Category: 612-13-5

Janssen-Mueller, Daniel published the artcileAnnulation of o-Quinodimethanes through N-Heterocyclic Carbene Catalysis for the Synthesis of 1-Isochromanones, Safety of 2-(Chloromethyl)benzonitrile, the publication is Organic Letters (2016), 18(17), 4444-4447, database is CAplus and MEDLINE.

The activation of 2-(bromomethyl)benzaldehydes using N-heterocyclic carbenes represents a novel approach to the generation of o-quinodimethane (o-QDM) intermediates. Coupling with ketones such as phenylglyoxylates, isatins, or trifluoromethyl ketones via [4 + 2] annulation gives access to functionalized 1-isochromanones.

Organic Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Safety of 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, Victor E. published the artcileA convenient synthesis of benzofuro[3,2-c]isoquinolines and naphtho[1′,2′:4,5]furo[3,2-c]isoquinolines, Product Details of C8H6ClN, the publication is Tetrahedron Letters (2011), 52(14), 1557-1560, database is CAplus.

A convenient method for the preparation of benzofuro[3,2-c]isoquinoline derivatives is described. The condensation reaction of Me 2-(chloromethyl)benzoate with substituted salicylonitriles (I) and intramol. cyclization of the resulting substituted Me 2-[(2-cyanobenzyl)oxy]benzoates using potassium tert-butoxide results in substituted benzofuro[3,2-c]isoquinolin-5(6H)-ones. The same sequence of reactions starting from 2-(chloromethyl)benzonitrile and I gave substituted 5-aminobenzofuro[3,2-c]isoquinolines. In addition, this method is useful for the synthesis of other heterocycles. For example, using 1-cyano-2-naphthol, instead of I, gives naphtho[1′,2′:4,5]furo[3,2-c]isoquinolines.

Tetrahedron Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Product Details of C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, V. E. published the artcileThe synthesis of substituted 5-aminopyrido[3′,2′:4,5]thieno[3,2-c]isoquinolines and their sulfinyl and sulfonyl derivatives, Formula: C8H6ClN, the publication is Russian Chemical Bulletin (2018), 67(5), 902-911, database is CAplus.

5-Aminopyrido[3′,2′:4,5]thieno[3,2-c]isoquinolines were synthesized via alkylation of 3-cyanopyridine-2(1H)-thiones with 2-(chloromethyl)benzonitrile followed by treatment of the products with potassium tert-butoxide. The oxidation of the alkylated products to corresponding sulfoxides or sulfones followed by treatment with potassium tert-butoxide provided the corresponding 11-oxides or 11,11-dioxides.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Formula: C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, V. E. published the artcileThe synthesis of 3-cyano-2-(organylamino)thieno[3,2-c]isoquinoline derivatives, Quality Control of 612-13-5, the publication is Russian Chemical Bulletin (2019), 68(3), 588-596, database is CAplus.

A method for the preparation of 3-cyano-2-(organylamino)thieno[3,2-c]isoquinoline derivatives was developed. Alkylation of (2,2-dicyano-1-organylaminovinyl)thiolates with Me 2-(chloromethyl)benzoate or N-substituted 2-(chloromethyl)benzamides with the subsequent treatment of the alkylation products with potassium tert-butoxide gave 3-cyano-2-(organylamino)thieno[3,2-c]isoquinolin-5(4H)-ones. In the case of utilization of (chloromethyl)benzonitrile in this synthesis, 5-amino-3-cyano-2-organylaminothieno[3,2-c]iso-quinolines were obtained.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Quality Control of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, V. E. published the artcileSynthesis of 5-aminopyrido[3′,2′:4,5]thieno[3,2-c]isoquinoline derivatives from 3-cyanopyridine-2(1H)-thiones and 2-(chloromethyl)benzamide, Formula: C8H6ClN, the publication is Russian Chemical Bulletin (2018), 67(8), 1492-1499, database is CAplus.

Substituted 5-aminopyrido[3′,2′:4,5]thieno[3,2-c]isoquinolines were synthesized by condensation of substituted 3-cyanopyridine-2(1H)-thiones with 2-(chloromethyl)benzamide and subsequent treatment of the condensation products with potassium tert-butoxide. Oxidation of the condensation products to sulfoxides and sulfones followed by treatment of these compounds with potassium tert-butoxide gave substituted 5-aminopyrido[3′,2′:4,5]thieno[3,2-c]isoquinoline 11-oxides and substituted 5-aminopyrido[3′,2′:4,5]thieno[3,2-c]isoquinoline 11,11-dioxides in good yields.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Formula: C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, V. E. published the artcileSynthesis of substituted 5-aminobenzothieno[3,2-c]isoquinolines and their sulfinyl and sulfonyl derivatives, Category: nitriles-buliding-blocks, the publication is Russian Chemical Bulletin (2015), 64(4), 878-882, database is CAplus.

A method for the preparation of substituted 5-aminobenzothieno[3,2-c]isoquinolines I, (R = H, Me, Cl), in good yields by the condensation of substituted 2-mercaptobenzonitriles with 2-(chloromethyl)benzonitrile and a subsequent treatment of the condensation products with potassium tert-butoxide was suggested. The oxidation of the condensation products to sulfoxides or sulfones and a subsequent treatment of these compounds with potassium tert-butoxide led to the preparation of substituted 5-aminobenzothieno[3,2-c]isoquinoline 11-oxides or 5-aminobenzothieno[3,2-c]isoquinoline 11,11-dioxides in good yields.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, V. E. published the artcileSynthesis of derivatives of pyrido[3′,2′:4,5]furo[3,2-c]isoquinoline heterocyclic system, Computed Properties of 612-13-5, the publication is Russian Chemical Bulletin (2014), 63(2), 426-430, database is CAplus.

An approach to the synthesis of derivatives of new heterocyclic system, pyrido[3′,2′:4,5]-furo[3,2-c]isoquinoline I [R = R¹= Me; R = Ph, R¹ = 4-MeC₆H₄, 2-thienyl; R = CF₃, R¹ = Ph], was suggested. A condensation reaction of substituted 3-cyanopyridin-2(1H)-ones with Me 2-(chloromethyl)benzoate and subsequent treatment of the condensation product with potassium tert-butoxide leads to substituted pyrido[3′,2′:4,5]furo[3,2-c]-isoquinolin-5(6H)-ones. Similarly, a condensation reaction of substituted 3-cyanopyridin-2(1H)-ones with 2-(chloromethyl)benzonitrile and subsequent treatment of the condensation product with potassium tert-butoxide gives substituted 5-aminopyrido[3′,2′:4,5]furo[3,2-c]-isoquinolines II.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Computed Properties of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhang, Hong-Jian published the artcileSynthesis and pharmacological evaluation of new 3,4-dihydroisoquinolin derivatives containing heterocycle as potential anticonvulsant agents, Formula: C8H6ClN, the publication is Molecules (2016), 21(12), 1635-1650, database is CAplus and MEDLINE.

Novel, fused 3,4-dihydroisoquinolines I (R¹ = H, Me, n-C₅H₁₁, etc.) and II [R² = n-C₆H₁₃ (III), n-C₇H₁₅, n-C₈H₁₇, PhCH₂, 4-ClC₆H₄CH₂] were synthesized and evaluated for their anticonvulsant activity using maximal electroshock (MES) test and pentylenetetrazole (PTZ)-induced seizure test. Among them, compound III showed significant anticonvulsant activity in MES tests with an ED₅₀ value of 63.31 mg/kg and it showed wide margins of safety with protective index (PI > 7.9). Compound III showed much higher anticonvulsant activity than that of valproate. Compound III also demonstrated potent activity against PTZ-induced seizures. A docking study of compound III in the benzodiazepine (BZD)-binding site of γ-aminobutyric acid_A (GABA_A) receptor confirmed possible binding of compound with the BZD receptors.

Molecules published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C5H7NO, Formula: C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Huang, R. published the artcileSynthesis and performances of extended conjugated stilbene fluorescent dye, Application In Synthesis of 612-13-5, the publication is Pigment & Resin Technology (2017), 46(4), 1-14, database is CAplus.

The purpose of this research is to explore the optical performance of extended stilbene derivative Five steps were adopted to synthesize novel 4, 4′-bis(2-cyanostyryl) stilbene, which contained three vinyl units in the skeleton (S3E). The structure of S3E was characterized by ¹H NMR and EI-MS. Its absorption and emission spectra were given as well. Compared to C.I. Fluorescent Brightener 199, which contains two vinyl units in the skeleton, S3E showed obvious bathochromic shifts in both UV-VIS and FL spectra. The maximum absorption wavelength and fluorescent wavelength were at 390 nm and 464 nm, resp., with Stoke’s shift of 74 nm. The absolute fluorescence quantum yield was 0.42. Thermogravimetric anal. revealed that the weight loss of S3E was less than 5% at 300°C. Moreover, the light resistance test showed that S3E in PVC plate can keep the good fluorescent intensity for more than 7 days exposed to xenon light. Therefore, it is believed that S3E could satisfy the requirements of coloring PVC as a fluorescent dye. S3E can be used as a candidate of fluorescent dye in the development of thermoplastics. The present work designed and synthesized a new derivative of stilbene, which could become a preferred colorant for thermoplastics.

Pigment & Resin Technology published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ustinov, A. K. published the artcileSynthesis of γ-carbolines containing NO-donor fragment and assessment of their anticholinesterase activity, Category: nitriles-buliding-blocks, the publication is Russian Chemical Bulletin (2016), 65(11), 2718-2721, database is CAplus.

Hybrid γ-carboline-based compounds containing a nitrooxy group as an NO-donor were prepared It was shown that the introduction of this group did not affect the inhibitory activity of γ-carboline pharmacophore against acetyl- and butyrylcholinesterase.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C5H5F3O2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts