Category: 591769-05-0

591769-05-0, Name is 3-Cyclopentylacrylonitrile, molecular formula is C8H11N, belongs to nitriles-buliding-blocks compound, is a common compound. In a patnet, author is Fu, Teng, once mentioned the new application about 591769-05-0, Formula: C8H11N.

Flame-responsive aryl ether nitrile structure towards multiple fire hazards suppression of thermoplastic polyester

Multiple fire hazards (heat, smoke, dripping) caused by thermoplastic polymers pose integrated risks. Halogen or phosphorus flame-retardants tend to increase toxic, smoke or dripping hazards due to their flame-retardant mechanism. The physical blending flame-retardants into matrixes also presents a migration dilemma with causing potential environmental threats. Herein, we propose a novel multi-hazards inhibition strategy by chemical-incorporating aryl ether nitrile structures into poly(ethylene terephthalate)(PET), which is a typical thermoplastic polymer and a major contributor of multiple fire hazards. Through flame-responsive cyclotrimerization and aliphatic fragment capture, the flammability risks and multi-hazards (heat, smoke, toxicity, dripping) are significantly suppressed. The limiting oxygen index of the modified PET increases from 21.0 to 31.0. The peak of heat release, total smoke release, and carbon monoxide production decrease by 49.0 %, 31.1 %, and 52.6 %, respectively. The dripping hazards are eliminated, and the UL-94 rating reaches to V-0 level with no dripping production. Hence, this state-of-art strategy supplies a new approach for the fire hazards suppression of thermoplastic polymers.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 591769-05-0. The above is the message from the blog manager. Formula: C8H11N.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 591769-05-0, Name is 3-Cyclopentylacrylonitrile, SMILES is N#C/C=C/C1CCCC1, in an article , author is Hermann, Markus R., once mentioned of 591769-05-0, Category: nitriles-buliding-blocks.

Covalent inhibitor reactivity prediction by the electrophilicity index-in and out of scope

Drug discovery is an expensive and time-consuming process. To make this process more efficient quantum chemistry methods can be employed. The electrophilicity index is one property that can be calculated by quantum chemistry methods, and if calculated correctly gives insight into the reactivity of covalent inhibitors. Herein we present the usage of the electrophilicity index on three common warheads, i.e., acrylamides, 2-chloroacetamides, and propargylamides. We thoroughly examine the properties of the electrophilicity index, show which pitfalls should be avoided, and what the requirements to successfully apply the electrophilicity index are.

Interested yet? Read on for other articles about 591769-05-0, you can contact me at any time and look forward to more communication. Category: nitriles-buliding-blocks.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 591769-05-0, Name is 3-Cyclopentylacrylonitrile, molecular formula is C8H11N. In an article, author is Wang, Lve,once mentioned of 591769-05-0, SDS of cas: 591769-05-0.

Failure analysis of LiNi0.83Co0.12Mn0.05O2/graphite-SiOx pouch batteries cycled at high temperature

The combination of Ni-rich layered oxide and graphite-SiOx is regarded as a high-energy-density system for the lithium-ion power batteries. It is significant to elaborate the failure mechanism of the two materials in full batteries, especially at high temperature. In this study, the failure behavior of LiNi0.83Co0.12Mn0.05O2/graphite-SiOx pouch batteries (>= 50 Ah) cycled at 45 degrees C has been studied by using the non-destructive electrochemical methods and physico-chemical methods for the cathode and anode materials. Compared with the failure mechanism of lithium-ion batteries cycled at room temperature, it is more inclined to occur at high temperature that transition metal ions dissolve out from cathode and deposit on the anode, electrolyte decomposes, and solid electrolyte interphase grows. The resulting phenomena show that the cathode deterioration is slight, and the anode degradation is the main factor of pouch battery degradation. After failure analysis, the concentrationgradient NCM cathode and nitrile-containing electrolyte additive are assembled into the pouch batteries, and the capacity retention increases from 75.24% (pristine batteries at 280 cycles) to 83.44% (improved batteries at 1500 cycles). Therefore, we suggest that power batteries operating at high temperature should be with minimized transition metal dissolution of cathode materials and stable solid electrolyte interphase.

Interested yet? Keep reading other articles of 591769-05-0, you can contact me at any time and look forward to more communication. SDS of cas: 591769-05-0.

Let¡¯s face it, organic chemistry can seem difficult to learn, Quality Control of 3-Cyclopentylacrylonitrile, Especially from a beginner¡¯s point of view. Like 591769-05-0, Name is 3-Cyclopentylacrylonitrile, molecular formula is nitriles-buliding-blocks, belongs to nitriles-buliding-blocks compound. In a document, author is Mallela, Yadagiri L. N. K., introducing its new discovery.

Crosslinked poly(allyl glycidyl ether) with pendant nitrile groups as solid polymer electrolytes for Li-S batteries

Synthesis of Poly(allyl glycidyl ether)s (PAGE), the modification of ally! side chains of PAGE with 3-((2-(2-(2-mercaptoethoxy)ethoxy)ethyl)thio)propanenitrile (CN) and furfuryl mercaptan (FM) (CN/FM-PAGE) for Li-salt dissociation and crosslinking, respectively, is reported. A CN/FM-PAGE with 3% crosslinking ratio as a solid polymer electrolyte (SPE) for Li-S battery exhibits the highest Li-ion conductivity of 1.01 x 10(-4) S cm(-1) with a [Li]/[O] ratio of 0.2 at 30 degrees C. Moreover, the SPEs manifest favorable operation up to 80 charge-discharge cycles with high coulombic efficiency (>95%) and good lithium plating/stripping performance. (C) 2020 Elsevier Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 591769-05-0, Quality Control of 3-Cyclopentylacrylonitrile.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 591769-05-0, 591769-05-0, Name is 3-Cyclopentylacrylonitrile, SMILES is N#C/C=C/C1CCCC1, belongs to nitriles-buliding-blocks compound. In a document, author is Chen, Lin, introduce the new discover.

Simulation and experimental study of a new structural rubber seal for the roller-cone bit under high temperature

Seal element is an important component of roller-cone bit. In order to improve the sealing performance and service life of roller-cone bit under high temperature, a new seal structure with multi-segment arcs is designed and the structural parameters of this sealing ring are optimized by response surface method and finite element method. Firstly, the hydrogenated nitrile-butadiene rubber is used to improve the seal performance under high temperature, and the uniaxial, planar, and biaxial tensile experiments are carried out to study the constitutive model of this rubber. Then, a three-dimension transient thermo-mechanical coupling model is established. The comparison of sealing performance between the new structural seal and the traditional O-ring seal is implemented under high temperature through the proposed FEM and laboratory experiments. The results show that the new structural seal has lower contact pressure and Mises stress than the standard O-ring seal, and the service life of the former is almost twice of the later one. Additionally, a composite drill bit using the new structural seal is applied to a deep drilling. After servicing a certain time, it shows that the wearing capacity is very small. The results show that the new structure seal ring can adapt to high temperature environment and the optimization method is feasible.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 591769-05-0 is helpful to your research. Recommanded Product: 591769-05-0.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 591769-05-0, name is 3-Cyclopentylacrylonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 591769-05-0

To a solution of ethyl 4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-3-formate (173 mg, 0.446 mmol, 1.0 eq.) and 3-cyclopentylacrylonitrile (135 mg, 1.11 mmol, 2.5 eq., prepared from the step A of Example 1) in acetonitrile (10 mL) was added 1,8-diazabicyclo[5.4.0]undec-7-ene (142 mg, 0.94 mmol, 2.1 eq.) at room temperature. The reaction liquid was stirred overnight at room temperature, then heated to 60¡ãC and reacted for 5 hrs. After the mixture was cooled to room temperature, the mixture was diluted with brine and ethyl acetate, and extracted with ethyl acetate. The combined organic phase was dried over sodium sulfate, filtered and concentrated in vacuo. The resulting residue was separated by column chromatography on silica gel column to give the titled compound (79 mg, 35percent yield), as a off-white solid. 1H NMR (CDCl3) delta 8.88 (1H, s), 7.98 (1H, s), 7.32 (1H, d, J = 3.6 Hz), 6.46 (1H, d, J = 3.6 Hz), 5.65 (2H, s), 4.27-4.35 (1H, m), 4.23 (2H, q, J = 7.2 Hz), 3.53 (2H, t, J = 8.4 Hz), 3.11 (1H, dd, J = 17.2 Hz, 7.6 Hz), 2.97 (1H, dd, J = 17.2 Hz, 4.0 Hz), 2.58-2.69 (1H, m), 1.88-1.99 (1H, m), 1.51-1.74 (4H, m), 1.22-1.30 (3H, m), 1.08 (3H, t, J = 7.2 Hz), 0.90 (2H, t, J = 8.4 Hz), -0.05 (9H, s). m/z=509[M+1]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Centaurus BioPharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co.,Ltd; Lianyungang Runzhong Pharmaceutical Co., Ltd.; ZHU, Li; XIAO, Dengming; HU, Yuandong; DAI, Liguang; DUAN, Xiaowei; SUN, Yinghui; PENG, Yong; KONG, Fansheng; LUO, Hong; HAN, Yongxin; YANG, Ling; WANG, Shanchun; (94 pag.)EP3235819; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 591769-05-0, name is 3-Cyclopentylacrylonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 591769-05-0, SDS of cas: 591769-05-0

To a solution of 4-[3-(difluoromethyl)-1H-pyrazol-4-yl)-7-{[2-(trimethylsilyl)ethoxy] methyl}-7H-pyrrolo[2,3-d]pyrimidine (1.0 eq.) and 3-cyclopentylacrylonitrile (2.5 eq., prepared from the step A of Example 1) in acetonitrile was added 1,8-diazabicyclo[5.4.0]undec-7-ene (2.0 eq.) at room temperature. The reaction liquid was stirred for 5 hrs at room temperature, then warmed to 60¡ãC and stirred overnight. After the reaction liquid was cooled to room temperature, the reaction liquid was diluted with brine and ethyl acetate, and extracted with ethyl acetate. The combined organic phase was dried over sodium sulfate, filtered and concentrated in vacuo. The resulting residue was separated by column chromatography on silica gel column to give the titled compound. m/z=487[M+1]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Cyclopentylacrylonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Centaurus BioPharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co.,Ltd; Lianyungang Runzhong Pharmaceutical Co., Ltd.; ZHU, Li; XIAO, Dengming; HU, Yuandong; DAI, Liguang; DUAN, Xiaowei; SUN, Yinghui; PENG, Yong; KONG, Fansheng; LUO, Hong; HAN, Yongxin; YANG, Ling; WANG, Shanchun; (94 pag.)EP3235819; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 591769-05-0, name is 3-Cyclopentylacrylonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Cyclopentylacrylonitrile

To a solution of 4-(1H-pyrazol- 4-yl)-7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidine (15.0 g, 0.0476 mol) in ACN (300 mL) was added 3-cyclopentylacrylonitrile (15 g, 0.12 mol) (as a mixture of cis and trans isomers), followed by DBU (15 mL, 0.10 mol). The resulting mixture was stirred at room temperature overnight. The ACN was evaporated. The mixture was diluted with ethyl acetate, and the solution was washed with 1.0 N HCl. The aqueous layer was back-extracted with three portions of ethyl acetate. The combined organic extracts were washed with brine, dried over sodium sulfate, filtered and concentrated. The crude product was purified by silica gel chromatography (gradient of ethyl acetate/hexanes) to yield a viscous clear syrup, which was dissolved in ethanol and evaporated several times to remove ethyl acetate, to afford 19.4 g of racemic adduct (93percent). The enantiomers were separated by preparative-HPLC, (OD-H column, 15percent ethanol/hexanes) and used separately in the next step to generate their corresponding final product. The final products (see Step 3) stemming from each of the separated enantiomers were found to be active JAK inhibitors; however, the final product stemming from the second peak to elute from the preparative-HPLC was more active than its enantiomer. The products may be isolated by preparative HPLC or other means known to those of skill in the art for use in Step 3 below. 1H NMR (300 MHz, CDCl3): delta 8.85 (s, 1H), 8.32 (s, 2H), 7.39 (d, 1H), 6.80 (d, 1H), 5.68 (s, 2H), 4.26 (dt, 1H), 3.54 (t, 2H), 3.14 (dd, 1H), 2.95 (dd, 1H), 2.67-2.50 (m, 1H), 2.03- 1.88 (m, 1H), 1.80-1.15 (m, 7H), 0.92 (t, 2H),?0.06 (s, 9H); MS(ES): 437 (M+1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ACERTA PHARMA B.V.; HAMDY, Ahmed; ROTHBAUM, Wayne; IZUMI, Raquel; LANNUTTI, Brian; COVEY, Todd; ULRICH, Roger; JOHNSON, Dave; BARF, Tjeerd; KAPTEIN, Allard; (637 pag.)WO2015/193740; (2015); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 591769-05-0, name is 3-Cyclopentylacrylonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H11N

(3R)- and (3S)-3-Cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile[0112] To a solution of 4-(1H-pyrazol-4-yl)-7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidine(15.0 g, 0.0476 mol) in ACN (300 mL) was added 3-cyclopentylacrylonitrile (15 g, 0.12 mol) (as a mixture of cisand trans isomers), followed by DBU (15 mL, 0.10 mol).The resulting mixture was stirred at room temperatureovernight. The ACN was evaporated. The mixture wasdiluted with ethyl acetate, and the solution was washedwith 1.0 N HCl. The aqueous layer was back-extractedwith three portions of ethyl acetate. The combined organic extracts were washed with brine, dried over sodiumsulfate, filtered and concentrated. The crude product waspurified by silica gel chromatography (gradient of ethylacetate/hexanes) to yield a viscous clear syrup, whichwas dissolved in ethanol and evaporated several timesto remove ethyl acetate, to afford 19.4 g of racemic adduct (93percent). The enantiomers were separated by preparative-HPLC, (OD-H, 15percent ethanol/hexanes) and usedseparately in the next step to generate their corresponding final product. The final products (see Step 3) stemming from each of the separated enantiomers were foundto be active JAK inhibitors; however, the final productstemming from the second peak to elute from the preparative-HPLC was more active than its enantiomer.1H NMR (300 MHz, CDCl3): delta8.85 (s, 1H), 8.32 (s, 2H),7.39 (d, 1H), 6.80 (d, 1H), 5.68 (s, 2H), 4.26 (dt, 1H), 3.54(t, 2H), 3.14 (dd, 1H), 2.95 (dd, 1H), 2.67-2.50 (m, 1H),2.03-1.88 (m, 1H), 1.80-1.15 (m, 7H), 0.92 (t, 2H), -0.06(s, 9H); MS(ES):437 (M+1).

The synthetic route of 3-Cyclopentylacrylonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Incyte Holdings Corporation; FRIEDMAN, Paul A.; FRIDMAN, Jordan S.; LUCHI, Monica E.; WILLIAMS, William V.; (27 pag.)EP2349260; (2016); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 591769-05-0, name is 3-Cyclopentylacrylonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 591769-05-0, category: nitriles-buliding-blocks

0.15g of compound 3 and 0.14g of compound 5a were dissolved in 30mL acetonitrile. To the above solution, 0.10g of 1,8-diazabicyclo undec-7-ene was added and reacted at 65¡ãC for 5-6 days. After distilling off the solvent, it was dissolved in ethyl acetate then water and aqueous citric acid solution was added. 100mL saturated sodium chloride solution was washed 3 times each. The organic phase was dried over anhydrous magnesium sulfate overnight. The mixture was filtered and the solvent was distilled off under reduced pressure to give a crude product. The product was purified by column chromatography (methylene chloride/methanol 80:1) to give 0.10g of intermediate 6a as a yellow solid, yield: 37percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Cyclopentylacrylonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Shandong University; Zhang, Yingjie; Xu, Wenfang; Liang, Xuewu; (24 pag.)CN105418616; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts