Category: 654-70-6

Related Products of 654-70-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, This compound has unique chemical properties. The synthetic route is as follows.

Preparation by process ?B?: 14.74 g (79.21 mmol) of 4-amino-2-trifluoromethyl-benzonitrile were dissolved in 200 ml of dry acetonitrile. This solution was added dropwise with stirring to a 20% solution, heated to 70 C., of phosgene in toluene and then stirred for 1 h. The cooled reaction solution was concentrated under reduced pressure, and the residue was taken up with toluene and concentrated again under reduced pressure. Finally, the residue was dissolved in 150 ml of dry acetonitrile and the solution was admixed with stirring with 15.5 g (79.21 mmol) of tert-butyl 2-amino-2-methylpropionate hydrochloride. 12.02 g (118.8 mmol) of triethylamine were slowly added dropwise to the reaction mixture and then it was stirred at room temperature for 45 min. Thereafter, the mixture was admixed cautiously with 50 ml of concentrated hydrochloric acid and stirred at 70 C. for 1 h. The cooled reaction mixture was concentrated under reduced pressure and the residue was admixed with ethyl acetate and water. The organic phase was removed, washed with saturated sodium hydrogencarbonate solution and then with water, dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by chromatography using silica gel with 2:1 heptane /ethyl acetate. This afforded 21.2 g (90% yield) of 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile 1.2 with melting point 208-211 C.

The chemical industry reduces the impact on the environment during synthesis 4-Cyano-3-trifluoromethylaniline. I believe this compound will play a more active role in future production and life.

Reference:
Patent; SANOFI-AVENTIS; US2011/178134; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 654-70-6, name: 4-Cyano-3-trifluoromethylaniline

At room temperature, 1 ml of thiophosgene is added to 22 ml of water to form a suspension.Then 2.23 g of 4-amino-2-trifluoromethylbenzonitrile was added dropwise to the above solution.The dropwise addition time was 20 minutes, and after completion of the dropwise addition, stirring was continued for 1 hour at room temperature. After completion of the reaction, the reaction solution was extracted with 2 x 20 ml of methylene chloride. The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure (about 0.4 mmHg) to give 2.72 g of the title compound,Brown oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Cyano-3-trifluoromethylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Beijing Haimeiyuan Pharmaceutical Technology Co., Ltd.; Wang Yingzhao; Di Wei; Liu Yanling; (34 pag.)CN104341351; (2018); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts