Category: 82380-17-4

Labadie, Sharada et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2015 | CAS: 82380-17-4

2-Bromo-4-hydroxybenzonitrile (cas: 82380-17-4) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Quality Control of 2-Bromo-4-hydroxybenzonitrile

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase was written by Labadie, Sharada;Dragovich, Peter S.;Chen, Jinhua;Fauber, Benjamin P.;Boggs, Jason;Corson, Laura B.;Ding, Charles Z.;Eigenbrot, Charles;Ge, HongXiu;Ho, Qunh;Lai, Kwong Wah;Ma, Shuguang;Malek, Shiva;Peterson, David;Purkey, Hans E.;Robarge, Kirk;Salphati, Laurent;Sideris, Steven;Ultsch, Mark;VanderPorten, Erica;Wei, BinQing;Xu, Qing;Yen, Ivana;Yue, Qin;Zhang, Huihui;Zhang, Xuying;Zhou, Aihe. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Quality Control of 2-Bromo-4-hydroxybenzonitrile This article mentions the following:

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enone using structure-based design strategies resulted in inhibitors with considerable improvement in biochem. potency against human lactate dehydrogenase A (LDHA). These potent inhibitors were typically selective for LDHA over LDHB isoform (4-10 fold) and other structurally related malate dehydrogenases, MDH1 and MDH2 (>500 fold). An X-ray crystal structure of enzymically most potent mol. bound to LDHA revealed two addnl. interactions associated with enhanced biochem. potency. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-hydroxybenzonitrile (cas: 82380-17-4Quality Control of 2-Bromo-4-hydroxybenzonitrile).

2-Bromo-4-hydroxybenzonitrile (cas: 82380-17-4) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Quality Control of 2-Bromo-4-hydroxybenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bezborodov, V. S. et al. published their research in Zhidkie Kristally i Ikh Prakticheskoe Ispol’zovanie in 2015 | CAS: 82380-17-4

2-Bromo-4-hydroxybenzonitrile (cas: 82380-17-4) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.HPLC of Formula: 82380-17-4

Liquid crystalline compounds with positive dielectric anisotropy was written by Bezborodov, V. S.;Lapanik, V. I.;Mikhalyonok, S. G.. And the article was included in Zhidkie Kristally i Ikh Prakticheskoe Ispol’zovanie in 2015.HPLC of Formula: 82380-17-4 This article mentions the following:

In this paper we present the results of the investigations of liquid crystalline (LC) compounds with pos. dielec. anisotropy. The anal. of the properties of polar mesomorphic compounds and the electrooptical and dynamic parameters of the LC compositions based on them has shown that the polar liquid crystalline 1,3,2- dioxaborinane derivatives have several advantages in comparison with other analogous polar compounds They are characterized by a low formation temperature and a wide temperature range of the nematic phase, and allow preparation of liquid crystalline compositions with a low threshold voltage and shorter switching times. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-hydroxybenzonitrile (cas: 82380-17-4HPLC of Formula: 82380-17-4).

2-Bromo-4-hydroxybenzonitrile (cas: 82380-17-4) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.HPLC of Formula: 82380-17-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts