Category: 51762-67-5

Application of 51762-67-5, A common heterocyclic compound, 51762-67-5, name is 3-Nitrophthalonitrile, molecular formula is C8H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The synthetic procedure was adopted from Mayukh etal. with some modifications [37]. A mixture of 4-mercaptophenol (1.26g, 0.01mol) and K2CO3 (4.15g, 0.03mol) in dry dimethylformamide (DMF) (25mL) was stirred vigorously in nitrogen atmosphere for 30min and then 3-nitrophthalonitrile (1.75g, 0.01mol) was added into the reaction mixture followed by a stirring for 16h at 90C. The reaction mixture was allowed to cool room temperature and poured into 1M HCl and the precipitate formed was filtered off and washed with water until the filtrate was neutral and dried in vacuum. The precipitate was extracted with ethyl acetate. The combined organic phases were treated with distilled water, dried with anhydrous sodium sulfate and solvent removed under reduced pressure to obtain solid orange colored powder. The product was further purified by chromatography over a silica gel column using Ethyl acetate and hexane (3:1) mixture as eluent. Yield: 1.73g, (68%); m.p. 162-164C. FT-IR numax/cm-1; 3403 (Ar-OH), 3077-2923 (Ar-H), 2241 (C?N). 1H NMR (DMSO-d6) delta/ppm: 10.18 (s, 1H, Ar-OH), 7.84 (d, 1H, Ar-H), 7.68 (t, 1H Ar-H), 7.42 (d, 2H, Ar-H), 7.09 (d, 1H, Ar-H), 6.91ppm (d, 2H, Ar-H); 13C NMR (DMSO-d6) delta/ppm: 160.21 (aromatic C-O), 147.51, 137.76, 134.51, 130.96, 117.97, 116.40 (C?N), 114.57, 110.27. Anal. Calcd. for C14H8N2OS (252.291g/mol); C 66.65, H 3.20, N 11.10; Found: C 66.56, H 3.09, N 11.08. MS (GC/MS): m/z: 252 [M]+.

The synthetic route of 51762-67-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Suerguen, Serdar; Arslano?lu, Yasin; Hamuryudan, Esin; Dyes and Pigments; vol. 100; 1; (2014); p. 32 – 40;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 51762-67-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51762-67-5, name is 3-Nitrophthalonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Using 3-nitrophthalonitrile and N,N-dimethyl-m-hydroxyaniline as reactants,The feed ratio of the two is 1:1 to 1.5 with dimethyl sulfoxide as the solvent.The amount of solvent required is 3 to 4 mL per mmol of 3-nitrophthalonitrile.In the presence of potassium carbonate and nitrogen protection,The reaction is stirred at room temperature ~60C for 48-72 hours.The amount of potassium carbonate used is 1.5 to 3 mmol per mmol of 3-nitro-phthalonitrile.Monitored by thin layer chromatographyThe reaction was terminated when the 3-nitro-phthalonitrile was almost consumed, and water was allowed to stand for 4 to 8 hours.Precipitate, double filter paper atmospheric pressure filtration,Freeze-drying gave a brown-yellow powdery solid, yield 61.15%.

The chemical industry reduces the impact on the environment during synthesis 3-Nitrophthalonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Fuzhou University; Huang Jiandong; Li Xingshu; Peng Xiaohui; (23 pag.)CN107722024; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 51762-67-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51762-67-5, name is 3-Nitrophthalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

3-nitrophthalonitrile (20 mmol) and 2,4,6-tris(dimethylaminomethyl)-phenol (20-70 mmol, preferably 60 mmol) as reactants, dimethyl sulfoxide (40) -200 mL, preferably 140 mL, is the solvent, and the reaction is stirred at room temperature ~ 60C (preferably 60C) for 24 to 72 hours in the presence of potassium carbonate (30 to 90 mmol, preferably 80 mmol) and nitrogen, and monitored by thin layer chromatography. Should be filtered to remove the reaction mixture was insoluble potassium carbonate, evaporated to dryness, adding 50 ~ 100mL of chloroform, stirred and filtered to remove insolubles, evaporated to dryness, add 50 ~ 100mL of water to the solid and 15 ~ 45mL HCl (1mol/L) stirred and filtered to remove insolubles. NaOH was added to the filtrate. The solids were precipitated and filtered. The solids were washed with water and dried in vacuo at 50C to give 3-(2,4,6-tris(dimethylamino). Methyl)-phenoxy)phthalonitrile, yield 64%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitrophthalonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Fuzhou University; Huang Jiandong; Peng Xiaohui; Zheng Bingde; (25 pag.)CN107915740; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 51762-67-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51762-67-5, name is 3-Nitrophthalonitrile, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of compound 1 (1.73 g, 7.29 mol) and 3-nitrophthalonitrile (1.26 g, 7.28 mol) in DMSO (30 mL) was stirred at room temperature for 10 min, and K2CO3 (2.52 g, 1.82 mol) was added with further stirring for 24 h. The reaction mixture was poured into 200 mL ice-water to give a great deal of yellow precipitate, which was collected by filtration and then washed with water. After dryness in vacuo, the product was obtained as a yellow solid (2.04 g, 94%). 1 H NMR (400 MHz, acetone-d6, ppm): d 7.85 (t, J 8.2 Hz, 1 H), 7.75 (d, J 7.6 Hz, 1 H), 7.40 (d, J 8.2 Hz, 2 H), 7.26 (d, J 8.7 Hz, 1 H), 7.19 (d, J 8.2 Hz, 2 H), 3.34 (t, J 7.0 Hz, 2 H), 2.86 (t, J 7.2 Hz), 1.40 (s, 9 H). MS (ESI): m/z 386.12 [M Na].

The chemical industry reduces the impact on the environment during synthesis 3-Nitrophthalonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Peng, Xiao-Hui; Chen, Shao-Fang; Zheng, Bi-Yuan; Zheng, Bing-De; Zheng, Qiao-Feng; Li, Xing-Shu; Ke, Mei-Rong; Huang, Jian-Dong; Tetrahedron; vol. 73; 4; (2017); p. 378 – 384;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51762-67-5 as follows. Recommanded Product: 51762-67-5

General procedure: (1R,2R)-1,2-bis(3-phenylphenyl)ethane-1,2-diol 1 (1.0 mmol,1.0 equiv.) and 4mL of DMSO were placed in two-neck flask under anitrogen atmosphere at room temperature. To this reaction mixturewas added 3- or 4-nitrophthalonitrile (1.0 mmol, 1.0 equiv.) andstirred for 15 min under inert atmosphere. Finely ground anhydrousK2CO3 (1.0 mmol, 1.0 equiv.) was then added to the resultingmixture at room temperature. The reaction was monitored by thin layer chromatography and completed in 2 h. The reaction mixturewas poured into water-ice (1:3 v/v) resulting in the formation oflight-yellow precipitate and then extracted with dichloromethane.The combined organic layer was dried over anhydrous Na2SO4 andthe solvent was evaporated under reduced pressure to give a crudeproduct that was purified by silica gel chromatography. The elutionwas carried out with dichloromethaneeethyl acetate (95:5).

According to the analysis of related databases, 51762-67-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Goek, Halil Zeki; Goek, Ya?ar; Journal of Molecular Structure; vol. 1206; (2020);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts