Category: nitriles-buliding-blocks

Olgun, Ugursoy published the artcileNano-gold-based synthesis, characterization and band gap energies of gold(III)-2(3)-tetrakis(allyloxy)-substituted phthalocyanine and gold(III)-phthalocyanine dyes, Quality Control of 91-15-6, the main research area is gold tetrakis allyloxy phthalocyanine band gap oxidation.

In this study, we have attempted to synthesize Au (III)-phthalocyanine (Au-Pc) and Au (III)-2 (3)-tetrakis (allyloxy) phthalocyanine (Au-AoPc) by using phthalonitrile (Pn), 3 allyloxy-substituted phthalonitrile (Ao-Pn) and gold nanoparticles (AuNPs) as the starting materials. The N,N′-dimethyl amino ethanol (DMAE)-stabilized AuNPs were prepared from the HAuCl4 solution The purple color AuNPs were obtained by the reduction of HAuCl4 solution by the addition of DMAE and adjusting pH 6-7 at room temperature Then, the blue color Au-Pc and the green color Au-AoPc dye materials were synthesized at 120 °C temperature by the reactions of the AuNPs with Pn and AoPn. The obtained AuNPs, Au-Pc and Au-AoPc complexes were characterized using optical microscopy, transmission electron microscopy (TEM), UV-Vis absorption, FT-IR and electrospray ionization-mass spectrometry. The TEM anal. results showed that the sizes of AuNPs were mostly 30-40 nm and distributed within the range of 10-100 nm. By using the Tauc method, the optical band gap energies (Eg) were calculated as 1.66 eV for the Q-band and 3.12 eV for the B-band of the Au-Pc, and as 1.79 eV for the Q-band and 3.32 eV for the B-band of the Au-AoPc. The DMAE-stabilized AuNPs, the Au-Pc and the soluble Au-AoPc dyes with low band gap energy can be utilized for various technologies in electronics, imaging, sensors and solar cells.

Journal of Materials Science: Materials in Electronics published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bhatia, Harsh published the artcileAsymmetric-donor (D2D2)-acceptor (A) conjugates for simultaneously accessing intrinsic blue-RTP and blue-TADF, Formula: C8H4N2, the main research area is donor acceptor photoluminescent room temperature phosphorescence.

The development of new photoluminescent (PL) materials with simultaneous room-temperature phosphorescence (RTP) and thermally activated delayed fluorescence (TADF) features is highly desirable for bio-imaging, security applications and sensors due to the involvement of both singlet and longer-lived triplet states. Here, we report two carbazolyl-phenoxy-phthalonitrile conjugates (CPPN, CPPNF). Spectroscopic studies combining two daughter compounds (PPN, PPNF) in polar and nonpolar hosts confirmed efficient blue-RTP from the higher-energy triplet state (TPPN) due to the phenoxy-phthalonitrile (PPN) part, and blue-TADF via reverse intersystem crossing from the low-lying triplet state (TCzPN) of the carbazolyl-phthalonitrile (CzPN) part to the singlet (S1) state of the same CzPN part, utilizing the TPPN state that acts as an intermediate for spin-vibronic coupling. Such PL characteristics are observed due to the energetic proximity of 3LEPPN, 1CTCzPN and 3CTCzPN. In the hydrogen-bonded matrix and crystals, we found faint persistent green-RTP characteristics of the PPNF due to supramol. interactions and aggregation of the mol. This study could pave the way to understanding the involvement of different excited states associated with TADF and RTP processes of asym.-donor-acceptor systems.

Materials Advances published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Wenzhi published the artcileMethoxypolyethylene Glycol-Substituted Zinc Phthalocyanines for Multiple Tumor-Selective Fluorescence Imaging and Photodynamic Therapy, Computed Properties of 91-15-6, the main research area is photodynamic therapy fluorescence imaging pharmacokinetics.

Highly tumor-tissue-selective drugs are a prerequisite for accurate diagnosis and efficient photodynamic therapy (PDT) of tumors, but the currently used fluorescent dyes and photosensitizers generally lack the ability for high accumulation and precise localization in tumor tissues. Here we report that monomethoxy polyethylene glycol (MPEG)-modified zinc phthalocyanine (ZnPc) can be selectively accumulated in multiple tumor tissues, and that the selectivity is controlled by the chain length of MPEG. MPEG-monosubstituted ZnPcs with different chain lengths were synthesized, among which the shorter chain (mw < 2k)-modified ZnPc did not show tumor tissue selectivity, while MPEG2k-5k-substituted ZnPc could be rapidly and selectively accumulated in H22 tumor tissues in mice after i.v. injection. Especially, MPEG4k-Pc showed the best tumor tissue selectivity with a tumor/liver (T/L) ratio of 1.7-2.2 in HepG2, MDA-MB231, AGS, and HT-29 tumor-bearing mice. It also exhibited potent photodynamic therapy effects after one PDT treatment, and tumor growth was significantly inhibited in H22-bearing mice with an inhibition rate over 98% and no obvious toxicity. Consequently, MPEG-modified ZnPc could serve as a potential platform for selective fluorescence imaging and photodynamic therapy of multiple tumors. Biomacromolecules published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ishikawa, Yuta published the artcileRed-light-activatable ruthenium phthalocyanine catalysts, Name: Phthalonitrile, the main research area is ruthenium phthalocyanine red light activatable catalyst.

Phthalocyanine ruthenium complexes were identified as red-light activatable catalysts for trifluoromethylation reactions. The red-light mediated chlorotrifluoromethylation of alkenes could proceed without any sacrificial reducing reagents. This reaction exhibited good compatibility with a blue-light-absorbing substrate, while under irradation with blue light, i.e., under traditional photoreaction conditions, this substrate decomposed completely.

Chemical Communications (Cambridge, United Kingdom) published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Name: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rocker, Johannes published the artcileAlternatives to Iridium: A Polyaza[7]helicene as a Strongly Reductive Visible Light Photoredox Catalyst, Name: Picolinonitrile, the main research area is poly azahelicene photo redox catalyst.

The use of a readily accessible polyazahelicene as a strongly reducing metal-free alternative to the commonly used precious metal based photo redox catalysts is demonstrated. An improved two-step synthesis of the catalyst is described, and its photophys. properties with respect to its use as a photo redox catalyst are evaluated. Its activity under visible light irradiation is proven by application in two double radical light-driven multi-component reactions. The azahelicene gave comparable results to an iridium-based catalyst originally used for the same transformations.

ACS Organic & Inorganic Au published new progress about Absorption. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Watson, Angus A. published the artcilePurine N-oxides. 66. Synthesis of 9-hydroxyadenine, Product Details of C10H11N3O3S, the publication is Journal of Organic Chemistry (1977), 42(9), 1610-12, database is CAplus and MEDLINE.

The synthesis of 9-hydroxyadenine (I, R = H), by a variation of the Shaw purine synthesis, involved the condensation of Et N-(dicyanomethyl)formimidate tosylate with benzyloxyamine to a cyanoimidazole derivative II (R = H), which was then ring-closed to III (R = H) and hydrolyzed to the desired purine derivative This is the 3rd adenine N-oxide isomer available for carcinogenicity testing. Analogously prepared was I (R = Me).

Journal of Organic Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C7H16Cl2Si, Product Details of C10H11N3O3S.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Yicun published the artcileDesign, synthesis, and pharmacological evaluation of haloperidol derivatives as novel potent calcium channel blockers with vasodilator activity, Quality Control of 612-13-5, the publication is PLoS One (2011), 6(11), e27673, database is CAplus and MEDLINE.

Several haloperidol derivatives with a piperidine scaffold that was decorated at the nitrogen atom with different alkyl, benzyl, or substituted benzyl moieties were synthesized at our laboratory to establish a library of compounds with vasodilator activity. Compounds were screened for vasodilatory activity on isolated thoracic aorta rings from rats, and their quant. structure-activity relationships (QSAR) were examined Based on the result of QSAR, N-4-tert-Bu benzyl haloperidol chloride (16c) was synthesized and showed the most potent vasodilatory activity of all designed compounds 16C dose-dependently inhibited the contraction caused by the influx of extracellular Ca²⁺ in isolated thoracic aorta rings from rats. It concentration-dependently attenuated the calcium channel current and extracellular Ca²⁺ influx, without affecting the intracellular Ca²⁺ mobilization, in vascular smooth muscle cells from rats. 16C, possessing the N-4-tert-Bu benzyl piperidine structure, as a novel calcium antagonist, may be effective as a calcium channel blocker in cardiovascular disease.

PLoS One published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Quality Control of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Miaomiao published the artcileTransition Metal-Free Oxidative Cross-Coupling Reaction of Activated Olefins with N-Alkyl Amides, Category: nitriles-buliding-blocks, the publication is Journal of Organic Chemistry (2021), 86(5), 3989-3998, database is CAplus and MEDLINE.

The K₂S₂O₈-mediated transition metal-free oxidative cross-coupling reaction of activated olefins with N-alkyl amides was developed, and the reaction gave N-allylic amides in moderate to good yield. This reaction protocol was suitable for different kinds of activated olefins.

Journal of Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Xie, Yan published the artcileSynthesis of 2-(2-Aryl)ethylbenzoic acid, Computed Properties of 612-13-5, the publication is Zhongguo Yiyao Gongye Zazhi (2012), 43(2), 87-89, database is CAplus.

2-(2-Phenylethyl)benzoic acid or 2-(thiophene-2-ylethyl)benzoic acid was synthesized from o-cyanobenzyl chloride via Wittig-Horner reaction with benzaldehyde or 2-thiopene carboxaldehyde, hydrolysis and then hydrogenation, with the overall yield of about 64% or 60%.

Zhongguo Yiyao Gongye Zazhi published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C3H7NO2, Computed Properties of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhou, Wenjun published the artcileSynthesis and characterization of o-cyanostilbenes, Application In Synthesis of 612-13-5, the publication is Huagong Shengchan Yu Jishu (2011), 18(3), 28-31, database is CAplus.

The preparation and characterization of five o-cyanostilbenes from o-cyanobenzyl chloride, tri-Et phosphate, aromatic aldehydes in N,N-DMF via Wittig-Horner reaction with yields ranged from 83.8% to 93.1% were reported. The reported method had the advantages of reliable and high yields, simple operations, cheap and readily available raw materials.

Huagong Shengchan Yu Jishu published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C15H24O2, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts