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Extended knowledge of C8H9N

Category: nitriles-buliding-blocks. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Somoza-Martin, JM; Vazquez-Casal, A; Suarez-Cunqueiro, M; Garcia-Garcia, A; Gandara-Vila, P; Perez-Sayans, M or concate me.

Category: nitriles-buliding-blocks. I found the field of Dentistry, Oral Surgery & Medicine very interesting. Saw the article A new morphologic classification of the alveolar ridge after distraction osteogenesis in human patients. A 17 years retrospective case series study published in 2021, Reprint Addresses Perez-Sayans, M (corresponding author), Univ Santiago de Compostela, Fac Dent, Oral Med & Surg Unit, Entrerrios S-N, Santiago De Compostela 15782, Spain.. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile.

Background: To perform a morphologic classification based on the results of bone augmentation after a distraction osteogenesis. Material and Methods: Thirty-four (34) patients (24 women and 10 men; mean age, 47.1 years (SD=9.5); age range, 23 to 62 years) underwent a total of 42 alveolar ridge distractions before the placement of a total of 89 dental implants. Ridge bone morphology was evaluated as the main ordinal variable. Chi-squared, Kruskal-Wallis and ANOVA one-way test were used. Results: Category I (30.95%): consisted of wide alveolar rim and no bone defects Category II (28.57%): wide alveolar rim, lateral bone surface concavity. Category III (23.81%): narrow alveolar rim, lateral bone surface concavity. Category IV (2.38%): distraction transport segment forming a bridge, without bone formed beneath and requiring guided bone regeneration. Category V (9.52%): return of the transport segment to its initial position due to the reverse rotation of the distractor screw. Category VI (4.76%): distraction transport segment completely lost. Subcategory D (28.57%), consisted of lingual deviation of the distraction axis, occurring in any of the categories I to IV. More men (76.9%) presented with category I (p<0.001). The use of the chisel resulted mainly in categories I and II (69.4%) (p<0.001). GBR was only required in 23.1% of the cases in Category I (p=0.011). The bone height achieved decreases as the category increases, due to the accompanying osteogenic limitations (p<0.001). The implants placed in category I were longer 11.5 +/- 0.9 mm (CI95% 10.9-11.9 mm) compared to those placed in category III with a length of 10.4 +/- 1.5 mm (CI95% 9.5-11.4 mm) (p=0.035). Conclusions: The alveolar ridge after distraction osteogenesis could be divided into six morphologic categories which provide a useful basis for decision-making regarding implant placement. Category: nitriles-buliding-blocks. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Somoza-Martin, JM; Vazquez-Casal, A; Suarez-Cunqueiro, M; Garcia-Garcia, A; Gandara-Vila, P; Perez-Sayans, M or concate me.

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Final Thoughts on Chemistry for 5-Norbornene-2-carbonitrile

Product Details of 95-11-4. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Pews-Davtyan, A; Scharnagl, FK; Hertrich, MF; Kreyenschulte, C; Bartling, S; Lund, H; Jackstell, R; Beller, M or concate me.

Authors Pews-Davtyan, A; Scharnagl, FK; Hertrich, MF; Kreyenschulte, C; Bartling, S; Lund, H; Jackstell, R; Beller, M in ROYAL SOC CHEMISTRY published article about LIQUID-PHASE HYDROGENATION; HIGHLY-ACTIVE HYDROGENATION; ORGANIC FRAMEWORK NODES; ASYMMETRIC HYDROGENATION; SELECTIVE HYDROGENATION; CATALYTIC-HYDROGENATION; COMPLEXES; ISOOCTENES; KINETICS; CO in [Pews-Davtyan, Anahit; Scharnagl, Florian Korbinian; Hertrich, Maximilian Franz; Kreyenschulte, Carsten; Bartling, Stephan; Lund, Henrik; Jackstell, Ralf; Beller, Matthias] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany in 2019, Cited 62. Product Details of 95-11-4. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4

Catalytic hydrogenation of olefins using noble metal catalysts or pyrophoric RANEY (R) nickel is of high importance in the chemical industry. From the point of view of green and sustainable chemistry, design and development of Earth-abundant, less toxic, and more environmentally friendly catalysts are highly desirable. Herein, we report the convenient preparation of active cobalt catalysts and their application in hydrogenations of a wide range of terminal and internal carbon-carbon double bonds in water under mild conditions. Catalysts are prepared on multi-gram scale by pyrolysis of cobalt acetate and uracil, guanine, adenine or l-tryptophan. The most active material Co-Ura/C-600 showed good productivity in industrially relevant hydrogenation of diisobutene to isooctane and in natural oil hardening.

Get Up to Speed Quickly on Emerging Topics:95-11-4

Category: nitriles-buliding-blocks. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Rogers, SN; Horisk, K; Groom, P; Lowe, D or concate me.

An article Management of anaemia and blood in patients having neck dissections or free flaps for head and neck cancer WOS:000476865000009 published article about TRANSFUSION PREDICTION; PRIMARY SURGERY; IMPACT; RADIOTHERAPY; HEMOGLOBIN in [Rogers, S. N.] Edge Hill Univ, Fac Hlth & Social Care, Evidence Based Practice Res Ctr EPRC, St Helens Rd, Ormskirk L39 4QP, England; [Rogers, S. N.; Horisk, K.] Aintree Univ Hosp NHS Fdn Trust, Reg Maxillofacial Unit, Liverpool L9 1AE, Merseyside, England; [Groom, P.] Aintree Univ Hosp NHS Fdn Trust, Liverpool L9 1AE, Merseyside, England; [Lowe, D.] Edge Hill Univ, Fac Hlth, Evidence Based Practice Res Ctr EPRC, St Helens Rd, Ormskirk L39 4QP, England in 2019, Cited 24. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4. Category: nitriles-buliding-blocks

Our main aims were to assess haemoglobin (Hb) concentrations from preoperative assessment to discharge from hospital, and to review which patients had blood transfusions and compliance with national transfusion guidelines. We studied a consecutive series of 131 patients between October 2016 and September 2017 who had either neck dissection or resection and free microvascular tissue transfer. Half the patients had soft tissue free flaps (n=65), 26% had composite free flaps (n = 34), and 24% neck dissection only (n =32). Using the WHO definition of anaemia, 4% (1/28) of patients who had neck dissections and 19% (16/85) of those who had free flaps were anaemic preoperatively. The median (IQR) Hb at discharge was 131 (119-144) g/L for patients who had neck dissections, 103 (95-114) g/L for those who had soft free flaps, and 95 (90-104) g/L for those who had composite free flaps. No patients who had neck dissection were given a red blood cell (RBC) transfusion, whereas they were given to 26/99 (26%) of those who had free flaps. Hb concentrations were checked after each unit in 31/39 transfusions (79%). Concentrations for those who had free flaps fell by about 30 g/L from admission to operation, and only four patients were given tranexamic acid peroperatively. Postoperatively Hb remained at similar concentrations until discharge, with 23/98 (24%) given iron orally on discharge. In terms of compliance with blood transfusion guidelines there was a notable absence of the use of tranexamic acid and of iron intravenously. An increase in their use could potentially reduce the number of blood transfusions required and the postoperative incidence of anaemia, and have a favourable effect on outcomes such as complications, fatigue, and overall quality of life. (C) 2019 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Category: nitriles-buliding-blocks. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Rogers, SN; Horisk, K; Groom, P; Lowe, D or concate me.

Chemical Research in 5-Norbornene-2-carbonitrile

Computed Properties of C8H9N. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Bar-Or, RL; Kor, A; Jaljuli, I; Lev-Ran, S or concate me.

