Category: nitriles-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 37719-02-1, name is 2,2-Dimethyl-3-oxobutanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37719-02-1, name: 2,2-Dimethyl-3-oxobutanenitrile

The effects of temperature on KH for Examples 2-6 to 2-11 were measured using Technique 2 and are listed in Table 2. The van’t Hoff equation was then fit to a plot of KH vs. temperature; energy standard deviation were calculated from the fit of the equation to the raw data. (0078) Examples 2-6 and 2-11 were prepared using variations to the standard procedure. Example 2-6 was prepared with a concentration of 50 mM, so that it was soluble in water. For Example 2-11, a small amount of enol was also observed (about 0.08 relative to ketone). To account for this, we calculated KH for Example 2-11 as diol/(ketone+enol), assuming enol formation from the ketone is reversible.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2-Dimethyl-3-oxobutanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; University of Pittsburgh – Of the Commonwealth System of Higher Education; Beckman, Eric J.; Bourmpakis, Ioannis; Tavenor, Nathan Albert; (18 pag.)US2020/78703; (2020); A1;,
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Reference of 74231-65-5, The chemical industry reduces the impact on the environment during synthesis 74231-65-5, name is 4-(Dichloromethyl)benzonitrile, I believe this compound will play a more active role in future production and life.

Under argon protection,Add 400 mL dioxane to a 2 L round bottomed flaskwithCyano dichlorobenzene 55g,The mixture was cooled to -30 C,Then slowly added dropwise 200mL,1mol / L dimethyl zinc n-hexane solution.Bi completed,The reaction was stirred at this temperature for 2 hours,A large number of reaction bottle appeared brown precipitate,For p-cyanodimethylzinc complex.Weigh 146g of triphenylphosphine ruthenium dichloride,With 180mL dissolved in dioxane was added to the reaction,The reaction was stirred at -20 C for 2 hours.Weigh tricyclohexyl phosphine 136g,Dissolved in 160mL dioxane was added to the reaction flask,The reaction was stirred for 1 hour,A purple solution.Most of the solvent and the volatile matter were distilled off under reduced pressure,The residue was recrystallized from 800 mL of methanol for 1 hour at room temperature,Get a lot of brown red product,filter,The solid was washed several times with methanol,Vacuum drying provided catalyst precursor 1 (89 g,Yield 71%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Dichloromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhongyou Haike Ranqi Co., Ltd.; Shanghai Chemical Institute Co., Ltd.; Luo Yong; Ping Jian; Wang Yuan; Shen Kaimin; Yang Weicheng; Chen Fuxiang; Fang Chao; (9 pag.)CN107216355; (2017); A;,
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Synthetic Route of 27387-23-1,Some common heterocyclic compound, 27387-23-1, name is 2-(2-Bromo-5-methoxyphenyl)acetonitrile, molecular formula is C9H8BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2: (2-Bromo-5-hydroxy-phenyl)-acetonitrile[00447] To (2-bromo-5-methoxy-phenyl)-acetonitrile (2.6g, 11.5mmol) in CH2Cl2 (2OmL) at O0C under N2 was added boron tribromide (IM in CH2Cl2; 25.4mL, 25.4mmol). The mixture was stirred for 15 minutes at O0C, and at room temperature overnight. After a work-up with H2O and CH2Cl2, the crude material was purified by silica gel chromatography to give the desired product as a white SoUd (1.5g).

The synthetic route of 27387-23-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; WO2009/102893; (2009); A2;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 159847-80-0 as follows. category: nitriles-buliding-blocks

4-Amino-3-cyano-benzoic acid methyl ester (1.4 g, 7.95 mmol) was dissolved in a mixed solution of tetrahydrofuran and methanol (1/1, 50 mL), and iodine (I2, 2.2 g, 8.74 mmol) and silver nitrate (AgNO3, 1.5 g, 8.74 mmol) were added dropwise thereto. The mixture was stirred for 6 hours at room temperature and filtered with celite. The filtrate was added with 10% sodium thiosulfate aqueous solution and extracted with ethyl acetate. The extract was washed with brine, dried with anhydrous magnesium sulfate and filtered. The filtrate was distilled under reduced pressure. The residue was separated by column chromatography to obtain the title compound (2.0 g, 84%).

According to the analysis of related databases, 159847-80-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG LIFE SCIENCES LTD.; PAEK, Seung Yup; LEE, Sung Bae; PARK, Deok Seong; LEE, Won Hyung; WO2014/129796; (2014); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 508203-48-3, name is 2,3-Difluoro-4-methylbenzonitrile, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

To a suspension of 2,3-difluoro-4-methylbenzonitrile (5.0 g, 32.6 mmol) in ethanol (1 1 1 mL) at 25C was added hydroxylamine hydrochloride (4.5 g, 65.3 mmol). The reaction mixture was heated at 30 80C for 2 hours. After allowing the reaction to reach room temperature the volatiles were removed under reduced pressure thus affording a white solid that was used in the next step without purification. (0450) NMR (400 MHz, CDCI3) delta ppm: 7.30 (m, 1 H), 6.95 (m, 1 H), 6.50 (brs, 1 H), 5.05 (brs, 2H), 2.30 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; HOFFMAN, Thomas, James; STIERLI, Daniel; BEAUDEGNIES, Renaud; POULIOT, Martin; HAAS, Ulrich, Johannes; (101 pag.)WO2018/177880; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6476-32-0, name is 2-Phenoxybenzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C13H9NO

A solution of 2-phenoxybenzonitrile (from step (ii) above (10.1 g, 0.0517 mol) in THF (50 ml) was added dropwise to the well-stirred suspension of LAH (4.9 g, 0.129 mol) in THF (50 ml) at 0 C. under nitrogen atmosphere and then allowed to stir at room temperature for overnight. The reaction mixture was quenched with 6(N) KOH (5 ml) 0 C. and stirred with THF (50 ml) for another 30 minutes. The reaction mixture was filtered and the residue was washed with ethyl acetate. The filtrate was concentrated to give the crude amine. Satd. HCl in diethyl ether (20 ml) was added to the solution of crude amine in diethyl ether (20 ml) and stirred for 2 h. Then the reaction mixture was filtered and residue was dried to give the title compound (10 g, 97.08

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ASTRAZENECA AB; US2008/15237; (2008); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 99835-27-5 as follows. Computed Properties of C7H2BrCl2N

Synthesis of compound 9.3. To a solution of compound 9.2 (1.6 g, 6.37mmol, 1.0 equiv) in toluene (28 mL) was added ammonium chloride (1.7g, 31.8mmol, 5.0 equiv) at room temperature. Trimethylaluminum solution (2M in toluene) (2.29g, 31.8 mmol, 5.0 equiv) was added slowly under a nitrogen atmosphere. The mixture was heated at 110 C for 48 hrs. Upon completion, the reaction mixture was cooled to room temperature and silica was added followed by chloroform (50 mL). The resulting suspension was stirred for 30 minutes, filtered and the filter cake washed with 20% methanol in dichloromethane. The filtrate was concentrated under reduced pressure to obtain crude material, which was triturated with 10% ethyl acetate in hexane to yield compound 9.3 (1.6 g, 93%). MS (ES): m/z 269 [M+H]+.

According to the analysis of related databases, 99835-27-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NIMBUS LAKSHMI, INC.; MASSE, Craig E.; GREENWOOD, Jeremy Robert; ROMERO, Donna L.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; SHELLEY, Mee; KENNEDY-SMITH, Joshua Jahmil; DAHLGREN, Markus; WO2015/131080; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 362527-61-5, name is Ethyl 3-bromo-4-cyanobenzoate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 362527-61-5, name: Ethyl 3-bromo-4-cyanobenzoate

STEP 1 : A mixture of ethyl 3-bromo-4-cyanobenzoate (500 mg, 2.08 mmol), 2-methylpropan-l -amine (250 muL, 4.16 mmol), Pd2(dba)3 (96 mg, 5 mol%), Xantphos (120 mg, 10 mol%) and potassium phosphate (959 mg, 4.16 mmol) in dioxane (10 mL) was stirred for overnight at 95 0C. After cooling to room temperature the mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated followed by column chromatography (10 % ethyl acetate in hexanes) to give ethyl 4- cyano-3-[(2-methylpropylamino)]benzoate (393 mg, 76.7 %) as a yellow solid. ‘ MS(EI) for C14H18N2O2: 247.1 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-bromo-4-cyanobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EXELIXIS, INC.; WO2009/55077; (2009); A1;,
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Application of 13726-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13726-21-1, name is 2-(4-Chloro-3-methoxyphenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Gaseous HCl was slowly bubbled into a cooled solution of 4-chloro-3-methoxyacetonitrile (9b) in toluene (10 mL), ether (10 mL) and EtOH (1 mL) for about 10 min. The reaction was stoppered and stored at -30 C. for one week. TLC failed to detect any remaining starting material. The solvent was evaporated and the yellow solid was stirred with Et2O, filtered and washed with Et2O and dried in a vacuum oven to yield 0.57 g (90%) of ethyl 4-chloro-3-methoxyphenylmethylimidate (9d).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Chloro-3-methoxyphenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Roche Palo Alto LLC; US2004/192704; (2004); A1;,
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Electric Literature of 129931-47-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 129931-47-1, name is 3-Chloro-2-fluoro-5-(trifluoromethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(i) 1-(2-Chloro-6-cyano-4-trifluoromethylphenyl)-5-bromo-4-trifluoromethyl-2-pyridone (Compound No 16 in Table II) was prepared by the reaction of 3-chloro-4-fluoro-5-cyanotrifluoromethylbenzene and 5-bromo-4-trifluoromethyl-2-pyridone. 1 H NMR delta(CDCl3) 8.10 (1H,d); 8.01 (1H,d); 7.45 (1H,s); 7.13 (1H,s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-2-fluoro-5-(trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Imperial Chemical Industries PLC; US5109004; (1992); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts