Some tips on 10406-25-4

According to the analysis of related databases, 10406-25-4, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10406-25-4 as follows. HPLC of Formula: C8H8N2

(3) 0.1 g of intermediate C was added3, With the raw material0.1g in THF as a solvent at room temperature for 3h, the intermediate D-AWY113, yield 66%; specific reaction equation is as follows:

According to the analysis of related databases, 10406-25-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong University of Technology; Zhao, Suqing; Jiang, Zhengyun; Wu, Panpan; Zhang, Kun; Hong, Weiqian; Cui, Xiping; Chen, Yingshan; Hu, Qingqing; Jiao, Luoying; Xia, Nana; Chen, Ding; (21 pag.)CN106083742; (2016); A;,
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Share a compound : 20925-27-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-2-chlorobenzonitrile, and friends who are interested can also refer to it.

Reference of 20925-27-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20925-27-3 name is 4-Amino-2-chlorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a typical experiment, a solution of sodium hydrogen carbonate (62.72 mmol) in 20 mL of water was stirred for 10 min and to it was added dichloromethane (20 mL) followed by substituted aniline (15.68 mmol). The reaction mixture was cooled to 0 C, thiophosgene (23.52 mmol) was introduced dropwise over a period of 30 min and continuously stirred at room temperature for 1 h. The reaction mixture was washed with brine solution; the organic layer was dried over anhydrous sodium sulphate and concentrated to get a crude gummy compound which was recrystalized in hexane under cold condition. The precipitate was filtered and dried to get the desired compound. The products were characterized by analytical and spectral methods.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-2-chlorobenzonitrile, and friends who are interested can also refer to it.

Reference:
Article; Khatik, Gopal L.; Kaur, Jasmine; Kumar, Varun; Tikoo, Kulbhushan; Venugopalan; Nair, Vipin A.; European Journal of Medicinal Chemistry; vol. 46; 8; (2011); p. 3291 – 3301;,
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Simple exploration of 1558-81-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-Cyano-1-cyclopropanecarboxylate, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 1558-81-2, name is Ethyl 1-Cyano-1-cyclopropanecarboxylate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1558-81-2, Formula: C7H9NO2

To a solution of ethyl 1 -cyanocyclopropanecarboxylate (1-127) (5 g, 36 mmol) in DME/MeOH (80 mL/8 mL) was added NaBH4 (10.65 g, 0.288 mol) in a portionwise manner at 0 ~ 5 C. The mixture was stirred at room temperature for 4 hr. TLC (petroleum ether: EtOAc=1 :1 ) showed the reaction was complete. The reaction mixture was diluted with saturated aq. NaHC03 (60 mL) and then extracted with 10% MeOH/CH2CI2 (8 x 100 mL). The combined organic layers were dried over Na2S04 and concentrated to give 1 -(hydroxymethyl)cyclopropanecarbonitrile (1-128) (3 g, 85%) as a light yellow oil, which was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-Cyano-1-cyclopropanecarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
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Continuously updated synthesis method about 1187-42-4

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diaminomaleonitrile, its application will become more common.

Synthetic Route of 1187-42-4,Some common heterocyclic compound, 1187-42-4, name is Diaminomaleonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A compound F (0.70 g, 1.46 mmol), diaminomaleonitrile (0.19 g, 1.76 mmol), 40 mL of ethanol, 40 mL of THF, and 0.23 mL of 12M hydrochloric acid were charged in a three-necked flask having a capacity of 300 mL, and the mixture was stirred while conducting heating at 40 C. for 24 hours. Water was added to the resultant solution, the resultant mixture was subjected to extraction with chloroform, and then the resultant extract was dried by adding sodium sulfate thereto. Sodium sulfate hydrate was removed by conducting filtration, and the solvent was distilled off from the filtrate using an evaporator. The resultant solid was purified by silica gel column chromatography (developing solvent: toluene) to obtain a red solid (yield amount: 0.52 g, yield: 64%).Chemical shift values (delta) of the compound measured by 1H NMR (400 MHz, CDCl3) were as follows: delta 9.16 (t, J=8.4 Hz, 2H), 8.76 (d, J=1.6 Hz, 1H), 8.70 (d, 8.4 Hz, 1H), 8.01 (dd, J=8.8 Hz, 2.0 Hz 1H), 7.96 (td, J=8.4 Hz, 1.2 Hz, 1H), 7.84 (td, J=8.4 Hz, 1.2 Hz, 1H), 7.66 (dt, J=8.8 Hz, 2.0 Hz 2H), 7.19-7.10 (m, 10H), 2.36 (s, 6H). It was confirmed by 1H NMR measurement that the obtained compound was a compound 2 (Da-CNBQx).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diaminomaleonitrile, its application will become more common.

Reference:
Patent; KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION; Nippon Soda Co., Ltd.; YASUDA, Takuma; FURUE, Ryuhei; ISHIHARA, Hiroyuki; FUKUSHIMA, Yukio; (61 pag.)US2019/330162; (2019); A1;,
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Some scientific research about 105-34-0

According to the analysis of related databases, 105-34-0, the application of this compound in the production field has become more and more popular.

Synthetic Route of 105-34-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 105-34-0 as follows.

The mixture of benzaldehyde (0.5 mmol) and methyl cyanoacetate(0.5 mmol) in toluene 1 mL was incubated in the presence of Candida cylindracea lipase (30 mg) at 50 C for 4 days. The reaction was monitored by TLC analysis. After this time enzyme was filtered out and the solvent was evaporated in vacuo. The resulting residue was purified by column chromatography (silica gel, eluent ethyl acetate/hexanes) to obtain desired product 5a with 40% yield. 4.7. Characterization of obtained products 5a-u.4.7.1. Methyl (E)-2-cyano-3-phenylprop-2-enoate; (5a)White solid; melting point 89 C; 1H NMR (400 MHz, CDCl3) delta 8.20(s, 1H), 7.92 (dd, J=7.1, 1.5 Hz, 2H), 7.53-7.40 (m, 3H), 3.87 (s, 3H).13C NMR (100 MHz, CDCl3) delta 162.9, 155.3, 133.4, 131.4, 131.1, 129.3,115.4, 102.6, 53.4. All the resonances of 1H, 13C NMR spectra andmelting point were consistent with reported values [32]

According to the analysis of related databases, 105-34-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wilk, Monika; Trzepizur, Damian; Koszelewski, Dominik; Brodzka, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
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Some tips on 26391-06-0

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Cyano-N,N-diethylacetamide, and friends who are interested can also refer to it.

Electric Literature of 26391-06-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26391-06-0 name is 2-Cyano-N,N-diethylacetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1 Preparation of N,N-diethyl-2-cyano-3-(-3-methoxy-4-hydroxy-5-nitrophenyl-)-acrylamide; (V) A suspension of 3-methoxy-4-hydroxy-5-nitro-benzaldehyde (100 g, 0.507 mol) in methanol (0.5 I) under nitrogen atmosphere at room temperature, is added with N,N-diethylamino-cyano-acetamide (142 g, 1.01 mol) and a sodium hydroxide solution (30.4 g, 0.761 mol) in methanol (0.5 1). The resulting mixture is reacted under mechanical stirring for 16 hours. After completion of the reaction, a 20% hydrochloric acid solution (0.5 I) is dropped in the mixture which is left to spontaneously cool to room temperature. The resulting product is filtered, washing with water (0.1 I for three times), then dried in the air. 155 g of product are obtained. Yield: 95%. 1H-NMR (300 MHz), delta (DMSO): 8.10 (d, 1 H); 7.85 (d, 1 H); 7.70 (s, 1 H); 3.40 (m, 4H); 1.15 (m, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Cyano-N,N-diethylacetamide, and friends who are interested can also refer to it.

Reference:
Patent; Dipharma Francis S.r.l.; EP1935873; (2008); A1;,
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The important role of 214623-57-1

The synthetic route of 5-Amino-2-methoxybenzonitrile has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Amino-2-methoxybenzonitrile

General procedure: A solution of 5-amino-2-alkoxybenzonitrile (20mmol), glacial acetic acid (50mL) and water (20mL) was added to the reaction flask at -10C under stirring, water-soluble sodium azide (30 mmol) was slowly added dropwise to the reaction mixture for 30 min, and the addition was completed,the reaction temperature is maintained steady 3h, extracted with dichloromethane, the organic layers combined, washed with brine, dried over anhydrous sodium sulfate , filtered, and concentrated to dryness under reduced pressure the crude product purified by column chromatography (ethyl acetate: petroleum ether = 1: 5) to give pure product.

The synthetic route of 5-Amino-2-methoxybenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHINA MEDICAL UNIVERSITY; MENG, FANHAO; ZHANG, TINGJIAN; WU, QINGXIA; WANG, LIN; SUN, QI; LIANG, JINGWEI; HE, XIN; (22 pag.)CN105294584; (2016); A;,
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Simple exploration of 332-25-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethoxy)benzonitrile, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 332-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4-Trifluoromethoxybenzaldehyde Diisobutylaluminium hydride (11.8 ml. 1M solution in toluene) was added to a stirred solution of 4-cyanophenyl trifluoromethyl ether (2.0 g., Fairfield) in dry diethyl ether (100 ml.). The mixture was refluxed with stirring for 3 hours. The mixture was cooled and dioxane (5 ml.) containing water 1.0 ml.) was added. Dilute hydrochloric acid was added (60 ml. of 10percent solution). The mixture was stirred for 30 minutes and extracted with diethyl ether. The ethereal extracts were washed with water and dried over anhydrous magnesium sulphate. The solvent was removed in vacuo and the residue was purified by chromatography on silica, eluding with 9:1 hexane:diethyl ether. 4-Trifluoromethoxybenzaldehyde was obtained as a colourless liquid (1.65 g.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethoxy)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Wellcome Foundation; The Regents of the University of California; US5502073; (1996); A;,
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Extracurricular laboratory: Synthetic route of 194853-86-6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Fluoro-2-(trifluoromethyl)benzonitrile, its application will become more common.

Application of 194853-86-6,Some common heterocyclic compound, 194853-86-6, name is 4-Fluoro-2-(trifluoromethyl)benzonitrile, molecular formula is C8H3F4N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 3 t-Butyl 4-(4-cyano-3-trifluoromethylphenyl)-3-methylpiperazine-1-carboxylate A 4.46 g portion of t-butyl 3-methylpiperazine-1-carboxylate synthesised in Reference Example 2, 6.74 g of 4-fluoro-2-trifluoromethylbenzonitrile and 7.76 ml of diisopropylethylamine were stirred in 50 ml of DMF at 100C for 2 days. The reaction solution was diluted with water and extracted with ethyl acetate, the organic layer was washed and dried and then the solvent was evaporated under reduced pressure. The residue was subjected to a silica gel column chromatography and eluted with hexane-ethyl acetate (3:1, v/v) to obtain 5.6 g of the title compound as white crystals.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Fluoro-2-(trifluoromethyl)benzonitrile, its application will become more common.

Reference:
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1122242; (2001); A1;,
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Extended knowledge of 2338-75-2

The synthetic route of 2338-75-2 has been constantly updated, and we look forward to future research findings.

Reference of 2338-75-2,Some common heterocyclic compound, 2338-75-2, name is 4-(Trifluoromethyl)phenylacetonitrile, molecular formula is C9H6F3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of MeONa in MeOH (5%,1.5 mL) was added 3a (ca. 122 mg, 0.5 mmol, 1 eq), immediatelyfollowed by cyano derivative (1.1 eq) at room temperature. Thereaction mixture was heated under reflux for 1.5 h. After coolingfor 1 h in ice bath, the solid was filtered and washed with a minimumof cold MeOH. If not pure, crude product was purified by columnchromatography on silica gel with CH2Cl2/MeOH: 99:1?90:10 as eluent.

The synthetic route of 2338-75-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; N’Guessan, Jean-Paul Deto Ursul; Delaye, Pierre-Olivier; Penichon, Melanie; Charvet, Claude L.; Neveu, Cedric; Ouattara, Mahama; Enguehard-Gueiffier, Cecile; Gueiffier, Alain; Allouchi, Hassan; Bioorganic and Medicinal Chemistry; vol. 25; 24; (2017); p. 6695 – 6706;,
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