Computed Properties of C8H9N. Authors Bar-Or, RL; Kor, A; Jaljuli, I; Lev-Ran, S in KARGER published article about in [Bar-Or, Ruth Lev; Kor, Ariel; Lev-Ran, Shaul] Israel Ctr Addict ICA, Hazoran St 2, IL-4250602 Netanya, Israel; [Bar-Or, Ruth Lev] Hebrew Univ Jerusalem, Hadassah Sch Publ Hlth & Community Med, Jerusalem, Israel; [Kor, Ariel] Interdisciplinary Ctr IDC, Herzliyya, Israel; [Kor, Ariel] Yale Univ, Yale Sch Med, New Haven, CT USA; [Jaljuli, Iman] Tel Aviv Univ, Dept Stat & Operat Res, Tel Aviv, Israel; [Lev-Ran, Shaul] Lev Hasharon Med Ctr, Netanya, Israel; [Lev-Ran, Shaul] Tel Aviv Univ, Dept Psychiat, Sackler Fac Med, Tel Aviv, Israel in , Cited 51. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4

Introduction: Substance use disorders (SUDs) are a leading cause of morbidity and mortality worldwide, having a profound and global impact on health, well-being, safety, and productivity. Although traditionally the prevalence of SUDs in Israel has been estimated to be lower than those in high-income countries, estimates and characteristics of individuals with SUDs in the past decade are lacking. In this work, we explored the prevalence of SUDs among the adult Jewish population in Israel, per different classes of substances across sex, age group, and other sociodemographic factors. Methods: Data from an online representative sample of 4,025 respondents were collected, including the alcohol, smoking, and substance involvement screening test (ASSIST) metric and sociodemographic data. Results: We found that the most common SUDs were alcohol (10.5% [9.5-11.4]), cannabis (9.0% [8.2-9.9]), and sedative (3.6% [3.0-4.2]) use disorders. Alcohol-cannabis (3.2% [2.7-3.7]) and alcohol-sedative (1.04% [0.7-1.35]) were the most prevalent co-occurring SUDs. Among those with cannabis use disorder, the prevalence of alcohol use disorder was found to be 35.3% [30.4-40.2]. The estimated risk for alcohol use disorder was found to be inversely proportional to age, cannabis use disorder increased, peaked, and decreased with age, and that of sedative use disorder increased with age, particularly among women. While older individuals (in the 51-60 years of age group) were at lower risk (OR = 0.5 [0.3, 0.8]) compared to those <20 years of age for alcohol use disorder, they were at increased risk for sedative use disorder (OR = 3.1 [1.2, 9.7]). Conclusions: These findings represent substantially higher rates of SUDs in Israel than those previously reported and should affect resources allocated to addiction prevention and treatment. Further research on the role of gender, age, culture, and ethnicity in the propensity to develop SUDs is necessary for the development of more focused preventive and intervention measures. Focusing on non-Jewish populations in Israel and broadening the scope to include behavioral addictions should be addressed in future studies. Computed Properties of C8H9N. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Bar-Or, RL; Kor, A; Jaljuli, I; Lev-Ran, S or concate me.

Why do aromatic interactions matter of compound:C8H9N

Application In Synthesis of 5-Norbornene-2-carbonitrile. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Gao, QW; Shang, Y; Song, FZ; Ye, JX; Liu, ZS; Li, LS; Cheng, HG; Zhou, QH or concate me.

Application In Synthesis of 5-Norbornene-2-carbonitrile. I found the field of Chemistry very interesting. Saw the article Modular Dual-Tasked C-H Methylation via the Catellani Strategy published in 2019, Reprint Addresses Zhou, QH (corresponding author), Wuhan Univ, Engn Res Ctr Organosilicon Cpds & Mat, Sauvage Ctr Mol Sci, Coll Chem & Mol Sci,Minist Educ, Wuhan 430072, Peoples R China.; Zhou, QH (corresponding author), Wuhan Univ, Inst Adv Studies, Wuhan 430072, Peoples R China.. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile.

We report a dual-tasked methylation that is based on cooperative palladium/norbornene catalysis. Readily available (hetero)aryl halides (39 iodides and 4 bromides) and inexpensive MeOTs or trimethylphosphate are utilized as the substrates and methylating reagent, respectively. Six types of ipso terminations can modularly couple with this ortho C-H methylation to constitute a versatile methylation toolbox for preparing diversified methylated arenes. This toolbox features inexpensive methyl sources, excellent functional-group tolerance, simple reaction procedures, and scalability. Importantly, it can be uneventfully extended to isotope-labeled methylation by switching to the corresponding reagents CD3OTs or (CH3OTs)-C-13. Moreover, this toolbox can be applied to late-stage modification of biorelevant substrates with complete stereoretention. We believe these salient and practical features of our dual-tasked methylation toolbox will be welcomed by academic and industrial researchers.

Final Thoughts on Chemistry for 5-Norbornene-2-carbonitrile

HPLC of Formula: C8H9N. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Cossio-Bolanos, M; Gomez-Campos, R; de Campos, LFCC; Sulla-Torres, J; Urra-Albornoz, C; Lopes, VP or concate me.

An article Muscle strength and body fat percentage in children and adolescents from the Maule region, Chile WOS:000576374100007 published article about HANDGRIP STRENGTH; PHYSICAL-ACTIVITY; FITNESS; GRIP; MATURITY; OBESITY; WEIGHT; VALUES; MASS in [Cossio-Bolanos, Marco] Univ Catolica Maule, Dept Sci Phys Act, Talca, Chile; [Gomez-Campos, Rossana] Univ Catolica Maule, Dept Divers & Inclus Classroom, Talca, Chile; [Correia de Campos, Luis Felipe Castelli] Univ Bio Bio, Dept Educ Sci, Chillan, Chile; [Sulla-Torres, Jose] Univ Natl San Agustin Arequipa, Arequipa, Peru; [Urra-Albornoz, Camilo] Univ Santo Tomas, Sch Kinesiol, Sch Hlth, Talca, Chile; [Lopes, Vitor Pires] Polytech Inst Braganca, Sport Sci Dept, Res Ctr Sports Sci Hlth Sci & Human Dev CIDESD, Braganca, Portugal in 2020, Cited 25. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4. HPLC of Formula: C8H9N

Objective. To analyze the association between relative handgrip strength (RHGS) and fat mass (FM) after controlling for the potential effect of maturity status. Methodology. Both male and female children and adolescents aged >= 7.5 to <= 15.49 years were studied. RHGS was assessed using a hydraulic hand dynamometer. FM percentage was established using a dual-energy X-ray absorptiometry. Age and sex differences in RHGS levels between normal weight and obese participants were studied with an analysis of covariance. A covariate was years from peak height velocity (maturity status). The association between RHGS and FM levels was analyzed using a partial correlation and controlling for age at peak height velocity. Results. A total of 1685 students (731 girls and 954 boys) participated. Four age groups were established (7.5-9.4 years, 9.5-11.4 years, 11.5-13.4 years, and 13.5-15.4 years). RHGS increased with age in both males and females. FM values were high in all age groups. No differences were observed in groups 3 and 4 among girls or in group 4 among boys. Participants classified as normal weight showed a significantly higher RHGS than their obese peers. A negative association was noted between RHGS and FM. Conclusion. RHGS was shown to be negatively associated with FM after controlling for the effect of maturity status. HPLC of Formula: C8H9N. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Cossio-Bolanos, M; Gomez-Campos, R; de Campos, LFCC; Sulla-Torres, J; Urra-Albornoz, C; Lopes, VP or concate me.

What unique challenges do researchers face in 5-Norbornene-2-carbonitrile

Safety of 5-Norbornene-2-carbonitrile. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Pews-Davtyan, A; Scharnagl, FK; Hertrich, MF; Kreyenschulte, C; Bartling, S; Lund, H; Jackstell, R; Beller, M or concate me.

Recently I am researching about LIQUID-PHASE HYDROGENATION; HIGHLY-ACTIVE HYDROGENATION; ORGANIC FRAMEWORK NODES; ASYMMETRIC HYDROGENATION; SELECTIVE HYDROGENATION; CATALYTIC-HYDROGENATION; COMPLEXES; ISOOCTENES; KINETICS; CO, Saw an article supported by the State of Mecklenburg Western Pomerania, the BMBFFederal Ministry of Education & Research (BMBF) [03XP0060]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Pews-Davtyan, A; Scharnagl, FK; Hertrich, MF; Kreyenschulte, C; Bartling, S; Lund, H; Jackstell, R; Beller, M. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile. Safety of 5-Norbornene-2-carbonitrile

Brief introduction of C8H9N

COA of Formula: C8H9N. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Bar-Or, RL; Kor, A; Jaljuli, I; Lev-Ran, S or concate me.

COA of Formula: C8H9N. Authors Bar-Or, RL; Kor, A; Jaljuli, I; Lev-Ran, S in KARGER published article about in [Bar-Or, Ruth Lev; Kor, Ariel; Lev-Ran, Shaul] Israel Ctr Addict ICA, Hazoran St 2, IL-4250602 Netanya, Israel; [Bar-Or, Ruth Lev] Hebrew Univ Jerusalem, Hadassah Sch Publ Hlth & Community Med, Jerusalem, Israel; [Kor, Ariel] Interdisciplinary Ctr IDC, Herzliyya, Israel; [Kor, Ariel] Yale Univ, Yale Sch Med, New Haven, CT USA; [Jaljuli, Iman] Tel Aviv Univ, Dept Stat & Operat Res, Tel Aviv, Israel; [Lev-Ran, Shaul] Lev Hasharon Med Ctr, Netanya, Israel; [Lev-Ran, Shaul] Tel Aviv Univ, Dept Psychiat, Sackler Fac Med, Tel Aviv, Israel in , Cited 51. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4

Introduction: Substance use disorders (SUDs) are a leading cause of morbidity and mortality worldwide, having a profound and global impact on health, well-being, safety, and productivity. Although traditionally the prevalence of SUDs in Israel has been estimated to be lower than those in high-income countries, estimates and characteristics of individuals with SUDs in the past decade are lacking. In this work, we explored the prevalence of SUDs among the adult Jewish population in Israel, per different classes of substances across sex, age group, and other sociodemographic factors. Methods: Data from an online representative sample of 4,025 respondents were collected, including the alcohol, smoking, and substance involvement screening test (ASSIST) metric and sociodemographic data. Results: We found that the most common SUDs were alcohol (10.5% [9.5-11.4]), cannabis (9.0% [8.2-9.9]), and sedative (3.6% [3.0-4.2]) use disorders. Alcohol-cannabis (3.2% [2.7-3.7]) and alcohol-sedative (1.04% [0.7-1.35]) were the most prevalent co-occurring SUDs. Among those with cannabis use disorder, the prevalence of alcohol use disorder was found to be 35.3% [30.4-40.2]. The estimated risk for alcohol use disorder was found to be inversely proportional to age, cannabis use disorder increased, peaked, and decreased with age, and that of sedative use disorder increased with age, particularly among women. While older individuals (in the 51-60 years of age group) were at lower risk (OR = 0.5 [0.3, 0.8]) compared to those <20 years of age for alcohol use disorder, they were at increased risk for sedative use disorder (OR = 3.1 [1.2, 9.7]). Conclusions: These findings represent substantially higher rates of SUDs in Israel than those previously reported and should affect resources allocated to addiction prevention and treatment. Further research on the role of gender, age, culture, and ethnicity in the propensity to develop SUDs is necessary for the development of more focused preventive and intervention measures. Focusing on non-Jewish populations in Israel and broadening the scope to include behavioral addictions should be addressed in future studies. COA of Formula: C8H9N. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Bar-Or, RL; Kor, A; Jaljuli, I; Lev-Ran, S or concate me.

Our Top Choice Compound:95-11-4

About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Somoza-Martin, JM; Vazquez-Casal, A; Suarez-Cunqueiro, M; Garcia-Garcia, A; Gandara-Vila, P; Perez-Sayans, M or concate me.. COA of Formula: C8H9N

Recently I am researching about VERTICAL DISTRACTION; COMPLICATIONS; AUGMENTATION; IMPLANTS; DEVICES, Saw an article supported by the . COA of Formula: C8H9N. Published in MEDICINA ORAL S L in VALENCIA ,Authors: Somoza-Martin, JM; Vazquez-Casal, A; Suarez-Cunqueiro, M; Garcia-Garcia, A; Gandara-Vila, P; Perez-Sayans, M. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile

Background: To perform a morphologic classification based on the results of bone augmentation after a distraction osteogenesis. Material and Methods: Thirty-four (34) patients (24 women and 10 men; mean age, 47.1 years (SD=9.5); age range, 23 to 62 years) underwent a total of 42 alveolar ridge distractions before the placement of a total of 89 dental implants. Ridge bone morphology was evaluated as the main ordinal variable. Chi-squared, Kruskal-Wallis and ANOVA one-way test were used. Results: Category I (30.95%): consisted of wide alveolar rim and no bone defects Category II (28.57%): wide alveolar rim, lateral bone surface concavity. Category III (23.81%): narrow alveolar rim, lateral bone surface concavity. Category IV (2.38%): distraction transport segment forming a bridge, without bone formed beneath and requiring guided bone regeneration. Category V (9.52%): return of the transport segment to its initial position due to the reverse rotation of the distractor screw. Category VI (4.76%): distraction transport segment completely lost. Subcategory D (28.57%), consisted of lingual deviation of the distraction axis, occurring in any of the categories I to IV. More men (76.9%) presented with category I (p<0.001). The use of the chisel resulted mainly in categories I and II (69.4%) (p<0.001). GBR was only required in 23.1% of the cases in Category I (p=0.011). The bone height achieved decreases as the category increases, due to the accompanying osteogenic limitations (p<0.001). The implants placed in category I were longer 11.5 +/- 0.9 mm (CI95% 10.9-11.9 mm) compared to those placed in category III with a length of 10.4 +/- 1.5 mm (CI95% 9.5-11.4 mm) (p=0.035). Conclusions: The alveolar ridge after distraction osteogenesis could be divided into six morphologic categories which provide a useful basis for decision-making regarding implant placement. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Somoza-Martin, JM; Vazquez-Casal, A; Suarez-Cunqueiro, M; Garcia-Garcia, A; Gandara-Vila, P; Perez-Sayans, M or concate me.. COA of Formula: C8H9N

Properties and Exciting Facts About 95-11-4

About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Alepee, N; Adriaens, E; Abo, T; Bagley, D; Desprez, B; Hibatallah, J; Mewes, K; Pfannenbecker, U; Sala, A; Van Rompay, AR; Verstraelen, S; McNamee, P or concate me.. Quality Control of 5-Norbornene-2-carbonitrile

I found the field of Toxicology very interesting. Saw the article Development of a defined approach for eye irritation or serious eye damage for liquids, neat and in dilution, based on cosmetics Europe analysis of in vitro STE and BCOP test methods published in 2019. Quality Control of 5-Norbornene-2-carbonitrile, Reprint Addresses Adriaens, E (corresponding author), Adriaens Consulting BVBA, Bellemdorpweg 95, B-9881 Aalter, Belgium.. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile

The focus of Cosmetics Europe’s programme on serious eye damage/eye irritation is on development of testing strategies and defined approaches for identification of ocular effects of chemicals in the context of OECD’s Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation. Cosmetics Europe created a comprehensive database of chemicals for which in vitro data are available with corresponding historical in vivo Draize eye data. This database allowed further exploration of the initially proposed strategies from the CON4EI project and to identify opportunities for refinement. The current analysis focused on the development of a defined approach, applicable to liquid non-surfactant chemicals, neat and in dilution, that can distinguish between the three UN GHS categories (Cat. 1, Cat. 2, and No Cat.). Combining the modified-protocol Short Time Exposure (STE) test method (OECD TG 491 with extension to highly volatile substances) with the Bovine Corneal Opacity and Permeability Laser Light-Based Opacitometer (BCOP LLBO) test method in a Bottom-Up approach identified 81.2% Cat. 1, 56.3% Cat. 2, and 85.3% No. Cat correctly, with an NPV of 96.7% and a PPV of 68.6%. Therefore, the performance of the defined approach was better than the standalone test methods.