Category: 91-15-6

Ashraf, Muhammad Aqeel published the artcileFe3O4@L-lysine-Pd(0) organic-inorganic hybrid: As a novel heterogeneous magnetic nanocatalyst for chemo and homoselective [2+3] cycloaddition synthesis of 5-substituted 1H-tetrazoles, Recommanded Product: Phthalonitrile, the main research area is tetrazole preparation green chem chemo homoselective; aryl nitrile sodium azide cycloaddition reaction palladium nanocatalyst.

An efficient and sustainable synthetic protocol has been presented to synthesis and 5-substituted 1H-tetrazole privileged heterocyclic substructures I (R = Ph, 4-formylphenyl, pyridin-2-yl, etc.). The synthetic protocol involves two-component reaction between aryl nitriles RCN and NaN3 in water using complex of L-lysine-palladium nanoparticles (NPs) modified Fe3O4 nanoparticles as magnetically separable, recyclable, and reusable heterogeneous catalyst. Magnetically retrievable L-lysine-Pd(0) modified Fe3O4 nanoparticles were applied in [2+3] cycloaddition synthesis of 5-substituted 1H-tetrazoles I. The advantages of this strategy include easy recovery and efficient reusability of the expensive Pd NPs, obtaining high yields of [2+3] cycloaddition and short reaction times, and all of the reported synthetic strategies are being performed in water as green solvent for a wide range of substrates.

Applied Organometallic Chemistry published new progress about [3+2] Cycloaddition reaction (chemoselective). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yildirim, Nuri published the artcileSynthesis of novel 3-(4-tert-butylphenyl)-5-cylopropyl-4H-1,2,4-triazole derivatives with antioxidative and antimicrobial activities, Related Products of nitriles-buliding-blocks, the main research area is antioxidant antimicrobial imine amine phthalonitrile b subtilis ampicillin.

Background: In this work, new heterocyclic compounds containing 3-(4-tertbutylphenyl)-5-cyclopropyl-4H-1,2,4-triazole ring were synthesized, starting from iminoester hydrochlorides and 4-tert-butylbenzhydrazide. Methods: Et N-[(4-tert-butylphenyl)carbonyl]cyclopropanecarbohydrazonoate was used to synthesize 4-amino-3-(4-tert-butylphenyl)-5-cyclopropyl-4H-1,2,4-triazole, 3-(4-tert-butylphenyl)-5-cyclopropyl-4-(arylmethyleneamino)-4H-1,2,4-triazole, 3-(4-tert-butylphenyl)-5-cyclopropyl-4-(arylmethylamino)-4H-1,2,4-triazole and their phthalonitrile derivatives sequentially. Results: Seventeen new 3-(4-tert-butylphenyl)-5-cyclopropyl-4H-1,2,4-triazole derivatives were synthesized and their antioxidant and antimicrobial activities were determined Conclusion: Imine and amine derivatives were better antioxidants than phthalonitrile derivatives Doubly fluorination compounds appeared to result in higher activity. The compounds tested with five microorganisms showed better activity against B. subtilis with the antimicrobial activity of two far exceeding that of ampicillin. Imine and amine derivatives were better antimicrobials than phthalonitrile derivatives

Letters in Drug Design & Discovery published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Forni, Jose A. published the artcileAn electrochemical γ-C-H arylation of amines in continuous flow, Formula: C8H4N2, the main research area is arylated sulfonamide regioselective preparation; cyanoarene aryl sulfonamide electrochem gamma CH arylation continuous flow.

A regioselective C(sp3)-C(sp2) cross coupling reaction between inert γ-C(sp3)-H bonds in aliphatic amines and cyanoarenes under electrochem. conditions in flow was reported. The developed methodol. took advantage of a removable redox active auxiliary, which triggered selective 1,7-hydrogen atom transfer to functionalized an aliphatic C-H bond at the γ-position of an alkyl amine. In this reaction, a cyanoarene radical anion functions as both a selective arylating reagent and a redox active mediator, enabled the controlled one electron reduction of the redox active auxiliary. This strategy offered a new approach toward γ-C(sp3)-H bond functionalization allowing generation of, amongst others, sterically crowded carbon centers under mild reaction conditions and in the absence of addnl. catalysts or radical initiators.

Tetrahedron Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Sheng published the artcileRegioselective umpolung addition of dicyanobenzene to α,β-unsaturated alkenes enabled by electrochemical reduction, Computed Properties of 91-15-6, the main research area is dicyanobenzene unsaturated alkene regioselective electrochem reduction.

An umpolung addition of dicyanobenzene to α,β-unsaturated alkenes has been developed using an electroreductive strategy. This electrochem. protocol is well compatible with a broad range of conventionally challenging substrates, including α,β-unsaturated esters, nitriles and trisubstituted enones. Moreover, good to excellent regioselectivities are observed in the reaction of cinnamates with dicyanobenzene. Synthetic utility of this electrochem. approach is further demonstrated by direct late-stage functionalization of (S)-verbenone and 16-dehydropregnenolone acetate.

Organic Chemistry Frontiers published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Talukdar, Ranadeep published the artcileIrIII-Catalyzed direct syntheses of amides and esters using nitriles as acid equivalents: a photochemical pathway, HPLC of Formula: 91-15-6, the main research area is amide preparation photochem; amine nitrile amidation iridium photocatalyst; ester preparation photochem; nitrile alc esterification iridium photocatalyst.

An unprecedented IrIII[df(CF3)ppy]2(dtbbpy)PF6-catalyzed simple photochem. process for direct addition of amines RNHR1 [R = H, iso-Pr, benzyl, 4-methoxyphenyl, Bu, adamantan-1-yl; R1 = H, iso-Pr, benzyl, hydroxyethyl; RR1 = -(CH2)4-, -(CH2)5-, -(CH2)2O(CH2)2-] and alcs. R2OH (R2 = Bu, cyclohexyl, benzyl, indol-1-yl, etc.) to the relatively less reactive nitrile triple bond is described herein. Various amides RN(R1)C(O)R3 (R3 = Me, cyclohexyl, Ph, pyridin-4-yl, etc.) and esters R2OC(O)R3 are synthesized as the reaction products, with nitriles R3CN being the acid equivalent A mini-library of different types of amides and esters is made using this mild and efficient process, which uses only 1 mol% of photocatalyst under visible light irradiation (λ = 445 nm). The reaction strategy is also efficient for gram-scale synthesis.

New Journal of Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhao, Yiyong published the artcileSO2F2-Promoted Dehydration of Aldoximes: A Rapid and Simple Access to Nitriles, HPLC of Formula: 91-15-6, the main research area is nitrile preparation; aldoxime dehydration.

A rapid, simple and mild process for the dehydration of aldoximes RCH=NOH (R = benzyl, 4-fluorophenyl, naphth-1-yl, pyridin-2-yl, etc.) to give the corresponding nitriles RCN, which utilizes SO2F2 as an efficient reagent, has been developed. A variety of (hetero)arene, alkene, alkyne and aliphatic aldoximes proceeded with high efficiency to afford nitriles in excellent to quant. yields with great functional group compatibilities in acetonitrile under ambient conditions. Moreover, the eco-friendly conditions of SO2F2/Na2CO3/aqueous methanol were suitable for converting nitrobenzaldoximes R1C6H4CH=NOH (R1 = 2-nitro, 3-nitro, 4-nitro) into nitrobenzonitriles R1C6H4CN. In addition, a one-pot synthetic strategy of obtaining nitrobenzonitriles R1C6H4CN from nitrobenzaldehydes R1C6H4CHO has been confirmed to be feasible.

Synlett published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Deqiang published the artcileA Lewis Base Supported Terminal Uranium Phosphinidene Metallocene, HPLC of Formula: 91-15-6, the main research area is uranium phospinidene metallocene preparation reactivity imine diazene carbodiimide nitrile; phospinidene uranium metallocene adduct imine diazene nitrile preparation; crystal structure uranium phospinidene metallocene adduct imine diazene nitrile; mol structure uranium phospinidene metallocene adduct imine diazene nitrile.

A Lewis base supported terminal U phosphinidene, [η5-1,3-(Me3C)2C5H3]2U(:P-2,4,6-tBu3C6H2)(OPMe3) (5), is isolated from the reaction of the U Me chloride [η5-1,3-(Me3C)2C5H3]2U(Cl)Me (4) with 2,4,6-(Me3C)3C6H2PHK in toluene in the presence of Me3PO. Also, the reactivity of the U phospinidene 5 toward small mols. were comprehensively explored. While no reactivity of 5 with internal alkynes is observed attributed to steric hindrance, it readily reacts with various small mols. including isothiocyanates, aldehydes, imines, diazenes, carbodiimides, nitriles, isonitriles, and organic azides, yielding U sulfides, oxides, metallaheterocycles, and imido complexes, in good yields. A Lewis base supported actinide phosphinidene metallocene was isolated and its reactivity toward small mols. was studied. It exhibits a rich reaction chem. toward a variety of heterounsatd. mols. and the steric hindrance imposed by the Cp ligand plays an important role in the formation and reaction chem. of U phosphinidene metallocenes.

Inorganic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Shichun published the artcileSynthesis and reactivity of the uranium phosphinidene metallocene [η5-1,3-(Me3Si)2C5H3]2U(:P-2,4,6-iPr3C6H2)(OPMe3): influence of the coordinated Lewis base, Product Details of C8H4N2, the main research area is reactivity uranium phosphinidene metallocene Lewis base; isothiocyanate aldehyde nitrile isonitrile azide reactivity uranium phosphinidene metallocene.

This paper describes the synthesis and reactivity of [η5-1,3-(Me3Si)2C5H3]2U(:P-2,4,6-iPr3C6H2)(OPMe3) (6) which is accessible from a ligand exchange reaction between [η5-1,3-(Me3Si)2C5H3]2U(:P-2,4,6-iPr3C6H2)(OPPh3) (2) and Me3PO at ambient temperature Phosphinidene 6 exhibits no reactivity towards internal alkynes, but readily reacts with various hetero-unsaturated mols. such as isothiocyanates, aldehydes, nitriles, isonitriles, and organic azides, forming uranium sulfido, oxido, imido, and uranaheterocyclic compounds Nevertheless, with the bidentate ortho-dicyanobenzene o-C6H4(CN)2 the zwitterionic species [η5-1,3-(Me3Si)2C5H3]2U[NHC(N){C6H4CP(2,4,6-iPr3C6H2)CH2PMe2O}] (13) is isolated in good yield. Moreover, 6 converts with Ph2S2 to the uranium(III) phenylthiolate compound [η5-1,3-(Me3Si)2C5H3]2USPh(OPMe3) (7) in good isolated yield. Furthermore, the influence of the Lewis base on the reactivity of the uranium phosphinidene metallocenes has also been evaluated.

Dalton Transactions published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Deqiang published the artcileReactivity studies involving a Lewis base supported terminal uranium phosphinidene metallocene [η5-1,3-(Me3C)2C5H3]2U(=P-2,4,6-iPr3C6H2)(OPMe3), Related Products of nitriles-buliding-blocks, the main research area is uranium phosphinidene metallocene lewis base supported reactivity study.

The Lewis base supported terminal uranium phosphinidene metallocene [η5-1,3-(Me3C)2C5H3]2U(=P-2,4,6-iPr3C6H2)(OPMe3) (2) could be isolated from a salt metathesis reaction in toluene at ambient temperature between [η5-1,3-(Me3C)2C5H3]2U(Cl)Me (1) and 2,4,6-iPr3C6H2PHK in the presence of Me3PO, and its structure and reactivity were probed in detail. No reaction of 2 with internal alkynes was observed, but it reacts in the presence of various heterounsatd. mols. such as CS2, isothiocyanates, aldehydes, imines, diazenes, carbodiimides, nitriles, isonitriles, diazoalkane, and organic azides, forming carbodithioates, sulfidos, oxidos, metallaheterocycles, and imido complexes, in good yields. Moreover, on reaction with the diazoalkane derivative Me3SiCHN2 the pseudophosphinimido uranium(III) complex [η5-1,3-(Me3C)2C5H3]2U(N=P-2,4,6-iPr3C6H2)(OPMe3) (20) can be isolated in good yield.

Dalton Transactions published new progress about Aldehydes Role: NUU (Other Use, Unclassified), USES (Uses). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yadav, Kumar Karitkey published the artcileCopper(II) phthalocyanine as an efficient and versatile catalyst for click reactions at room temperature, Recommanded Product: Phthalonitrile, the main research area is copper phthalocyanine catalyst benzyl halide one pot click reaction.

Herein, we report the efficient synthesis of copper(II) phthalocyanines in the presence of DBU as a strong base. These synthesized copper(II) phthalocyanines are utilized as a catalyst for the click reactions of sensitive compounds including metal-free porphyrins under mild reaction conditions at room temperature Further, we have developed a one-pot procedure for the click reactions of benzyl halides with different alkynes in good to excellent yields. The reaction proceeds at room temperature to 40°C and gives 83-99% of products. The reactions are carried out in DMSO solvent. The present reaction condition offers copper(II) phthalocyanines as an efficient and convenient catalyst for different electron-rich and electron-deficient substrates including macrocyclic compounds Electron-deficient substrates and less steric substrates provide a better result. The catalyst is easily separated from the reaction by a simple filtration technique and is reused up to 5 times without significant loss of its catalytic activity.

Journal of the Iranian Chemical Society published new progress about Alkynes Role: IMF (Industrial Manufacture), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts