoacetate malonate anion, grignard reagent amination phosphinylhydroxylamine, hydroxylamine phosphinyl amination phosphonoacetate anion and other aspects.Category: nitriles-buliding-blocks

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 15, 2019, Jung, J.; Menzies, D. J.; Thissen, H.; Easton, C. D.; Evans, R. A.; Henry, R.; Deletic, A.; McCarthy, D. T. published an article.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was New prebiotic chemistry inspired filter media for stormwater/greywater disinfection. And the article contained the following:

Greywater and stormwater have received significant attention due to increasing water scarcity. Passive filtration such as biofiltration has been a popular treatment method with its low energy input and environmental friendliness. However, pathogen removal capacity needs improvement to achieve safe water quality. In this study, a prebiotic chem. inspired copolymer based on aminomalononitrile and 3,4,5-trihydroxybenzaldehyde (AMNT30) was introduced to develop antimicrobial media for passive filtration. The AMNT30 polymer provided an adhesive coating on zeolite substrates following a spontaneous polymerization process at room temperature AMNT30 coated media were investigated for metal loading capacity, surface morphol., E. coli removal and metal leaching after filtration of different water sources (i.e. stormwater, greywater, and deionized water) at low/high conductivity The coating enhanced metal ion loading on the surface and demonstrated that >8 log reduction of E. coli can be achieved for silver loaded materials compared to a 1 log reduction for copper loaded materials. The coating also increased the stability of the metals on the media irresp. of inflow characteristics. This study provided the first example using AMNT30 to create antimicrobial water purification media. It is expected that this technol. will find applications in the water treatment industry. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to prebiotic chem inspired media stormwater greywater disinfection, antimicrobial media, disinfection, filter media, greywater, prebiotic chemistry inspired polymer, stormwater and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 12, 2015, Motiyenko, Roman A.; Margules, Laurent; Alekseev, Eugen A.; Guillemin, Jean-Claude published an article.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was High-Resolution Millimeter Wave Spectroscopy and Ab Initio Calculations of Aminomalononitrile. And the article contained the following:

The HCN trimer aminomalononitrile (H2NCH(CN)2, AMN) is considered as a key compound in prebiotic chem. and a potential candidate for detection in the interstellar medium. In this view, we studied the rotational spectrum of AMN in the 120-245 GHz frequency range. The spectroscopic work was augmented by high-level ab initio calculations The calculations showed that between two existing rotamers, sym. and asym., the most stable is the asym. conformation, and it is the only conformation observed in the recorded spectra. The sym. conformation is 6.7 kJ/mol higher in energy and thus has a very low Boltzmann factor. The anal. of the rotational spectra of the A conformation has shown that the observed lines exhibit a doublet or quartet structure owing to two large-amplitude motions, C-N torsion and amino group inversion. To study the large-amplitude motions in detail, we calculated a two-dimensional potential energy surface and determined the barrier heights for the torsion and inversion, Vt = 12.5 kJ/mol and Vi = 19.1 kJ/mol. About 2500 assigned rotational transitions in the ground vibrational state were fitted within exptl. accuracy using the reduced axes system Hamiltonian. The set of obtained spectroscopic parameters allows accurate calculation of transition frequencies and intensities for an astrophys. search of AMN. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to aminomalononitrile millimeter wave spectroscopy ab initio, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 31, 2020, Kuroda, Chiaki; Kobayashi, Reiri; Kurebayashi, Saeka; Tazawa, Kanako; Masuda, Arisa; Takeuchi, Ryo; Washio, Ayako; Onuki, Hiroyuki published an article.Formula: C10H11N3O3S The title of the article was Reaction of Aminomalononitrile and Benzylic Compounds as a Plausible Route to Phenylalanine. And the article contained the following:

As a possible route to phenylalanine, reaction of aminomalononitrile with benzylic compounds was studied. 2-Benzyl-2-aminomalononitrile was obtained in a good yield when aminomalononitrile p-toluenesulfonate was treated with benzyl bromide in THF using triethylamine as a base. The reaction proceeded in the presence of water. 2-Benzyl-2-aminomalononitrile was hydrolyzed to afford phenylalanine. The aminomalononitrile route can explain the presence of not only 1 methylene in aromatic amino acids, but also 伪-hydrogen in all 20 proteinogenic amino acids. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Formula: C10H11N3O3S

The Article related to aminomalononitrile benzylic compound benzylation, benzyl aminomalononitrile hydrolysis, phenylalanine preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Formula: C10H11N3O3S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 5, 2018, Bollier, Melanie; Klupsch, Frederique; Six, Perrine; Dubuquoy, Laurent; Azaroual, Nathalie; Millet, Regis; Leleu-Chavain, Natascha published an article.Electric Literature of 5098-14-6 The title of the article was One- or Two-Step Synthesis of C-8 and N-9 Substituted Purines. And the article contained the following:

A novel and original strategy to obtain rapidly a large diversity of C-8 and N-9 substituted purines was developed. The present procedure describes annulation reactions in one or two steps starting from 5-aminoimidazole-4-carbonitriles 1-8 in moderate to good yields. 8,9-Disubstituted-6,9-dihydro-1H-purin-6-ones 9-14, 6-amino-8,9-disubstituted-3,9-dihydro-2H-purin-2-ones 15-20, 8,9-disubstituted-3,9-dihydro-2H-purin-2,6-diamines 21-24 and 6-imino-1-phenyl-8,9-disubstituted-6,9-dihydro-1H-purin-2-(3H)-ones 25-26 were synthesized in one step using formic acid, urea, guanidine carbonate, and Ph isocyanate, resp., whereas 8,9-disubstituted-9H-purin-6-amines 27-31 and 6-imino-8,9-disubstituted-6,9-dihydro-1H-purin-1-amines 32-33 were obtained in two steps using formamide and hydrazine, resp. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Electric Literature of 5098-14-6

The Article related to disubstituted purine preparation, aminoimidazole carbonitrile preparation cyclization urea guanidine carbonate phenyl isocyanate, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Electric Literature of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 8, 2020, Liao, Tzu-Ying; Easton, Christopher D.; Thissen, Helmut; Tsai, Wei-Bor published an article.Product Details of 5098-14-6 The title of the article was Aminomalononitrile-Assisted Multifunctional Antibacterial Coatings. And the article contained the following:

Medical device associated infections remain a significant problem for all classes of devices at this point in time. Here, we have developed a surface modification technique to fabricate multifunctional coatings that combine antifouling and antimicrobial properties. Zwitterionic polymers providing antifouling properties and quaternary ammonium containing polymers providing antimicrobial properties were combined in these coatings. Throughout this study, aminomalononitrile (AMN) was used to achieve one-step coatings incorporating different polymers. The characterization of coatings was carried out using static water contact angle (WCA) measurements, XPS, profilometry, and SEM, whereas the biol. response in vitro was analyzed using Staphylococcus epidermidis and Escherichia coli as well as L929 fibroblast cells. Zwitterionic polymers synthesized from sulfobetaine methacrylate and 2-aminoethyl methacrylate were demonstrated to reduce bacterial attachment when incorporated in AMN assisted coatings. However, bacteria in suspension were not affected by this approach. On the other hand, alkylated polyethylenimine polymers, synthesized to provide quaternary ammonium groups, were demonstrated to have contact killing properties when incorporated in AMN assisted coatings. However, the high bacterial attachment observed on these surfaces may be detrimental in applications requiring longer-term bactericidal activity. Therefore, AMN-assisted coatings containing both quaternary and zwitterionic polymers were fabricated. These multifunctional coatings were demonstrated to significantly reduce the number of live bacteria not only on the modified surfaces, but also in suspension. This approach is expected to be of interest in a range of biomedical device applications. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Product Details of 5098-14-6

The Article related to aminomalononitrile multifunctional antibacterial coating zwitterion biofouling quaternary ammonium, aminomalononitrile, biofouling, coating, contact-killing, quaternary ammonium compounds, zwitterionic polymer and other aspects.Product Details of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts