Category: nitriles-buliding-blocks

Yu, Euy Kyung published the artcileStudies on the synthesis of the 2-desamino and 2-desamino-2-methyl analogs of aminopterin intermediate at pteridine-C₇ side chain, SDS of cas: 5098-14-6, the publication is Journal of the Korean Chemical Society (1993), 37(1), 131-5, database is CAplus.

Title aminopterin intermediates I (R = H, Me, NH₂) were prepared from pyrazine II. Thus, dithiobisbenzoate III was reduced by NaBH₄ and then treated with II to give pyrazine IV. The cyclization of IV with RC(:NH)NH₂.HCl (R = H, Me, NH₂) in the presence of NaOEt followed by basic hydrolysis gave I (R = H, Me, NH₂).

Journal of the Korean Chemical Society published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C9H9NO, SDS of cas: 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ohashi, Masato published the artcilePalladium-catalyzed base-free Suzuki-Miyaura coupling reactions of fluorinated alkenes and arenes via a palladium fluoride key intermediate, Product Details of C12H14BNO2, the publication is European Journal of Organic Chemistry (2013), 2013(3), 443-447, database is CAplus.

A new strategy for C-C bond formation with organoboronates through C-F activation of fluorinated alkenes and arenes was developed. In this Pd-catalyzed Suzuki-Miyaura-type cross-coupling reaction, neither a base for enhancing the reactivity of the organoboron reagents nor a Lewis acid for promoting C-F bond activation was required. A fluoro-palladium intermediate played an essential role in this reaction. In addition, a Ni(NHC) catalyst was efficient for C-C coupling through C-F bond activation of fluoroarenes.

European Journal of Organic Chemistry published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, Product Details of C12H14BNO2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Sato, Nobuhiro published the artcileStudies on pyrazines. 17. An efficient synthesis of pteridine-6-carboxylic acids, Application of 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is Journal of Heterocyclic Chemistry (1988), 25(6), 1737-40, database is CAplus.

2,4-Diaminopteridine-6-carboxylic acid (I) and pterin-6-carboxylic acid (II) were prepared by permanganate oxidation of the corresponding 6-(2-furyl)-substituted pteridines under mild conditions. Several attempts to cleave the furan ring with other oxidizing agents are also described.

Journal of Heterocyclic Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Application of 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Somawardhana, C. W. published the artcileRadiopharmaceutical for differential diagnosis of tuberculoma: synthesis of carbon-11 labeled 2-[¹¹C]cyanoisonicotinic acid hydrazide, Application In Synthesis of 135048-32-7, the publication is Applied Radiation and Isotopes (1991), 42(6), 559-62, database is CAplus.

The radiochem. synthesis of 2-[¹¹C]cyanoisonicotinic acid hydrazide (I) was accomplished. Carbon-11 cyano group was introduced at the 2-position of the pyridine ring of 1-methoxy-4-methoxycarbonyl pyridinium Me sulfate via a Reissert-Kaufmann type reaction. The reaction was performed on a solid support (silica gel) to yield no-carrier-added Me 2-[¹¹C]cyano-isonicotinate in (32.4%) yield. This method is unique for the incorporation of [¹¹C]HCN to base sensitive substrates. The carbon-11-labeled Me ester was treated with hydrazine to give I. The final radiochem. yield was 10% and the synthesis time was approx. 35 min.

Applied Radiation and Isotopes published new progress about 135048-32-7. 135048-32-7 belongs to nitriles-buliding-blocks, auxiliary class Pyridine,Nitrile,Hydrazine,Amine,Hydrazide,Amide, name is 2-Cyanoisonicotinohydrazide, and the molecular formula is C9H10O4, Application In Synthesis of 135048-32-7.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kikushima, Kotaro published the artcileCopper-mediated one-pot synthesis of trifluorostyrene derivatives from tetrafluoroethylene and arylboronate, Quality Control of 214360-44-8, the publication is Chemistry Letters (2015), 44(7), 1019-1021, database is CAplus.

The copper-mediated synthesis of trifluorostyrenes ArCF:CF₂ (Ar = C₆H₅, 4-MeOC₆H₄, 2-naphthyl, etc.) from aryl boronates and tetrafluoroethylene through the transmetalation-carbocupration-β-fluorine elimination process under one-pot procedure was described. β-Fluorine elimination of a 2-aryl-1,1,2,2-tetrafluoroethylcopper complex, generated in situ from arylboronate, copper tert-butoxide, and 1,10-phenanthroline/bathophenanthroline with tetrafluoroethylene via carbocupration, was promoted by the addition of a Lewis acid.

Chemistry Letters published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, Quality Control of 214360-44-8.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Jordan-Hore, James A. published the artcileMild and Ligand-Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones, Formula: C10H12F6N4O6PdS2, the publication is Organic Letters (2012), 14(10), 2508-2511, database is CAplus and MEDLINE.

Ligand-free cationic Pd(II) catalyst with NaNO₃ as an additive is a highly active catalytic system for conjugate additions to sterically hindered γ-substituted cyclohexenones. More challenging γγ- and βγ-substrates also react well to produce products with quaternary centers in good dr. The conjugate additions occur in a diastereoselective fashion under mild, practical and air-stable conditions, using readily available com. reagents.

Organic Letters published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Formula: C10H12F6N4O6PdS2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Jalal, Swapnadeep published the artcileSynthesis of nitroalkenes involving a cooperative catalytic action of iron(iii) and piperidine: A one-pot synthetic strategy to 3-alkylindoles, 2H-chromenes and N-arylpyrrole, Category: nitriles-buliding-blocks, the publication is European Journal of Organic Chemistry (2013), 2013(22), 4823-4828, database is CAplus.

An efficient and simple strategy has been developed to synthesize various substituted nitroalkenes involving a cooperative catalytic system of FeCl₃ and piperidine. This dual catalytic protocol simultaneously activates both electrophile and nucleophile and works under mild reaction conditions so that many sensitive functional groups were tolerated. Moreover, this cooperative catalytic reaction is also suitable for various one-pot reactions involving nitroalkenes such as, 2H-chromenes, N-arylpyrrole and Michael reaction with indole. Notably, this method is low-cost, efficient and environmentally friendly.

European Journal of Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Alimohammadi, Kamal published the artcileAn expedient approach for the regio- and stereoselective synthesis of novel spiroindolizidines via [3+2] cycloaddition, Category: nitriles-buliding-blocks, the publication is Comptes Rendus Chimie (2014), 17(2), 156-163, database is CAplus.

A new series of spiroindolizidines was synthesized by one-pot, three-component condensation of azomethine ylides, generated from 1,2,3,4-tetrahydroisoquinoline with ninhydrin or isatin derivatives by a 1,5-prototropic shift route, with various derivatives of trans-β-nitrostyrene in a regio- and stereoselective manner. X-ray crystal structure anal. and NMR confirmed the structure outcome of the cycloaddition reaction.

Comptes Rendus Chimie published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Hamzehloueian, Mahshid published the artcileAn experimental and theoretical study on the regioselective synthesis of a new class of spiropyrrolothiazoles with quinoxaline motifs via a 1,3-dipolar cycloaddition reaction. An evaluation of DFT methods, Quality Control of 5153-73-1, the publication is RSC Advances (2015), 5(93), 76368-76376, database is CAplus.

A series of novel spiropyrrolothiazoles I (R = Ph, 4-MeC₆H₄, 2-O₂NC₆H₄, 2-furyl, 2-thienyl, 1-naphthyl, etc.) with quinoxaline motifs was synthesized by a four-component 1,3-dipolar cycloaddition reaction of various trans-β-nitroalkenes RCH:CHNO₂ and an azomethine ylide, generated in situ from 1,3-thiazolidine-4-carboxylic acid, ninhydrin and 1,2-phenylenediamine. The stereochem. of the products was confirmed by single crystal X-ray structure and spectroscopic techniques. Theor. calculations were carried out using DFT methods at the B3LYP/6-31G(d,p), wB97xD/6-31G(d,p) and M06-2X/6-31G(d,p) levels. The regio- and stereoselectivity was explained on the basis of transition state stabilities and global and local reactivity indexes of the reactants. The assessment of geometries and energetics of transition states revealed the importance of π/π interactions between aromatic rings in the regioselectivity of the cycloaddition reaction. The B3LYP functional was unable to deal with this weak interaction in the proposed TSs and led to an incorrect conclusion about the reaction regioselectivity. In this report, wB97xD and M06-2X functionals to calculate the transition states relative energies were successfully employed.

RSC Advances published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Quality Control of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Huang, Shengying published the artcileAsymmetric sequential double Michael reactions of γ,δ-unsaturated β-ketoesters to nitroolefins catalyzed by Ni (II)-diamine complex, HPLC of Formula: 5153-73-1, the publication is Catalysis Communications (2017), 67-70, database is CAplus.

The asym. sequential double Michael reactions of γ,δ-unsaturated β-ketoesters and nitroolefins catalyzed by 2 mol% of readily prepared Ni(II)-bis[(R,R)-N,N’-dibenzylcyclohexane-1,2-diamine] complex and then with 1 equiv of tetramethylguanidine (TMG) for cyclization have been developed. The reaction gave the corresponding Michael adducts of multifunctional cyclohexenol derivatives with three chiral stereocenters in good yields, moderate diastereoselectivities, and high enantioselectivities under mild reaction conditions. Thus, e.g., γ,δ-unsaturated β-ketoester I + trans-β-nitrostyrene â†?II (82%, dr = 5:1, 92% ee).

Catalysis Communications published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, HPLC of Formula: 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts