Category: nitriles-buliding-blocks

Electric Literature of 52133-67-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52133-67-2, name is Ethyl 2-cyano-4,4-diethoxybutyrate, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of the intermediate from Step A (1.01 g, 5.29 mmol) and NaOEt (0.72 g, 10.6 mmol) in EtOH (20 mL) was stirred at RT for 20 min. A solution of ethyl 2-cyano-4,4-diethoxybutanoate (1.34 g, 5.82 mmol) in 20 mL of EtOH was added and the resulting mixture was refluxed for 18 h. The reaction mixture was cooled to RT, concentrated in vacuo and the residue was diluted with EtOAc. The solution was then washed with water, dried over MgS04, filtered, and concentrated in vacuo. The crude product was purified by silica gel chromatography using a 0percent to 15percent MeOH (with 2M NH3) in DCM gradient to give the title compound.

The chemical industry reduces the impact on the environment during synthesis Ethyl 2-cyano-4,4-diethoxybutyrate. I believe this compound will play a more active role in future production and life.

Related Products of 1953-99-7,Some common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Five grams of 3,4,5,6-tetrachlorophthalonitrile, 3.06 grams of 2,6-dichlorophenol, 3.9 grams of K2CO3, and 25 milliliters of acetone were placed in a 100-milliliter flask and then Stir while heating at 70 °C. When the reaction was completed, the resultant was filtered and washed with acetone, and the resulting liquid was distilled to obtain a solid. Here, the obtained solid was dissolved in a small amount of dichloromethane and then washed with hexane several times, filtered and dried under vacuum to obtain 3,4,6-dichloro-5- (2,6-bis Chloro-phenoxy) -phthalonitrile.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its application will become more common.

Electric Literature of 50670-64-9,Some common heterocyclic compound, 50670-64-9, name is 5-Amino-2-methylbenzonitrile, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of 3-((4-(1,8-naphthyridin-2-yl)phenoxy)methyl)benzoic acid (8) (100 mg, 0.28 mmol)in dimethyl formamide (2 mL), tetrahydrofuran (2 mL)was added corresponding anilines R-NH2 (9a-9k) (0.42mmol), 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (0.42 mmol) and 4-dimethylaminopyridine(0.02 mmol) at room temperature and stirred at room temperature for 16 h. The reaction mixture was poured into ice water (4 mL) and extracted with ethyl acetate (3× 5 mL). The combined organic layers were washed with water (5 mL) followed by brine solution (5 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure, crude material was washed with 50% of dichloromethane in pet ether to afford the pure compounds(10a-10k). Yields of the products varied between 40 and 75%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-2-methylbenzonitrile, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1194-65-6, name is 2,6-Dichlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: nitriles-buliding-blocks

In a 500 ml reaction flask, 51.6 g (0.3 mol) of 2,6-dichlorobenzonitrile, 41.6 g of water, and 0.6 g of a 30% sodium hydroxide solution were added.The temperature was raised to 35 C, and 55.65 g (0.45 mol) of 27.5% hydrogen peroxide was added dropwise.After 5 hours, the addition is completed.After the completion of the dropwise addition, the sample was controlled, and 2,6-dichlorobenzonitrile was ?0.5% qualified. Filtered, the filter cake was rinsed with 83.2 g of water.The wet product is dried to obtain 2,6-dichlorobenzamide 55g.The purity was >99.0%, and the yield was 97%.

The synthetic route of 1194-65-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 218632-01-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 218632-01-0, name is 3-Fluoro-4-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 3-fluoro-4-nitrobenzonitrile (200 mg, 1.2 mmol) in THF (2 mL) under an inert atmosphere was added 2,2,2-trifluoroethan-1-amine (0.11 mL, 1.44 mmol) and diisopropylethylamine (0.45 mL, 2.4 mmol) at room temperature. The reaction mixture was stirred at 100 C. for 16 h. After consumption of starting material (by TLC), the reaction mixture was diluted with water (20 mL) and extracted with EtOAc (2*20 mL). The combined organic extracts were washed with water (20 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude material was purified by silica gel column chromatography (eluent: 15-20% EtOAc/hexane) to afford 4-nitro-3-((2,2,2-trifluoroethyl amino)benzonitrile (260 mg, 1.09 mmol, 88%) as yellow solid. 1H NMR (400 MHz, DMSO-d6): delta 8.35-8.27 (m, 1H), 8.22 (d, J=8.7 Hz, 1H), 7.91 (s, 1H), 7.19 (dd, J=8.7, 1.5 Hz, 1H), 4.46-4.33 (m, 2H)

The synthetic route of 3-Fluoro-4-nitrobenzonitrile has been constantly updated, and we look forward to future research findings.

Related Products of 127946-77-4, The chemical industry reduces the impact on the environment during synthesis 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, I believe this compound will play a more active role in future production and life.

E. Synthesis of the Intermediate Amide 6H The carboxylic acid 5A (195 mg, 0.5 mmol), 1-aminocyclopropanecarbonitrile hydrochloride (65.2 mg, 550 mumol), HATU (380 mg, 1.00 mmol) and ethyldiisopropyl amine (262 muL, 1.5 mmol) were dissolved in acetonitrile (10 mL) and stirred at room temperature over night. The reaction was concentrated under reduced pressure. The residue was diluted with 5% aqueous sodium carbonate solution and extracted twice with ethyl acetate. The combined organic layers were washed with 1M aqueous hydrogen chloride solution and with saturated aqueous sodium chloride solution, dried over Na2SO4, filtered and concentrated under reduced pressure to yield (2S,4R)-tert-butyl 4-(2-chlorophenylsulfonyl)-2-(1-cyanocyclopropylcarbamoyl)-pyrrolidine-1-carboxylate 6H as a yellow oil (66%). MS ISP (m/e): 354.2 (100) [(M-BOC+H)]+, 398.1 (25) [(M-Isobutylene+H)]+, 454.1 (12) [(M+H)]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, other downstream synthetic routes, hurry up and to see.

Application of 50846-36-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50846-36-1, name is 2-Amino-2-methylpropanenitrile hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred mixture of 3-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(2,2,2- trifluoroethoxy) benzofuran-5-yl)benzoic acid (40 mg, 0.082 mmol) and 2-amino-2- methylpropanenitrile hydrochloride (9.90 mg, 0.082 mmol) in DMF (2.5 mL) at room temperature under a N2 atmosphere was added DIPEA (0.072 mL, 0.410 mmol). The mixture was cooled to 0C, and HATU (46.8 mg, 0.123 mmol) was added to the mixture, and then stirring was continued at r.t for 16 hr. After completion of the reaction, the mixture was diluted with water and the product extracted with EtOAc (25 ml x 3). The combined organic layers were washed with saturated brine solution, dried over Na2S04, filtered and concentrated under reduced pressure. The crude solid product was purified by Prep HPLC to obtained 5-(3-((2-cyanopropan-2- yl)carbamoyl)phenyl)-2-(4-fluorophenyl)-N-methyl-6-(2,2,2- trifluoroethoxy )benzofuran-3-carboxamide as a white solid. Yield: 12.00 mg, (26.40 %). PREPARATIVE HPLC: Column: X-BRIDGE C-18(19* 150)mm*5u, Mobile Phase: lOmM Ammonium acetate (A): MeCN (B), Flow: 15 ml/min, Rt: 10.38 min. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm = 7.93 – 7.84 (m, 4 H), 7.82 (s, 1 H), 7.72 – 7.69 (m, 1 H), 7.56 – 7.51 (m, 1 H), 7.20 (t, J= 8.7 Hz, 2 H), 7.14 (s, 1 H), 6.22 (s, 1 H), 5.84 (bs, 1H), 4.36 (q, J= 8.1 Hz, 2 H), 3.01 (d, J= 4.9 Hz, 3 H), 1.84 (s, 6 H). 19F NMR (376.6 MHz, CHLOROFORM-d) delta: -73.38, -109.44. LCMS: (ES+) m/z = 554.2 (M+H)+, Column-Acentis Express C18 (50 x 2.1 mm; 2.7 urn), Buffer : lOmM Ammonium Formate in Water pH 4.5, Mobile phase A: Buffer : MeCN (98 : 2), Mobile phase B: Buffer : MeCN (2 : 98), Flow: l .Oml/min. Rt: 2.18 min, wavelength: 220nm. HPLC Method: SUNFIRE (150 X 4.6mm) 3.5micron, Buffer: 0.05% TFA in water, Mobile Phase A: Buffer: MeCN (95:5), Mobile Phase B: MeCN: Buffer (95:5), Flow: 1.0 ml/min, Wavelength: 254 nm, Rt: 19.37 min, Wavelength: 220 nm, Rt: 19.37 min. HPLC Method: XBridge Phenyl (150 X 4.6mm) 3.5micron SC/749, Buffer: 0.05% TFA in water, Mobile Phase A: Buffer: MeCN (95:5), Mobile Phase B: Buffer: MeCN (5:95), Flow: 1.0 ml/min, Wavelength: 254 nm, Rt: 17.00 min, Wavelength: 220 nm, Rt: 17.00 min.

The chemical industry reduces the impact on the environment during synthesis 2-Amino-2-methylpropanenitrile hydrochloride. I believe this compound will play a more active role in future production and life.

151-18-8, name is 3-Aminopropanenitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 3-Aminopropanenitrile

To a suspension of (S)-3-((tert-butoxycarbonyl)amino)-5-methyl-4-oxo-2,3,4,5- tetra-hydrobenzo[b][l,4]oxazepine-7-carboxylic acid (185.0 mg, 0.550 mmol) in DCM (5.0 mL) was added l-chloro-N,N,2-trimethylprop-l -en- 1 -amine (88 mg, 0.660 mmol) as a solution in DCM (0.10 ml) dropwise over 1 min. The reaction mixture was stirred at rt for lh and became a homogeneous solution. The reaction mixture was cooled in an ice-bath then 3-aminopropanenitrile (154 mg, 2.200 mmol) was added dropwise as a solution in DCM (0.25 mL). After 10 min, the ice-bath was removed then 10 % aq citric acid solution was added and the mixture was stirred vigorously for 15 min . The organic phase was separated, washed with sat. aq sodium bicarbonate, brine then dried over Na2S04and concentrated in vacuo. The residue was purified by FCC [EtO Ac-Hex: 45-80%] to yield the desired product (190.0 mg, 89%).MS (m/z) 389.3 (M+H+).

The synthetic route of 151-18-8 has been constantly updated, and we look forward to future research findings.

Related Products of 77326-36-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77326-36-4, name is 2-Amino-6-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-ethylbutan-l-ol (1.02 g, 10.0 mmol) in dry THF (60 mL) was carefully added NaH (60% in mineral oil, 480 mg, 12.0 mmol) in small portions at 0 C under nitrogen. The reaction mixture was stirred at 0 C under nitrogen for 2 hrs. To this solution was added 2- amino-6-fluorobenzonitrile (1.36 g, 10.0 mmol), and the reaction solution was stirred at 0 C – RT for 2 hrs, and then at 65 C overnight under nitrogen. The reaction was cooled down to room temperature then quenched with brine, and extracted with EtOAc (3X). The combined organic layers were washed with brine, dried over Na2S04. Filtered and evaporated under reduced pressure. The residue was purified by chromatography on silica gel (eluent: 20% EtOAc in hexanes) to give the title compound as colorless oil (1.29 g, 59%). 1H NMR (400 MHz, CDC13) delta 0.93 (t, J= 8 Hz, 6H), 1.55-1.43 (m, 4H), 1.73- 1.65 (m, 1H), 3.90 (d, J= 4 Hz, 2H), 4.10 (brs, 2H), 6.25 (d, J = 8 Hz, 1H), 6.34 (d, J = 8 Hz, 1H), 7.20 (t, J = 8 Hz, 1H).

The chemical industry reduces the impact on the environment during synthesis 2-Amino-6-fluorobenzonitrile. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 621-50-1, name is 2-(3-Nitrophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-(3-Nitrophenyl)acetonitrile

Example 5 Preparation of N-[3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-phenyl]-methanesulfonamide hydrochloride STR112 1-Chloromethyl-3-nitro-benzene (5 g) and 4.28 g of sodium cyanide were dissolved in a mixture of 15 ml of water and 50 ml of dioxane and the two phase mixture was heated to 100 C. for 12 hr. The dioxane was removed by evaporation and the aqueous solution was extracted with dichloromethane. The organic extract was washed with brine, dried, and evaporated. The residue was purified by flash column chromatography eluding with EtOAc:hexane (1:4) to afford 2.86 g of a tan solid, mp 51.7-52.7 C., of (3-nitro-phenyl)-acetonitrile. STR113 (3-Nitro-phenyl)-acetonitrile (2.79 g) was dissolved in 50 ml of ethyl acetate and the mixture was treated with 19.5 g of tin (II) chloride dihydrate and stirred at room temperature for 72 hr. The mixture was diluted with ethyl acetate and treated with saturated sodium bicarbonate solution, separated, and extracted with ethyl acetate. The extracts were combined, dried, and evaporated, leaving 2.1 g of tan oil of (3-amino-phenyl)-acetonitrile. STR114

According to the analysis of related databases, 621-50-1, the application of this compound in the production field has become more and more popular.