Category: nitriles-buliding-blocks

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 868-54-2

A 10% aqueous solution of KOH (5.60 ml, 10 mmol) andbenzyl chloride (1.15 ml, 10 mmol) were added consecutivelyto a stirred solution of of malononitrile dimer 1 (1.32 g,10 mmol) in DMF (20 ml). The mixture was stirred for 4 hat 20C and diluted with an equal volume of H2O. Theformed precipitate was filtered off, washed with H2O,EtOH, and hexane. Yield 1.80g (81%), colorless crystals,mp 140-142 (Et). IR spectrum, , cm-1: 3397-3295(N), 2219 (C?N). 1H NMR spectrum, delta, ppm (J, Hz):3.21 (1, dd, J = 7.8, J = 13.4) and 3.33 (1, dd, J = 8.6,J = 13.4, 2Ph); 4.18 (1, t, J = 8.0, CHCN); 7.27-7.36(5, m, H Ph); 8.80 (1, br. s) and 9.03 (1, br. s, NH2).Mass spectrum, m/z (Irel, %): 221 [M-]+ (100). Found, %:C 70.33; H 4.58; N 25.09. C13H10N4. Calculated, %:C 70.26; H 4.54; N 25.21.

The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Quality Control of 4-Fluoro-3-nitrobenzonitrile

Potassium hexamethyldisilazane [0.5 M in toluene] (12.04 mL, 24.08 mmol) was added to a solution of isopropanol (0.921 mL, 12.04 mmol) in tetrahydrofuran (20 mL) at 0° C. and stirred for 10 minutes. The resulting solution was added dropwise to a solution of commercially available 4-fluoro-3-nitrobenzonitrile at room temperature and stirred for several hours. Water was added and the product was extracted with ethyl acetate, dried with sodium sulfate and evaporated in vacuo to give the title compound

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 2920-38-9,Some common heterocyclic compound, 2920-38-9, name is [1,1′-Biphenyl]-4-carbonitrile, molecular formula is C13H9N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the reaction vessel was added 30mol% CuCl, the reaction tube was evacuated, filled with oxygen,In an oxygen atmosphere, 0.2 mmol of p-phenylbenzonitrile, 0.6 mmol of ammonium chloride, 1 ml of acetonitrile and 1 ml of N, N-dimethylformamide were added, the reaction vessel was sealed, and reacted at 25 C,After the reaction is completed, it is washed with water, extracted with ethyl acetate, dried and concentrated by evaporation under reduced pressure to remove the solvent. The crude product is separated by column chromatography to obtain the desired product in a yield of 70%.

The synthetic route of 2920-38-9 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1023971-89-2, name is 2-Bromo-6-fluoro-4-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1023971-89-2

Example 150A 4-Bromo-6-methyl-1H-indazol-3-amine 2-Bromo-6-fluoro-4-methylbenzonitrile (4.26 g, 19.9 mmol) was dissolved in ethanol (100 mL) and treated with hydrazine hydrate (3.99 g, 79.6 mmol). After stirring at reflux for 4 h, the mixture was cooled to RT and concentrated in vacuo. The residue was dissolved in a mixture of water and ethyl acetate. The aqueous layer was extracted once more with ethyl acetate. The combined organic layers were washed with water and with brine, dried over magnesium sulfate, concentrated in vacuo and dried to yield the title compound (4.40 g, 41% of theory) in a purity of 42%. LC-MS (Method 1B): Rt=0.72 min, MS (ESIPos): m/z=226 [M+H]+

According to the analysis of related databases, 1023971-89-2, the application of this compound in the production field has become more and more popular.

Application of 151-18-8, A common heterocyclic compound, 151-18-8, name is 3-Aminopropanenitrile, molecular formula is C3H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 7; N-Cbz-3-aminopropionitriIe (18).; 3-Aminopropionitrile 17 (0.56 g, 8.0 mmol) was suspended in water (10 mL) and THF (10 mL). The pH was adjusted to 9.0 by addition of NaOH (0.2 g, 5 mmol). Benzyl chloroformate (1.7 g, 10 mmol) was added dropwise over 2 h at 20-25 0C to the resulting clear solution, and the pH EPO was kept constant at 9.0 by addition of aqueous NaOH (4 M, 2.5 mL). The mixture was stirred for 1 h at pH 9.0, extracted with ethyl acetate, and dried with Na2SO4. The solvents were removed by rotary evaporation to give crude 18 (1.6 g, 98%) as an oil. 1H NMR (400 MHz, OMSO-d6) delta.3 (s, 5H), 5.0 (s, 2H), 3.22 ~ 3.27 (m, 2H), 2.6 (t, 2H5 J= 6.4 Hz).

The synthetic route of 151-18-8 has been constantly updated, and we look forward to future research findings.

Electric Literature of 118431-88-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Hydrazine hydrochloride 14a or b was refluxed with nitrile 12a,b or c in EtOH overnight. The reaction solution was evaporated in vacuo to furnish the corresponding pyrazolo amine, which was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyclopropyl-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Electric Literature of 6609-57-0,Some common heterocyclic compound, 6609-57-0, name is 2-Ethoxybenzonitrile, molecular formula is C9H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Trifluoroacetic acid (4 mL) was added to a mixture of nitrile(1.0 mmol) and thiosemicarbazide (1.1 mmol). The reaction mixturewas stirred and refluxed for 6 h. Then, it was cooled to roomtemperature and aqueous ammonia was added. The precipitatedsolidwas filtered,washed with hot water and air-dried. It should benoted that the compounds f1-f35 were directly used for the nextreaction without further purification.

The synthetic route of 6609-57-0 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 135748-35-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 135748-35-5, name is 4-Chloro-2,5-difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

a [3-(5-Chloro-2-cyano-4-fluorophenoxy)hexyl]methylcarbamic Acid, 1,1-dimethylethyl Ester The subtitle compound was prepared according to the method of Example 3 step (b) using (3-hydroxyhexyl)methylcarbamic acid, 1,1-dimethylethyl ester and 4-chloro-2,5-difluorobenzonitrile in N,N-dimethylformamide. 1H NMR 300 MHz (CDCl3) 7.33 (1H, d), 6.99 (1H, bs), 4.33 (1H, m), 3.34 (2H, m), 2.85 (3H, s), 1.95 (2H, m), 1.70 (2H, m), 1.41 (11H, m), 0.95 (3H, t).

The synthetic route of 4-Chloro-2,5-difluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Application of 214623-57-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Sodium nitrite (l.llg, 16.17 mmol) in water (5 ml) was added with stirring over 15 min to a cold (0 C) solution of A (2.18 g,14.7 mmol) in concentrated hydrochloric acid (7 ml) and ice (10 g). The mixture was stirred at 0 C for a further 20 min. and the cold solution was added over 30 min to a stirred solution (room temperature) of potassium iodide (12.2 g, 73 mmol) in water (15 ml). The mixture was left standing at room temperature overnight and extracted with dichlormethane (2×50 ml). The combined organic extracts were washed successively with 10% NaOH, water, and dried (Na2S04). Evaporation of the solvent and silica gel column chromatography of the residue (Hexanes/EtOAc) gave iodide B (3.46 g, 80%).

The chemical industry reduces the impact on the environment during synthesis 5-Amino-2-methoxybenzonitrile. I believe this compound will play a more active role in future production and life.

Some common heterocyclic compound, 16932-49-3, name is 2,6-Dimethoxybenzonitrile, molecular formula is C9H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C9H9NO2

EXAMPLE 69: Preparation of N-[2-Hydroxy-3-(2-cyano-3-methoxyphenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl) ethylamine Hydrochloride, Compound 118 STR69 Powdered sodium cyanide (9.0 g, 184 mmol) and 2,6-dimethoxybenzonitrile were added to 50 mL of dimethylsulfoxide and heated to 145 C. for 110 min under nitrogen. The reaction was cooled and poured into ether and dilute HCl. The ether layer was separated, washed twice with dilute acid, once with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The yield of 2-cyano-3-methoxyphenol was 8.1 g.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16932-49-3, its application will become more common.