Category: nitriles-buliding-blocks

Li, Jiajie team published research in Advanced Synthesis & Catalysis in 2022 | 3032-92-6

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Recommanded Product: 4-Ethynylbenzonitrile.

Li, Jiajie;Xu, Xin;Luo, Zhenli;Yao, Zhen;Yang, Ji;Zhang, Xin;Xu, Lijin;Wang, Peng;Shi, Qian research published 《 Rhodium(III)-Catalyzed Regioselective C-H Annulation and Alkenylation of 2-Pyridones with Terminal Alkynes》, the research content is summarized as follows. Cp*Rh(III)-catalyzed regioselective C-H annulation and alkenylation of 2-pyridones with terminal alkynes was developed. The cationic Cp*Rh(III) catalytic system containing FeCl3 additive enables annulation of 1-(2-pyridyl)-2-pyridones with terminal alkynes, providing efficient access to 5,7-diarylated 2-quinolinones I [R = H, 4-Me, 3-Br, etc.; R1 = H, 4-Me, 5-F, etc.; Ar = Ph, 2-MeC6H4, 2-naphthyl, etc.]. The reaction pathway could be switched to alkenylation with [Cp*RhCl2]2 as the catalyst, NaOAc as the additive and HOAc as the solvent, affording C6-alkenylated 1-(2-pyridyl)-2-pyridones II [R2 = Ph, 3-MeC6H4, 2-naphthyl, etc.; R3 = H, 4-Me, 3-Br, etc.] in high yields. These protocols accommodated a wide range of substrates with good functional group compatibility.

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Jian team published research in ChemistrySelect in 2022 | 31643-49-9

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Computed Properties of 31643-49-9

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Computed Properties of 31643-49-9.

Li, Jian;Wu, Minjie;Rong, Jianxin;Zhang, Qian;Yu, Xiaoyan;Zhang, Qingxin research published 《 Synthesis and Properties of Phthalonitrile Polymer with a Novel Piperazine Structural Curing Agent》, the research content is summarized as follows. A novel autocatalytic phthalonitrile (PN) monomer containing piperazine structure, namely 4-[1-(4-aminophenyl)-4-(4-phenyl)piperazine-oxy]phthalonitrile (APPN), is synthesized from the nucleophilic substitution reaction of 1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine and 4-nitrophthalonitrile. The structure of the APPN monomer is characterized by NMR (NMR) spectroscopy and Fourier Transform IR (FTIR) spectroscopy. The novel 4-nitrophthalonitrile end-capped compound APPN is firstly used to promote the curing reaction of PN monomer 1,3-bis(3,4-dicyanophenoxy)benzene (m-BDB). Thermogravimetric Anal. (TGA) and Dynamic Mech. Anal. (DMA) showed that the PN resin in the presence of 10% of APPN possessed outstanding thermal and thermo-oxidative stabilities as well as good mech. properties, better than the properties of those with 20% of APPN and 10% of APPH. Its glass transition temperature (Tg) is higher than 400°, and the polymer loses 5% of its weight (T5%) at 524° and shows a storage modulus of 1373 MPa at 400°.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Computed Properties of 31643-49-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Jing team published research in Chemistry – A European Journal in 2021 | 105-34-0

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Application of C4H5NO2

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Application of C4H5NO2.

Li, Jing;Lear, Martin J.;Hayashi, Yujiro research published 《 Direct Cyclopropanation of α-Cyano β-Aryl Alkanes by Light-Mediated Single Electron Transfer Between Donor-Acceptor Pairs》, the research content is summarized as follows. The one-pot intermol. cyclopropanation of alkanes by redox active C1 units has remained unrealised. Herein, authors achieved this process simply by exposing β-aryl propionitriles and C1 radical precursors (N-oxy esters) to base and blue light. The overall process is redox-neutral and a photocatalyst, whether metal- or organic-based, is not required. Findings support that single electron transfer (SET) from the α-cyano carbanion of the propionitrile to the N-oxy ester is facilitated by blue-light via their electron donor-acceptor (EDA) complex. The α-cyano carbon radical thus formed can then lose a β-proton to form a π-resonance stabilized radical anion that preferentially couples at the benzylic β-position with a decarboxylated C1 radical unit. This new transition metal-free chem. tolerates both electron rich and electron deficient (hetero)aryl systems, even sulfide or alkene functionality, to afford a range of cis-aryl/cyano cyclopropanes bearing congested tetrasubstituted quaternary carbons.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Application of C4H5NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Laiqiang team published research in Journal of Organic Chemistry in 2022 | 3032-92-6

SDS of cas: 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. SDS of cas: 3032-92-6.

Li, Laiqiang;Hou, Zhong-Wei;Li, Pinhua;Wang, Lei research published 《 Electrochemical Dearomatizing Spirocyclization of Alkynes with Dimethyl 2-Benzylmalonates to Spiro[4.5]deca-trienones》, the research content is summarized as follows. An electrochem. dearomatizing spirocyclization of alkynes with di-Me 2-benzylmalonates for the preparation of spiro[4.5]deca-trienones had been developed. This approach adopted ferrocene (Cp2Fe) as an electrocatalyst to produce carbon-centered radical intermediates from C-H-based malonates, which obviated the forthputting of noble-metal reagents, sacrificial chem. oxidants and 2-bromomalonates. A wide variety of spiro compounds were efficiently prepared with satisfactory results under mild conditions.

SDS of cas: 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kemp, W. et al. published their research in Journal of the Chemical Society [Section] C: Organic in 1971 |CAS: 2510-01-2

The Article related to indanylidene malononitriles nmr, configuration indanylidenemalononitriles, stereochemistry indanylidenemaloninitriles, malononitriles indanylidene nmr, chem shift indanylidenemalononitriles, cyanomethylene indans nmr and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Kemp, W.; Bahl, A. K. published an article in 1971, the title of the article was Nuclear magnetic resonance evidence regarding the stereochemistry of cyanoindanylidene compounds.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile And the article contains the following content:

The stereochemistry of indan derivatives with an exocyclic double bond (I, R = CN, R1 = CO2Et, CO2Me, CN, CONH2, CO2H; R = H, R1 = CN) was deduced from chem. shifts. Stereochem. assignments extend, and are different from, those reported (Jones, G., and Rae, W. J., 1966). The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to indanylidene malononitriles nmr, configuration indanylidenemalononitriles, stereochemistry indanylidenemaloninitriles, malononitriles indanylidene nmr, chem shift indanylidenemalononitriles, cyanomethylene indans nmr and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ahadi, Somayeh et al. published their research in Journal of the Iranian Chemical Society in 2016 |CAS: 2510-01-2

The Article related to dihydrofluorenothiazinide preparation, carbon disulfide dialkyl fluorene dicarboxylate tandem condensation, dialkyl fluorene dicarboxylate preparation, dihydroindanylidene malononitrile dialkylacetylene dicarboxylate and other aspects.Computed Properties of 2510-01-2

On February 29, 2016, Ahadi, Somayeh; Zolghadr, Mahdi; Shakibaei, Ghazaleh Imani; Bazgir, Ayoob published an article.Computed Properties of 2510-01-2 The title of the article was An efficient synthesis of highly functionalized fluorenes and fluorenothiazines. And the article contained the following:

An efficient synthesis of highly functionalized dialkyl 3-amino-4-cyano-9-oxo-9H-fluorene-1,2-dicarboxylates and dialkyl 3-amino-4-cyano-9H-fluorene-1,2-dicarboxylate were isolated in good yields. Reaction of 3-amino-4-cyano-9-oxo-9H-fluorene-1,2-dicarboxylate with carbon disulfide in the presence of DBU was investigated and 4,6-dioxo-2-thioxo-4,6-dihydrofluoreno[3,2-d][1,3]thiazin-1-ides was obtained in good isolated yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Computed Properties of 2510-01-2

The Article related to dihydrofluorenothiazinide preparation, carbon disulfide dialkyl fluorene dicarboxylate tandem condensation, dialkyl fluorene dicarboxylate preparation, dihydroindanylidene malononitrile dialkylacetylene dicarboxylate and other aspects.Computed Properties of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Deshmukh, Mahesh S. et al. published their research in RSC Advances in 2013 |CAS: 34662-29-8

The Article related to fluoro nitrobenzene diamine dual aromatic nucleophilic substitution, quinoxaline preparation, aminoalc fluoro nitrobenzene dual aromatic nucleophilic substitution, benzoxazine preparation, diol fluoro nitrobenzene dual aromatic nucleophilic substitution, benzodioxine preparation and other aspects.Recommanded Product: 34662-29-8

Deshmukh, Mahesh S.; Das, Biswajit; Jain, Nidhi published an article in 2013, the title of the article was Dual SNAr reaction in activated ortho-halonitrobenzene: direct synthesis of substituted 1,2,3,4-tetrahydroquinoxalines, 2,3-dihydro-1,4-benzoxazines and 1,4-benzodioxines.Recommanded Product: 34662-29-8 And the article contains the following content:

An unprecedented one-pot synthesis of substituted 1,2,3,4-tetrahydroquinoxalines, 2,3-dihydro-1,4-benzoxazines and 1,4-benzodioxines from activated ortho-halonitrobenzenes was accomplished by dual nucleophilic aromatic substitution (SNAr) of halogen followed by substitution of the nitro group by secondary diamines, secondary amino alcs. and diols resp. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

The Article related to fluoro nitrobenzene diamine dual aromatic nucleophilic substitution, quinoxaline preparation, aminoalc fluoro nitrobenzene dual aromatic nucleophilic substitution, benzoxazine preparation, diol fluoro nitrobenzene dual aromatic nucleophilic substitution, benzodioxine preparation and other aspects.Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Marco, Jose L. et al. published their research in Bioorganic & Medicinal Chemistry in 2004 |CAS: 5098-14-6

The Article related to heterocyclic derivative preparation acetylcholinesterase butyrylcholinesterase inhibitor, calcium channel modulator heterocyclic derivative, nicotinic receptor inhibitor heterocyclic derivative, tacrine analog preparation acetylcholinesterase butyrylcholinesterase inhibitor and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

On May 1, 2004, Marco, Jose L.; de los Rios, Cristobal; Garcia, Antonio G.; Villarroya, Mercedes; Carreiras, M. Carmo; Martins, Carla; Eleuterio, Ana; Morreale, Antonio; Orozco, M.; Luque, F. Javier published an article.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors. And the article contained the following:

The synthesis and the biol. activity of heterocyclic derivatives as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as modulators of voltage-dependent Ca2+ channels and nicotinic receptors, are described. These mols. are tacrine analogs, which have been prepared from polyfunctionalized 6-amino-5-cyano-4H-pyrans, 6-amino-5-cyano-pyridines and 5-amino-2-aryl-3-cyano-1,3-oxazoles via Friedlander reaction with selected cycloalkanones. These compounds are moderate acetylcholinesterase and butyrylcholinesterase inhibitors, the BuChE/AChE selectivity of the most active mols. ranges from 10.0 to 76.9. Interestingly, the oxazolo-tacrine’ derivatives are devoid of any activity. All compounds showed an important inhibitory effect on the nicotinic acetylcholine receptor. Most of them also blocked L-type Ca2+ channels, and three of them blocked the non-L type of Ca2+ channels. Mol. modeling studies suggest that these compounds might bind at the peripheral binding site of AChE, which opens the possibility to design inhibitors able to bind at both, the catalytic and peripheral binding sites of the enzyme. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to heterocyclic derivative preparation acetylcholinesterase butyrylcholinesterase inhibitor, calcium channel modulator heterocyclic derivative, nicotinic receptor inhibitor heterocyclic derivative, tacrine analog preparation acetylcholinesterase butyrylcholinesterase inhibitor and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gazit, Aviv et al. published their research in Journal of Medicinal Chemistry in 1996 |CAS: 75629-62-8

The Article related to quinoxaline tyrosine kinase inhibitor preparation structure, platelet growth factor receptor kinase preparation, quinoline tyrosine kinase inhibitor preparation structure, indole tyrphostin tyrosine kinase inhibitor preparation, msbar tyrosine kinase inhibitor tyrphostin and other aspects.HPLC of Formula: 75629-62-8

On May 24, 1996, Gazit, Aviv; App, Harald; McMahon, Gerald; Chen, Jefferey; Levitzki, Alexander; Bohmer, Frank D. published an article.HPLC of Formula: 75629-62-8 The title of the article was Tyrphostins. 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase: Structure-Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrphostins. And the article contained the following:

A series of 3-indoleacrylonitrile tyrphostins, 2-chloro-3-phenylquinolines, and 3-arylquinoxalines were prepared and tested for inhibition of platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) activity. The potency of the inhibitors was quinoxalines >quinolines >indoles. Lipophilic groups (Me, methoxy) in the 6 and 7 positions and Ph at the 3 position of quinoxalines and quinolines were essential for potency, in contrast to the hydrophilic catechol group in tyrphostins active against EGFR kinase inhibition at different sites. The inhibitors showed selectivity for PDGF and were not active against EGF receptor and HER-2/c-ErbB-2 receptor. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).HPLC of Formula: 75629-62-8

The Article related to quinoxaline tyrosine kinase inhibitor preparation structure, platelet growth factor receptor kinase preparation, quinoline tyrosine kinase inhibitor preparation structure, indole tyrphostin tyrosine kinase inhibitor preparation, msbar tyrosine kinase inhibitor tyrphostin and other aspects.HPLC of Formula: 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Frasson, Ilaria et al. published their research in European Journal of Medicinal Chemistry in 2019 |CAS: 5098-14-6

The Article related to triazolo naphthyridine preparation photocytotoxic activity, oxazolo naphthyridine preparation photocytotoxic activity, photochemiotherapy, photosensitizing agents, reactive oxygen species, [1,2,3]triazolo[4,5-h][1,6]naphthyridines, [1,3]oxazolo[5,4-h][1,6]naphthyridines and other aspects.Name: 2-Aminomalononitrile 4-methylbenzenesulfonate

On January 15, 2019, Frasson, Ilaria; Spano, Virginia; Di Martino, Simona; Nadai, Matteo; Doria, Filippo; Parrino, Barbara; Carbone, Anna; Cascioferro, Stella Maria; Diana, Patrizia; Cirrincione, Girolamo; Freccero, Mauro; Barraja, Paola; Richter, Sara N.; Montalbano, Alessandra published an article.Name: 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines. And the article contained the following:

[1,2,3]Triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines were synthesized with the aim to investigate their photocytotoxic activity. Upon irradiation, oxazolo-naphtapyridines induced light-dependent cell death at nanomolar/low micromolar concentrations (EC50 0.01-6.59 μM). The most photocytotoxic derivative showed very high selectivity and photocytotoxicity indexes (SI = 72-86, PTI>5000), along with a triplet excited state with exceptionally long lifetime (18.0 μs) and high molar absorptivity (29781 ± 180 M-1cm-1 at λmax 315 nm). The light-induced production of ROS promptly induced an unquenchable apoptotic process selectively in tumor cells, with mitochondrial and lysosomal involvement. Altogether, these results demonstrate that the most active compound acts as a promising singlet oxygen sensitizer for biol. applications. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Name: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to triazolo naphthyridine preparation photocytotoxic activity, oxazolo naphthyridine preparation photocytotoxic activity, photochemiotherapy, photosensitizing agents, reactive oxygen species, [1,2,3]triazolo[4,5-h][1,6]naphthyridines, [1,3]oxazolo[5,4-h][1,6]naphthyridines and other aspects.Name: 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts