Category: nitriles-buliding-blocks

Yang, Xulin published the artcileDesigning phthalonitrile/hydroxyl compound systems for high performance CFRP composites, HPLC of Formula: 91-15-6, the main research area is phthalonitrile hydroxyl compound system carbon fiber reinforced polymer composite.

High mech. residues at/after elevated temperatures are basic prerequisites for the engineering applications of carbon fiber reinforced polymer (CFRP) composites in special fields like aerospace. In this study, phthalonitrile (PNP) copolymers based on hydroxyl compounds of BP monomer, PEP and BZCN resin were designed and their curing behavior and processability were investigated for realizing the corresponding CFRP composites. High temperature mech. performances of PNP/hydroxyl compound/CF composites under instantaneous and non-instantaneous states are systematically assessed. At 300°C, PNP/hydroxyl compounds/CF composite showed a retention rate of tensile, compressive, flexural strength and flexural modulus higher than 35%, 95%, 80% and 90%, resp. After 300°C/50 h thermal aging, their flexural properties show no obvious attenuation. Even after being aged at 350°C for 50 h, the residue of flexural modulus is above 90% while that of flexural strength is over 60%. The mass residue of PNP/hydroxyl compounds/CF composites were all higher than 98% and 90% after aging at 300°C and 350°C for 50 h. PNP/hydroxyl compounds/CF composites, with the excellent comprehensive mech. properties, can be used as high performance engineering materials.

Materials Research Express published new progress about Bending strength. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yu, Bin published the artcileDesign, Synthesis, and Evaluation of the Antifungal Activity of Novel Pyrazole-Thiazole Carboxamides as Succinate Dehydrogenase Inhibitors, HPLC of Formula: 1885-29-6, the main research area is pyrazole thiazole carboxamide derivative preparation succinate dehydrogenase inhibitor antifungal; fungicidal activity; molecular docking; structure−activity relationships; succinate dehydrogenase inhibitors.

Succinate dehydrogenase (SDH) is regarded as a promising target for fungicide discovery. To continue our ongoing studies on the discovery of novel SDH inhibitors as fungicides, novel pyrazole-thiazole carboxamides were designed, synthesized, and evaluated for their antifungal activity. The results indicated that compounds 9ac, 9bf, and 9cb showed excellent in vitro activities against Rhizoctonia cerealis with EC50 values from 1.1 to 4.9 mg/L, superior to that of the com. fungicide thifluzamide (EC50 = 23.1 mg/L). Compound 9cd (EC50 = 0.8 mg/L) was far more active than thifluzamide (EC50 = 4.9 mg/L) against Sclerotinia sclerotiorum. Compound 9ac exhibited promising in vivo activity against Rhizoctonia solani (90% at 10 mg/L), which was better than that of thifluzamide (80% at 10 mg/L). The field experiment showed that compound 9ac had 74.4% efficacy against Rhizoctonia solani on the 15th day after two consecutive sprayings at an application rate of 4.80 g a.i./667 m2, which was close to that of thifluzamide (83.3%). Furthermore, mol. docking explained the possible binding mode of compound 9ac in the RcSDH active site. Our studies indicated that the pyrazole-thiazole carboxamide hybrid is a new scaffold of SDH inhibitors.

Journal of Agricultural and Food Chemistry published new progress about Botrytis cinerea. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yu, Yueh-Cheng published the artcileConceptual design, environmental, and economic evaluation of direct copolymerization process of carbon dioxide and 1,4-butanediol, Category: nitriles-buliding-blocks, the main research area is carbon dioxide butanediol copolymerization.

The routes to convert CO2 into environmentally benign materials have attracted wide attentions. In this work, an emerging process to produce poly(butylene carbonate) (or PBC) from direct copolymerization of carbon dioxide and 1,4-butanediol is firstly simulated with analyses on the CO2 emission ratio (CO2-e, in kg-CO2/kg-PBC) and yearly unit manufacturing cost of product (YUMC, in USD/kg). In order to address the issues associated with large amount of solvents used in the lab scale, two proposed scenarios including the reduction of solvent amount, and heat integration by vapor recompression cycle (VRC) were simulated. It is found that CO2-e is reduced by 82.0% (from 30.06 to 5.42) when the solvent amount is reduced to 10%, and another 19.9% reduction in CO2-e (to 4.34) when applying the VRC. YUMCs are reduced by ca. 68% for both proposed scenarios (from 5.62 to ca. 1.8). The findings reported in this study may prove informative for developing CO2 conversion technologies from lab scale to industrial scale.

Journal of the Taiwan Institute of Chemical Engineers published new progress about Copolymerization. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mougeot, Romain published the artcileConvergent and Practical Synthesis of Fluorescent Triphenylamine Derivatives and Their Localization in Living Cells, Quality Control of 100-70-9, the main research area is pyridine oxazole thiazole preparation fluorescence.

In the search for new fluorescent triphenylamine (TP) derivatives, authors studied the influence of the position and substitution of diverse heterocyclic substituents. A library of 10 fluorescent triphenylamines bearing either oxazoles or thiazoles and pyridiniums, substituted at different positions has been developed. The approach is based on a convergent C-H activation reaction between pyridine-oxazoles or pyridine-thiazoles and di-iodo triphenylamine. Author’s showed that the nature and substitution pattern of the 5-membered- (oxazole, thiazole) or 6-membered heterocycle (pyridine) has a strong influence on their fluorescence properties and on their localization in living cells as they stain either the nucleus or mitochondria.

European Journal of Organic Chemistry published new progress about Fluorescent dyes. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guo, Hongguang published the artcileHigh Potential of Methane Production from Coal by Fungi and Hydrogenotrophic Methanogens from Produced Water, HPLC of Formula: 91-15-6, the main research area is methane coal fungus hydrogenotrophic methanogen water bacteria organic.

Studying in situ microorganisms is essential to understand the formation of biogenic coalbed methane (CBM). Only a few studies have studied the fungi community inhabiting in coal seams although fungi degrade refractory compounds and solubilize coal and even work with methanogens to produce methane. Produced H2O was collected from Qinshui Basin and used as the source of microflora to degrade coal. The function of fungi was analyzed by inhibition of bacteria with antibiotics. The inhibition of bacteria in the microcosms significantly increased the methane yield. Fungi were more favorable to cooperate with hydrogenotrophic methanogens when bacteria were inhibited as Methanobacterium were the predominant archaea accounting for 45.98-86.98% of the sequence reads. The relatively unchanged fungal community and high volatile fatty acids (VFAs) yields (48.70-85.72%) in the presence of antibiotics might contribute to H2 production to facilitate hydrogenotrophic methanogenesis. On the contrary, the dominant methanogens in microcosms without antibiotics gradually changed from Methanobacterium (89.85%) to Methanoceta (46.19%) and finally to Methanobacterium (87.72%). The bacterial community and organic intermediates have also changed greatly over time, which can be the reason for the succession of the methanogens. Probably fungi in produced H2O can play an important role in coal biodegradation to produce VFAs and H2 that support hydrogenotrophic methanogenesis, which could be neg. impacted by the existence of bacteria.

Energy & Fuels published new progress about Acetoanaerobium. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Koppala, Srinivasarao published the artcileDevelopment and validation of a novel stability-indicating RP-HPLC method for the simultaneous determination of related substances of ketoprofen and omeprazole in combined capsule dosage form, Name: 2-(3-Benzoylphenyl)propanenitrile, the main research area is ketoprofen omeprazole capsule RP HPLC.

A novel, simple, sensitive, selective and reproducible stability-indicating high performance liquid chromatog. method was developed for the quant. determination of degradation products and process-related impurities of ketoprofen (KET) and omeprazole (OMZ) in combined oral solid dosage form. Chromatog. separation was achieved on a Phenomenex Luna C18 (2) column (150 × 4.6 mm, 5 μm) under gradient elution by using a binary mixture of potassium dihydrogen phosphate buffer and acetonitrile at a flow rate of 0.8 mL/min. Chromatogram was monitored at 233 nm for KET impurities and at 305 nm for OMZ impurities using a dual wavelength UV detector. Resolution for KET and OMZ and 14 impurities was found to be >1.5 for any pair of components. Typical retention behaviors of impurities at various pH values were depicted graphically. To prove the stability-indicating power of the method, the drug product was subjected to hydrolytic, oxidative, photolytic, humidity and thermal stress conditions as per ICH. The developed method was validated according to the current ICH guidelines for specificity, limit of detection, limit of quantification, linearity, accuracy, precision, ruggedness and robustness.

Journal of Chromatographic Science published new progress about Acid hydrolysis. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Name: 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shakya, Bhushan published the artcile2-Pyridineformamide N(4)-ring incorporated thiosemicarbazones inhibit MCF-7 cells by inhibiting JNK pathway, Computed Properties of 100-70-9, the main research area is neoplasm antitumor 2 pyridineformamide thiosemicarbazone JNK pathway; 2-Pyridineformamide thiosemicarbazone; A375; A431; Cell viability; HeLa; MCF-7.

In an effort to develop a more potent anticancer therapeutic agent, a series of 2-pyridineformamide thiosemicarbazones (I) (R = H, 4-CH3, 5-F, 6-CH3; heterocycle = pyrrolidine, piperidine, morpholine, thiomorpholine, azepane, 1-(2-pyridinyl)-piperazine) have been synthesized and evaluated for their anti-cancer activities against the cancer cells MCF-7 (breast cancer cell line), A-431 and A375 (epidermoid carcinoma cell line), and HeLa (cervical cancer cell line) using MTT assay. All these 2-pyridineformamide thiosemicarbazones exhibited anti-proliferative activities towards these cell lines. 5FAmPyrr(II) possess most profound effects against MCF-7 cells with IC50 of 0.9 μM. In flow cytometry using Propidium Iodide, II was found to induce cell death significantly in a dose dependent manner (100 nM-3 μM) and inhibited colony formation of MCF-7 cells. This compound induced pro-apoptotic protein Bax and inhibited anti apoptotic protein Bcl-2 as well as both c-Jun and Jun N-terminal kinase (abbreviated as JNK) in concentration dependent manner. Further pro-caspase 3 and PARP were inhibited by II at concentration of 3 μM. The results suggest that II exhibit anticancer potency and induced cell death by inhibiting MAPK signaling and inducing intrinsic apoptotic pathway. All these indicate that 2-pyridineformamide thiosemicarbazones could be developed as future therapeutics agents to treat cancer.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zheng, Ke published the artcileNovel pH-Triggered Doxorubicin-Releasing Nanoparticles Self-Assembled by Functionalized β-Cyclodextrin and Amphiphilic Phthalocyanine for Anticancer Therapy, Application of Phthalonitrile, the main research area is cyclodextrin nanotheranostic pH sensitive release combination therapy phthalocyanine; combination therapy; cyclodextrin; nanotheranostics; pH-sensitive release; phthalocyanine.

Cyclodextrins (CDs), as pharmaceutical excipients with excellent biocompatibility, non-immunogenicity, and low toxicity in vivo, are widely used to carry drugs by forming inclusion complexes for improving the solubility and stability of drugs. However, the limited space of CDsâ€?lipophilic central cavity affects the loading of many drugs, especially with larger mols. In this study, β-CDs were modified by acetonization to improve the affinity for the chemotherapy drug doxorubicin (DOX), and doxorubicin-adsorbing acetalated β-CDs (Ac-CD:DOX) self-assembled to nanoparticles, followed by coating with the amphiphilic zinc phthalocyanine photosensitizer ZnPc-(PEG)5 for antitumor therapy. The final product ZnPc-(PEG)5:Ac-CD:DOX was demonstrated to have excellent stability and pH-sensitive drug release characteristics. The cell viability and apoptosis assay showed synergistic cytotoxic effects of chemotherapy and phototherapy. The mechanism of cytotoxicity was analyzed in terms of intracellular reactive oxygen species, mitochondrial membrane potential, and subcellular localization. More importantly, in vivo experiments indicated that ZnPc-(PEG)5:Ac-CD:DOX possessed significant tumor targeting, prominent antitumor activity, and less side effects. Our strategy expands the application of CDs as drug carriers and provides new insights into the development of CD chem.

ACS Applied Materials & Interfaces published new progress about Antitumor agents. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xu, Yiming published the artcileNew modification strategy of matrine as Hsp90 inhibitors based on its specific L conformation for cancer treatment, Formula: C7H6N2, the main research area is radicicol thermal shift assay anticancer activity mechanism of action; Anticancer activity; L-shaped matrine derivatives; Mechanism of action; Radicicol; Thermal shift assay.

The similarity of spatial structure between radicicol and matrine urged us to perform conformation modification of matrine, followed by L-shaped matrine derivatives, 6, 12, 21a-h and 22a-h were originally designed, synthesized and evaluated for Hsp90N inhibitors as anticancer agents. TSA (Thermal Shift Assay) results indicated that 21e, 22a-c and 22e-g exhibited strong binding force against Hsp90N with|ΔTm| > 3, meanwhile, MTT assay also revealed these compounds displayed potent anticancer activity with IC50 values below 25μM against HepG2, HeLa and MDA-MB-231 cells lines. Then, compound 22g with a high ΔTm = 10.92 was chosen as a representative to perform further mechanism study. It can induce cell apoptosis, arrest the cell cycle at the S phase and decrease the expression level of Hsp90 in Hela cell. These results originally provided targeted modification strategy for matrine derivatives to serve as Hsp90 inhibitors for cancer therapy.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Uruma, Yoshiyuki published the artcileSynthesis and biological evaluation of glucose conjugated phthalocyanine as a second-generation photosensitizer, Synthetic Route of 91-15-6, the main research area is glucose conjugated phthalocyanine preparation PDT photosensitizer cancer; Glucose; Hypoxia; Near-infrared (NIR) irradiation; Photodynamic therapy (PDT); Photosensitizers (PSs); Phthalocyanine (Pc).

Photodynamic therapy (PDT) is a treatment method using light and photosensitizers (PSs), which is categorized as a non-invasive surgery treatment for cancers. When the tumor is exposed to a specific light, the PSs become active and generate reactive oxygen species (ROS), mainly singlet oxygen which kills nearby cancer cells. PDT is becoming more widely recognized as a valuable treatment option for localized cancers and pre-cancers of skin as it has no long-term effects on the patient. But, due to the limited penetration rate of light into the skin and other organs, PDT can’t be used to treat large cancer cells or cancer cells that have grown deeply into the skin or other organs. Hence, in this study, our focus centers on synthesizing glucose-conjugated phthalocyanine (Pc) compatible with near-IR (NIR) irradiation as second-generation photosensitizer, so that PDT can be used in a wider range to treat cancers without obstacles.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts