Nitriles-buliding-blocks

Griffiths, M. H. published the artcileThe comparative metabolism of 2,6-dichlorothiobenzamide (Preflx) and 2,6-dichlorobenzonitrile in the dog and rat, Related Products of nitriles-buliding-blocks, the publication is Biochemical Journal (1966), 98(3), 770-81, database is CAplus and MEDLINE.

A single oral dose of either 2,6-dichlorothiobenzamide-¹⁴C (I) or 2,6-dichlorobenzonitrile-¹⁴C (II) fed to rats is almost entirely eliminated in 4 days; 84.8-100.5% of ¹⁴C from I is excreted 67.3-79.7% in the urine; 85.8-97.2% of ¹⁴C from II is excreted, 72.3-80.7% in the urine. Only 0.37% of the I dose and 0.25 ± 0.03% of the II dose are present in the carcass plus viscera after gut removal. Rats do not show sex differences in the pattern of elimination of the resp. metabolites of the two herbicides. The rates of elimination of ¹⁴C from the two compounds in the 24-hr. and 48-hr. urines are not different from one another. After oral administration to dogs, 85.9-106.1% of ¹⁴C from I is excreted, 66.6-80.9% in the urine, and 86.8-92.5% of ¹⁴C from II is excreted, 60.0-70.1% in the urine. Dogs do not show sex differences in the pattern of eliminating the metabolites of either I or II. Dogs and rats do not show species differences in the patterns of elimination of the two herbicides. I and II are completely metabolized; unchanged I and II are absent from the urine and feces, and from the carcasses when elimination is complete. In the hydrolyzed urine of rats dosed with either I or II, 2,6-dichloro-3-hydroxybenzonitrile accounts for approx. 42% of the ¹⁴C, a further 10-11% is accounted for by 2,6-dichlorobenzamide, 2,6-dichlorobenzoic acid, 2,6-dichloro-3- and -4-hydroxybenzoic acid and 2,6-dichloro-4-hydroxybenzonitrile collectively, and 25-30% by six polar constituents, of which two are S-containing amino acids. In the unhydrolyzed urines of rats dosed with either I or II, there are present free 2,6-dichloro-3- and -4-hydroxybenzonitrile, their glucuronide conjugates, ester glucuronides of the principal aromatic acids that are present in the hydrolyzed urines, and two S-containing metabolites analogous to mercapturic acids or premercapturic acids.

Biochemical Journal published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ooi, T. published the artcileZr(OBu^t)₄ as an effective promoter for the Meerwein-Ponndorf-Verley alkynylation and cyanation of aldehydes: development of a new asymmetric cyanohydrin synthesis, COA of Formula: C8H6ClNO, the publication is Tetrahedron (2001), 57(5), 867-873, database is CAplus.

Zr(OBu^t)₄ can serve as an effective promoter for the Meerwein-Ponndorf-Verley alkynylation of aldehydes and also facilitate MPV type cyanide transfer to aldehyde carbonyls with com. available acetone cyanohydrin under mild conditions. Based on this finding, a new procedure for asym. cyanohydrin synthesis has been developed employing (4R,5R)-2,2-dimethyl-α,α,α’,α’-tetraphenyl-1,3-dioxolane-4,5-dimethanol (TADDOL, I) as a chiral ligand. For instance, sequential treatment of a CH₂Cl₂ solution of I (1 equiv) with Zr(OBu^t)₄ (1 equiv) and acetone cyanohydrin (2 equiv) at room temperature for 1 h, and subsequent reaction with 3-phenylpropanal at -40° for 7.5 h resulted in formation of the corresponding cyanohydrin in 63% isolated yield with 85% ee. The scope and limitations of this method have been clarified with various aldehydes as substrates.

Tetrahedron published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, COA of Formula: C8H6ClNO.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Junek, Hans published the artcileSyntheses with nitriles, LIV. Reduction of oximinomalonitrile to aminomalonitrile using Raney catalysts, HPLC of Formula: 5098-14-6, the publication is Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie (1979), 34B(2), 280-2, database is CAplus.

An improved synthesis of aminomalononitrile H₂NCH(CN)₂ (I) by using Raney-catalyst for the reduction of HON:C(CN)₂ (II) at H₂-pressure of 4 atm and 20° was given. Due to the reactivity of II some new derivatives of oximinocyanoacetamide are obtained by O– and N-acylation. Condensation of III with benzilmonoxime gave 2-amino-5,6-diphenylpyrazinecarbonitrile; with N-phenylformamidate 2-amino-2,2-dicyano-1-(N-phenylimino)-acetaldehyde was obtained.

Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, HPLC of Formula: 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Gupta, Dinesh published the artcileCu (II)-β-CD as Water-Loving Catalyst for One-Pot Synthesis of Triazoles and Biofuels Intermediate at Room Temperature without Any Other Additive, Name: 2-(Chloromethyl)benzonitrile, the publication is ChemistrySelect (2017), 2(10), 2997-3008, database is CAplus.

The applications of Cu(II)-β-CD as water soluble green catalyst for the one-pot conversion benzyl halide to benzyl azide and 1,2,3-trizoles at room temperature and very short reaction time (15-70 min) was presented. Products were separated without any workup, simple by filtration, with >99 % selectivity and purity. As-synthesized material was characterized by, HR-TEM, XPS, FESEM, FT-IR, TGA and XRD to understand its structural properties as well as attachment of copper by host-guest interaction. This catalyst also showed effectiveness for the condensed ketone and aldehydes moiety, which produced biofuels intermediate. The recyclability of this catalytic system was tested up to five cycles and only a very slight loss of catalytic activity was detected.

ChemistrySelect published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Name: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Sosic, Izidor published the artcileDiscovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B, HPLC of Formula: 612-13-5, the publication is European Journal of Medicinal Chemistry (2011), 46(9), 4648-4656, database is CAplus and MEDLINE.

Cathepsin B is a lysosomal cysteine protease that has various physiol. and pathophysiol. functions. We present here the discovery of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B, starting from screening of a library of variously 2,4,6-trisubstituted 1,3,5-triazines and 1,3,5-triazin-2(1H)-ones on three different human cathepsins. The synthesis and enzymic evaluation of a focused library of new 1,3,5-triazin-2(1H)-ones, e.g. I [R – o-OMe, m-F, p-NO₂, etc.], is also described. The detailed kinetics analyses have shown that these compounds can act as reversible, partial mixed-type inhibitors of cathepsin B, with K_i and K_i‘ values in the low micromolar range. The inhibitory activities of selected compounds were also assessed against two related cysteine proteases, cathepsin H and cathepsin L, to estimate their selectivity; these compounds have a selective profile for catB and catL over catH.

European Journal of Medicinal Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C9H22OSi, HPLC of Formula: 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Tang, Ren-Jin published the artcileFriedel-Crafts alkylation reaction with fluorinated alcohols as hydrogen-bond donors and solvents, Application of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is RSC Advances (2018), 8(19), 10314-10317, database is CAplus and MEDLINE.

An effective and clean Friedel-Crafts alkylation of indoles and electron-rich arenes with β-nitroalkenes in hexafluoroisopropanol is reported. The desired products were formed rapidly in excellent yields under mild conditions without the need for any addnl. catalysts or reagents. Further, this methodol. could be applied to one-pot synthesis of biol. active tryptamine derivatives

RSC Advances published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C6H12Br2, Application of (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Guo, Shuhui published the artcileTetraarylphosphonium inner-salts (TAPIS) as both Lewis base catalyst and phase tag, Name: (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Tetrahedron Letters (2017), 58(30), 2881-2884, database is CAplus.

Tetraarylphosphonium inner-salts (TAPIS) were designed, synthesized and verified as recyclable and reusable Lewis base catalysts. The resulted TAPIS catalyst was successfully applied in Michael addition, cyanation and trifluoromethylation reactions.

Tetrahedron Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Name: (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Jung, J. published the artcileNew prebiotic chemistry inspired filter media for stormwater/greywater disinfection, Product Details of C10H11N3O3S, the publication is Journal of Hazardous Materials (2019), 120749, database is CAplus and MEDLINE.

Greywater and stormwater have received significant attention due to increasing water scarcity. Passive filtration such as biofiltration has been a popular treatment method with its low energy input and environmental friendliness. However, pathogen removal capacity needs improvement to achieve safe water quality. In this study, a prebiotic chem. inspired copolymer based on aminomalononitrile and 3,4,5-trihydroxybenzaldehyde (AMNT30) was introduced to develop antimicrobial media for passive filtration. The AMNT30 polymer provided an adhesive coating on zeolite substrates following a spontaneous polymerization process at room temperature AMNT30 coated media were investigated for metal loading capacity, surface morphol., E. coli removal and metal leaching after filtration of different water sources (i.e. stormwater, greywater, and deionized water) at low/high conductivity The coating enhanced metal ion loading on the surface and demonstrated that >8 log reduction of E. coli can be achieved for silver loaded materials compared to a 1 log reduction for copper loaded materials. The coating also increased the stability of the metals on the media irresp. of inflow characteristics. This study provided the first example using AMNT30 to create antimicrobial water purification media. It is expected that this technol. will find applications in the water treatment industry.

Journal of Hazardous Materials published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Product Details of C10H11N3O3S.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhao, Tong published the artcileDiscovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing, HPLC of Formula: 612-13-5, the publication is European Journal of Medicinal Chemistry (2019), 111619, database is CAplus and MEDLINE.

For more in-depth exploration of the chem. space around the entrance channel of HIV-1 reverse transcriptase (RT), a series of novel indolylarylsulfones (IASs) bearing different chiral N-substituted pyrrolidines (R/S)-I [R¹ = methanesulfonyl, pyridin-3-ylmethyl, (2-fluorophenyl)methyl, (4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl, etc.], azetidines II or substituted sulfonamide groups III [R² = 2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)ethyl, ethanesulfonyl, cyclopropanesulfonyl, etc.] at indole-2-carboxamide were designed and synthesized as potent HIV NNRTIs by structure-guided scaffold morphing approach. All the IASs exhibited moderate to excellent potency against wild-type HIV-1 with EC₅₀values ranging from 0.0043 μM to 4.42 μM. Notably, compound (R)-I (R¹ = methanesulfonyl) (EC₅₀ = 4.7 nM, SI = 5183) and (S)-I (R¹ = methanesulfonyl) (EC₅₀ = 4.3 nM, SI = 7083) were identified as the most potent compounds, which were more active than nevirapine, lamivudine and efavirenz, and also reached the same order of etravirine. Furthermore, some compounds maintained excellent activity against various single HIV-1 mutants (L100I, K103 N, E138K, Y181C) as well as one double mutant (F227L/V106A) with EC₅₀ values in low-micromolar concentration ranges. Notably, II (R² = carbamoylmethyl) displayed outstanding potency against F227L/V106A (EC50 = 0.094 μM), and also showed exceptional activity against E138K (EC₅₀ = 0.014 μM), L100I (EC₅₀ = 0.011 μM) and K103 N (EC₅₀ = 0.025 μM). Addnl., most compounds showed markedly reduced cytotoxicity (CC₅₀) compared to lead compounds, especially II [R² = (2-cyanophenyl)methyl] (CC₅₀ >234.91 μM, SI >18727) and II (R² = methanesulfonyl) (CC₅₀ >252.49 μM, SI >15152). Preliminary SARs and mol. modeling studies were also discussed in detail, which may provide valuable insights for further optimization.

European Journal of Medicinal Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C10H9NO, HPLC of Formula: 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Silva, Daniel published the artcileSynthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is Drug Development Research (2020), 81(2), 215-231, database is CAplus and MEDLINE.

Based on the monoamine oxidase (MAO) inhibition properties of aminoheterocycles with a carbonitrile group we have carried out a systematic exploration to discover new classes of carbonitriles endowed with dual MAO and AChE inhibitory activities, and Aβ anti-aggregating properties. Eighty-three nitrile-containing compounds, 13 of which are new, were synthesized and evaluated. In vitro screening revealed that 31, a new compound, presented the best lead for trifunctional inhibition against MAO A (0.34μM), MAO B (0.26μM), and AChE (52μM), while 32 exhibited a lead for selective MAO A (0.12μM) inhibition coupled to AChE (48μM) inhibition. Computational anal. revealed that the malononitrile group can find an advantageous position with the aromatic cleft and FAD of MAO A or MAO B. However, the total binding energy can be handicapped by an internal penalty caused by twisting of the ligand mol. and subsequent disruption of the conjugation (32 in MAO B compared to the conjugated 31). Conjugation is also important for AChE as well as the hydrophilic character of malononitrile that allows this group to be in close contact with the aqueous environment as seen for 83. Although the effect of 31 and 32 against Aβ_1-42, was very weak, the effect of 63 and 65, and of the new compound 75, indicated that these compounds were able to disaggregate Aβ_1-42 fibrils. The most effective was 63, a (phenylhydrazinylidene)propanedinitrile derivative that also inhibited MAO A (1.65μM), making it a potential lead for Alzheimer’s disease application.

Drug Development Research published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C12H16BN3O2, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts