nitriles-buliding-blocks Archives - Page 303 of 1091

Zhuo, Jun-Rui et al. published their research in Tetrahedron in 2020 |CAS: 2510-01-2

The Article related to dibenzoheterocyclic compound green preparation, nitrobenzoheterocycle dicyanoalkene tandem annulation base mediated, polycyclic heteroaromatic compound preparation, fused benzofuran carbonitrile derivative oxidative dehydrogenation, amino phenyl dihydrophenanthrobenzofuran carbonitrile preparation and other aspects.SDS of cas: 2510-01-2

On April 24, 2020, Zhuo, Jun-Rui; Quan, Bao-Xue; Zhao, Jian-Qiang; Zhang, Ming-Liang; Chen, Yong-Zheng; Zhang, Xiao-Mei; Yuan, Wei-Cheng published an article.SDS of cas: 2510-01-2 The title of the article was Base-mediated [4+2] annulation of electron-deficient nitrobenzoheterocycles and α,α-dicyanoalkenes in water: Facile access to structurally diverse functionalized dibenzoheterocyclic compounds. And the article contained the following:

A base-mediated [4 + 2] annulation of electron-deficient nitrobenzoheterocycles with α,α-dicyanoalkenes for the synthesis of structurally diverse dibenzoheterocyclic compounds was reported. Reaction of 2-nitrobenzofurans/2-nitrobenzothiophenes with α,α-dicyanoalkenes afforded fused-benzofuran-carbonitrile derivatives and fused-benzothiophene-carbonitrile derivatives I [R1 = H, 10-Me, 10-Cl, etc.; R2 = H, 3-Me, 2-OMe, 4-Br, etc.; R3R4 = H, (CH2)2, OCH2, etc.; X = O, S]. Reaction between 3-nitrobenzothiophenes and α,α-dicyanoalkenes was developed to give fused-benzothiophene-carbonitrile derivatives II [R5 = H, 10-Me, 10-F, 10-Cl, 10-Ph; R6R7 = H, (CH2)2, OCH2, etc.]. Synthesis of fused-indole derivatives III [R8 = H, 10-F, 10-Cl, 11-Br; R9 = acetyl, tert-butyloxycarbonyl, tosyl; R10R11 = H, OCH2, (CH2)2, (CH2)3] by reaction of 3-nitroindoles and α,α-dicyanoalkenes was reported. Preparation of polycyclic heteroaromatic compounds IV [R12 = H, 10-OMe, 10-F, etc.] via oxidative dehydrogenation of some of the fused-benzofuran-carbonitrile derivatives I was reported. The reaction proceeded smoothly via a tandem vinylogous Michael addition/cyclization/tautomerization/elimination process in water with cesium carbonate as base, affording a wide range of dibenzofurans, dibenzothiophenes and carbazoles in good to high yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Tian-Yu et al. published their research in Journal of the American Chemical Society in 2007 |CAS: 2510-01-2

The Article related to dicyanoolefin aldimine chiral thiourea tertiary amine asym vinylogous mannich, dicyanovinyl amine stereoselective preparation reduction hydrolysis, amino acid stereoselective preparation amidation, lactam stereoselective preparation, asym vinylogous mannich catalyst chiral thiourea tertiary amine and other aspects.Application of 2510-01-2

On February 21, 2007, Liu, Tian-Yu; Cui, Hai-Lei; Long, Jun; Li, Bang-Jing; Wu, Yong; Ding, Li-Sheng; Chen, Ying-Chun published an article.Application of 2510-01-2 The title of the article was Organocatalytic and Highly Stereoselective Direct Vinylogous Mannich Reaction. And the article contained the following:

The first direct asym. vinylogous Mannich (AVM) reaction of α,α-dicyanoolefins and N-Boc aldimines was described promoted by a simple chiral bifunctional thiourea-tertiary amine organocatalyst. The reaction was highly efficient (S/C up to 1000) and regio-, stereoselective (generally >99% de, >96% ee) at room temperature for a broad array of substrates. Enantiomerically pure δ-amino acid and subsequential δ-lactam could be smoothly prepared from the adduct. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Geuns-Meyer, Stephanie D. et al. published their patent in 2005 |CAS: 13544-06-4

The Article related to nitrogen heteroaryl containing protein kinase modulator antitumor antiinflammatory, aurora kinase modulator nitrogen heteroaromatic compound preparation, cmet tyrosine kinase modulator nitrogen heteroaromatic compound preparation, braf kinase modulator nitrogen heteroaromatic compound preparation and other aspects.Synthetic Route of 13544-06-4

On December 1, 2005, Geuns-Meyer, Stephanie D.; Hodous, Brian L.; Chaffee, Stuart C.; Tempest, Paul A.; Olivieri, Philip R.; Johnson, Rebecca E.; Albrecht, Brian K.; Patel, Vinod F.; Cee, Victor J.; Kim, Joseph L.; Bellon, Steven; Zhu, Xiaotian; Cheng, Yuan; Xi, Ning; Romero, Karina; Nguyen, Hanh Nho; Deak, Holly L. published a patent.Synthetic Route of 13544-06-4 The title of the patent was Preparation of nitrogen-heteroaryl-containing protein kinase modulators for use against cancer and other diseases. And the patent contained the following:

The present invention relates to nitrogen-heteroaryl-containing compounds (shown as I; variables defined below; e.g. 4-fluoro-3-[[3-(pyrimidin-4-yl)pyridin-2-yl]amino]-N-[3-[(tetrahydrofuran-2-yl)methoxy]-5-trifluoromethylphenyl]benzamide (shown as II)) and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases. For I: A is N or CR10; B is N or CR11; D is N or CR12; E is N or CH; G is NR13, O, S, C(O), S(O), SO2, CR13R13 or CR13R14; H1 is N or CR5; H2 is N or CR6; H3 is N or CR7; H4 is N or CR5; H5 is N or CR9; R1 is H, halo, haloalkyl, NO2, CN, NR13R13, OR13, SR13 (CHR13)nR13, or R15; alternatively R1 taken together with R10 forms a partially or fully unsaturated 5- or 6-membered ring of C atoms optionally including 1-3 heteroatoms = O, N and S, and the ring (un)substituted; R2 is H, halo, haloalkyl, oxo, NO2, CN, SR13, et al.; each of R3 and R4, independently, is H, halo, haloalkyl, oxo, NO2, CN, SR13, et al.; addnl. details including provisos are given in the claims. Although the methods of preparation are not claimed, preparations and/or characterization data for >1200 examples of I and intermediates are included. For example, II was prepared in 2 steps starting with condensation of 4-(2-chloropyridin-3-yl)pyrimidine (preparation given) with 3-amino-4-fluorobenzoic acid in Et3N-TFA to give 4-fluoro-3-[[3-(pyrimidin-4-yl)pyridin-2-yl]amino]benzoic acid, which was condensed with [3-[(tetrahydrofuran-2-yl)methoxy]-5-trifluoromethylphenyl]amine using EDC and DMAP in DMF. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Synthetic Route of 13544-06-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nishiyabu, Ryuhei et al. published their research in Journal of the American Chemical Society in 2005 |CAS: 2510-01-2

The Article related to antipyretic ibuprofen salicylate naproxen carboxylate chromogenic calixpyrrole preparation, chromogenic calix pyrrole sensor anion preparation, sensor anion complex chromogenic calixpyrrole preparation color change, polyurethane sensor film anion complex chromogenic calixpyrrole color change and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

On June 15, 2005, Nishiyabu, Ryuhei; Anzenbacher, Pavel Jr. published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Sensing of Antipyretic Carboxylates by Simple Chromogenic Calix[4]pyrroles. And the article contained the following:

A simple, two- or three-step method for the synthesis of chromogenic octamethyl calix[4]pyrrole-based (OMCP) sensors for anions was presented. Electrophilic aromatic substitution allows for converting the pyrrole moieties of OMCP into a dye. The formation of a sensor-anion complex results in partial charge transfer and a dramatic change in color. The absorption (UV-vis) and NMR titration experiments show that the chromogenic OMCPs sense anions administered as aqueous solutions, even at high ionic strength (∼0.1 M NaCl), while displaying selectivity for pyrophosphate and carboxylate anions. The experiments with polyurethane sensor films show a strong response for aqueous carboxylates, such as antipyretics naproxen ≈ ibuprofen > salicylate, without being biased by bicarbonate or carboxy termini of blood plasma proteins. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ioannidis, Stephanos et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2009 |CAS: 5098-14-6

The Article related to pyridineethyl pyrimidineethyl pyrazoleaminopyrazine preparation selective jak2 kinase inhibitor, structure pyridineethyl pyrimidineethyl pyrazoleaminopyrazine jak2 kinase inhibition selectivity, pharmacokinetics pharmacodynamics pyrimidineethyl pyrazoleaminopyrazine jak2 kinase inhibitor and other aspects.HPLC of Formula: 5098-14-6

On December 1, 2009, Ioannidis, Stephanos; Lamb, Michelle L.; Davies, Audrey M.; Almeida, Lynsie; Su, Mei; Bebernitz, Geraldine; Ye, Minwei; Bell, Kirsten; Alimzhanov, Marat; Zinda, Michael published an article.HPLC of Formula: 5098-14-6 The title of the article was Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors. And the article contained the following:

Pyridineethyl- and pyrimidineethyl-substituted pyrazoleaminopyrazines such as I (R = Me; X = N) and I (R = H; X = CH) are prepared as selective JAK2 kinase inhibitors for potential use as anticancer agents; the GI50 values for their JAK2 and JAK3 kinase inhibition are determined The activities of selected pyridineethyl- and pyrimidineethyl-substituted pyrazoleaminopyrazines in a functional phosphorylation model in mice and their inhibition of aurora B kinase, cyclin-dependent kinase 2, and TrkA are determined; the pharmacokinetics and pharmacodynamics of I (R = Me; X = N) and of I (R = H; X = CH) in rats and beagles are also determined The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).HPLC of Formula: 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Matsnev, Andrej et al. published their research in Angewandte Chemie, International Edition in 2010 |CAS: 2510-01-2

The Article related to ortho ethynylaryltrifluoromethylsulfane preparation triflic acid intramol cyclization, benzothiophenium salt trifluoromethyl derivative preparation yagupolskii umemoto reagent analog, beta keto ester sulfur trifluoromethyl benzothiophenium salt electrophilic trifluoromethylation and other aspects.Computed Properties of 2510-01-2

Matsnev, Andrej; Noritake, Shun; Nomura, Yoshinori; Tokunaga, Etsuko; Nakamura, Shuichi; Shibata, Norio published an article in 2010, the title of the article was Efficient Access to Extended Yagupolskii-Umemoto-Type Reagents: Triflic Acid Catalyzed Intramolecular Cyclization of ortho-Ethynylaryltrifluoromethylsulfanes.Computed Properties of 2510-01-2 And the article contains the following content:

S-(trifluoromethyl)benzo[b]thiophenium salts, as analogs of Yagupolskii-Umemoto type reagents, were synthesized by novel triflic acid mediated intramol. cyclization of ortho-ethynylaryltrifluoromethylsulfanes. Cyclopropyl analog I is especially useful for the electrophilic trifluoromethylation of β-ketoesters and dicyanoalkylidenes. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Computed Properties of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kang, Xiaokang team published research in Organic Letters in 2021 | 20099-89-2

Recommanded Product: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4â?-cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4â?-cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Recommanded Product: 4-(2-Bromoacetyl)benzonitrile.

Kang, Xiaokang;Liang, Xiayu;Zeng, Qingle research published ã?Water-Mediated Intramolecular Cyclization/Oxidation of Î±-Carbonyl Sulfur Ylides: Synthesis of Corey-Chaykovsky Reagent Type Heterocyclesã? the research content is summarized as follows. A new class of Corey-Chaykovsky reagent type five-membered heterocycles with an oxosulfonium ylide moiety has been synthesized by the water-mediated intramol. cyclization/oxidation of Î±-carbonyl sulfur ylides generated in situ from sulfonium salts under mild conditions.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kantekin, Halit team published research in Polyhedron in 2021 | 31643-49-9

Quality Control of 31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Nitrile is any organic compound with a −C≡N functional group. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Quality Control of 31643-49-9.

Kantekin, Halit;Yalazan, Halise;Barut, Burak;Gungor, Omer;Unluer, Dilek;Demirbas, Umit;Ozel, Arzu;Durmus, Mahmut research published ã?Dual-purpose both peripheral and non-peripheral triazole substituted Zn^II, Mg^II and Pb^II phthalocyanines: Synthesis, characterization, photophysicochemical and acetylcholinesterase inhibitory propertiesã? the research content is summarized as follows. Both peripheral and non-peripheral 4-(3,4-dimethoxyphenethyl)-5-ethyl-2H-1,2,4-triazol-3(4H)-one substituted zinc(II), magnesium(II) and lead(II) phthalocyanines were synthesized in this paper. Techniques used to illuminate the structure of these phthalocyanines included FT-IR, MALDI TOF, UV-Vis, NMR spectroscopy. The Zn^IIPcs (p/np–ZnPcs), Mg^IIPcs (p/np–MgPcs) and Pb^IIPcs (p/np–PbPcs) exhibited outstanding solubility in common organic solvents such as 1,4-Dioxane, acetonitrile, chloroform, dichloromethane, DMF, dimethylsulfoxide, Et acetate and THF. The photophysicochem. properties of Zn^IIPcs, Mg^IIPcs and Pb^IIPcs were researched in DMSO. The positions of the substituents (peripheral or non-peripheral) and the effects of the central metal ions (Zn²⁺, Mg²⁺, Pb²⁺) on the photophysicochem. properties were reported by comparison. The singlet oxygen quantum yield values of Zn^IIPcs, Mg^IIPcs and Pb^IIPcs ranged from 0.11 to 0.78 in DMSO. The newly synthesized peripherally tetra substituted zinc(II) phthalocyanine (p–ZnPc) exhibited high singlet oxygen generation in DMSO compared to unsubstituted zinc(II) phthalocyanine used as standard These results indicate that the (p–ZnPc) can be a candidate as photosensitizer for PDT. Besides, the inhibitory properties of the compounds were determined using the spectrophotometric method on AChE and Î±-glucosidase. IC₅₀ values showed that np-MgPc has highest inhibitory actions among the tested compounds on AChE and Î±-glucosidase.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Karaca, Huseyin team published research in Journal of Molecular Structure in 2021 | 31643-49-9

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., SDS of cas: 31643-49-9

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. SDS of cas: 31643-49-9.

Karaca, Huseyin;Delibas, Nagihan Caylak;Saglam, Serap;Piskin, Hasan;Sezer, Serdar;Hokelek, Tuncer;Teker, Murat research published ã?Metallophthalocyanines derived with phenyl sulfide by bridging triazole using click chemistry: Synthesis, Computational Study, Redox Chemistry and Catalytic Activityã? the research content is summarized as follows. Synthesis and characterization of new metallophthalocyanines (M = Zn, Co(II) and Ni(II)) carrying four new triazole units in peripheral positions was presented. First, 4-(prop-2-yn-1-yloxy)phthalonitrile, l3, was synthesized. Second, azidomethyl Ph sulfide, 4, was added to this structure to obtain a triazole unit catalyzed by sodium ascorbate and CuSO₄.5H₂O in DMSO. Common spectroscopic methods such as FTIR, ¹H-NMR, ¹³C-NMR, HRMS and UV-visible spectroscopy techniques was used for characterization of synthesized structures. The mol. structure of the phthalonitrile compound 5 was confirmed by single-crystal x-ray diffraction experiment Morover, by using HF and B3LYP method and 6-31++g(d,p) basis set, ¹H and ¹³C NMR chem. shifts, IR and UV-visible spectra were theor. calculated in gas phase for the optimized structure of 5. The obtained FTIR spectra and NMR spectra showed that the desired mols. were synthesized, and mass spectra confirmed these mols. Electronic absorption spectra showed that phthalocyanines are non-aggregable mols. The cyclic voltammetry data of the phthalocyanines showed that the Pc-6 has two reduction reactions and two oxidation reactions while the Pc-7 and Pc-8 have one reduction reaction and one oxidation reaction. Furthermore, the cobalt(II)phthalocyanine, Pc-7, was studied as oxidation catalyst for the catalytic oxidation of 2-mercaptoethanol. Turnover number, initial reaction rate and the oxygen consumption values were found in the catalytic oxidation of 2-mercaptoethanol as 18.09, 0.12Î¼mol.s^-1 and 6.88Î¼mol.min^-1, resp.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Karakilic, Emel team published research in Applied Organometallic Chemistry in 2022 | 31643-49-9

Category: nitriles-buliding-blocks, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Category: nitriles-buliding-blocks.

Karakilic, Emel;Alim, Zuhal;Emirik, Mustafa;Baran, Arif research published ã?Some characteristics of new and innovative COX inhibitor derivatives: Potent hCA-I and hCA-II inhibitors supported by molecular docking studiesã? the research content is summarized as follows. In this study, two novel metallophthalocyanines (ZnPc and CoPc) were synthesized using the corresponding metal salts 4-(4-(4-[4-chlorophenyl]-5-methylisoxazol-3-yl)phenoxy)-phthalonitrile (11), prepared from the reaction of 4-nitrophthalonitrile and 4-(4-[4-chlorophenyl]-5-methylisoxazol-3-yl)phenol (9). These metallophthalocyanines (MPcs) showed quite solubility in organic solvents such as dichloromethane (DCM), THF (THF), DMF (DMF), and dimethylsulfoxide (DMSO). The novel compounds 11a and 11b have been characterized using their UV-Vis, FT-IR, ¹H NMR, ¹³C NMR, X-Ray, and MALDI-TOF mass spectra. Supporting information concerning with the study has been supplied. Photochem., photophys., and cyclic voltammetry properties of these novel 4-(4-[4-chlorophenyl]-5-methylisoxazol-3-yl)phenoxy substituted metallophthalocyanines (11a and 11b) were determined in DMF. DNA binding, metal chelating effect assay, and DPPH [2,2-diphenyl-1-picrylhydrazyl hydrate] radical scavenging assay and electrochem. studies of MPcs were investigated. Further, the inhibitory effects of the COX-inhibitor based novel metallophthalocyanines (11a and 11b) and their ligands (10 and 11) were examined on human erythrocyte carbonic anhydrase I (hCA-I) and II (hCA-II) isoenzymes, and the synthesized mols. exhibited very strong inhibitory effects on both isoforms. In addition, the hCA-I and hCA-II inhibition potential of Zn (II) and Co (II) Phthalocyanine complexes was supported by mol. docking studies. The binding interaction of metallophthalocyanines complexes 11a, 11b enzymes were analyzed in detail.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts