Category: 91-15-6

Naraoka, Asuka published the artcileTransfer Hydration of Dinitriles to Dicarboxamides, COA of Formula: C8H4N2, the main research area is dicarboxamide preparation; dinitrile hydration palladium catalyst acetamide water donor.

A robust method for double transfer hydration of dinitriles to afford diamides was presented. The transfer hydration of 1,n-dinitriles (n = 1-6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.

Synlett published new progress about Diamides Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, COA of Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ghanbari, Zahra published the artcileDiastereoselective Synthesis of Some Spiroheterocycles Using Base Reusable Heterogeneous Achiral Nanocatalyst in Aqueous Media, Application In Synthesis of 91-15-6, the main research area is silica coat nickel ferrite support tetrazole preparation thermal stability; aryl aldehyde dione tetrazol catalyst Knoevenagel condensation green chem; spiropyrimidinequinazoline diastereoselective preparation.

This research was based on the synthesis of some new diastereoselective spiroheterocycles relying on the application of nanocatalysts designed from the functionalized magnetic nanoparticles with tetrazole. Also, the achievement of suitable product with stereopurity through base catalytic path. Water as a green solvent, NiFe2O4 magnetic nanoparticles as a separable and reusable catalyst and using simple and high efficiency method were some important advantages of this research.

ChemistrySelect published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application In Synthesis of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tamoradi, Taiebeh published the artcileLa complex supported on magnetic nanoparticles: green, efficient, novel and reusable nanocatalyst for the synthesis of 5-substituted tetrazoles and the oxidation reactions in neat condition, Recommanded Product: Phthalonitrile, the main research area is iron oxide lanthanum complex nanocatalyst tetrazole preparation green chem.

In the present work, we were interested in the synthesis of green and novel magnetic nanocatalyst by anchoring La complex on Fe3O4. The nanocatalyst was successfully synthesized and characterized by FT-IR, SEM, TGA, XRD, EDX, and ICP techniques. The designed procedure shows many benefits such as short reaction time, high yield, excellent purity, eco-friendly catalyst, easy workup and easy recovery from the reaction mixture by external magnet.

Journal of the Iranian Chemical Society published new progress about Disulfides Role: IMF (Industrial Manufacture), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tamoradi, Taiebeh published the artcileImmobilization of La on THH-CO2H@Fe3O4 nanocomposite for the synthesis of one pot multicomponent reactions, Recommanded Product: Phthalonitrile, the main research area is tetrazole preparation; nitrile sodium azide two component cyclization lanthanum catalyst; amine triethylorthoformate sodium azide three component cyclization lanthanum catalyst; cyanoguanidine sodiumazide aldehyde acetoacetate ester cyclization lanthanum catalyst.

The current research represents a facile and competent methodol. in the development of a novel magnetic nanocatalyst. This composite was synthesized by immobilizing La on Fe3O4 nanoparticles pre-functionalized with tetrahydroharman-3-carboxylic acid ligand. The material was catalytically investigated towards the synthesis of 5-substituted 1H-tetrazoles I (Ar = C6H5, 4-O2NC6H4, 4-BrC6H4, 2-NCC6H4, 4-FC6H4, 2-HOC6H4), 1-substituted 1H-tetrazoles II (Ar1 = C6H5, 4-O2NC6H4, 4-CH3OC6H4, 4-ClC6H4, 4-CH3C6H4, 2-CH3C6H4) and tetrazolopyrimidine derivatives III (R1 = C6H5, 4-FC6H4, 2,4-(Cl)2C6H3, etc., R2 = Me, ethyl) following different multicomponent pathways. The reactions were highly efficient affording high yields. The catalyst was retrieved magnetically and recycled in six consecutive runs without much reduction in activity.

Materials Research Express published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ghadermazi, Mohammad published the artcileIntroduction of Fe into mesoporous MCM-41 for the synthesis of 5-substituted 1H-Tetrazoles from aryl nitriles in water, Related Products of nitriles-buliding-blocks, the main research area is mesoporous supported iron silica catalyst preparation; tetrazole sulfoxide preparation green chem; aryl nitrile sulfide oxidation water.

In this exploration, new recyclable mesoporous-supported iron particles with the ligand and without ligand (MCM-41@ 3,4,5-tri hydroxyphenyl acetic acid @Fe and MCM-41@Fe) have been developed through post-functionalization modification of silica MCM-41. These catalysts were demonstrated to be novel, effective, and green for the synthesis of 5-substituted 1H-tetrazoles from aryl nitriles in water. In these systems, 5-substituted 1H-tetrazoles are produced as the only product. Fe3+ species were identified as active sites. The ordered mesoporous iron-silica catalyst with the ligand displayed better catalytic activity compared to iron-silica catalyst without the ligand, which was ascribed to the improvement of the inter-action of iron with the support. The catalysts can be easily separated using simple recovery and reused several times with consistent activity.

Microporous and Mesoporous Materials published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Miao, Meng published the artcileVisible-light-mediated external-reductant-free reductive cross coupling of benzylammonium salts with (hetero)aryl nitriles, Product Details of C8H4N2, the main research area is diarylmethane preparation; benzylammonium salt aryl nitrile photocatalyst cross coupling.

A novel visible-light-mediated external reductant-free reductive cross coupling for the construction of C sp2-C sp3 bonds was reported. A variety of benzylammonium salts RCH(R1)N+(CH3)3O-S(O)2CF3 (R = naphthalen-2-yl, 1-benzothiophen-3-yl, 4-tert-butylphenyl, etc.; R1 = H, Me, n-Pr) and 1,2,3,4-tetrahydro-N,N,N-trimethyl-1-naphthalenaminium 1,1,1-trifluoromethanesulfonate underwent selective coupling with (hetero)aryl nitriles R2CN (R2 = 4-cyano-3-methylphenyl, 2-phenylpyridin-4-yl, isoquinolin-1-yl, etc.) to deliver important diarylmethanes RCH(R1)R2 and 4-(1,2,3,4-tetrahydronaphthalen-1-yl)benzonitrile under mild reaction conditions. Importantly, photocatalysts can be omitted for many cases, which might involve the electron donor acceptor (EDA) complex. Mechanistic studies indicated that benzylic radicals might be involved as the key intermediates. Moreover, the in situ NMe3 generated via cleavage of C-N bond in ammonium salts acts as the electron donor, thus avoiding the use of external-reductant.

Science China: Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zeynizadeh, Behzad published the artcileA hassle-free and cost-effective transfer hydrogenation strategy for the chemoselective reduction of arylnitriles to primary amines through in situ-generated nickel (II) dihydride intermediate in water, Name: Phthalonitrile, the main research area is benzonitrile reduction chemoseslective green chem; benzyl amine preparation.

A new, simple, efficient, inexpensive, and chemoselective transfer hydrogenation strategy was introduced for the straightforward reduction of arylnitriles to corresponding primary amines using sodium borohydride (NaBH4) and nickel acetate tetrahydrate (Ni(OAc)2â€?H2O) through in situ-generated nickel (II) dihydride intermediate in the water medium at 50°. The presented methodol. featured moderate reaction conditions, nickel boride (Ni2B)-free trajectory, good-to-excellent yields of the products, relatively short reaction times, satisfactory chemoselectivity, and did not involve the use of toxic organic solvent and also any base or ligand.

Journal of Molecular Structure published new progress about Aromatic amides Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Name: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Samanta, Partha Kumar published the artcileMesoporous silica supported samarium as recyclable heterogeneous catalyst for synthesis of 5-substituted tetrazole and 2-substituted benzothiazole, Quality Control of 91-15-6, the main research area is mesoporous silica supported samarium catalyst tetrazole benzothiazole synthesis.

Synthesis of nitrogen-containing heterocycles such as tetrazoles and benzothiazoles gains immense importance as they are omnipresent structural modules often utilized in pharmaceuticals. In the present study, well ordered MCM-41 type mesoporous silica with large pore (l-MSN) was synthesized and impregnated with samarium nitrate (Sm@l-MSN). Due to high abundance of samarium relative to many catalytically active transition metals (e.g. Ru, Ir, Pt), it may offer an opportunity to develop sustainable catalysts for organic conversions. The synthesized materials were characterized using nitrogen sorption, SEM, energy-dispersive X-ray, elemental mapping and transmission electron microscopy. The catalytic efficiency of the materials was explored for the synthesis of tetrazoles and benzothiazoles, two very important heterocyclic moieties in medicinal chem. and biol. The catalyst was readily recovered and recycled up to five consecutive runs without noteworthy loss of activity or leaching.

Journal of Porous Materials published new progress about Benzothiazoles Role: IMF (Industrial Manufacture), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Han published the artcileCatalytic oxidative conversion of aldehydes into nitriles using NH3·H2O/FeCl2/NaI/Na2S2O8: A practical approach to febuxostat, Product Details of C8H4N2, the main research area is oxidative cyanation aldehyde nitrile synthesis febuxostat synthesis.

A novel approach to convert aldehydes into nitriles using NH3·H2O/FeCl2/NaI/Na2S2O8 has been developed. Both alkyl and aryl nitriles were obtained in good to excellent yields. Electron-withdrawing and electron-donating groups, such as fluoro, chloro, bromo, nitro, ester, cyano, trifluoromethyl and alkoxy were tolerated. Notably, febuxostat (I) and its intermediate, Et 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylate, were obtained in excellent yields.

Tetrahedron Letters published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reidl, Tyler W. published the artcileLewis Basic Salt-Promoted Organosilane Coupling Reactions with Aromatic Electrophiles, Application of Phthalonitrile, the main research area is arylalkane preparation; organosilane aromatic electrophile coupling Lewis basic salt promoted.

Lewis basic salts promoted organotrimethylsilane coupling with (hetero)aryl nitriles, sulfones and chlorides as a new route to 1,1-diarylalkanes. This method combined the substrate modularity and selectivity characteristic of cross-coupling with the practicality of a base-promoted protocol. In addition, a Lewis base strategy enabled a complementary scope to existing methods, employed stable and easily prepared organosilanes and achieved selective arylation in the presence of acidic functional groups. The utility of this method was demonstrated by the synthesis of pharmaceutical analogs and its use in multicomponent reactions.

Journal of the American Chemical Society published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation) (aryl). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts