Category: nitriles-buliding-blocks

On June 30, 2009, Li, Xun; Ng, Raymond A.; Zhang, Yongzheng; Russell, Ronald K.; Sui, Zhihua published an article.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile The title of the article was An efficient synthetic process for scale-up production of 4,5-diamino-2-(trifluoromethyl)benzonitrile and 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine. And the article contained the following:

Starting from 4-amino-2-(trifluoromethyl)benzonitrile, an efficient and nonchromatog. process was developed for multihundred gram production of 4,5-diamino-2-(trifluoromethyl)benzonitrile in 73% yield and 98 HPLC area% purity over four synthetic steps. The same synthetic strategy was applied to 4-bromo-2-(trifluoromethyl)aniline that afforded 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine in 81% overall yield and 99% HPLC area% purity. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

The Article related to fluoromethyldiaminobenzonitrile production, bromotrifluoromethylbenzenediamine production, amination aniline fluoromethyl derivative, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 1980, Moriya, Tamon; Hagio, Katsuaki; Yoneda, Naoto published an article.Application of 75629-62-8 The title of the article was Preparation and reactions of 3-(aminomethylene)-3H-indoles. And the article contained the following:

3-(Aminomethylene)-3H-indoles I (R = H, 5-OMe, 6-Me, 6-Cl; NR1R2 = pyrrolidino, piperidino, morpholino, NEt2, NBu2, NMe2) were prepared by the condensation of 3-indolecarboxaldehydes with secondary amines. Some were obtained as stable colorless prisms, while 3-(piperidinomethylene)-3H-indole and 3-(morpholinomethylene)-3H-indole readily polymerized in refluxing benzene. Reaction of I with electrophiles, such as alkyl and acyl halides, gave 1-substituted 3-aminomethylene-3H-indolium salts, which were converted to the corresponding 1-substituted 3-indolecarboxaldehydes by hydrolysis. Reaction of I with active methylene compounds proceeded under mild conditions to afford the condensation products in good yields. Successive reaction of I with electrophiles and nucleophiles provided a convenient route to 1,3-disubstituted indole derivatives The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application of 75629-62-8

The Article related to indolecarboxaldehyde enamine preparation reaction, aminomethyleneindole preparation substitution, indolium salt aminomethylene, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 31, 2016, Muhammad, Munira T.; Khan, Khalid M.; Taha, Muhammad; Khan, Tariq; Hussain, Shafqat; Fakhri, Muhammad I.; Perveen, Shahnaz; Voelter, Wolfgang published an article.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was New Facile, Eco-Friendly and Rapid Synthesis of Trisubstituted Alkenes Using Bismuth Nitrate as Lewis Acid. And the article contained the following:

A facile, eco-friendly and rapid method for Knoevenagel condensations using bismuth nitrate as Lewis acid was presented. In a typical reaction, 1 mmol of aromatic aldehyde with 1.1 mmol of malanonitrile in the presence of bismuth nitrate (3 mmol%) was refluxed in water (10 mL) for 25-30 min. In order to generalize the newly developed methodol., a variety of aldehydes were selected to synthesize different trisubstituted alkenes and it was found that this method can also be applied on aromatic aldehydes. For comparison purposes, the reaction was carried out in ethanol in parallel to water and found that water is the best solvent for this reaction. The advantages of bismuth nitrate as a catalyst were: easy to remove from the reaction mixture by simple filtration, recyclable, required water as solvent, was eco-friendly and afforded high yields (90-97%). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to aryl aldehyde malononitrile bismuth nitrate catalyst knoevenagel condensation, arylidene malononitrile preparation green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 23, 2019, Jung, Won Hyeok published a patent.Name: 5-Bromo-3-hydroxypicolinonitrile The title of the patent was Preparation of phenylacetylene derivatives as inhibitors against interaction between PD-1 and PD-L1. And the patent contained the following:

The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof that are useful for the prevention and treatment of cancer or autoimmune disease as inhibitors against interaction between programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1). Compounds of formula I wherein X1=X2 is N=C-R11, R11-C=N, N=N, or C=C; R1 is (CH)n-CO2H, O-R9, CO-(NH-R9), CO-R9, NH-R9, N(R9)2, N(R9)(R10), etc.; n is 0-4; R2 is H, halo, alkyl, cyano, hydroxy, amino, CO-alkyl, O-alkyl, O-(CH2)m-heteroaryl, O-(CH2)m-cycloalkyl, O-(CH2)m-heterocyclyl, NH-alkyl, etc.; m is 0-4; R3, R6, R7, R8, and R11 are independently H, halo, alkyl, cyano, hydroxy, amino, O-alkyl, NH-alkyl, etc.; R4 is H, halo, alkyl, cyano, hydroxy, amino, O-alkyl, NH-alkyl, CO-alkyl, etc.; R5 is (un)substituted (hetero)aryl, (un)substituted cycloalkyl, or (un)substituted heterocyclyl; R9 and R10 are independently (un)substituted alkyl; are claimed. Example compound II was prepared via Sonogashira coupling reaction of Me 6-ethynylpyridazine-3-carboxylate with 3-bromo-2-methyl-[1,1′-biphenyl], followed by Dibal-H reduction, reductive amination with Me glycinate hydrochloride, and basic hydrolysis. The invention compounds were evaluated for the inhibitory activity against interaction between PD-1 and PD-L1 (biol. activity given). The experimental process involved the reaction of 5-Bromo-3-hydroxypicolinonitrile(cas: 1160936-51-5).Name: 5-Bromo-3-hydroxypicolinonitrile

The Article related to phenylacetylene derivative preparation pd1 pdl1 inhibition cancer autoimmune disease, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Name: 5-Bromo-3-hydroxypicolinonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 18, 2019, Jung, Won-Hyuk published a patent.Application of 1160936-51-5 The title of the patent was Preparation of phenylacetylene derivatives as inhibitors against interaction between PD-1 and PD-L1. And the patent contained the following:

The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof that are useful for the prevention and treatment of cancer or autoimmune disease as inhibitors against interaction between programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1). Compounds of formula I wherein X1=X2 is N=C-R11, R11-C=N, N=N, or C=C; R1 is (CH)n-CO2H, O-R9, CO-(NH-R9), CO-R9, NH-R9, N(R9)2, N(R9)(R10), etc.; n is 0-4; R2 is H, halo, alkyl, cyano, hydroxy, amino, CO-alkyl, O-alkyl, O-(CH2)m-heteroaryl, O-(CH2)m-cycloalkyl, O-(CH2)m-heterocyclyl, NH-alkyl, etc.; m is 0-4; R3, R6, R7, R8, and R11 are independently H, halo, alkyl, cyano, hydroxy, amino, O-alkyl, NH-alkyl, etc.; R4 is H, halo, alkyl, cyano, hydroxy, amino, O-alkyl, NH-alkyl, CO-alkyl, etc.; R5 is (un)substituted (hetero)aryl, (un)substituted cycloalkyl, or (un)substituted heterocyclyl; R9 and R10 are independently (un)substituted alkyl; are claimed. Example compound II was prepared via Sonogashira coupling reaction of Me 6-ethynylpyridazine-3-carboxylate with 3-bromo-2-methyl-[1,1′-biphenyl], followed by Dibal-H reduction, reductive amination with Me glycinate hydrochloride, and basic hydrolysis. The invention compounds were evaluated for the inhibitory activity against interaction between PD-1 and PD-L1 (biol. activity given). The experimental process involved the reaction of 5-Bromo-3-hydroxypicolinonitrile(cas: 1160936-51-5).Application of 1160936-51-5

The Article related to phenylacetylene derivative preparation pd1 pdl1 inhibition cancer autoimmune disease, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application of 1160936-51-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 1, 1981, Yamashita, Yoshiro; Suzuki, Daisuke; Masumura, Mitsuo published an article.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Synthesis of vinyl-substituted indolizine derivatives by a novel reaction of indolizines with ethoxyethylenes having electron-withdrawing substituents. And the article contained the following:

The vinylindolizines I (R1 = Me, Ph, p-BrC6H4; R2, R3 = H, Me; R4 = R5 = CN, CO2Et, R4 = CN, COMe; R5 = CO2Et) were prepared in 22-85% yields by Michael addition of the indolizines II with EtOCH:CR4R5. Hydrolysis of I (R1 = Ph, R2 = H, Me; R3 = H, R4 = R5 = CN) gave the corresponding 3-formylindolizines. Pyrrole and 1-methylpyrrole underwent similar addition with EtOCH:C(CN)2 to give the pyrroles III (R = H, Me). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indolizine addition ethoxyethylene, vinylindolizine, Heterocyclic Compounds (One Hetero Atom): Other Areno- and Diarenopyridines (Including Also Quinuclidines, etc.) and other aspects.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts