Category: 75629-62-8

On February 15, 2022, Paul, Priya Kumari; Mehta, Raj Kumar; Yadav, Mahendra; Obot, I. B. published an article.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Theoretical, electrochemical and computational inspection for anti-corrosion activity of triazepine derivatives on mild steel in HCl medium. And the article contained the following:

The two triazepine derivatives, 2-amino-9-(1H-indol-3-yl)-4-(4-methoxyphenyl)-7-oxo-1,7-dihydropyrido[1,2-b][1,2,4]triazepine-3,8,10-tricarbonitrile [AITT] and Et 2-amino-8,10-dicyano-9-(2-hydroxy-3-methoxyphenyl)-4-(4-methoxyphenyl)-7-oxo-1,7-dihydropyrido [1,2 -b][1,2,4]triazepine-3-carboxylate [EHTC] were successfully synthesized and demonstrated as corrosion inhibitor for mild steel in 15% HCl medium. Their auspicious inhibiting performance was measured by weight loss measurement and the electrochem. impedance spectroscopic method. The adsorption of inhibitors chem. or phys. on the exposed metal surface is the main key factor behind the protection mechanism. The investigation at an optimum concentration of 200 ppm (303 K) showed the inhibitor AITT and EHTC with 96.88% and 95.56% inhibition efficiency. The functional groups attached to inhibitor AITT encourages the electron d. over the whole mol. and makes it more efficient as a corrosion inhibitor than EHTC. The minimization of cathodic as well as anodic reactions from the potentiodynamic polarization method reveals the inhibitors as mixed-type inhibitors which is also supported by the computed free energy of adsorption values from best fitted Langmuir Adsorption isotherm. The extreme improvement in damaged surface (inhibitor-free medium) was found on the application of inhibitors which is characterized by the surface topog. analyses FESEM and AFM. The elemental anal. of the inhibited metal surface was executed by XPS anal. The computational methods as Monte-Carlo Simulation, DFT and Fukui calculations, were also employed for the justification of outcomes from exptl. methods. All the observations were mutually supported. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to triazepine derivative synthesis mild steel anti corrosion evaluation, Placeholder for records without volume info and other aspects.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

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On May 31, 1987, Morales-Rios, M. S.; Espineira, J.; Joseph-Nathan, P. published an article.Related Products of 75629-62-8 The title of the article was Carbon-13 NMR spectroscopy of indole derivatives. And the article contained the following:

The chem. shifts of 298 naturally occurring and synthetic compounds containing the indole chromophoric group are listed. Substituent effects on 13C chem. shifts (SCS) induced by substitution on the heteroaromatic five-membered ring are discussed. The data provide a reference set for future 13C NMR investigations and highlight the need for unambiguous exptl. evidence to resolve controversial assignments for differently substituted representative indole derivatives Many original assignments have been changed, and values not considered to be unambiguously assigned are delineated. The 1J(CH) values for the parent indole were measured. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Related Products of 75629-62-8

The Article related to carbon nmr indole derivative, Alkaloids: Alkaloids Containing Two Nitrogen Atoms and other aspects.Related Products of 75629-62-8

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On September 30, 2018, Hebishy, Ali M. S.; Abdelhamid, Ismail A.; Elwahy, Ahmed H. M. published an article.Product Details of 75629-62-8 The title of the article was Synthesis of novel bis(dihydropyridine) and terpyridine derivatives. And the article contained the following:

A synthesis of novel bis(cyanopyridones) by the reaction of the appropriate bis(cyanoacetamide) with the corresponding arylidenemalononitrile in the presence of basic catalysts was reported. In some cases, the corresponding bis(2-cyano-3-arylacrylamide) derivatives were isolated from these reactions as single products. The multicomponent strategy for the synthesis of the target compounds was also investigated. The utility of bis(cyanoacetamides) as building blocks for novel bisquinolinones was also studied. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Product Details of 75629-62-8

The Article related to cyanopyridone preparation, cyanoacetamide arylidenemalonitrile michael addition cyclization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Product Details of 75629-62-8

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Srour, Aladdin M.; Dawood, Dina H.; Saleh, Dalia O. published an article in 2021, the title of the article was Synthesis, 3D-pharmacophore modelling and 2D-QSAR study of new pyridine-3-carbonitriles as vasorelaxant active agents.Related Products of 75629-62-8 And the article contains the following content:

A new set of pyridine-3-carbonitriles conjugated with various five-membered ring systems at pyridinyl C-6 were designed and synthesized as vasorelaxant active agents. The majority of the new target derivatives exhibited noteworthy vasodilation efficacy and nine compounds were the most potent analogs with IC50 values = 220.7, 256.7, 164.1, 252.2, 229.8, 265.2, 247.9, 239.1 and 159.8μM, resp., which were superior to that of prazosin hydrochloride (IC50 = 272.8μM). Moreover, four compounds displayed significant α1-adrenergic receptor (α1-AR) blocking efficiency ranging from 65.38 to 87.86% compared with 89.34% for prazosin hydrochloride. Furthermore, a 2D-QSAR study and 3D-pharmacophore model were introduced to carry out compare-fit study for the designed mols. with the generated hypothesis and creating a statistically significant model. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Related Products of 75629-62-8

The Article related to pyridine carbonitrile preparation pharmacophore modeling vasorelaxant active agent hypertension, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 75629-62-8

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On September 8, 2016, Rajkumar, Vadla; Babu, Srinivasarao Arulananda; Padmavathi, Rayavarapu published an article.HPLC of Formula: 75629-62-8 The title of the article was Regio- and diastereoselective construction of a new set of functionalized pyrrolidine, spiropyrrolidine and spiropyrrolizidine scaffolds appended with aryl- and heteroaryl moieties via the azomethine ylide cycloadditions. And the article contained the following:

Highly regio- and diastereoselective syntheses of a new set of functionalized pyrrolidines, spiro-pyrrolidine/pyrrolizidine oxindoles, spiroacenaphthylenolyl-pyrrolidines/pyrrolizidines and spiro-1,3-indandionolyl-pyrrolidines/pyrrolizidines appended with various aryl- and heteroaryl moieties via the azomethine ylide cycloaddition reaction are reported. The Ag-catalyzed [3+2] cycloaddition of azomethine ylides derived from N-benzylideneiminoglycinates with various arylidene/heteroarylidenemalononitriles gave C-3,C-5-aryl/heteroaryl substituted C-4,C-4-dicyanopyrrolidine-2-carboxylate scaffolds with good regio- and diastereoselectivity. Further, the [3+2] cycloaddition of azomethine ylides derived from the decarboxylative reactions of different 1,2-dicarbonyls and α-amino acids with the indole/pyrrole-based dipolarophiles were studied. In the context of enriching the library of functionalized spiropyrrolidine- and spiropyrrolizidine scaffolds, these reactions led to the assembling of various spiro-pyrrolidine/pyrrolizidine oxindoles, spiroacenaphthylenolyl-pyrrolidines/pyrrolizidines and spiro-1,3-indandionolyl-pyrrolidines/pyrrolizidines appended with the indolyl- and pyrrolyl moieties at the C-3 position of the spiro-pyrrolidine/pyrrolizidine rings. The stereochem. of the cycloadducts was assigned based on the single crystal x-ray structures of representative major diastereomers obtained from the azomethine ylide cycloaddition reactions. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).HPLC of Formula: 75629-62-8

The Article related to spiropyrrolidine spiropyrrolizidine aryl azomethine ylide cycloaddition regio diastereoselective preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 75629-62-8

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On June 22, 2017, Mobashery, Shahriar; Speri, Enrico; Chang, Mayland published a patent.Formula: C12H7N3 The title of the patent was Potentiators of beta-lactam antibiotics and combination therapy. And the patent contained the following:

Proteins of methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic sensor/signal transducer, are phosphorylated on exposure to β-lactam antibiotics. This event is critical for the onset of the biochem. events that unleash induction of antibiotic resistance. The phosphorylation and the antibiotic-resistance phenotype can be abrogated in the presence of phenylpropanenitrile derivatives, eg. I, (X= O, CH2, S, SO2, or a direct bond; R1= CN, SO2Me, CONH2, CO2H, etc.; m= 1,2,3,4; n= 1,2,3,4,5; R2= H, halo, alkyl, alkoxy, heteroaryl, etc.; R3= halo, alkyl, alkoxy, heteroaryl, etc.), that restore susceptibility of the organism to β- lactam antibiotics. The invention thus provides compounds and methods for abrogating antibiotic resistance to β-lactam antibiotics and for treating infections causes by antibiotics prone to developing resistance by potentiating β-lactam antibiotics. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to phenylpropanenitrile derivative betalactam antibiotic resistance mrsa, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Formula: C12H7N3

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On August 31, 1988, Hiremath, Shivayogi P.; Ullagaddi, Ashok; Sekhar, K. Raja; Purohit, Muralidhar G. published an article.Application of 75629-62-8 The title of the article was Synthesis of various pyrazole-1-carbonylindoles. And the article contained the following:

2-Indolecarbohydrazides were treated with MeCOCH2CO2Et to give pyrazolinones I (R1 = H, Me; R2 = OMe, Me, Cl, Br H, OEt; R3 = H Me; R4 = Me, Ph, H). Pyrazoles II were prepared from hydrazides and MeCOCH2COMe. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application of 75629-62-8

The Article related to pyrazole indolecarbonyl, indole pyrazolecarbonyl, indolecarbohydrazide cyclocondensation acetoacetate acetylacetone, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 75629-62-8

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Red’kin, R. G.; Shemchuk, L. A.; Chernikh, V. P.; Shishkin, O. V.; Shishkina, S. V. published an article in 2007, the title of the article was Synthesis of 4-(1H-indol-3-yl) derivatives of 2-amino-4H-pyran and 2-amino-4,6,7,8-tetrahydro-1H-quinolin-5-one.Recommanded Product: 75629-62-8 And the article contains the following content:

The novel heterocyclic compounds I (X = O, NR3; R1 = CN, CO2Et; R2 = H, Me; R3 = Ph, 4-MeC6H4, 4-HOC6H4, 4-MeOC6H4) were synthesized either by one-pot three-component condensation of 3-formylindole with active methylene compounds R1CH2CN and 1,3-diketone analogs, 3-HX-5,5-R22-substituted 2-cyclohexenones (II), or by two-step condensation of 3-formylindole with R1CH2CN followed by heterocyclization of the intermediate (indolyl)acrylonitriles with II. Acetylacetone, 4-hydroxycoumarin and 3-methyl-5-pyrazolone were also successfully used instead of II providing access to monocyclic and heterocycle-fused derivatives of I. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 75629-62-8

The Article related to quinolinone amino tetrahydro indolyl preparation, pyran amino indolyl preparation crystal structure, indole formyl condensation nitrile diketone, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Recommanded Product: 75629-62-8

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On March 31, 2000, Abdelhamid, Abdou O.; Zohdi, Hussein F.; Ziada, Mahmoud M. published an article.Recommanded Product: 75629-62-8 The title of the article was A facile synthesis of [1,2,4]triazino[4,5-a]benzimidazoles, pyrazolo[5,1-c]triazines, triazolo[5,1-c]triazines and pyrido[1,2-a]benzimidazoles. And the article contained the following:

Triazino[4,5-a]benzimidazoles have been obtained by coupling of arenediazonium chlorides with Et (1-ethoxycarbonyl)benzimidazole-2-acetate. Pyrazolo[5,1-c]triazines and triazolo[5,1-c]triazines have been synthesized via coupling of diazotized heterocyclic amines with Et benzimidazole-2-acetate. Et benzimidazole-2-acetate reacts with 1,1-dicyano-2-substituted ethenes and 1-cyano-1-ethoxycarbonyl-2-substituted ethenes to give pyrido[1,2-a]benzimidazoles, resp. Structures of the newly synthesized compounds are confirmed on the basis of elemental analyses, spectral data and alternative methods whenever possible. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 75629-62-8

The Article related to triazinobenzimidazole preparation, pyrazolotriazine preparation, triazolotriazine preparation, pyridobenzimidazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Recommanded Product: 75629-62-8

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On May 31, 1997, Ram, Vishnu Ji; Nath, Mahendra published an article.SDS of cas: 75629-62-8 The title of the article was Synthesis of diheteroarylmethanes from activated nitriles. And the article contained the following:

Novel procedures for the preparation of diheteroarylmethanes, e.g., the pyrimidinylindolylmethanes I (R = H, benzyl; R1 = amino, Me, Ph, pyridyl, morpholino), were developed from the base-catalyzed condensation-cyclization of indolylmethylmalononitrile II (R = H, R1 = H, benzyl) with amidine, dicyandiamide, hydroxylamine, hydrazine, and thioglycolic acid. The acid catalyzed reaction of II (R2 = bond) with thiosemicarbazide affords thiadiazole III. Base-catalyzed reaction of 3-indolylacetonitrile with dicyandiamide gives sym. triazine IV. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).SDS of cas: 75629-62-8

The Article related to diheteroarylmethane preparation, methane diheteroaryl preparation, nitrile condensation cyclization, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.SDS of cas: 75629-62-8

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