Category: 96606-37-0

96606-37-0, The chemical industry reduces the impact on the environment during synthesis 96606-37-0, name is 2,4,6-Trifluorobenzonitrile, I believe this compound will play a more active role in future production and life.

Under a nitrogen atmosphere,1 mol of potassium tert-butoxide was dissolved in 20 ml of DCM and stirred for 1 hour,The DML solution containing 1 mol of methoxycarbazole was then added dropwise,After all the additions, stir for 1 hour.Subsequently, a solution of 0.33 mol of 2,4,6-trifluorobenzonitrile in DMF was added dropwise,Stir for 5 hours. The reaction solution was then poured into water and filtered to give a solid.Separated by column. C9, yield 90%.

The chemical industry reduces the impact on the environment during synthesis 2,4,6-Trifluorobenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Tsinghua University; Duan, Lian; Zhang, Dongdong; Zhu, Yingguang; Zhang, Guohui; Liu, Song; (22 pag.)CN106316924; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

96606-37-0, A common heterocyclic compound, 96606-37-0, name is 2,4,6-Trifluorobenzonitrile, molecular formula is C7H2F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 3: Synthesis OF 3-AMINO-6- (4-AMINO-PIPERIDIN-1-YL)-4-FLUORO- BENZOLB] THIOPHENE-2-CARBOXYLIC acid amide H N i N O F NHZ NN O N i HN 0- HS-NH, N F N O F F THF, 50 C, 3h DMF, 15h F 0A0 F NH2 HCI NH2 na ff) / MeOH, 3 days 0 H2N~ 3 ‘3 To a solution of 1.0 g (6.4 mmol) of 2, 4,6-trifluorobenzonitrile in MEOH (25 mL) was added 1.3 g (6.5 mmol) OF 4-N-BOC-AMINO-PIPERIDINE along with 1.2 mL (6.7 mmol) of N, N-diisopropylethylamine. The mixture was stirred at room temperature for 3 days then concentrated under reduced pressure to provide a white, solid. The solid was washed with large amounts OF H20 and dried under vacuum. The solid was RECRYSTALLIZED from hexane /EtOAc to provide 1.23 g (56%) of [1- (4-CYANO-3, 5-difluoro-phenyl) -piperidin-4-yl]- carbamic acid tert-butyl ester as a white solid.

The synthetic route of 96606-37-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2005/12283; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts