Category: nitriles-buliding-blocks

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Product Details of 1009-35-4

A mixture of 4-fluoro-3-nitrobenzonitrile (1 .0 g; 6.02 mmol), 0.502 ml (6.62 mmol) of 3- amino-propan-1 -ol and 1 .15 ml (6.62 mmol) of diisopropylethylamine in 5 ml THF is stirred at rt for 1 hr (temperature raises somewhat at the beginning). After concentration in vacuo the residue is dissolved in 50 ml of ethyl acetate, washed with 50 ml of 4percent aqueous sodium hydrogen carbonate and brine, dried and concentrated. 1 .32 g of pure title compound as a solid are thus obtained (99 percent yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-52-7, name is 2-Methylenepentanedinitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H6N2

129 g (1 M) of N-(2-aminoethyl)imidazolidin-2-one and2 g of water are charged to a 500 cm3 reactor equipped with a mechanical stirrer, a jacket for heating, a dropping funnel and a system for rendering inert with nitrogen. The product is brought to 75-80 C. and then 116 g (1.1 M) of methyleneglutaronitrile are run in slowly. Reaction is allowed to take place, the reaction being monitored by potentiometric titration of the primary amines to given secondary amines. At the end of the reaction, the dinitrile is obtained with a yield of 89%. The product can be used as is.

According to the analysis of related databases, 1572-52-7, the application of this compound in the production field has become more and more popular.

Related Products of 35525-86-1, These common heterocyclic compound, 35525-86-1, name is 4-((Dimethylamino)methyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The reported procedure was applied with modification [42]. A solution of 4-(aminomethyl)benzonitrile (7), dissolved in tetrahydrofuran was added dropwise under a nitrogen atmosphere to a stirred suspension of LiAlH4 (4 eq) in tetrahydrofuran. The reaction mixture was stirred overnight at room temperature. The reaction was quenched by minimum amount of aqueous saturated sodium sulfate solution under a chilling temperature. The slurry mixture was filtered under vacuo and the residue washed with ethyl acetate. The combined filtrates dried over sodium sulfate, and evaporated in vacuo to afford oil or white solid products in 41-82% yields.

The synthetic route of 35525-86-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 621-50-1, A common heterocyclic compound, 621-50-1, name is 2-(3-Nitrophenyl)acetonitrile, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of (3-nitro-phenyl)-acetonitrile (11.4 g, 70.4 mmol) in THF (100 ml) was heated to reflux and borane dimethylsulfide (2M in THF, 77.34 mmol) was added.The mixture was stirred for 2 h under reflux. After complete conversion the mix¬ ture was allowed to come to room temperature and a solution of HCI in ethanolM/45293 EPO (1 M) was added. After stirring the mixture for 30 min it was concentrated under reduced pressure. The residue was triturated with diethylether, filtered, washed with diethylether and dried in vacuo to give the product as a yellow powder (13.1 g, 92%).

The synthetic route of 621-50-1 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 6393-40-4, name is 4-Amino-3-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H5N3O2

In DMF (15 ml), 3-nitro-4-aminobenzonitrile (500 mg) was dissolved, and the solution was added with sodium hydride (135 mg), followed by stirring at room temperature for 9 hours. The solution was added with 1-iodopropane (328 ml) and stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off under reduced pressure and the residue was then dissolved in chloroform. The solution was washed with water and then subjected to extraction with chloroform. The organic layer was washed with saturated saline solution and dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off under reduced pressure and the residue was then purified through silica gel column chromatography (chloroform), thereby obtaining the subject compound (362 mg) as a white solid. MS(FAB,Pos.):m/z=206[M+H]+ 1H-NMR(500MHz,CDCl3):delta=1.08(3H,t,J=7.6Hz),1.79(2H,sext.,J=7.3Hz),3.33(2H,q,J=7.1Hz),6.91(1H,d,J=9.0Hz),7.60(1H,d,J=9.0Hz),8. 43(1H,br),8.52(1H,s).

The synthetic route of 4-Amino-3-nitrobenzonitrile has been constantly updated, and we look forward to future research findings.

Related Products of 455-18-5, A common heterocyclic compound, 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, molecular formula is C8H4F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of arylnitrile (2.0 mmol) and WR (1.07 g, 2.0 mmol) in 20 mL of dry toluene was refluxed for 8 h. Upon cooling to 90C 1.0 mL of water was added, the mixture was refluxed for another 1 h. After cooling to room temperature the reaction mixture was concentrated to ca. 5.0 mL and extracted with dichloromethane (20 mL x 3), the combined dichloromethane extracts were dried over MgSO4. The final residue was purified by silica gel chromatography (9 : 1 ethyl acetate /dichloromethane as eluent) to give the compounds 1a-1i.

The synthetic route of 455-18-5 has been constantly updated, and we look forward to future research findings.

712-74-3, name is Benzene-1,2,4,5-tetracarbonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 712-74-3

EXAMPLE 81 5,6-dicyano-1,3-diiminoisoindoline Anhydrous ammonia was slowly bubbled through a stirred mixture of benzene-1, 2,4,5-tetracarbonitrile (1.78 g), and dry methanol (40 ml) for 1 hour. The product was collected by filtration, washed sequentially with methanol (10 ml) and ether (10 ml), vacuum dried and weighed (2.07 g).

The synthetic route of 712-74-3 has been constantly updated, and we look forward to future research findings.

Related Products of 874-97-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 874-97-5, name is 3-Cyanobenzyl alcohol belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

E4 3-(((2,2-dimethyl-5-oxo-l,2,3,5-tetrahydroimidazo[l,2-c]pyrimidin-7-yl)oxy)methyl)benzo- nitrile To a solution of 7-chloro-2,2-dimethyl-l-(methylsulfonyl)-2,3-dihydroimidazo[l,2-c]pyrimidin- 5(lH)-one (200 mg, 0.720 mmol) and 3-(hydroxymethyl)benzonitrile (288 mg, 2.16 mmol) in N,N- dimethylformamide (DMF) (3.5 mL) was added K2C03 (299 mg, 2.16 mmol). The reaction mixture was sealed in a microwave vial and irradiated with a microwave using initial normal to 100 C for 1 h. Purification via mass -directed auto-preparation afforded the title product as a white solid. LCMS (ESI): m/z 297 [M + H]+; 2.24 min (ret time)

The synthetic route of 3-Cyanobenzyl alcohol has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 50670-64-9, name is 5-Amino-2-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H8N2

A mixture of 2-(methylthio)-6-propylpyrimidin-4(3H)-one (5 g, 27.1 mmol) prepared in Step 1 of Preparation 1 and 5-amino-2-methylbenzonitrile (7 g, 53 mmol) was stirred at 160 C. overnight. The reaction mixture was cooled to room temperature and then ethanol (30 ml) was added thereto. The reaction mixture was stirred for 1 hour and then filtered to give 6.3 g of the titled compound as a pale yellow solid. [0525] 1H-NMR (400 MHz, CD3OD) delta 8.12 (d, 1H), 7.70-7.60 (m, 1H), 7.35 (d, 1H), 5.80 (s, 1H), 2.50-2.40 (m, 5H), 1.73 (q, 2H), 0.99 (t, 3H)

The synthetic route of 5-Amino-2-methylbenzonitrile has been constantly updated, and we look forward to future research findings.

Related Products of 330793-38-9,Some common heterocyclic compound, 330793-38-9, name is 4-Bromo-2-methoxybenzonitrile, molecular formula is C8H6BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 5.349g (lOOmmol) of ammonium chloride in 200mL of toluene was dropped lOOmL (lOOmmol) of IM-triethylaluminum/hexane, and the mixture was stirred for 1.5 hours at room temperature. Then, to this mixture was added 8.48g (40mmol) of the compound obtained in the Manufacturing Example 2, and the mixture was stirred for 24 hours at 80°. After the reaction mixture was cooled with ice water, 30g of silica gel and 300mL of chloroform were added to the mixture and the mixture was stirred for 30 minutes under the roomtemperature. The mixture was filtrated with Celite.(R). and the residue was washed with 400mL of methanol. The organic layer was concentrated and 200mL of chloroform/methanol (9/1) solution was added to the residue. The mixture was filtrated and the filtrate was concentrated and the residue was washed sequentially with ether to give 3.47g (33percent) of the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2-methoxybenzonitrile, its application will become more common.