Category: 51762-67-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51762-67-5, name is 3-Nitrophthalonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C8H3N3O2

The phthalonitrile compund ( 5) was synthesized by the reaction between 5-Methyl-1,3,4-thiadiazole-2-thiol (1) and 3-nitrophthalonitrile (3) in dry DMF in the presence of K2CO3 according to literature [25].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Demirba?, Uemit; Pi?kin, Mehmet; Bayrak, R?za; Durmu?, Mahmut; Kantekin; Journal of Molecular Structure; vol. 1197; (2019); p. 594 – 602;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 51762-67-5, name is 3-Nitrophthalonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51762-67-5, category: nitriles-buliding-blocks

General procedure: 8-hydroxyquinoline-5-sulfonic acid (1.30 g, 5.78 mmol) was dissolved in dry DMF (8.00 mL) at 45 C and anhydrous K2CO3(1.5 g, 11.56 mmol) was added. After stirring for 15 min, 3-nitrophthalonitrile (1) was added dropwise in 2 h with efficient stirring. The reaction mixture was stirred under nitrogen at 45C for 4 days. After being cooled to room temperature, the mixture was poured into ca. 200 mL ice-water media and 1 M HCl (50 mL)was added in it. After completion of the precipitation approximately in 0.5 h, the creamy precipitate that formed was filtered and then washed with ca. 100 mL water until the washings became neutral. Column chromatography with methanol/dichloromethane (5:1) eluent on silica gel was employed to obtain the pure product. As expected, the yellow products were soluble in DMF and DMSO. Yield of 1: 1.36 g (67%); m.p.: Anal. Calc. for C17H9N3O4S (Mw:351.34): C, 58.12; H, 2.58; N, 11.96. Found: C, 57.90; H, 2.56; N,11.81%. FT-IR (KBr disc) n/cm-1: 3082, 3027, 2980 (Ar H), 2240 (CN), 1590, 1574, 1550 (Ar), 1273 (ArOAr), 1191, 1154 (SO2),789, 774, 674. 1H NMR (DMSO-d6): d ppm = 7.10-9.50 (m, 8H, ArH). UV/vis (DMSO): lambdamax = 299, 259.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Guensel, Arma?an; Bilgicli, Ahmet T.; Kirbac, Erkan; Gueney, Sevgi; Kandaz, Mehmet; Journal of Photochemistry and Photobiology A: Chemistry; vol. 310; (2015); p. 155 – 164;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51762-67-5 as follows. Recommanded Product: 3-Nitrophthalonitrile

3-nitrophthalonitrile (0.500 g, 2.888 mmol) was dissolved in anhydrous dimethylformamide (75 mL) under Ar and hydroxymethyl-EDOT (0.500 g, 2.903 mmol) was added. After stirring for 10 min, finely ground anhydrous K2CO3 (1.200 g, 8.682 mmol) was added in portions over 2 h with efficient stirring. The reaction mixture was stirred at room temperature for 120 h under Ar. Then the solution was poured into ice-water. The resulting white solid was collected by filtration and washed first with water and then with hexane. Yield 0.493 g (57%). Mp: 192 C. FT-IR: numax, cm-1 3116.56 (CH, aromatic), 2963.20 (CH, aliphatic), 2230.15 (C?N). 1H NMR (400 MHz, DMSO-d6, 298 K): delta, ppm 7.88-7.69 (3H, benzene -CH), 6.64 (2H, thiophene -CH), 4.63-4.13 (5H, -CH and -CH2). 13C NMR (400 MHz, CDCl3, 298 K): delta, ppm 160.38, 141.00, 140.83, 135.87, 126.21, 118.72, 115.71, 115.35, 113.48, 103.10, 100.16, 71.49, 68.00, 64.77. GC-MS: m/z 298 [M]+. C15H10N2O3S (298.04): calcd. C 60.39, H 3.38, N 9.39; found C 60.37, H 3.37, N 9.40.

According to the analysis of related databases, 51762-67-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Karada?, Sebahattin; Bozo?lu, Ceyda; Kasim ?ener; Koca, Atif; Dyes and Pigments; vol. 100; 1; (2014); p. 168 – 176;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

51762-67-5, name is 3-Nitrophthalonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks

4-(methylthio)phenol (0.809 g, 5.78 mmol) was dissolved in10 cm3 dry DMF and thenfinely dried K2CO3 (~2.00 g, excess) wasadded to this mixture. Then 3-nitrophthalonitrile (1.00 g,5.78 mmol) was added to this mixture dropwise by stirringeffectively at 40 C under the N2 atmosphere. The reaction mixturewas kept for 3 day at this temperature under N2 atmosphere. Afterthe reaction mixture was cooled to room temperature, it waspoured into ca. 200 cm3 ice-water media. The occured precipitatewasfiltered and then washed with ca. 100 cm3 water up to thewashings became neutral. The occured precipitate wasfiltered anddissolved in CHCl3 and washed with%5 NaHCO3 to eliminate thebeginning residual compounds. The creamy solution was thentreated with anhydrous Na2SO4 until become dry andfiltered. Itwas purified by chromatography over a silica gel column by using aeluent that is a mix of CHCl3: MeOH (100/5), giving white powder,(1). Finally, the pure powder was dried in a vacuo. Yield of (1): 1.28 g (83%); m.p. = 119 C; Anal. Calcd forC15H10N2OS (266 g mol1C, 67.65; H, 3.78; N, 10.52 Found: C,67.58; H, 3.52; N, 10.30. FT-IR (cm1); 3068 (w, Ar-CH), 2922 (w,Alip-CH), 2228 (CRN, st), 1610(CC), 1567 (CN), 1484(st), 1273(Ar-S-Alip-CH), 1088, 1009, 985, 847, 795. 1H NMR (DMSO-d6) delta:8.11 (t, 1H, meta to Ar-O-Ar and CN), 7.88 (d, 1H, ortho to Ar-O-Ar),7.52 (d,1H, ortho to CN), 7,367.01 (m, 4H, O-Ar-S) 2.23(s, 3H, CH3-S-Ar). 13C NMR (DMSO-d6) delta: 165.4, 156.7, 141.4, 141.1, 133.5, 133.4,127.1, 126.3, 121.2, 121.1, 118.8, 110.2, 20.4. EI/MS m/z: 266.12 [M]+.

The synthetic route of 51762-67-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Guensel, Arma?an; Guezel, Emre; Bilgicli, Ahmet T.; ?i?man, ?lkay; Yarasir, M. Niluefer; Journal of Photochemistry and Photobiology A: Chemistry; vol. 348; (2017); p. 57 – 67;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51762-67-5, name is 3-Nitrophthalonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Nitrophthalonitrile

2-(3,4-Dimethoxyphenyl)ethanol (2.10?g, 11.56?mmol) was stirred in dry DMSO in the presence of finely ground anhydrous K2CO3 (?2.00?g, excess). After stirring for 30?min under an N2 atmosphere, 3-nitrophthalonitrile (2.00?g, 11.56?mmol) was added to this mixture dropwise. The reaction mixture was monitored by TLC (CHCl3) for 3?days at ca. 50?C. The mixture was then cooled to ambient temperature and poured into ca. 250?mL ice-water. After completion of the precipitation, the solid product was filtered and purified by column chromatography using a mixture of CHCl3:MeOH (2:1 v/v) as the eluent. The obtained products are excellently soluble in CHCl3, THF, DMF and DMSO. Yield of 2: 0.69?g (78%), m.p.: 138?C. Anal. Calc. for C18H16N2O3 (308.33?g/mol): C, 70.12; H, 5.23; N, 9.09. Found: C, 70.09; H, 5.20; N, 9.05%. FT-IR (thin film) nu/cm-1: 3094, 2968, 2832, 2241, 1608, 1582, 1530, 1464, 1405, 1378, 1269, 1159, 1033, 960, 813, 459. 1H NMR ([d6]-DMSO) delta, ppm: 8.10, 7.80, 7.62, 6.85, 6.80, 6.65, 4.40, 3.80, 3.00. 13C NMR ([d6]-DMSO) delta, ppm: 161.5, 149.1, 148.1, 137.1, 130.7, 121.3, 119.1, 116.4, 116.0, 113.6, 113.4, 112.4, 71.1, 63.1, 56.1, 55.9, 34.8.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 51762-67-5, The chemical industry reduces the impact on the environment during synthesis 51762-67-5, name is 3-Nitrophthalonitrile, I believe this compound will play a more active role in future production and life.

Using 3-nitrophthalonitrile (20 mmol) and sodium p-hydroxybenzenesulfonate (20-70 mmol, preferably 60 mmol) as reactants and dimethyl sulfoxide (40-200 mL, preferably 140 mL) as solvent in carbonic acid Potassium (30 to 90 mmol, preferably 80 mmol) is present and under nitrogen protection, the reaction is stirred at room temperature to 60C (preferably 60C) for 24 to 72 hours and monitored by thin layer chromatography. After the reaction was completed, the reaction solution was poured into ice chloroform to precipitate a yellow-white precipitate, which was filtered, washed with ethanol and acetone until the filtrate was colorless, and dried in vacuum at 50 C. to obtain a pale yellow product with a yield of 92%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitrophthalonitrile, other downstream synthetic routes, hurry up and to see.

Electric Literature of 51762-67-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51762-67-5 as follows.

