Category: nitriles-buliding-blocks

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Name: 4-Nitrophthalonitrile.

Nie, Wo;Yang, Jian;Wu, Jiahui;Hu, Liu research published 《 Synthesis and photophysical properties of vice-like 1,8-naphthalimide fluorescent sensor for sensitive detection of Mn²⁺ and Zn²⁺》, the research content is summarized as follows. Building fluorescence sensors with intelligent performance on detecting target substrate in our living environment is of great significance. Two 1,8-naphthalimide fluorescence sensors with “vice” like phthalic acid recognition groups (NAC1, NAC2) were designed and synthesized via a facile method. The photophys. properties of the two compounds were investigated and compared. The research on structure-performance difference showed that NAC2, containing a n-dodecylamino group at the 4-position of the 1,8-naphthalimide moiety, had better fluorescence “turn-off” performance to Mn²⁺ and Zn²⁺. DFT calculations were applied to verify the results. NAC2 can detect the two kinds of metal ions within 1 min, and the detection limit was resp. determined to be 0.040 mg/L (for Mn²⁺), 0.085 mg/L (for Zn²⁺). NAC2 was also applied in the practical sample anal., indicating that it is a potential visualization tool in environmental monitoring.

Name: 4-Nitrophthalonitrile, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Reference of 31643-49-9.

Ning, Yi;Li, Dian-sen;Wang, Ming-cun;Jiang, Lei research published 《 Bio-resourced eugenol derived phthalonitrile resin for high temperature composite》, the research content is summarized as follows. Eugenol (EG) is an abundant renewable compound that has been widely used in the synthesis of bio-based thermosetting resin, but there are few reports on the phthalonitrile (PN) resin derived from EG. In this study, a new kind of bio-based PN resin (MEG-PN) derived from EG derivative was successfully synthesized. PN is a traditional class of high-performance thermosets with poor processability for its ultra-high m.p. and curing temperature The MEG-PN resin possesses excellent processability: its melting temperature is much lower (77°C), and it can be cured at a moderate temperature (281°C) in the absence of curing agents. The cured MEG-PN resin exhibited great heat resistance according to its 5% weight loss temperature at 448°C and its char yield percentage as high as 75.6% at 800°C under nitrogen. The properties of the carbon-fiber reinforced MEG-PN composite were comparable to those of petroleum-based PN resins: the glass transition temperature was around 397°C; the flexural strength and modulus were as high as 756 MPa and 119 GPa, resp. Overall, a bio-based PN thermoset with great comprehensive performance was synthesized possessing the potential in the application of advanced composite.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Reference of 31643-49-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. SDS of cas: 31643-49-9.

Olariu, Marius Andrei;Hamciuc, Corneliu;Asandulesa, Mihai;Hamciuc, Elena;Epure, Elena-Luiza;Tsakiris, Violeta;Lisa, Gabriela research published 《 Study on highly thermostable low-k polymer films based on fluorene-containing polyetherimides》, the research content is summarized as follows. Highly thermostable low-k polymer films with potential applications as dielec. materials in microelectronic industry were synthesized starting from 9,9-bis[4-(3,4-dicarboxyphenoxy)phenyl]fluorene dianhydride and various diamines. A polyetherimide/silica nanocomposite film was obtained using methyltriethoxysilane as precursor of inorganic phase. The chem. structure was confirmed by FTIR and ¹H NMR spectroscopy. Water vapor’s sorption capacity, thermal stability, glass transition temperature, thermal diffusivity, sp. heat, thermal conductivity, and dielec. characteristics of the films were determined All the films exhibited excellent thermal stability, with an initial decomposition temperature in the range of 500-530°C. They showed low dielec. constant of 1.98-2.86 and low dielec. loss of 0.0037-0.011, at a frequency of 1 Hz and room temperature The subglass γ- and β-relaxations, primary α-relaxation, and conductivity relaxation processes were discussed according to the chem. structure of the samples. Quant. structure-property relationship (QSPR) study was conducted, and linear regression models were formulated to describe the causal relationships between different parameters and polyetherimide properties.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., SDS of cas: 31643-49-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Electric Literature of 20099-89-2.

Oliveira, Nereu Junio Candido;Teixeira, Iasmin Natalia Santos;Fernandes, Philipe Oliveira;Verissimo, Gabriel Correa;Valerio, Aline Dias;Moreira, Carolina Paula de Souza;Freitas, Tulio Resende;Fonseca, Anna Clara Ventura;Sabino, Adriano de Paula;Johann, Susana;Maltarollo, Vinicius Goncalves;de Oliveira, Renata Barbosa research published 《 Computer-aided molecular design, synthesis and evaluation of antifungal activity of heterocyclic compounds》, the research content is summarized as follows. In this perspective, heterocyclic compounds namely thiazolylhydrazones I [R¹ = H, Me, F, Cl, CN; R² = CHt-Bu, CMe(CH₂)₂OH, etc.], furans II [R¹ = Cl, NO₂], tetrazoles III [R¹ = Me, NO₂; R² = CH₂CH₂OH, cyclohexyl, (CH₂)₃CH₂OH, (CH₂)₅CH₂OH], triazole IV [R¹ = (CH₂)₃CH₂OH, (CH₂)₅CH₂OH] and thiadiazoline derivatives were synthesized and tested in vitro against seven clin. importance Cryptococcus and Candida species. In this study, virtual screening techniques were applied using a scaffold-hopping database, FDA approved drugs and a ZINC subset. Some of the compounds evaluated showed promising antifungal activity against C. albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, C. neoformans and C. gatti, displaying minimal inhibitory concentration (MIC) values in the range of 0.12-250μM.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Electric Literature of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: 4-Nitrophthalonitrile.

Orlova, A. M.;Tsegelskaya, A. Yu.;Kolesnikov, T. I.;Abramov, I. G.;Kuznetsov, A. A. research published 《 Novel polyetherimides based on 5-methyl-1,3-phenylene-bis-4-oxyphthalic acid dianhydride: synthesis and physicochemical properties》, the research content is summarized as follows. A novel monomer for the synthesis of polyimides, 5-methyl-1,3-phenylene-bis-4-oxyphthalic acid dianhydride was developed. The synthesis was carried out in three stages: the reaction of nucleophilic nitro substitution of 4-nitrophthalonitrile with 5-methylresorcinol (orcinol) potassium salt and subsequent hydrolysis of the nitrile groups have afforded 5-methyl-1,3-phenylene-bis-4-oxyphthalic acid, dehydration of which has given the corresponding dianhydride. A series of new thermoplastic high mol. weight polyetherimides based on 5-methyl-1,3-phenylene-bis-4-oxyphthalic acid dianhydride and several aromatic diamines of various structures were synthesized by the method of one-stage catalytic polycondensation in a benzoic acid melt. Inherent viscosity and weight-average mol. mass of the polyetherimides have been of 0.28-1.20 dL/g and (33-114) × 10³, resp. The polyetherimides have been soluble in chloroform, THF, DMF, dimethylacetamide, N-methylpyrrolidone, and DMSO and have revealed film-forming properties. According to the DSC and wide-angle X-ray scattering data, the polyetherimides have been found completely amorphous, the glass transition temperature being in the 185-307° range.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Recommanded Product: 4-Nitrophthalonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Recommanded Product: 4-(2-Bromoacetyl)benzonitrile.

Osmaniye, Derya;Gorgulu, Sennur;Saglik, Begum Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim research published 《 Design, synthesis, in vitro and in silico studies of some novel thiazole-dihydrofuran derivatives as aromatase inhibitors》, the research content is summarized as follows. Aromatase inhibitors used against hormone-dependent breast cancer, especially in post-menopausal women, are very susceptible to the development of resistance due to their limited number and long-term use. In this study, it is aimed to obtain new aromatase inhibitors including thiazole and dihydrofuran ring systems. Synthesis of compounds (2a-2l) were performed according to literature methods. Their structures were elucidated by 1H NMR, 13C NMR and APCI-MS spectroscopic methods. MTT test was carried out to assess the cell proliferation effects of the different compounds on two different pulmonary cell lines (A549, CCD-19Lu) and mammary cell line (MCF7). According to MTT assay, it was observed that the calculated IC50 values of some compounds for the CCD-19Lu cell line were found higher than for the A549 and MCF7 cell lines. Considering the viability results, it was found that the selected compounds (2a, 2c, 2e, 2g, 2h, 2l) showed favorable safety profile and have anticancer activities. Apoptotic activities of the selected compounds were investigated by flow cytometry anal. And were found that have apoptotic effects on cancerous cell lines. In the light of this information, the aromatase inhibition potentials of 2g and 2l compounds, which are the most active derivatives, were examined in vitro and it was determined that they showed a similar inhibition profile with letrazole. Interaction modes between aromatase enzyme and compounds 2g and 2l were investigated by docking studies. In conclusion, findings of these study indicate that compounds 2g and 2l possess significant anticancer activity.

Recommanded Product: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Quality Control of 20099-89-2.

Osmaniye, Derya;Karaca, Sevval;Kurban, Berkant;Baysal, Merve;Ahmad, Iqrar;Patel, Harun;Ozkay, Yusuf;Asim Kaplancikli, Zafer research published 《 Design, synthesis, molecular docking and molecular dynamics studies of novel triazolothiadiazine derivatives containing furan or thiophene rings as anticancer agents》, the research content is summarized as follows. In this study, new triazolothiadiazine derivatives I [X = O, S; R = H, Me, MeO, Cl; R¹ = H, Cl; R² = H, Me, MeO, etc.] were synthesized and their anticancer activities were investigated. Compounds I [X = O, R = R² = Cl, R¹ = H; X = S, R = H, Cl, R¹ = H, R² = Cl] showed inhibitor activity against MCF-7 cell line with IC₅₀ = 4.63 ± 0.10; 2.23 ± 0.16; 3.13 ± 0.08μM value, resp. As a result of in-vitro aromatase enzyme inhibition test, compound I [X = S, R = R¹ = H, R² = Cl] was the most active derivative with IC₅₀ = 0.058 ± 0.023μM. In addition, DNA synthesis inhibition percentages of the compounds I were measured by the BrdU method. The intermol. interactions of the promising compounds I with aromatase enzyme were investigated through the SP docking approach, which revealed significant binding interaction energies associated with these compounds Following that, the interaction’s stability was assessed using a typical atomistic 100 ns dynamic simulation study. A number of parameters derived from MD simulation trajectories were computed and validated for the protein-ligand complex’s stability under the dynamic conditions.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Quality Control of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Category: nitriles-buliding-blocks.

Osmaniye, Derya;Gorguelue, Sennur;Saglik, Beguem Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim research published 《 Synthesis and biological evaluation of novel 1,3,4-oxadiazole derivatives as anticancer agents and potential EGFR inhibitors》, the research content is summarized as follows. Herein, novel quinoxalin-oxadiazole derivatives I (R¹ = H, F, Cl; R² = H, CH₃, CN, etc.) were synthesized as EGFR inhibitors in this study. Synthesis of compounds I was performed according to the literature methods. Structure elucidation was performed for compound I (R¹ = H; R² = NO₂) using 2D NMR technique. MTT test was performed to assess the cell proliferation effects of the different compounds on lung and mammary cell lines (A549, MCF7). In addition, obtained compounds I were screened against healthy CCD19-Lu cell line (human lung fibroblast normal cells) to determine selectivity of the cytotoxic activities. Among the tested compounds, I (R¹ = H; R² = NO₂) and I (R¹ = Cl; R² = Cl) showed significant cytotoxic activity against A549 cancer cell. Moreover, compound I (R¹ = H; R² = Cl) and I (R¹ = H; R² = Br) displayed good activity. And the compounds I (R¹ = H; R² = NO₂) and I (R¹ = Cl; R² = Cl) performed significant EGFR inhibition. Interaction modes of the compounds I (R¹ = H; R² = NO₂), I (R¹ = Cl; R² = Cl) were investigated against EGFR tyrosine kinase by means of docking studies. As a result of the studies, the importance of the quinoxaline ring and the NO₂ substituent has been understood. The activity can be contributed by using other heterocyclic rings instead of the oxadizaole ring.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Safety of 4-(2-Bromoacetyl)benzonitrile.

Osmaniye, Derya;Alasan, Ramazan;Saglik, Begum Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim research published 《 Novel thiazolyl-hydrazone derivatives including piperazine ring: synthesis, in vitro evaluation, and molecular docking as selective MAO-A inhibitor》, the research content is summarized as follows. MAO-A inhibitors are used in the treatment of depression. There are many studies showing that the thiazolyl-hydrazone structure is a pharmacophore structure for the MAO enzyme. In previous studies by our team, activity studies were carried out with thiazolyl-hydrazone derivatives containing pyrrolidine, morpholine, and piperazine. All of them were displayed MAO-A selective inhibition profile. Addnl., derivatives containing piperazine ring were most active. For this purpose, thiazolyl-hydrazone derivatives containing piperazine were synthesized, but this time an active group, formyl group, was added to the piperazine ring as a substituent. Based on this view, new thiazolyl-hydrazone compounds were synthesized, characterized, and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro fluorometric method. The structure of the compound was tried to be fully elucidated using 2D NMR technique. The compound including 2,4-di-Me substituent (3i) were found to be the most effective agents in the series against MAO-A enzyme with the IC50 value of 0.080 ± 0.003 μM. The docking study of compound 3i revealed that there is a strong interaction between the active sites of hMAO-A and analyzed compound

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Safety of 4-(2-Bromoacetyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Safety of 4-Nitrophthalonitrile.

Ozdemir, Mucahit;Artuc, Gamze Ozgul;Guler, Eray Metin;Yalcin, Bahattin;Salan, Umit;Bozali, Kubra;Gorgulu, Ahmet Orhan;Bulut, Mustafa research published 《 Phthalocyanines bearing silazane group for colorectal cancer》, the research content is summarized as follows. The synthesis of bis(trimethylsilyl)amine substituted zinc(II), and indium(III) chloride phthalocyanine complexes have been performed. The obtained compounds were characterized by spectroscopic methods. All synthesized phthalocyanine derivatives were evaluated for cytotoxic, genotoxic, and apoptotic activities on LoVo cell lines which are the standard colorectal cancer cell lines derived from metastatic site: left supraclavicular region. Non-peripheral silazane substituted zinc phthalocyanine (5) showed quite different behavior from all the other compounds analyzed and found to be the best cytotoxic, genotoxic, and apoptotic compound All derivatives showed no proliferative effect at all doses. All phthalocyanine compounds increased cytotoxicity, DNA damage, apoptosis, and intracellular ROS dose-dependent manner. To explain and verify in vitro tests, phthalocyanine compound structures were optimized using d. functional theory, and in silico mol. docking studies on B-DNA dodecamer were performed. Both the exptl. and theor. findings comply with each other.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Safety of 4-Nitrophthalonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts