Category: nitriles-buliding-blocks

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Quality Control of 31643-49-9.

Cong, Fangdi;Jiang, Hongzhen;Du, Xiguang;Yang, Wei;Zhang, Shulin research published 《 Facile, Mild-Temperature Synthesis of Metal-Free Phthalocyanines》, the research content is summarized as follows. It is important for the synthesis and research of phthalocyanine compounds for these compounds to be easily obtained at low temperature It was observed that metal-free phthalocyanine was sometimes found in a simple system used to synthesize phthalocyanine precursors at room temperature, and further studies showed that the key to the effective formation of phthalocyanines at low temperature lay in the presence of equal volumes of alc. and amine, in addition to substrate phthalonitriles and solvents, in the reaction system. A synthetic mechanism was proposed and facile syntheses have been realized, such as the synthesis of tetra-α(β)-nitrophthalocyanines and tetra-α(β)-(4- tert-butylphenoxy)phthalocyanines from the corresponding substituted phthalonitriles at mild temperature (37°C). The results are significant for the design and synthesis of new phthalocyanine derivatives, and the method is convenient and easy to adopt for general use in standard laboratories

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Quality Control of 31643-49-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Recommanded Product: Tetrafluoroterephthalonitrile.

Contreras-Martinez, Jorge;Mohsenpour, Sajjad;Ameen, Ahmed W.;Budd, Peter M.;Garcia-Payo, Carmen;Khayet, Mohamed;Gorgojo, Patricia research published 《 High-Flux Thin Film Composite PIM-1 Membranes for Butanol Recovery: Experimental Study and Process Simulations》, the research content is summarized as follows. Thin film composite (TFC) membranes of the prototypical polymer of intrinsic microporosity (PIM-1) have been prepared by dip-coating on a highly porous electrospun polyvinylidene fluoride (PVDF) nanofibrous support. Prior to coating, the support was impregnated in a non-solvent to avoid the penetration of PIM-1 inside the PVDF network. Different non-solvents were considered and the results were compared with those of the dry support. When applied for the separation of n-butanol/water mixtures by pervaporation (PV), the developed membranes exhibited very high permeate fluxes, in the range of 16.1-35.4 kg m^-2 h^-1, with an acceptable n-butanol/water separation factor of about 8. The PV separation index (PSI) of the prepared membranes is around 115, which is among the highest PSI values that have been reported so far. Hybrid PV-distillation systems have been designed and modeled in Aspen HYSYS using Aspen Custom Modeler for setting up the PIM-1 TFC and com. PDMS membranes as a benchmark. The butanol recovery cost for the hybrid systems is compared with a conventional stand-alone distillation process used for n-butanol/water separation, and a 10% reduction in recovery cost was obtained.

Recommanded Product: Tetrafluoroterephthalonitrile, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. SDS of cas: 105-34-0.

Bitai, Jacqueline;Nimmo, Alastair J.;Slawin, Alexandra M. Z.;Smith, Andrew D. research published 《 Cooperative Palladium/Isothiourea Catalyzed Enantioselective Formal (3+2) Cycloaddition of Vinylcyclopropanes and α,β-Unsaturated Esters》, the research content is summarized as follows. A protocol for the enantioselective synthesis of substituted vinylcyclopentanes I (R¹ = CN, 1,3-dioxo-2,3-dihydro-1H-inden-2-yl, CO₂CH₃, CO₂CH₂F, etc.; R² = CF₃, CO₂CH₂CH₃, (pyrrolidin-1-yl)carbonyl, etc.) has been realized using cooperative palladium and isothiourea catalysis. Treatment of vinylcyclopropanes with Pd(PPh₃)₄ generates a zwitterionic Π-allyl palladium intermediate that intercepts a catalytically generated α,β-unsaturated acyl ammonium species prepared from the corresponding α,β-unsaturated para-nitrophenyl ester and the isothiourea (R)-BTM. Intermol. formal (3+2) cycloaddition between these reactive intermediates generates functionalized cyclopentanes in generally good yields and excellent diastereo- and enantiocontrol (up to > 95 : 5 dr, 97 : 3 er), with the use of LiCl as an additive proving essential for optimal stereocontrol. To the best of knowledge a dual transition metal/organocatalytic process involving α,β-unsaturated acyl ammonium intermediates has not been demonstrated previously.

SDS of cas: 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. HPLC of Formula: 31643-49-9.

Biyiklioglu, Zekeriya;Bas, Hueseyin;Akkaya, Didem;Barut, Burak research published 《 Synthesis and biological evaluation of peripherally tetra-({6-[3-(dimethylamino)phenoxy]hexyl}oxy) substituted water-soluble phthalocyanines as cholinesterases inhibitors》, the research content is summarized as follows. The authors synthesized peripherally tetra-({6-[3-(dimethylamino)phenoxy]hexyl}oxy) substituted water-soluble metallophthalocyanines (DM-C6-CoQ, DM-C6-CuQ, DM-C6-MnQ) and studied their in vitro cholinesterases inhibitory properties by using the spectrophotometric method. The compounds inhibited cholinesterases and had remarkable inhibitory effects when compared with galantamine (p < 0.0001). The IC₅₀ values of the compounds ranged from 2.11 ± 0.20 to 16.40 ± 1.25μM for AChE and BuChE. Also, the inhibitory type and inhibition constant (K_i) of the compounds were evaluated using Lineweaver-Burk and Dixon plots. These plots showed that DM-C6-CoQ, DM-C6-CuQ, and DM-C6-MnQ were mixed inhibitors against AChE and DM-C6-MnQ is the strongest binding inhibitor to the enzyme. Also, DM-C6-CoQ inhibited BuChE via competitive manner with 10.05 ± 0.55μM of K_i value. The compounds might be effective agents against Alzheimer’s disease.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., HPLC of Formula: 31643-49-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Computed Properties of 105-34-0.

Blocka, Aleksandra;Chaladaj, Wojciech research published 《 Tandem Pd-Catalyzed Cyclization/Coupling of Non-Terminal Acetylenic Activated Methylenes with (Hetero)Aryl Bromides》, the research content is summarized as follows. A new method for a tandem Pd-catalyzed intramol. addition of active methylene compounds to internal alkynes ZCH(X)(CH₂)₃CCR (R = Me, Et, Ph; X = COOMe, CN, C(O)Me, COOi-Pr, SO₂Me; Y = COOMe, C(O)Me, C(O)i-Pr, SO₂Ph, COOEt) followed by coupling with aryl and heteroaryl bromides R¹Br (R¹ = Ph, thiophen-2-yl, benzodioxol-5-yl, etc.) was reported. Highly substituted vinylidenecyclopentanes (E)-I were obtained with good yields, complete selectivity, and excellent functional group tolerance. A plausible mechanism, supported by DFT calculations, involves the oxidative addition of bromoarene to Pd(0), followed by cyclization and reductive elimination. The excellent regio- and stereoselectivity arises from the 5-exo-dig intramol. addition of the enol form of the substrate to alkyne activated by the Π-acidic Pd(II) center, postulated as the rate-determining step.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Computed Properties of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Related Products of 20099-89-2.

Bora, Prerona;Manna, Suman;Nair, Mrutyunjay A.;Sathe, Rupali R. M.;Singh, Shubham;Sreyas Adury, Venkata Sai;Gupta, Kavya;Mukherjee, Arnab;Saini, Deepak K.;Kamat, Siddhesh S.;Hazra, Amrita B.;Chakrapani, Harinath research published 《 Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation》, the research content is summarized as follows. Persulfides and polysulfides, collectively known as the sulfane sulfur pool along with hydrogen sulfide (H2S), play a central role in cellular physiol. and disease. Exogenously enhancing these species in cells is an emerging therapeutic paradigm for mitigating oxidative stress and inflammation that are associated with several diseases. In this study, we present a unique approach of using the cell′s own enzyme machinery coupled with an array of artificial substrates to enhance the cellular sulfane sulfur pool. We report the synthesis and validation of artificial/unnatural substrates specific for 3-mercaptopyruvate sulfurtransferase (3-MST), an important enzyme that contributes to sulfur trafficking in cells. We demonstrate that these artificial substrates generate persulfides in vitro as well as mediate sulfur transfer to low mol. weight thiols and to cysteine-containing proteins. A nearly 100-fold difference in the rates of H₂S production for the various substrates is observed supporting the tunability of persulfide generation by the 3-MST enzyme/artificial substrate system. Next, we show that the substrate 1a permeates cells and is selectively turned over by 3-MST to generate 3-MST-persulfide, which protects against reactive oxygen species-induced lethality. Lastly, in a mouse model, 1a is found to significantly mitigate neuroinflammation in the brain tissue. Together, the approach that we have developed allows for the on-demand generation of persulfides in vitro and in vivo using a range of shelf-stable, artificial substrates of 3-MST, while opening up possibilities of harnessing these mols. for therapeutic applications.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Related Products of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Computed Properties of 20099-89-2.

Borkotoky, Lodsna;Borra, Satheesh;Maurya, Ram Awatar research published 《 Access to Pyrrolocoumarins through DBU-Mediated Coupling of 2-Oxo-2H-chromene-3-carbaldehydes and Phenacyl Azides》, the research content is summarized as follows. 1,8-Diazabicyclo [5.4.0]undec-7-ene (DBU) mediated annulation of 4-(benzylthio/arylthio)-2-oxo-2H-chromene-3-carbaldehydes with phenacyl azides for the synthesis of biol. relevant pyrrolocoumarins was developed. This operationally simple and unique synthetic strategy allows the formation of desired pyrrolocoumarin in good yields (67-84%), and generates a new C-C and C-N bond in the overall process.

Computed Properties of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Computed Properties of 31643-49-9.

Botnar, A. A.;Domareva, N. P.;Kazaryan, K. Yu.;Tikhomirova, T. V.;Abramova, M. B.;Vashurin, A. S. research published 《 Synthesis and spectral properties of tetraphenoxy substituted erbium phthalocyanines containing peripheral phenyl and cyclohexyl fragments》, the research content is summarized as follows. The synthesis of peripherally and non-peripherally substituted erbium phthalocyanines with cyclohexylphenoxyl or phenylphenoxyl fragments by the template condensation of substituted phthalonitrile and erbium chloride in boiling isoamyl alc. was studied. The role of the influence of the substituents in the macrocycle on the yield of the product was revealed. The change in the spectra of the synthesized compounds in various solvents was studied.

Computed Properties of 31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. COA of Formula: C8H3N3O2.

Botnar, Anna;Tikhomirova, Tatiyana;Kazaryan, Kristina;Bychkova, Anna;Maizlish, Vladimir;Abramov, Igor;Vashurin, Artur research published 《 Synthesis and properties of tetrasubstituted phthalocyanines containing cyclohexylphenoxy-groups on the periphery》, the research content is summarized as follows. The data on synthesis and spectroscopic-luminescent proportion of novel peripheral and non-peripheral substituted cyclohexylphenoxy-phthalocyanine derivatives and their metal complexes with magnesium and zinc are given in the work. By means of the nucleophilic substitution reaction of 3- or 4-nitrophthalonitrile and 4-cyclohexylphenol, the 3/4-(4-cyclohexylphenoxy)phthalonitriles were synthesized and further characterized by ¹H NMR, IR spectroscopy and elemental anal. Metal complexes synthesis were carried out by template fusion of substituted nitriles with appropriate metal acetates, whereas the ligands were obtained through demetallization of magnesium complexes in hydrochloric acid. It was found non-peripheral substituted magnesium and zinc complexes in the chloroform and toluene solutions forms J-type aggregates. Peripheral substituted metal complexes possess more pronounced fluorescent properties compare to non-peripheral ones.

COA of Formula: C8H3N3O2, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Formula: C9H6BrNO.

Bursavich, Matthew G.;Harrison, Bryce A.;Acharya, Raksha;Costa, Donald E.;Freeman, Emily A.;Hrdlicka, Lori A.;Jin, Hong;Kapadnis, Sudarshan;Moffit, Jeffrey S.;Murphy, Deirdre;Nolan, Scott J.;Patzke, Holger;Tang, Cuyue;Van Voorhies, Hilliary E.;Wen, Melody;Koenig, Gerhard;Blain, Jean-Francois;Burnett, Duane A. research published 《 Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator》, the research content is summarized as follows. The recent approval of aducanumab for Alzheimer′s disease has heightened the interest in therapies targeting the amyloid hypothesis. Our research has focused on identification of novel compounds to improve amyloid processing by modulating gamma secretase activity, thereby addressing a significant biol. deficit known to plague the familial form of the disease. Herein, we describe the design, synthesis, and optimization of new gamma secretase modulators (GSMs) based on previously reported oxadiazine 1. Potency improvements with a focus on predicted and measured properties afforded high-quality compounds further differentiated via robust Aβ₄₂ reductions in both rodents and nonhuman primates. Extensive preclin. profiling, efficacy studies, and safety studies resulted in the nomination of FRM-024 (I), (+)-cis-5-(4-chlorophenyl)-6-cyclopropyl-3-(6-methoxy-5-(4-methyl-1H-imidazole-1-yl)pyridin-2-yl)-5,6-dihydro-4H-1,2,4-oxadiazine, as a GSM preclin. candidate for familial Alzheimer′s disease.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Formula: C9H6BrNO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts