Category: nitriles-buliding-blocks

Application of 34667-88-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34667-88-4, name is 2-Fluoro-4-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[00293] A solution of 2-fluoro-4-nitrobenzonitrile (0.541 g, 2.43 mmol) in methanol (20 mL) and 6N hydrochloric acid (3 mL) was hydrogenated (55 psi) over 10percent palladium on carbon (164 mg) for 22 li. The reaction mixture was filtered and concentrated in vacuo to afford 77A (0.65 g, 100percent). 1H NMR (400 MHz, CD3OD) delta 4.23 (s, 2 H), 7.29 (d, J=8.79 Hz, 2 H), 7.68 (t, J=I.91 Hz, 1 H).

The synthetic route of 2-Fluoro-4-nitrobenzonitrile has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 654-01-3, name is 2-(2,6-Difluorophenyl)acetonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(2,6-Difluorophenyl)acetonitrile

Example 13; Preparation of 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid amide. 1-(2,6-Difluorophenyl)cyclopropanecarbonitrile was prepared as described in U.S. Pat. No. 4,859,232 by alkylation of 2,6-difluorophenylacetonitrile with 1,2-dibromoethane in 50% sodium hydroxide in the presence of catalytic amounts of tetrabutylammonium bromide (quantitative yield; GC/MS: m/z 179, RT 8.24 min.; 1H-NMR (DMSO-d6): delta 7.58-7.48 (m, 1H), 7.24-7.16 (m, 2H), 1.84-1.79 (m, 2H), 1.46-1.41 (m, 2H)).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 17626-40-3, These common heterocyclic compound, 17626-40-3, name is 3,4-Diaminobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of alkyne (0.2 mmol) in DMSO (2.0 mL) was added I2 (10.1 mg, 0.04 mmol). The solution was stirred at 130 oC for 24 h in air. Then the mixture was cooled to room temperature, and o-Phenylenediamine (0.3 mmol) was added. The solution was stirred at room temperature for 1 h. After completion, the solution was diluted with ethyl acetate, washed with H2O, dried over MgSO4, and concentrated in vacuo. The residue was purified by preparative thin-layer chromatography on silica gel with PE/EtOAc (15/1) as an eluent to give quinoxaline 3.

Statistics shows that 3,4-Diaminobenzonitrile is playing an increasingly important role. we look forward to future research findings about 17626-40-3.

Adding a certain compound to certain chemical reactions, such as: 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127946-77-4, Formula: C4H7ClN2

To prepare (2S,4R)-4-[2-chloro-4-((5)-2,2,2-trifluoro-1-methyl-ethoxy)-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide, example 183c (200 mg) was dissolved in DMF (2.0 mL). HATU (420 mg), DIEA (143 mg) and 1-amino-1-cyclopropane carbonitrile hydrochloride were added to the solution. The obtained suspension was stirred at ambient temperature for 2 h. After that the solvent was evaporated under reduced pressure to dryness. The residue was dissolved in CH2Cl2 (25 ml), was extracted in succession with aqueous 0.5 NHCl-solution, aqueous 10% Na2CO3-solution and brine. The water layers were washed with totally CH2Cl2 (50 ml), the combined organic layers were dried over Na2SO4, filtered and evaporated. The residue was purified over silica gel chromatography with n-heptan: AcOEt to yield 130 mg (59%) of the title compound as colorless amorphous solid. MS (ESI): m/z=602.1 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 114772-53-1, name is 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile, A new synthetic method of this compound is introduced below., Formula: C14H11N

Example 2: Production of CBAL (1) To monochlorobenzene (450 g) was added CMB (300 g, 1.55 mol), and solution prepared by dissolving sodium bromate (50.1 g, 0.33 mol) in 95.3 g of water was added. 2,2′-azobis(2-methylbutyronitrile)(2.0 g, 0.01 mol) was dissolved in monochlorobenzene(10g), and this solution was added to the above-mentioned solution at 75 to 85C, then, immediately, solution prepared by dissolving 2,2′-azobis(2-methylbutyronitrile)(89 g, 0.05 mol) in monochlorobenzene (48.8 g), and bromine (198.5 g, 1.24 mol) were dropped simultaneously respectively at 70 to 80C. The solution of 2,2′-azobis(2-methylbutyronitrile) was dropped at a rate of about 0.22 g/min and bromine was dropped at a rate of about 0.73 g/min. The added solution was stirred for 5 hours at 70 to 75C, and the reaction solution was checked under HPLC analysis conditions (1), and that the area percentage of raw materials reached 1% or less was confirmed, obtaining a mixed solution of CMBMB and CDBMB. The solution was analyzed under the HPLC analysis conditions (1), to find an area percentage of CMBMB of 63.6%, CDBMB of 36.2% and a raw material CMB of 0.2%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19924-43-7, name is 2-(3-Methoxyphenyl)acetonitrile, A new synthetic method of this compound is introduced below., Quality Control of 2-(3-Methoxyphenyl)acetonitrile

Step 1: 2-(3-Methoxyphenyl)-2-methylpropionitrile To a solution of (3-methoxyphenyl)-acetonitrile (8.0 g, 0.054 mol) in DMF (25 ml) cooled to 0 C., NaH (1.3 g, 0.054 mol) was added. The reaction was stirred for 30 min, and MeI (3.3 mL, 0.054 mol) was added. The reaction was stirred 1 h at room temperature. After this period, the reaction mixture was cooled again to 0 C., NaH (1.3 g, 0.054 mol) was added followed by MeI (3.3 ml, 0.054 mol) after 30 minutes. The reaction was stirred at room temperature overnight. DMF was evaporated and the crude diluted with brine and extracted with Et2O. The organic phase was washed with water, dried over Na2SO4, the solvent was evaporated under reduced pressure and the residue was purified by flash chromatography (petroleum ether:AcOEt 95:5) to give the title compound (4 g, 42% yield) as a colourless oil. ESI+MS: calcd for C11H13NO: 175.23; found: 176.1 (MH+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78473-00-4, name is 4-Amino-3,5-dichlorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Amino-3,5-dichlorobenzonitrile

To a solution of 4-amino-3,5-dichlorobenzonitrile (2.00 g, 10.63 mmol) in acetonitrile (12 ml) was added dropwise tetrafluoroboric acid (2.80 ml, 21.27 mmol). After stirring for 10 min, isoamyl nitrite (1.50 ml, 10.63 mmol) was added and the reaction mixture was cooled to 0 C. After a further 10 min, diethyl ether (50 ml) was added and the resulting precipitate was collected by filtration and dried to give the titled compound (1.9 g). 1H-NMR (D2O): 8.36-8.40 (2H)

According to the analysis of related databases, 78473-00-4, the application of this compound in the production field has become more and more popular.

886498-08-4, name is 2-Fluoro-5-(trifluoromethoxy)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2-Fluoro-5-(trifluoromethoxy)benzonitrile

2-fluoro-5-(trifluoromethoxy)benzylamine-d2: To a mixture of2-fluoro-5-(trifluoromethoxy)benzonitrile (374 mg, 1.823 mmol) and sodium borodeuteride (176 mg, 4.19 mmol) in THF (10 mL) at 0 C was added over 45 mm, iodine (463 mg, 1.823 mmol) as a solution in 4 ml THF. The reaction mixture was heatedat reflux for 2 h. After cooling to 0 C, 6 N HC1 (2 ml) was carefully added. This mixture was heated at reflux for 30 mm. After cooling to rt, the mixture was partitioned between EtOAc (40 mL) and 1 N NaOH (40 mL). The organic layer was washed with water (20 mL) and brine (20 mL). After drying over anhydrous sodium sulfate, the organic layer was filtered and concentrated to afford2-fluoro-5-(trifluoromethoxy)benzylamine-d2 (385 mg, 1.823 mmol, 100 % yield)

The synthetic route of 886498-08-4 has been constantly updated, and we look forward to future research findings.

Related Products of 1187-42-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1187-42-4 name is Diaminomaleonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: AlCl3 (15 molpercent) was added to a solution of DAMN (1 mmol), ketone (1 mmol) and isocyanide (1 mmol), in 5 ml of CH3CN. The resulting mixture was stirred for an appropriate time at room temperature. After completion of the reaction, as indicated by thin-layer chromatography (TLC; ethyl acetate=n-hexane 3=1), the product was precipitated by addition of 10 ml of water. The precipitate was filtered off, washed with water, and then recrystallized from acetone. In the case of aromatic aldehyde, precipitate after filtration was loaded on column chromatography with 20percent ethyl acetate?hexane as an eluent system to furnish the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diaminomaleonitrile, and friends who are interested can also refer to it.

114897-91-5, name is 2-(4-Bromo-2-fluorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-(4-Bromo-2-fluorophenyl)acetonitrile

(4-Bromo-2-fluoro-phenyl)-acetonitrile (0.255 g, 1.19 mmol), PdCl2(dppf).CH2Cl2 (0.039 g, 0.048 mmol) and N-{2-hydroxy-2-[4(4,4,5,5-tetramethyl-[1,3,2]dioxaboralan-2-yl)phenyl]propyl}-2-propanesulfonamide (0.383 g, 1.0 mmol) are mixed together in dry DMF (30 mL) under N2 at ambient temperature. To this stirred mixture is added 2M Na2CO3 (1.25 mL, 2.5 mmol) and the resulting mixture is heated and stirred at 80 C. for 6 h. The mixture is cooled and poured into EtOAc. The EtOAc is extracted several times with H2O, washed with brine, dried (MgSO4), filtered, and the filtrate evaporated in vacuo. Chromatography on silica gel eluting with EtOAc/hexane gives the intermediate title compound.

The synthetic route of 114897-91-5 has been constantly updated, and we look forward to future research findings.