3-Nitrophthalonitrile (1.73 g, 0.01 mol) and 4-tert-butylphenol (1.50 g, 0.01 mol) were dissolved in DMSO (30 mL), LiOH (0.42 g,0.01 mol) was then added. The resulted mixture was then stirred at 50 C for 24 h under N2 atmosphere. The product solution was cooled and then poured into NaCl solution (10% aqueous, 100 mL), the precipitated solid was filtered, washed with water and dried under vacuum. White needles were obtained after recrystallization in toluene. Yield: 51%. m.p. 116-118 C. IR (KBr), nu(cm-1): 3083, 3014, 2232 (C?N), 1695, 1632, 1563, 1506, 1485, 1465, 1429, 1386, 1351, 1275 (C-O-C), 1258, 1222, 1165, 1142, 1015, 938, 917. 1H NMR (400 MHZ, CDCl3, ppm): delta 1.353 (s, 9H, t-butyl), 6.992 (d, 2H, J=7 Hz, Ar-H), 7.245 (d, 1H, J=6 Hz, Ar-H), 7.510 (d, 2H, J=7 Hz, Ar-H), 7.799 (m, 2H, Ar-H), 7.835 (m, 1H, Ar-H). MS, m/z: 298.95 [M+Na]+.

According to the analysis of related databases, 51762-67-5, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51762-67-5, name is 3-Nitrophthalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H3N3O2

3-(2,4-Dimethyl-3-pentyloxy)phthalonitrile (1) was preparedas described previously with some modifications [41].Sodium hydride (1.92 g, 48 mmol, 60% dispersion in mineraloil) was added portion-wise to a cooled DMF (30 mL, 0 C)under argon, and then 2,4-dimethyl-3-pentanol (4.53 g, 39mmol) was added drop-wise, followed by stirring for 1 h. Asolution of 3-nitrophthalonitrile (5.19 g, 30 mmol) in DMF(10 mL) was added slowly to the above solution over 1 h. The resulting solution was warmed to room temperature, andstirred for 1 h. After the reaction, the reaction mixture waspoured into water (500 mL) and stirred for 1 h. The solidformed was recovered by filtration and washed with water(50 mL¡Á3). This crude product was purified by columnchromatography on silica gel using CHCl3 as eluent to givea white solid (4.83 g, 66% yield). 1H NMR (CDCl3, 500MHz): 0.95 (d, 6H), 1.01 (d, 6H), 2.13 (m, 2H), 4.05 (t, 1H),7.26 (d, 1H), 7.28(d, 1H), 7.57 (t, 1H).

The synthetic route of 51762-67-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jiang, Xiaoqing; Yu, Ze; Lai, Jianbo; Zhang, Yuchen; Lei, Ning; Wang, Dongping; Sun, Licheng; Science China Chemistry; vol. 60; 3; (2017); p. 423 – 430;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 51762-67-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51762-67-5, name is 3-Nitrophthalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(. 3. 18 g, 21 17 mmol), anhydrous potassium carbonate (. 15.20 g, 0 11 mol) was added to the IJ IOOml round-bottomed flask, dissolved in acetonitrile and heated to 90 C under nitrogen; 3- nitro-phthalonitrile (. 1.83 g, 10 58 mmol) dissolved in acetonitrile after transfer to constant pressure dropping funnel and slowly added dropwise to the flask, continued after the addition was complete the reaction at 90 C at 18 h; After completion of the reaction, acetonitrile was removed by rotary evaporation under reduced pressure, the residue was extracted with methylene chloride; the resulting crude product with dichloromethane – methanol 30: 1 (v / v) as eluent, separated by silica gel column chromatography to give a pale after yellow oily liquid Technology Xhttp://www.technology-x.net/A61K/201410486382_2.html

The synthetic route of 3-Nitrophthalonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fuzhou University; Liu, Jianyong; Ye, Farong; Lu, Yuan; (24 pag.)CN104311566; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 51762-67-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 51762-67-5 name is 3-Nitrophthalonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

With 3-hydroxybenzoic acid (15mmol) and 3-nitro-phthalonitrile (15mmol) as reactants, the solvent is anhydrous DMSO (30ml), potassium carbonate (45mmol) under nitrogen and the presence, stirred at room temperature The reaction 30 hours, by thin layer chromatography to monitor the end of reaction.The reaction mixture was diluted with sand core funnel filtration, the filtrate was collected, and the filtrate was added to 500ml of ice water mixture, adjusted with 1M hydrochloric acid solution until the solution was acidic precipitation heavy precipitate, was allowed to stand, an organic microporous membrane, repeated washing more times until the solution was neutral, the solid was collected and lyophilized to give a white solid, further use DMF- water purified by recrystallization to give a white desired product, a yield of about 78%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Nitrophthalonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Fuzhou University; Huang, Bindong; Chen, Xingwei; Zheng, Qiaofeng; Ke, Meirong; (19 pag.)CN105622682; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts