Category: nitriles-buliding-blocks

Electric Literature of 133116-83-3, The chemical industry reduces the impact on the environment during synthesis 133116-83-3, name is 2-Fluoro-6-(trifluoromethyl)benzonitrile, I believe this compound will play a more active role in future production and life.

Intermediate 30: (2-(piperidin-l-yl)-6-(trifluoromethyl)phenyl)methanamine Step 1: To a solution of 2-fluoro-6-(trifluoromethyl)benzonitrile (CAS: 133116-83-3) (2 mmol) and piperidine (2.2 mmol) in 10 mL of DMF was added K2CO3 (12 mmol). The reaction was stirred at 70 C for 12 h, then cooled to RT. The reaction mixture was then extracted with water and EtOAc, washed with brine, dried over Na2S04, concentrated in vacuo, then purified by prep- TLC to provide 2-(piperidin-l-yl)-6-(trifluoromethyl)benzonitrile as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-6-(trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KAROS PHARMACEUTICALS, INC.; DE LOMBAERT, Stephane; GOLDBERG, Daniel R.; BRAMELD, Kenneth Albert; SJOGREN, Eric Brian; WO2015/89137; (2015); A1;,
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Related Products of 326-62-5, These common heterocyclic compound, 326-62-5, name is 2-(2-Fluorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Procedure for the Synthesis of Arylquinolines (1). To a solution of 2.38 mmol (1.3 equiv) of an appropriate phenylacetonitrile in 3 mL of anhydrous DMF at 0 C. was added 2.38 mmol (1.3 equiv) of potassium tert-butoxide. The mixture was stirred for 15 min, and 1.83 mmol of 2-aminoaldehyde 5 in 1 mL of anhydrous DMF was added dropwise at 0 C. The mixture was allowed to warm to the room temperature and stirred for 3 h at 90 C. After cooling, the mixture was quenched in water with vigorous stirring. The solution was adjusted to pH 7 only in the case of 2-amino-3-(2-fluorophenyl)quinoline-7-carboxylic acid. A precipitate was collected by filtration and purified by recrystallization and/or chromatography as noted for individual compounds described below.

Statistics shows that 2-(2-Fluorophenyl)acetonitrile is playing an increasingly important role. we look forward to future research findings about 326-62-5.

Reference:
Patent; UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION; WATT, David S.; LIU, Chunming; RANGNEKAR, Vivek M.; SVIRIPA, Vitaliy M.; BURIKHANOV, Ravshan; ZHANG, Wen; (22 pag.)US2016/332971; (2016); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 935-44-4, name is 1-Phenyl-1-cyclopropanecarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C10H9N

INTERMEDIATE 45 4-(1-Cyanocyclopropyl)benzenesulfonyl chloride To a solution of 1-phenylcyclopropanecarbonitrile (0.5 g, 3.5 mmol) in 5 mL of chloroform was added 0.5 mL of ClSO3H at 0 C. After stirring at rt stirred overnight, the reaction mixture was poured into ice-water (50 mL) and the product was extracted with CHCl3 (75 mL). The extracts were washed with water (50 mL) and brine (50 mL), dried over anhydrous MgSO4, and concentrated to give the title compound. 1H NMR (500 MHz, CD3OD): delta 8.08 (2H, d), 7.77 (2H, d), 1.60 (2H, t), 1.21 (2H, t).

The synthetic route of 935-44-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Sharp & Dohme Corp.; EP2102201; (2010); B1;,
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These common heterocyclic compound, 79630-23-2, name is 3-Bromo-4-fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3-Bromo-4-fluorobenzonitrile

(Step 1) A suspension of 3-bromo-4-fluorobenzonitrile (0.851 g, 4.26 mmol), tetraethyltin (2.00 g, 8.51 mmol) and tetrakis(triphenylphosphine)palladium (98.4 mg, 0.0851 mmol) in HMPA (4 mL) was stirred at 60 C. for 15 hrs. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the concentrated residue was purified by silica gel column chromatography (20% ethyl acetate/hexane) to give 3-ethyl-4-fluorobenzonitrile as a pale-yellow oil (1.25 g, crude).

The synthetic route of 3-Bromo-4-fluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; Terauchi, Jun; Nara, Hiroshi; Oki, Hideyuki; Sato, Kenjiro; (166 pag.)US2015/329556; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4110-35-4, name is 3,5-Dinitrobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 3,5-Dinitrobenzonitrile

Preparation 133 A suspension of 3,5-dinitrobenzonitrile (2.75g) in methanol (15ml) and tetrahydrofuran (15ml) was hydrogenated over 10 % palladium on carbon (50% wet) under hydrogen atmosphere for 6 hours. The catalyst was filtered off. The filtrate was concentrated, purified with silica gel column chromatography and eluted with dichloromethane in 0-1% methanol to give 3-cyano-5-nitroaniline (951mg). ESI-mass;m/z162.3(M-H+) 1H-NMR(DMSO-d6): delta;6.33(2H,s), 7.24(1H,s), 7.6-7.8(2H,m)

The synthetic route of 4110-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; EP1264820; (2002); A1;,
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Synthetic Route of 77-57-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77-57-6, name is 1-Phenylcyclopentanecarbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A 40 ml vial was charged with substrate (0.3 mmol, 1.0 equiv.), Mn(CF3-PDP) 1 (0.03 mmol, 10 mol%), ClCH2CO2H (425 mg, 4.5 mmol, 15.0 equiv.) and a stir bar. Acetonitrile (MeCN, 0.6 ml, 0.50 M) was added along the wall to ensure all compounds were washed beneath the solvent level and the vial was sealed with a screw cap fitted with a polytetrafluoroethylene (PTFE)/silicone septum. The vial was cooled to 0 C with an ice/water bath. A separate solution of H2O2 ((204 mg, 3.0 mmol, 10.0 equiv.), 50% (wt) in H2O, purchased from Sigma-Aldrich) in MeCN (3.75 ml) was loaded into a 10 ml syringe fitted with a 25 G needle and added dropwise to the stirring reaction over 3 h via a syringe pump (1.25 ml h-1 addition rate) while maintaining the reaction vial at 0 C. On completion, the reaction mixture was concentrated to a minimum amount of solvent. The residue was dissolved in ~20 ml dichloromethane (DCM) and washed with 9 ml sat. NaHCO3 solution (caution: CO2 released) to remove ClCH2CO2H. The aqueous layer was extracted with ~15 ml DCM twice and the combined organic layer was dried with Na2SO4. The filtrate was concentrated and purified by flash chromatography on silica gel.

The chemical industry reduces the impact on the environment during synthesis 1-Phenylcyclopentanecarbonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Zhao, Jinpeng; Nanjo, Takeshi; de Lucca, Emilio C.; White, M. Christina; Nature Chemistry; vol. 11; 3; (2019); p. 213 – 221;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 103146-25-4, name is 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 103146-25-4

In a 200-ml four-necked flask equipped with a stirrer and a thermometer, 1.5 g [(4.] [38] m mol) of [()-4- [4-DIMETHYLAMINO-1- (4′-FLUOROPHENYL)-1-HYDROXYBUTYL]-3-] hydroxymethylbenzonitrile was dissolved in 30 ml of toluene, then 0.45 g of Novozym 435 (product [OF NOVOZYMES),] 0.347 g (4.38 m mol) of pyridine, 4.38 m mol of various kinds of acids and 1.00 g (8.76 m mol) of vinyl butyrate were added, and stirred at [40C] for between 16 and 21.5 hours. The result is shown in Table 4. Example 6 In a 200-ml four-necked flask equipped with a stirrer and a thermometer, 3.0 g [(8.] 76 m mol) of [( : L)-4- [4-DIMETLIYLAMINO-L- (41-FLUOROPHENYL)-L-HYDROXYBUTYL]-3-] hydroxymethylbenzonitrile was dissolved in 30 ml of toluene, then 0.9 g of Novozym [435] (product [OF NOVOZYMES),] 0.693 g (8.76 m mol) of pyridine, 8.76 m mol of various kinds of acids and 2.00 g (17.52 m mol) of vinyl butyrate were added, and stirred at [40C] for between 15.5 and 16.5 hours. The results are shown in Table 5.

The synthetic route of 103146-25-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; H. LUNDBECK A/S; WO2004/14821; (2004); A1;,
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Adding a certain compound to certain chemical reactions, such as: 658-99-1, name is 2-(3,4-Difluorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 658-99-1, Computed Properties of C8H5F2N

2-(3,4-difluorophenyl)acetonitrile (7.730 g, 50.480 mmol) in N,N-dimethylformamide (50 mL) at 0 C and sodium hydride (60.00%, 5.047 g, 126.200 mmol) was added and stirred at the same temperature for 30 minutes. To the reaction mixture 1,3-dibromopropane (10.191 g, 50.480 mmol) was added and further stirred at room temperature for 12 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and water was removed with anhydrous magnesium sulfate, followed by filtration and concentration under reduced pressure. The concentrate was purified by column chromatography (SiO2, 40 g cartridge; ethyl acetate / hexane = 0% to 20%) and concentrated to give the title compound (5.100 g, 52.3%) as a colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
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Synthetic Route of 114772-53-1, The chemical industry reduces the impact on the environment during synthesis 114772-53-1, name is 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile, I believe this compound will play a more active role in future production and life.

To the glass reactor, 4′-methyl-2-cyanobiphenyl was added5.00 kg, and methanol: 10.00 kgWith stirring2. 07 kg of sodium hydroxide,0.94 kgwaterSolubleliquid,Heated to 80 C, the reaction 10 hours,TLC test (developing solvent = petroleum ether: ethyl acetate = 1: 1), the reaction finished cooling to 40 C, and stirring 20 to 30 minutes, then add hydrochloric acid pH = 2 or so, stirring 30 minutes after the re-test pH , No change will continue to cool down to room temperature, some solid precipitation, continue stirring for two hours, centrifugal, washed to neutral, the product is dry 10 ~ 12 hours, the product 5. 30kg, yield 91. 06%Melting point 146 ~ 148 C, purity 99. 12%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; weite hunan pharmaceutical co ltd; He, liang; Luo, hui; Mo, wei; (10 pag.)CN105399627; (2016); A;,
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Adding a certain compound to certain chemical reactions, such as: 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1080-74-6, SDS of cas: 1080-74-6

General procedure: Compound T-TT-CHO (200 mg, 0.2 mmol), INCN (246 mg, 1.2 mmol), and chloroform (30 mL) were added into a 100 mL round bottom flask. After stirred for 10 min under argon protection, pyridine (1 mL) was added by injection and the mixture was stirred at 70C for 6 h. Then methanol (100 mL) was added and the precipitate was collected by filtration after removing the chloroform under reduced pressure. The residue was purified by column chromatography using chloroform as an eluent to give a blue-black powder (226 mg, 84.0%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Cheng, Qing; Cong, Zhiyuan; Gao, Chao; Liu, Jianqun; Liu, Shengna; Pan, Hui; Wang, Weiping; Wu, Haimei; Zhao, Baofeng; Dyes and Pigments; vol. 178; (2020);,
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