Category: nitriles-buliding-blocks

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51762-67-5, name is 3-Nitrophthalonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Nitrophthalonitrile

2-(3,4-Dimethoxyphenyl)ethanol (2.10?g, 11.56?mmol) was stirred in dry DMSO in the presence of finely ground anhydrous K2CO3 (?2.00?g, excess). After stirring for 30?min under an N2 atmosphere, 3-nitrophthalonitrile (2.00?g, 11.56?mmol) was added to this mixture dropwise. The reaction mixture was monitored by TLC (CHCl3) for 3?days at ca. 50?C. The mixture was then cooled to ambient temperature and poured into ca. 250?mL ice-water. After completion of the precipitation, the solid product was filtered and purified by column chromatography using a mixture of CHCl3:MeOH (2:1 v/v) as the eluent. The obtained products are excellently soluble in CHCl3, THF, DMF and DMSO. Yield of 2: 0.69?g (78%), m.p.: 138?C. Anal. Calc. for C18H16N2O3 (308.33?g/mol): C, 70.12; H, 5.23; N, 9.09. Found: C, 70.09; H, 5.20; N, 9.05%. FT-IR (thin film) nu/cm-1: 3094, 2968, 2832, 2241, 1608, 1582, 1530, 1464, 1405, 1378, 1269, 1159, 1033, 960, 813, 459. 1H NMR ([d6]-DMSO) delta, ppm: 8.10, 7.80, 7.62, 6.85, 6.80, 6.65, 4.40, 3.80, 3.00. 13C NMR ([d6]-DMSO) delta, ppm: 161.5, 149.1, 148.1, 137.1, 130.7, 121.3, 119.1, 116.4, 116.0, 113.6, 113.4, 112.4, 71.1, 63.1, 56.1, 55.9, 34.8.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 134450-56-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 134450-56-9 as follows.

Under nitrogen atmosphere, 16.2 g of the intermediate (D), 4.92 g of 4.5-difluorophthalonitrile, 9.12 g ofpotassium carbonate, 120 mL of N-methyl-2-pyrrolidinone were put into a flask and stirred at the room temperature for 10 hours. Water was added to the reaction solution. The obtained solution was filtered to obtain a deposited solid. The obtained deposited solid was washed with toluene, whereby 3.25 g (yield 17%) of a yellow solid of the compound 4 was obtained.

According to the analysis of related databases, 134450-56-9, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19619-22-8, name is 4-Aminoisophthalonitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H5N3

4-amino-3-[5-(4-methylpiperazinyl)benzimidazol-2-yl]-2-oxohydroquinoline-6-carbonitrile 4-Amino-isophthalonitrile and ethyl 2-[5-(4-methylpiperazinyl) benzimidazol-2-yl]acetate were reacted according to Example 46. LC/MS m/z 400.1 (MH+), Rt 1.54 minutes.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 124289-21-0,Some common heterocyclic compound, 124289-21-0, name is 3-Bromo-5-methylbenzonitrile, molecular formula is C8H6BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 1 -(4-(3,4-dichlorophenyl)-5-(isopropylthio)thiazol-2-yl)-5- (methoxycarbonyl)-3-methyl-1H-pyrazol-4-ylboronic acid (50 mg, 0.10 mmol), , 3-bromo-5- methylbenzonitrile (24 mg, 0.12 mmol), Pd(PPh3)4 (12 mg, 0.10 mmol), Na2003 (54 mg, 0.51 mmol) in degassed 1,4-dioxane and H20 (4:1, 2.1 mL) was heated at 85 C for 18 hours. Water (5 mL) was added and the mixture was extracted with EtOAc (3x5mL). The combined organic layers were dried with sodium sulfate, filtered and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel using a solution of ethyl acetate in hexanes (2 to 5%) and afforded the title compound (22 mg, 0.039 mmol, 38%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-5-methylbenzonitrile, its application will become more common.

6587-24-2, name is Methyl 2-cyanobenzoate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of Methyl 2-cyanobenzoate

From methyl 2-cyanobenzoate (1). To a freshly prepared solution of sodium methoxide obtained by dissolving sodium metal (0.69 g, 30 mmol) in dry MeOH (25 mL), methyl 2-cyanobenzoate (1) (1.61 g, 10 mmol) and malononitrile (1.98 g, 30 mmol) were added with stirring. The obtained yellow-orange solution was refluxed for 8 h till the TLC showed the absence of starting ester 1. Then the resulting suspension was cooled, fine pale yellow precipitate of compound 10a was filtered off, washed with MeOH (10 mL) and dried in air. Pale yellow powder. Yield: 2.00 g (68 %); mp 262-263 C.

The synthetic route of 6587-24-2 has been constantly updated, and we look forward to future research findings.

Related Products of 766-84-7,Some common heterocyclic compound, 766-84-7, name is 3-Chlorobenzonitrile, molecular formula is C7H4ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 0.01 mol of nitrile in 200 mL of ethanol was added a solution of 0.695 g (0.01 mol) of hydroxylamine hydrochloride in 10 mL of water, followed by the further addition of 0.420 g (0.005 mol) of sodium carbonate in 10 mL of water. The reaction mixture was stirred overnight at rt. The mixture was then concentrated to small volume under vacuum, diluted with cold water, and placed in refrigerator overnight. The precipitate that formed was recovered and recrystallized from ethanol. All amidoximes were known and characterized by comparison of their physical data with those prepared in accordance with literature procedures.1

The synthetic route of 766-84-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 2469-99-0,Some common heterocyclic compound, 2469-99-0, name is 3-Oxobutanenitrile, molecular formula is C4H5NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirring suspension of quinolin-5-yl-hydrazine (0.25 g, 1.6 mmol) in 3:1 ethanol/deionized water (2.5 mL) was added 3-oxo-butyronitrile (0.13 g, 1.6 mmol). The reaction mixture was then heated at 60 C. for 2 h. After cooling to room temperature, the reaction mixture was concentrated in vacuo and the resulting crude product was used directly without further purification (0.21 g, 1.5 mmol, 94%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Oxobutanenitrile, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Chloro-2-fluorobenzonitrile

Cyclopentylamine and potassium carbonate were added to a DMF solution of 4-chloro-2-fluorobenzonitrile, followed by stirring at 100C for 12 hours. By post-treating the reaction liquid, 4-chloro-2-(cyclopentylamino)benzonitrile was obtained.

According to the analysis of related databases, 57381-51-8, the application of this compound in the production field has become more and more popular.

Synthetic Route of 3939-09-1, These common heterocyclic compound, 3939-09-1, name is 2,4-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A – Synthesis of Intermediate Compound Int-2a To a solution of NaH (1.2 g, 30 mmol) in toluene (50 mL) was added but-3-en-l- ol (1.8 g, 25 mmol) dropwise and the mixture was allowed to stir at room temperature for 30 minutes. 2,4-Difluorobenzonitrile (4.2 g, 30 mmol) was then added in one portion and the mixture was allowed to stir at room temperature for 6 hours. Water (30 mL) was slowly added and the mixture was extracted with EtOAc and washed with brine. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo. The crude residue was purified using flash column chromatograpy on silica gel (20: 1 PE:EtOAc) to provide compound Int-2b (4.2 g, 78%) as a yellow oil. 1H MR (400 MHz, CDC13) delta 7.51-7.53 (m, 1H), 7.20-7.25 (m, 1H), 6.79- 6.81 (m, 1H), 5.85-5.89 (m, 1H), 5.05-5.11 (m, 2H), 4.05-4.11 (m, 2H), 2.47-2.51 (m, 2H).

Statistics shows that 2,4-Difluorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 3939-09-1.

Application of 22364-68-7, These common heterocyclic compound, 22364-68-7, name is 2-(o-Tolyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The general procedure of the CuI catalyst based synthesis method of carbazole derivatives 3 to 8 was as follows: 50 mL two-necked round flasks dried in an oven were charged with nitrosinenamaldehyde (0.5 mmol) or nitrochalcone (0.5 mmol). ,1.0 mmol of benzyl cyanide and 5 mol% CuIdissolved with Cs2CO3(1 equiv)dissolved in 5 mL THFwere added.Each reaction mixture was then refluxed for 6-10 hours until the reaction shown by TLC at open air conditions was complete.The solvent was then removed using a rotary evaporator under reduced pressure to give a residue.The residue was purified by flash column chromatography using silica gel to separate the pure product.

The synthetic route of 22364-68-7 has been constantly updated, and we look forward to future research findings.