Category: 6306-60-1

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6306-60-1 as follows. Product Details of 6306-60-1

EXAMPLE IV A mixture of 18.5 parts of 2,4-dichlorobenzeneacetonitrile and 180 parts of N,N-dimethylformamide is stirred and cooled in an ice-bath while nitrogen gas is introduced. 3.2 Parts of a sodium hydroxide solution 78% are added portionwise and the whole is stirred for one hour. Then there are added dropwise, during a one hour-period, 17.8 parts of (bromomethyl)cyclohexane while still cooling and while nitrogen gas is still introduced. Upon completion, stirring is continued for 2 hours at room temperature. The reaction mixture is poured onto water. The precipitated product is filtered off and triturated in a mixture of methanol and water. The product is filtered off and dried, yielding 25.5 parts of 2,4-dichloro-alpha-(cyclohexylmethyl)benzeneacetonitrile; mp. 58.8 C.

According to the analysis of related databases, 6306-60-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Janssen Pharmaceutica N.V.; US4598085; (1986); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 6306-60-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6306-60-1 as follows.

A. 2-(2,4-Dichlorophenyl)-4,4,4-trifluoro-3-oxobutanenitrile Slurry 2,4-dichlorophenylacetonitrile (I) (5.0 g, 26.9 mmol, 186.04 g/mol) in ethyl trifluoroacetate (6.4 mL, 7.6 g, 142.08 g/mol) and add 20 mL anhydrous THF. Portionwise at ambient temperature add NaH (1.88 g, 47.1 mmol, 60% in mineral oil) over 5 minutes. Heat reaction to reflux (90 C. bath temperature) overnight. Evaporate to thick red-brown oil and partition between Et2O (100 mL) and H2O (60 mL). Separate layers and extract H2O with Et2O (2*75 mL). Acidify the aqueous layer with 1.0 N HCl to pH 1 (becomes cloudy white suspension) and extract aqueous layer with CH2Cl2 (3*100 mL). Dry pooled CH2Cl2 layers over Na2SO4, filter and concentrate to yellow oil (7.5 g, 26.5 mmol). Use without further purification. LCMS=281.9 (MH+); 279.8 (M-)

According to the analysis of related databases, 6306-60-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Neurogen Corporation; Pfizer Inc.; US6372743; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 6306-60-1,Some common heterocyclic compound, 6306-60-1, name is 2-(2,4-Dichlorophenyl)acetonitrile, molecular formula is C8H5Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of alpha-(2,4-dichlorophenyl)-alpha-hydroxymethylene acetonitrile 0.6 g of metal sodium was added to dry ethanol to obtain an ethanol solution of sodium ethoxide. Then, a mixed liquid comprising 37.2 g of 2,4-dichlorophenyl acetonitrile and 22.2 g of ethyl formate, was added thereto under heating to 70 C. After the addition, the mixture was further heated and refluxed for 2 hours and then, left to stand for 1 day. The reaction solution was cooled to 0 C. and then subjected to filtration. After washing with diethyl ether, the sodium salt collected by filtration was added to 130 ml of distilled water, and 9 ml of acetic acid was dropwise added thereto under cooling at 0 C. After the dropwise addition, the mixture was stirred at room temperature for about 30 minutes. Then, the formed precipitate was collected by filtration and washed with water. It was dried to obtain 31.7 g (yield: 74%) of the desired product. Melting point: 162-163 C.

The synthetic route of 6306-60-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kumiai Chemical Industry Co., Ltd.; Ihara Chemical Industry Co., Ltd.; US6048823; (2000); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6306-60-1 as follows. Formula: C8H5Cl2N

EXAMPLE IV A mixture of 18.5 parts of 2,4-dichlorobenzeneacetonitrile and 180 parts of N,N-dimethylformamide is stirred and cooled in an ice-bath while nitrogen gas is introduced. 3.2 Parts of a sodium hydroxide solution 78% are added portionwise and the whole is stirred for one hour. Then there are added dropwise, during a one hour-period, 17.8 parts of (bromomethyl)cyclohexane while still cooling and while nitrogen gas is still introduced. Upon completion, stirring is continued for 2 hours at room temperature. The reaction mixture is poured onto water. The precipitated product is filtered off and triturated in a mixture of methanol and water. The product is filtered off and dried, yielding 25.5 parts of 2,4-dichloro-alpha-(cyclohexylmethyl)benzeneacetonitrile; mp. 58.8 C.

According to the analysis of related databases, 6306-60-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Janssen Pharmaceutica N.V.; US4598085; (1986); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

6306-60-1, name is 2-(2,4-Dichlorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks

EXAMPLE VIII To a stirred mixture of 18.5 parts of 2,4-dichlorobenzeneacetonitrile, 90 parts of N,N-dimethylformamide and 67.5 parts of benzene are added portionwise 3.2 parts of a sodium hydride dispersion 78% while nitrogen gas is introduced. After stirring for 1 hour at room temperature, 14.5 parts of (2-chloroethyl)cyclohexane are added. The whole is stirred first for 5 hours at 40-50 C. and further overnight at room temperature. The reaction mixture is poured onto water and the product is extracted twice with 2,2′-oxybispropane. The combined extracts are washed twice with water, dried, filtered and evaporated. The residue is distilled, yielding 16 parts (54%) of 2,2′-dichloro-alpha-(2-cyclohexylethyl)benzeneacetonitrile; bp. 145-148 C. at 0.05 mm. pressure.

The synthetic route of 6306-60-1 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 6306-60-1, name is 2-(2,4-Dichlorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-(2,4-Dichlorophenyl)acetonitrile

A suspension of sodium hydride (2.16 g) in dry dimethylsulphoxide (DMSO: 70 ml) was stirred at 50 C. under a nitrogen atmosphere for 2.5 hours and then cooled to 15 C. in an ice bath. A mixture of 2,4-dichlorophenylacetonitrile (8.37 g) and 3-methanesulphonyloxyhex-1-yl methanesulphonate (14.27 g) in DMSO (70 ml) was added dropwise to this solution over 15 minutes. The reaction mixture was stirred at room temperature for 0.5 hours, at 90 C. for 3 hours, and at 130 C. for 2 hours, and was then allowed to cool, diluted with water, and extracted with ether. The extracts were washed with water, dried over magnesium sulphate and concentrated to give a dark coloured oil (7.76 g). Purification of this crude product by bulb-to-bulb distillation gave a mixture of diastereomers of 1-cyano-1-(2,4-dichlorophenyl)-3-prop-1-ylcyclopentane (4.95 g, 39%) as a colourless oil (oven temperature: 230 C., ca. 10 torr).

The synthetic route of 2-(2,4-Dichlorophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Imperial Chemical Industries Plc; US4684396; (1987); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts