Category: nitriles-buliding-blocks

Bai, Hong Ye published the artcile1,8,16,23-Tetrakis(2-cyanobenzyl)bis-p-xylylbis-m-xylyldiamine, Application In Synthesis of 612-13-5, the publication is Acta Crystallographica, Section E: Structure Reports Online (2008), 64(11), o2142, o2142/1-o2142/11, database is CAplus and MEDLINE.

The title compound {systematic name: 2,2′,2”,2”’-[3,7,11,15-tetraaza-1(1,4),5(1,3),9(1,4),13(1,3)-tetrabenzenacyclohexadecaphane-3,7,11,15-tetrayltetramethylene]tetrabenzonitrile}, C₆₄H₅₆N₈, is a centrosym. macrocycle that is consolidated into the crystal structure by C-H···π interactions. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wang, Hui published the artcileSelective Coupling of 1,2-Bis-Boronic Esters at the more Substituted Site through Visible-Light Activation of Electron Donor-Acceptor Complexes, COA of Formula: C10H18BNO2, the publication is Angewandte Chemie, International Edition (2022), 61(18), e202202061, database is CAplus and MEDLINE.

1,2-Bis-boronic esters are useful synthetic intermediates particularly as the two boronic esters can be selectively functionalized. Usually, the less hindered primary boronic ester reacts, but herein, we report a coupling reaction that enables the reversal of this selectivity. This is achieved through the formation of a boronate complex with an electron-rich aryllithium which, in the presence of an electron-deficient aryl nitrile, leads to the formation of an electron donor-acceptor complex. Following visible-light photoinduced electron transfer, a primary radical is generated which isomerizes to the more stable secondary radical before radical-radical coupling with the arene radical-anion, giving β-aryl primary boronic ester products. The reactions proceed under catalyst-free conditions. This method also allows stereodivergent coupling of cyclic cis-1,2-bis-boronic esters to provide trans-substituted products, complementing the selectivity observed in the Suzuki-Miyaura reaction.

Angewandte Chemie, International Edition published new progress about 238088-16-9. 238088-16-9 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Aliphatic cyclic hydrocarbon,Boronic Acids,Boronate Esters, name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)butanenitrile, and the molecular formula is C14H31NO2, COA of Formula: C10H18BNO2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Ying published the artcileSynthesis and cytotoxicity of dihydroartemisinin ethers containing cyanoarylmethyl group, COA of Formula: C8H6ClNO, the publication is Bioorganic & Medicinal Chemistry (2003), 11(6), 977-984, database is CAplus and MEDLINE.

A new type of ether of dihydroartemisinin containing cyano and aryl groups was prepared and tested for cytotoxicity to A549, P388, L1210 and HT29 cells using the MTT assay. Compounds 12k and 12l were the most cytotoxic compounds Compound 13, lacking the peroxy group, showed a 1000-fold less potency than 12l. Similarly, the inactive compound 14 indicated that the position of cyano groups was also important. Flow cytometry data showed that the compounds caused an accumulation of P388 cells in the G₁-phase of the cell cycle.

Bioorganic & Medicinal Chemistry published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, COA of Formula: C8H6ClNO.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Zhi published the artcileSeparation of chiral cyanohydrin enantiomers by gas chromatography, Application In Synthesis of 13312-84-0, the publication is Fenxi Huaxue (1997), 25(6), 708-713, database is CAplus.

The enantiomers of 14 cyanohydrins were separated on permethylated β-cyclodextrin column (fused silica, 25 m × 0.22 mm) by derivatization. The acetyl chloride and trifluoroacetic anhydride were used as derivatization reagents. All racemates were separated to baseline with separation factors (α) = 1.02-1.13. The enantiomer excess values of some enantiomers from asym. synthesis samples were determined, and they were identical with those by optical purity and HPLC methods. The separation effect of the two derivatization methods and the separation mechanism of enantiomers are discussed.

Fenxi Huaxue published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Application In Synthesis of 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Yang, Bowen published the artcileDiscovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors, HPLC of Formula: 1036991-35-1, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127749, database is CAplus and MEDLINE.

In an inhouse screening, 1H-pyrrolo[2,3-b]pyridine scaffold was found to have high inhibition on TNIK. Several series of compounds were designed and synthesized, among which some compounds had potent TNIK inhibition with IC₅₀ values lower than 1 nM. Some compounds showed concentration-dependent characteristics of IL-2 inhibition. These results provided new applications of TNIK inhibitors and new prospects of TNIK as a drug target.

Bioorganic & Medicinal Chemistry Letters published new progress about 1036991-35-1. 1036991-35-1 belongs to nitriles-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, and the molecular formula is C14H12N2S, HPLC of Formula: 1036991-35-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Xiangmin published the artcileOne-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides, Application of 2-(Chloromethyl)benzonitrile, the publication is Organic Letters (2018), 20(7), 1712-1715, database is CAplus and MEDLINE.

A facile, one-pot approach for synthesizing deuterated aldehydes from arylmethyl halides was developed using D₂O as the deuterium source. The efficient process is realized by a sequence of formation, H/D exchange and oxidation of pyridinium salt intermediates. The mild and air-compatible reaction conditions enable efficient synthesis of diverse deuterated aldehydes with high deuterium incorporation.

Organic Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application of 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wu, Lulu published the artcileSynthesis of Optically Active 2H-Thiopyrano[2,3-b]quinolines with Three Contiguous Stereocenters via an Organocatalytic Asymmetric Tandem Michael-Henry Reaction [Erratum to document cited in CA160:033796], COA of Formula: C9H6N2O2, the publication is Advanced Synthesis & Catalysis (2014), 356(6), 1134, database is CAplus.

The authors were made of aware of an error regarding the x-ray anal. data for the absolute configuration of compound 5ad; the corrected structure is given and the NMR data and spectra can be found in the Supporting Information.

Advanced Synthesis & Catalysis published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C8H11NO, COA of Formula: C9H6N2O2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhao, Guangkuan published the artcileCucurbit[7]uril promoting PdCl₂-catalyzed cross-coupling reaction of benzyl halides and arylboronic acids in aqueous media, Recommanded Product: 2-(Chloromethyl)benzonitrile, the publication is Tetrahedron Letters (2014), 55(38), 5319-5322, database is CAplus.

The research provides a novel approach for producing diarylmethane derivatives using CB[7]-NaCl-PdCl₂ catalyzed Suzuki cross-coupling reaction of benzyl chloride derivatives and arylboronic acids in ethanol aqueous solution

Tetrahedron Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C5H10O2S, Recommanded Product: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wit, J. G. published the artcileMetabolism of the herbicide 2,6-dichlorobenzonitrile in rabbits and rats, Application In Synthesis of 3336-34-3, the publication is Biochemical Journal (1966), 698-706, database is CAplus and MEDLINE.

cf. preceding abstract. The metabolism of 2,6-dichlorobenzonitrile was studied in rabbits and rats. Oral administration caused an increased urinary excretion of glucuronides and ethereal sulfates. There was also an indication of mercapturic acid formation. 2,6-Dichloro-3-hydroxybenzonitrile and its 4-hydroxy analog were identified as metabolites in the urine. A small amount of the unchanged substance was recovered from the feces. By using 2,6-dichlorobenzonitrile-¹⁴C, the phenolic metabolites were determined quant. and some other possible metabolic routes were excluded. Incubation of 2,6-dichlorobenzonitrile with enzyme preparations (papain and high-speed supernatant of rat-liver homogenate plus glutathione) gave no indications for a reaction with thiol compounds

Biochemical Journal published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 3336-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wit, J. G. published the artcileMonophenolic metabolites of the herbicide, 2,6-dichlorobenzonitrile, in animals as uncouplers of oxidative phosphorylation, Safety of 2,6-Dichloro-3-hydroxybenzonitrile, the publication is Biochemical Journal (1966), 707-10, database is CAplus and MEDLINE.

Both monophenolic metabolites of 2,6-dichlorobenzonitrile (2,6-dichloro-3-hydroxybenzonitrile and its 4-hydroxy analog) added to starved yeast cells incubated with a limited quantity of glucose caused a significant rise in O consumption of the cells. The same compounds induce ATPase activity in isolated intact rat liver mitochondria. The possible role of the hydroxylation of 2,6-dichlorobenzonitrile in mammals, in relation to hepatic injury, is discussed.

Biochemical Journal published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C6H10O2S, Safety of 2,6-Dichloro-3-hydroxybenzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts