Category: nitriles-buliding-blocks

Related Products of 6136-93-2,Some common heterocyclic compound, 6136-93-2, name is 2,2-Diethoxyacetonitrile, molecular formula is C6H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of diethoxyacetonitrile (1 ,120 g, 930 mmol) in MeOH (500 ml_) was added a 17% solution of (NH4)2S in H20 (440 ml_) at rt. The mixture was stirred at rt overnight. The mixture was evaporated in vacuo to approximately 100 ml_ volume and filtered. The solid was washed with cooled water and dried in vacuo to afford the title compound 2 (92 g, 61 %) as a white solid, which was used as such in next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2-Diethoxyacetonitrile, its application will become more common.

Application of 69395-13-7, These common heterocyclic compound, 69395-13-7, name is 4-(2-Hydroxyethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A Preparation of 4-(2-hydroxyethyl)benzylamine A solution of 0.74 g (0.005 mol) of p-cyanophenethyl alcohol in 50 ml of ethanol containing 10 ml of concentrated hydrochloric acid was hydrogenated at 30 psi using 0.1 g 5% Pd/C for 72 hours. The catalyst was removed by filtration and the solvent was removed under reduced pressure.

Statistics shows that 4-(2-Hydroxyethyl)benzonitrile is playing an increasingly important role. we look forward to future research findings about 69395-13-7.

Reference of 57381-49-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57381-49-4 as follows.

Into a 19-mL sealed tube was placed 2-bromo-4-chlorobenzonitrile (216 mg, 1.00 mmol), dioxane (1.5 mL), water (0.3 mL), Pd(dppf)Cl2 (36 mg, 0.05 mmol), Na2CO3 (318 mg, 2.97 mmol), and phenylboronic acid (148 mg, 1.21 mmol). The resulting solution was stirred for 16 h at 95oC. The reaction was then quenched by the addition of 25 mL of water. The resulting solution was extracted with ethyl acetate (3×15 mL) and the organic layers were combined. The organic layer was washed with brine (25 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under vacuum. The residue purified via a silica gel chromatography with ethyl acetate/petroleum ether (1:20). This resulted in 50 mg (23% yield) of 4-chloro-2-phenylbenzonitrile as a white solid.1H NMR (400 MHz, DMSO-d6, ppm): delta 8.00 (d, J = 8.4 Hz, 1H), 7.74 (d, J = 2.1 Hz, 1H), 7.68 (dd, J = 8.3, 2.2 Hz, 1H), 7.65 – 7.59 (m, 2H), 7.58- 7.48 (m, 3H), 4.04 (dd, J = 1.9, 1.0 Hz,1H).

According to the analysis of related databases, 57381-49-4, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 96606-37-0, name is 2,4,6-Trifluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H2F3N

In one embodiment,The 6 mmol of the second reactant was dissolved in 15 ml to 25 ml of the first solvent tetrahydrofuran, and then 0.5 mmol to 2 mmol of the first additive sodium hydride was slowly added.The reaction is carried out for 20-50 minutes under room temperature conditions and under nitrogen.Then add 2 mmol of the first reactant and continue the reaction for 12 hoursTo obtain a mixture including the electroluminescent material.The mixture of the electroluminescent material is cooled to room temperature and poured into distilled water.Extraction with a first extraction solvent, and then washing with a first detergent,Drying with a first desiccant, and then performing chromatography,Obtain the first crude product, and then use the first eluent to obtain the electroluminescent material, and the electroluminescent material is a white solid,The yield was 64%.

According to the analysis of related databases, 96606-37-0, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 628-20-6, name is 4-Chlorobutyronitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 628-20-6, category: nitriles-buliding-blocks

A solution of 4-chlorobutyronitrile (2.5 mmol) in dimethylformamide (1 mL) was added during 1.5h to a mixture of the arylamine (2.5 mmol), Cs2CO3 (2.5 mmol) and KI (5 mmol) in dimethylformamide (4 mL). The mixture was stirred at the indicated temperature and time. After completion of the reaction, as indicated by TLC, the mixture was treated with ethyl ether (50 mL) and water (10 mL). The aqueous phase was separated and extracted with ethyl ether (30 mL). The combined organic layers were dried over anhydrous sodium sulphate and filtered. The solvent was evaporated in vacuo. The crude product was purified by column chromatography (Silica gel, hexane:DCM).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 1020252-22-5, name is 2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1020252-22-5, Formula: C14H12N2O4

c) 4-OXO-L, 4-DIHYDROQUI2OLINE-8-CARBONITRILE 2-{[(2,2-Dimethyl-4,6-dioxo-1, 3-dioxan-5-ylidene) methyl] amino} benzonitrile (4 g) was added portionwise to REFLUXING DIPHENYLETHER (40 mL). The reaction was refluxed for a further 5 min and then cooled to room temperature. The reaction mixture was poured into isohexane (100 mL) with vigorous stirring. The resulting yellow supernatant and the isohexane layer were decanted from the brown oily residue which was allowed to solidify at room temperature to afford the titled compound (2.1 g). 1H NMR (400 MHz, d6-DMSO) 8 11.79 (1H, s), 8.39 (1H, d), 8. 22 (1H, d), 7.86 (1H, t), 7.46 (1H, t), 6.18 (1 H, d).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile, other downstream synthetic routes, hurry up and to see.

76469-88-0, name is Methyl 4-(cyanomethyl)benzoate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Methyl 4-(cyanomethyl)benzoate

j00372j To a solution of product from Step 2 (200 mg, 0.695 mmol) in methanol (30 mL) were added methyl 4-(cyanomethyl)benzoate (0.83 4 mmol) and NaOH (1.39 mmol). The resulting mixture was stirred at 50C for 4h. After the reaction mixture was cooled, it was diluted with THF (20 mL) then stirred at room temperature for 10 minutes. The solids were isolated by filtration to provide the title compound (202 mg, 65%) as a yellow solid. LCMS [M+H]: 444.9.

The synthetic route of 76469-88-0 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 5414-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5414-21-1, name is 5-Bromovaleronitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 5-bromovaleronitrile (5.12 g, 30.0 mmol) in DMF (40 mL) was added potassium phthalimide (6.00 g, 32.4 mmol). The above suspension was heated at 60 oC for 16 h, concentrated, and partitioned between H20 and DCM. The DCM layer was separated, washed with HA0 (3x) and brine, dried over NA2S04, and concentrated to give the title compound (6.84 g, quantitative yield) as a white solid. 1H NMR (CDC13) : delta 7.87-7. 80 (m, 2H), 7.76-7. 70 (m, 2H), 3.73 (t, 2H, J= 6. 1HZ), 2.43 (t, 2H, J= 7.1 Hz), 1.89-1. 82 (m, 2H), 1.74-1. 67 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromovaleronitrile, other downstream synthetic routes, hurry up and to see.

Reference of 58633-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58633-04-8 name is 4-Amino-3,5-dibromobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of 4-amino-3,5-dibromobenzonitrile (11 g, 40 mmol) in toluene (80 ml) was added thiophosgene (5.06 g, 44 mmol, 1.1 eq.). The reaction mixture was stirred under reflux for 16 h. After cooling to RT, the volatile material was removed in-vacuo, residue was suspended in dioxane (80 mL) and treated with ammonium (27 w/w %, 9.85 g) with stirring at room temperature After for 30 min., dioxane was removed in-vacuo. The solid obtained was washed with ether (50 mL), water (50 mL) and ether (50 mL), dried in vacuo to provide 9.6 g (70% yield) of the title compound (2). 1H-NMR-(400 MHz, CDCl3)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-3,5-dibromobenzonitrile, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 3598-14-9, name is Phenoxyacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3598-14-9, name: Phenoxyacetonitrile

A mixture of 1 g of phenoxyacetonitrile, 2.4 g of K2CO3 and 1.2 g of hydroxylamine hydrochloride in 60 ml of EtOH and 10 ml of water is heated at reflux for 3 hours. The reaction mixture is concentrated under vacuum and the residue is taken up in water and extracted with AcOEt. The organic phase is extracted with 1N HCl solution, the aqueous phase is alkalified by adding 1N NaOH solution, extracted with AcOEt and dried over MgSO4, and the solvent is evaporated under vacuum. This gives 0.9 g of the expected compound in the form of a colourless oil which crystallizes. 1H NMR: CDCl3 (300 MHz): delta (ppm): 4.56: s: 2H; 4.90: s: 2H; 6.95-7.02: m: 3H; 7.26-7.32: m: 2H.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Phenoxyacetonitrile, other downstream synthetic routes, hurry up and to see.