Category: nitriles-buliding-blocks

21524-39-0, name is 2,3-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks

To a solution of 51-(pynOlidm-1-ylsulfonyl)spirofl ,3-dioxane-2,3′-indol]-2′(r//)-one (400 mg, 1.2 mmol) in DMF (12 mL) was added 60% NaH (60 mg, 1 5 mmol). After stir?ng for 10 minutes at room temperature, a 3.0 mL aliquot of this solution (0.3 mmol) was added to 2,3-difluorobenzonit?le (83 mg, 0.6 mmol) in DMF (2 mL), The resulting solution was stirred at 60 C for 12 hours. The reepsilonction was diluted with EtOAc, washed with H;O and brme, then dried (MgSO4), filtered, and concentrated. The crude residue was purified by flash chromatography on silica gel (30 1 CH2CI1/ EtOAc) to provide 87 mg (630O) of the title compound as a white solid. 1H NMR (400 MHz, CDCl3) consistent, MS (ES) m,z 458.1 (M-H)

The synthetic route of 21524-39-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 60710-80-7, name is 3-Amino-4-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60710-80-7, category: nitriles-buliding-blocks

To a solution of 2-chloro-4-phenylquinazoline (9.6 g, 40 mmol) in 2-propanol (130 mL) was added 4-aminobenzoic acid (8.2 g, 60 mmol) and the mixture was stirred at reflux for 4 h. The mixture was cooled to it and the precipitate was collected by filtration and washed with 2-propanol. The product, 4-(4-phenylquinazolin-2-ylamino)benzoic acid, was isolated as a yellow solid (12.9 g, 95 %).[00337] To a stirred mixture of 4-(4-phenylquinazolin-2-ylamino)benzoic acid (1.37 g, 4.02 mmol), 3-amino-4-methylbenzonitrile (529 mg, 4.01 mmol), and Hunig’s base (2.1 mL, 12 mmol) in dimethyl formamide (10 mL) was added HATU (3.04 g, 8.00 mmol). Thestirred mixture was heated to 80 0C overnight, then cooled to rt. The reaction was diluted with ethyl acetate and extracted with water. The organic layer was washed with saturated sodium bicarbonate and concentrated on a rotary evaporator. The residue was sonicated with acetonitrile and filtered to give a light yellow solid, which was again washed with water, acetonitrile, and dried under reduced pressure to give jV-(5-cyano-2-methylphenyl)-4-[(4- phenylquinazolin-2-yl)amino]benzamide (1.18 g, 65%) as a light yellow solid. 1H NMR (400 MHz, DMSOd6): delta 10.36 (s, IH), 9.87 (s, IH), 8.19 (d, 2H), 8.00 (d, 2H), 7.91-7.78 (m, 6H), 7.66-7.62 (m, 4H), 7.51 (d, IH), 7.42 (ddd, IH), 2.36 (s, 3H). MS (EI) for C29H21N5O: 456.1 (MH+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-4-methylbenzonitrile, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33279-01-5, name is 3-Oxopentanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-Oxopentanenitrile

A solution of 3-oxo-pentanenitrile (1.582 g, 16.49mmol), ethylene glycol (1.026 ml, 84. 59 mmol) and a catalytic amount of p-Toluene sulphonic acid (8 mg) in Toluene (10 ml) is refluxed at 150OC for 2 days using Dean-Stark apparatus. The reaction mixture is diluted with ethyl acetate and washed with saturated sodium bicarbonate solution. The organic phase is dried over MGS04, filtered, and the solvent evaporated to yield (2-ETHYL- [1, 3] dioxolan-2-yl)- acetonitrile. 1H NMR (400MHZ, CDC13) d 4.15 (2H, m), 4.05 (2H, m), 2.65 (2H, s), 1. 80 (2H, q), 0.95 (3H, t)

According to the analysis of related databases, 33279-01-5, the application of this compound in the production field has become more and more popular.

Reference of 2941-29-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2941-29-9, name is Cyclopentanone-2-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 181 2-(pyridazin-4-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3 -amine1007771 A suspension of 4-hydrazinylpyridazine hydrobromide (0.368 g, 1.93 nimol) in absolute EtOH (5 mL) was treated with 2-oxocyclopentanecarbonitrile (0.191 g, 1.75 mmol) and the mixture was heated at reflux for 22 hours. The mixture was cooled to ambient temperature and was concentrated to an orange solid. The solid was suspended in 1 M NaOH and stirred for 10 minutes. The solid was collected, washed thoroughly with H20 and Et20 and dried in vacuum to furnish title compound as a tan powder (.323 g, 92percent). MS (apci) mz = 202.1 (M+H).

The chemical industry reduces the impact on the environment during synthesis Cyclopentanone-2-carbonitrile. I believe this compound will play a more active role in future production and life.

Electric Literature of 654-70-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 654-70-6 name is 4-Cyano-3-trifluoromethylaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1) Preparation of 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethyl-benzonitrile (1.1); Compound 1.1 can be prepared by method ?N-A?. To this end, 14.74 g (79.21 mmol) of 4-amino-2-trifluoromethylbenzonitrile were dissolved in 200 ml of dry acetonitrile. This solution was added dropwise with stirring to a 20% solution, heated to 70 C., of phosgene in toluene and then stirred for 1 h. The cooled reaction solution was concentrated under reduced pressure, the residue was taken up with toluene and concentrated again under reduced pressure. Finally, the residue was dissolved in 150 ml of dry acetonitrile and the solution was admixed with stirring with 15.5 g (79.21 mmol) of tert-butyl 2-amino-2-methylpropionate hydrochloride. 12.02 g (118.8 mmol) of triethylamine were slowly added dropwise to the reaction mixture which was then stirred at room temperature for 45 min. Thereafter, the mixture was admixed cautiously with 50 ml of concentrated hydrochloric acid and stirred at 70 C. for 1 h. The cooled reaction mixture was concentrated under reduced pressure and the residue was admixed with ethyl acetate and water. The organic phase was removed, washed with saturated sodium hydrogencarbonate solution and then with water, dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified chromatographically using silica gel with 2:1 heptane/ethyl acetate. This afforded 21.2 g (90% yield) of 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile 1.1 with melting point 208-211 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Cyano-3-trifluoromethylaniline, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 621-50-1, name is 2-(3-Nitrophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 621-50-1, HPLC of Formula: C8H6N2O2

Example 32 3-(2-Aminoethyl)aniline (40). This compound was prepared as described above using (3-nitrophenyl)acetonitrile (2.2 g, 13.6 mmol). Evaporation of the solvent gave the product in a yield of 81% (1.5 g, brown liquid, over two steps): 1H NMR (400 MHz, CD3OD) 7.02 (t, J=7.2 Hz, 1H), 6.59 (m, 2H), 6.56 (m, 1H), 2.84 (t, J=7.2 Hz, 2H), 2.64 (t, J=7.2 Hz, 2H). HRMS (EI) m/z (M+) calcd for C8H12N2 136.1000, found 136.0980.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 633336-81-9, name is 4-(Aminomethyl)-3,5-difluorobenzonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 633336-81-9

[BOC- (S)] Aze-OH (1.14 g, 5.6 mmol) was dissolved in 45 [ML] of DMF. 4- Aminomethyl-2,6-difluorobenzonitrile (1.00 g, 5.95 mol, see Example [L] (xiv) above), [PYBOP] (3.10 g, 5.95 mmol) and DIPEA (3.95 mL, 22.7 mmol) were added and the solution was stirred at room temperature for 2 h. The solvent was evaporated and the residue was partitioned between H20 and EtOAc (75 [ML] each). The aqueous phase was extracted with 2 x 50 mL EtOAc and the combined organic phase was washed with brine and dried over [NA2S04.] Flash chromatography (Si02, EtOAc/heptane (3/1) ) yielded the sub-title compound (1.52 g, 77%) as an oil which crystallized in the refrigerator. ‘H-NMR (400 MHz; CD30D) : [8] 7.19 (m, 2H), 4.65-4. 5 (m, 3H), 3.86 (m, 1H), 3.73 (m, 1H), 2. [45-2.] 3 (m, 2H), 1.39 (s, 9H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19472-74-3, name is 2-Bromophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 19472-74-3

Step 1 : Nitrtle 19 (1.0 g, 5.10 mmol) was dissolved in DMF (20 mL) and was cooled to 0 C. NaH (60% in mineral oil, 449 mg, 11.22 mmol) was added and the reaction was warmed to 23 C and was stirred for 10 min. Dichloride {5, 1.3 g, 5.36 mmol) was added and the reaction was heated at 80 C overnight. The reaction was cooled to 23 C and was quenched with aqueous sat’d NH4CI (5 mL). The mixture was extracted with EtOAc (3x). The organic layers were washed with brine (1x), dried over MgS04, filtered and concentrated. The crude residue was recrystallized with EtOAc hexanes to obtain pure ferf-butyl 4-(2- bromophenyl)-4-cyanopiperidine-1-carboxylate as an off-white solid (20, 1.1 g, 59% yield). 1H NMR (400 MHz, CDCI3): delta 7.70-7.68 (m, 1 H), 7.39-7.37 (m, 2H), 7.25-7.21 (m, 2H), 4.31-4.27 (m, 2H), 3.29 (bt, 2H), 2.58-2.52 (m, 2H), 1.98 {td, 2H), 1.48 (s, 9H).

According to the analysis of related databases, 19472-74-3, the application of this compound in the production field has become more and more popular.

Reference of 71825-51-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 71825-51-9 as follows.

2-methyl-2-(4-nitro-phenyl)-propionitrile was dissolved in ethyl acetate (20ml) and treated with stannous chloride dihydrate (3.52g, 15.86mmol). After stirring overnight at room temperature, the reaction mixture was basified with aqueous sodium carbonate. The organic layer was separated, washed with water, dried and concentrated to oil. The crude compound was purified by column chromatography over silica gel using ethyl acetate/pet ether (1:9) as eluent to give 2-(4-aminophenyl)-2-methyl propionitrile (0.45g, 89%) as oil.

According to the analysis of related databases, 71825-51-9, the application of this compound in the production field has become more and more popular.

Electric Literature of 97165-77-0, A common heterocyclic compound, 97165-77-0, name is 3,5-Dibromobenzonitrile, molecular formula is C7H3Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,3,6,8-tetramethyl-9H-carbazole (1.07 g, 4.80 mmol), 3,5-dibromobenzonitrile (0.522 g, 2.00 mmol), sodium tert-butoxide (0.768 g, 8.00 mmol), tris (dibenzylideneacetone) dipalladium (O) (92.8 mg, 0.101 mmol) and tetrafluoroborate tri-tert-butylphosphine (0.220 g, 0.758 mmol) were added to a 100 mL three-neck flask having been substituted with nitrogen. The mixture was added with 35 mL of dehydrated toluene and stirred under heating at 95 C. for 12 hours. After the mixture was returned to room temperature, the mixture was added with chloroform and stirred. Then, the solution was rinsed with saturated saline. After the rinsing, the solution was added with anhydrous magnesium sulfate and dried. After the drying, the mixture was subjected to suction filtration for concentration, so that filtrate was obtained. The obtained filtrate was purified by silica gel column chromatography with hexane:chloroform (=2:1) as a developing solvent. The white solid matter obtained by concentrating the obtained fraction was stirred under heating by hexane and then filtered. The solid matter recovered by filtration was recrystallized with toluene, so that the white crystals of the target material were obtained in a yield amount of 470 mg and a yield of 45.0%. 1H-NMR (500 MHz, CDCl3, delta): 8.07 (d, J=2.0 Hz, 2H), 7.63 (s, 4H), 7.07 (t, J=2.0 Hz, 1H), 6.88 (s, 4H), 2.42 (s, 12H), 1.98 (s, 12H). ASAP mass spectrum analysis: Theoretical value: 545.7 Observed value: 545.7

The synthetic route of 97165-77-0 has been constantly updated, and we look forward to future research findings.