Category: nitriles-buliding-blocks

These common heterocyclic compound, 501-00-8, name is 2-(3-Fluorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6FN

To a solution of compound 36-2 (346 mg, 2.56 mmol) in THF (10 niL) was added Raney Ni. Then the mixture was adjusted to PH=IO with concentrated aqueous ammonia and stirred at 30 0C overnight. TLC showed the reaction was completed. The mixture was filtered through Celite and the filtrate was concentrated to give 36-3 as a yellow oil (120 mg, yield: 34 %).

The synthetic route of 2-(3-Fluorophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY; YUAN, Junying; MA, Dawei; LIU, Junli; ZHANG, Lihong; WO2011/11522; (2011); A2;,
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These common heterocyclic compound, 50594-78-0, name is 5-Fluoro-2-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 5-Fluoro-2-nitrobenzonitrile

The 4-chloro-6-(1,2,4-triazol-1-yl)quinazoline used as a starting material was obtained as follows: A mixture of 5-fluoro-2-nitrobenzonitrile (3 g), 1,2,4-triazole (4.92 g), triethylamine (9.9 ml) and DMSO (50 ml) was stirred and heated to 85 C. for 16 hours. The mixture was cooled to ambient temperature and water was added. The precipitate was isolated and dried to give 2-nitro-5-(1,2,4-triazol-1-yl)benzonitrile (1.9 g) which was used without further purification.

The synthetic route of 5-Fluoro-2-nitrobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zeneca Limited; US5955464; (1999); A;,
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Related Products of 13388-75-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A 50 mL round-bottomed flask was charged with 3 (0.177 g, 1 mmol), aromatic aldehyde or substituted aromatic aldehyde (1 mmol) and 10 mL methanol with stirring, and the mixture was heated to 60 C. After 30 min, sodium methoxide (0.027 g, 0.5 mmol) was added to the mixture and keep the temperature for 4-6 h. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to RT, and the precipitate was separated by filter and recrystallized from methanol to give 4a-4z and 5a-5d.

The chemical industry reduces the impact on the environment during synthesis 2-(3,5-Dimethoxyphenyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Ma, Jun; Li, Jiajun; Tian, Yu-Shun; Bioorganic and Medicinal Chemistry Letters; vol. 27; 1; (2017); p. 81 – 85;,
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Related Products of 1835-65-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1835-65-0 as follows.

Nickel complexes 3?6. A mixture of 1.00 g (3.2 mmol) of nitrile 1, 0.64 g (3.2 mmol) of nitrile 2, and 0.50 g (2.0 mmol) of nickel(II) acetate tetrahydrate was stirred during 1 h at 210 °C. After cooling the reaction mixture, it was dissolved in 50 mL of dichloromethane and filtered through a 5 cm layer of type II alumina. The solvent was distilled off, and the residue was purified by column chromatography on Kieselgel 60 silica gel (Merck). First, complexes 3 and 4 were isolated using dichloromethane as eluent, and then complexes 5 and 6 were isolated using a 95 : 5 (v/v) mixture of dichloromethane and ethanol as eluent.

According to the analysis of related databases, 1835-65-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Koptyaev; Galanin; Shaposhnikov; Russian Journal of General Chemistry; vol. 86; 4; (2016); p. 854 – 858; Zh. Obshch. Khim.; vol. 86; 4; (2016); p. 667 – 671,5;,
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Synthetic Route of 1813-33-8, The chemical industry reduces the impact on the environment during synthesis 1813-33-8, name is 2-Chloro-4-(trifluoromethyl)benzonitrile, I believe this compound will play a more active role in future production and life.

General procedure: Appropriate ROH (3.00 mmol) was added topotassium tert-butoxide (3.00 mmol) solution in toluene (7 ml).1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU, 3ml)was added to the mixture and stirred for 30 min at 80 C. Aftercooled down to ambient temperature of the reaction mixture,2-chloro-4-(trifluoromethyl)-benzonitrile (1.00 mmol) in toluenewas dropwise and stirred for 3 h at 80 C. The reaction wasquenched by adding water and extracted with EtOAc twice. Thecombined organic extracts were dried over MgSO4, filtered, andconcentrated in vacuo. The residue was purified by flash columnchromatography on silica gel using EtOAc/hexane (1:7) eluantcondition.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4-(trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ann, Jihyae; Jung, Aeran; Kim, Mi-Yeon; Kim, Hyuk-Min; Ryu, Hyungchul; Kim, Sunjoo; Kang, Dong Wook; Hong, Sunhye; Cui, Minghua; Choi, Sun; Blumberg, Peter M.; Frank-Foltyn, Robert; Bahrenberg, Gregor; Stockhausen, Hannelore; Christoph, Thomas; Lee, Jeewoo; Bioorganic and Medicinal Chemistry; vol. 23; 21; (2015); p. 6844 – 6854;,
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Related Products of 4592-94-3, The chemical industry reduces the impact on the environment during synthesis 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, I believe this compound will play a more active role in future production and life.

To a mixture of 3-(4-bromophenyl)-3-oxo-propanenitrile (7.00 g, 31.2 mmol) and nickel chloride hexahydrate (18.6 g, 78.1 mmol) in anhydrous tetrahydrofuran (150 mL)was added sodium borohydride (5.91 g, 156 mmol) portion-wise at 0 C under a nitrogen. The mixture was warmed to rt and stirred for 2 hours. On completion, ammonium chloride (10 mL) was added to the reaction and the mixture was extracted with EtOAc (3 X 100 mL). The organic layer was dried over anhydrous sodium sulfate, and filtered. The residue was concentrated in vacuo to give the title compound. LCMS: (ESj m/z (M+H) = 230.0, tR= 1.069.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Bromophenyl)-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (163 pag.)WO2017/156179; (2017); A1;,
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Electric Literature of 403-54-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 403-54-3, name is 3-Fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of nitrile (5 mmol), tert-butyl benzoate (5.5 mmol) and Zn(ClO4)2·6H2O (2 mol%) was placed in around bottom flask. Then, the reaction mixture was heated at 50 C for the given time. After completion of the reaction monitored by thin layer chromatography (TLC), the reaction mixture was quenched with 5-ml water. Then the reaction system was added 10 ml aqueous NaOH solution (1 mol/L) and continued to be stirred 5 min and extracted with ethyl acetate (3 × 10 ml). The organic layers were collected, combined, washed with water (3 × 10 ml), driedover anhydrous Na2SO4, and concentrated under vacuum.

The chemical industry reduces the impact on the environment during synthesis 3-Fluorobenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Feng, Cheng-Liang; Yan, Bin; Zhang, Min; Chen, Jun-Qing; Ji, Min; Chemical Papers; vol. 73; 2; (2019); p. 535 – 542;,
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Adding a certain compound to certain chemical reactions, such as: 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57381-51-8, category: nitriles-buliding-blocks

General procedure: Two runs were set side by side. A Schlenck tube was loadedwith [RuCl2(p-cymene)]2 (7.7 mg, 0.0125 mmol, 2.5 mol%), L3 (9.8 mg, 0.025 mmol, 5 mol%),K2CO3 (173 mg, 1.25 mmol), The tube was backfilled with Ar (3 ×). Under light backflow of Ar, NMP (2.5 mL) was added, followed by the required substrate (1c-1e) (0.6 mmol), and p-chloroanisole (2a;62 L, 71 mg, 0.5 mmol). The tube was sealed and the reaction mixture was stirred at 140 C for 24hours. After cooling to room temperature, the reaction mixtures from both tubes were combined in H2O(40 mL) and EtOAc (20 mL). The organic phase was separated and washed with H2O (3 × 30 mL),dried (MgSO4), filtered, and concentrated under reduced pressure. The monoarylated products (major)were isolated after flash chromatography.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-2-fluorobenzonitrile, and friends who are interested can also refer to it.

Reference:
Article; Li, You-Gui; Wang, Zhen-Yu; Zou, Ya-Ling; So, Chau-Ming; Kwong, Fuk-Yee; Qin, Hua-Li; Kantchev, Eric Assen B.; Synlett; vol. 28; 4; (2017); p. 499 – 503;,
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Synthetic Route of 1813-33-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1813-33-8, name is 2-Chloro-4-(trifluoromethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 2-Chloro-4-(trifluoromethyl)-benzonitrile(1.00 mmol) was dissolved in appropriate alcohol, and DBU(2.00 mmol) was added. The mixture was stirred for 3 h at 80 C.The reaction was quenched with water and extracted with EtOActwice. The combined organic extracts were dried over MgSO4,filtered, and concentrated in vacuo. The residue was purified byflash column chromatography on silica gel using EtOAc/hexane(1:4) eluant condition.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4-(trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ann, Jihyae; Jung, Aeran; Kim, Mi-Yeon; Kim, Hyuk-Min; Ryu, Hyungchul; Kim, Sunjoo; Kang, Dong Wook; Hong, Sunhye; Cui, Minghua; Choi, Sun; Blumberg, Peter M.; Frank-Foltyn, Robert; Bahrenberg, Gregor; Stockhausen, Hannelore; Christoph, Thomas; Lee, Jeewoo; Bioorganic and Medicinal Chemistry; vol. 23; 21; (2015); p. 6844 – 6854;,
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Adding a certain compound to certain chemical reactions, such as: 1897-52-5, name is 2,6-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1897-52-5, Formula: C7H3F2N

General procedure: To an oven dried round bottom flask charged with a mixture of 2-fluorobenzonitrile (1a, 1 mmol) and hydrazine (2a, 1mmol) in ethanol (3 ml), stirred the reaction mixture at 80 C, for 30 min. To the reaction mixture isatin (3a, 1 mmol), 5,5-dimethyl-1,3-cyclohexanedione (4a, 1 mmol) and p-TSA (40 mol %) was added and the reaction mixture was further stirred at 80 C for 4 h. The progress of the reaction was monitored by TLC. After completion of the reaction, solid products was filtered under vacuum, air dried, to obtain the analytically pure products. The compounds 5a-5r were also synthesized by adopting this procedure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Difluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Balwe, Sandip Gangadhar; Lim, Kwon Taek; Cho, Byung Gwon; Jeong, Yeon Tae; Synthetic Communications; vol. 49; 4; (2019); p. 602 – 610;,
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