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On April 10, 2003, Moeller, Hinrich; Oberkobusch, Doris; Hoeffkes, Horst published a patent.Application of 2510-01-2 The title of the patent was Hair dyes containing acetal derivatives of pyridine and quinoline. And the patent contained the following:

The invention concerns hair dyes that contain dimethoxy-, diethoxy Me and Et derivatives of pyridine and quinoline for use without or with oxidation agents. Further included are components from the group of primary and secondary amines, hydroxy compounds, aryl amines, N-containing heteroaryls, amino acids, 2-9 amino acid-composed oligopeptides, or CH-acids. Thus 4-diethoxymethyl-1-methylquinolinium-p-toluene sulfate was synthesized and used as a 5 mmol ingredient with 5 mmol 3-amino-2-methylamino-6-methoxypyridine dihydrochloride in a hair dyeing experiment; intense greenish brown color was obtained. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to hair dye acetal pyridine quinoline oniumacetal, Essential Oils and Cosmetics: Packaging (Chemical Implication) and other aspects.Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 27, 2002, Li, Guiying; Peterson, John M.; Albaugh, Pamela; Currie, Kevin S.; Cai, Guolin; Gustavson, Linda M.; Lee, Kyungae; Hutchison, Alan; Singh, Vinod; Maynard, George D.; Yuan, Jun; Ling, Hong Xie; Ghosh, Manuka; Liu, Nian; Luke, George P.; Mitchell, Scott; Allen, Martin Patrick; Liras, Spiros published a patent.Reference of 3-Chloro-4-nitrobenzonitrile The title of the patent was Aryl or heteroaryl fused imidazoles as selective GABAA receptor ligands. And the patent contained the following:

Title compounds I [W = N or CR3, X = N or CR4, Y = N or CR5, Z = N or CR6 with the provision that no more than two of W, X, Y and Z are N; Q = O or CR7R8; R1 = H, haloalkyl, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, etc.; R2 = nitrogen containing 5-7 membered (un)substituted heteroaryl or heterocycloalkyl ring with up to 4 heteroatoms independently selected from N, S, and O; R3, R4, R5 and R6 are independently selected from H, halo, OH, NO2, CN, (un)substituted alkyl, alkoxy, etc.] and there pharmaceutically acceptable salts are prepared and disclosed as selective GABAA receptor ligands. Thus, II was prepared in five steps from malonyl dichloride and Et vinyl ether with imidazole ring formation via cyclocondensation of 3-amino-4-ethylaminobenzonitrile with 1-(3-fluorophenyl)-5-carboxymethylpyrazole. The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. Preferred compounds of the invention exhibit Ki values of < 100 nM for binding at the benzodiazepine site with more preferred compounds exhibiting Ki values of < 10 nM. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. This invention also relates to the use of I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Addnl. this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

The Article related to imidazole aryl preparation gaba receptor ligand cns agent, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 10, 2010, Canne Bannen, Lynne; Chan, Diva Sze-Ming; Gu, Xiao-Hui; Mac, Morrison B.; Ng, Stephanie; Wang, Tie-Lin; Wang, Yong; Xu, Wei published a patent.Application of 34662-29-8 The title of the patent was Imidazo[1,2a]pyridine derivatives, their use as S1P1 agonists and methods for their production. And the patent contained the following:

The invention is directed to compounds of formula I as well as methods of making and using the compounds Compounds of formula I wherein R1 is H, halo, CN, C1-6 alkoxy, amino, etc.; R2 is H, Me, and MeO; R3 is H, C1-6 alkyl, C1-6 alkylsulfonyl, halo, C1-6 haloalkyl, etc.; R4 is H and C1-6 alkyl; A is 5-membered heteroarylene; R5 is (un)substituted Ph and (un)substituted heteroaryl; and stereoisomers, mixtures of isomers, and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their S1P1 agonistic activity. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application of 34662-29-8

The Article related to imidazopyridine preparation s1p1 agonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 31, 2002, Goker, Hakan; Kus, Canan; Boykin, David W.; Yildiz, Sulhiye; Altanlar, Nurten published an article.Formula: C7H3ClN2O2 The title of the article was Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species. And the article contained the following:

New 2-substituted-phenyl-1H-benzimidazole-5-carboxylic acids, ethyl-5-carboxylate, -5-carboxamides,-5-carboxaldehyde, -5-chloro-, -5-trifluoromethyl, and -5-carbonitriles, -6-carbonitrile were prepared and evaluated in vitro against Candida species. The cyano substituted compounds exhibited the greatest activity with MIC values of 3.12 μg/mL, values similar to that of fluconazole. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Formula: C7H3ClN2O2

The Article related to substituted phenyl benzimidazole carbonitrile candida activity, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Formula: C7H3ClN2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 13, 2006, Ng, Raymond; Sui, Zhihua; Guan, Jihua; Lanter, James C.; Alford, Vernon C., Jr. published a patent.COA of Formula: C8H6F3N3 The title of the patent was Preparation of benzimidazole derivatives as selective androgen receptor modulators. And the patent contained the following:

Title compounds represented by the formula I [wherein R1 = H, alkyl, CH2-aryl, alkyl-OH, etc.; R2 = H, halo, (halo)alkyl, etc.; n = 0 or 1; R10 = H, halo, (halo)alkyl or OCOR8; R8 = (cyclo)alkyl, (hetero)aryl, aralkyl, etc.; R11 = H or halo; or R10and R11 are taken together with the carbon atom to which they are bound to form CO, C=N(OH) or C=N(O-alkyl); R12 = (halo)alkyl, alkyl-OH, CH2-aryl, etc.; and pharmaceutically acceptable salts thereof] were prepared as selective androgen receptor modulators (SARMS). For example, oxidation of 2-(5,6-dichloro-1-ethyl-1H-benzimidazol-2-yl)-1-ethanesulfanylpropan-2-ol by mCPBA gave II. II showed activity in ventral prostate and seminal vesicle weight in vivo assay and ventral prostate and levator ani weight in vivo assay. Thus, I and their pharmaceutical compositions are useful for the treatment of disorders and conditions modulated by the androgen receptor. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).COA of Formula: C8H6F3N3

The Article related to benzimidazole preparation selective androgen receptor modulator, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.COA of Formula: C8H6F3N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 13, 2006, Ng, Raymond; Sui, Zhihua; Guan, Jihua; Lanter, James C.; Alford, Vernon C., Jr. published a patent.Electric Literature of 882978-62-3 The title of the patent was Preparation of benzimidazole derivatives as selective androgen receptor modulators. And the patent contained the following:

Title compounds represented by the formula I [wherein R1 = H, alkyl, CH2-aryl, alkyl-OH, etc.; R2, R3 = independently H, halo, (halo)alkyl, etc.; n = 0 or 1; R4 = H, (halo)alkyl or OCOR8; R8 = (cyclo)alkyl, (hetero)aryl, aralkyl, etc.; R5 = H, halo or (halo)alkyl; R6 = (halo)alkyl, alkyl-OH, CH2-aryl, etc.; and pharmaceutically acceptable salts thereof] were prepared as selective androgen receptor modulators (SARMS). For example, oxidation of 2-(5,6-dichloro-1-ethyl-1H-benzimidazol-2-yl)-1-ethanesulfanylpropan-2-ol by mCPBA gave II. II showed activity in ventral prostate and seminal vesicle weight in vivo assay and ventral prostate and levator ani weight in vivo assay. Thus, I and their pharmaceutical compositions are useful for the treatment of disorders and conditions modulated by the androgen receptor. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Electric Literature of 882978-62-3

The Article related to benzimidazole preparation selective androgen receptor modulator, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 882978-62-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 3, 2018, Harried, Scott S.; Resnick, Lynn; Topalov, George T.; Boyd, Steven A.; Belardi, Justin K.; Flentge, Charles A.; Hale, James S.; Mareska, David A.; Zhang, Kai published a patent.Name: 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of benzoimidazolylamide derivatives for use as Kv7 potassium channel activators. And the patent contained the following:

Title compounds I [A = alkyl; X = H, F, alkyl, or (un)substituted Ph; Y = H, F, or a moiety having a mol. weight of 15 Da to 300 Da and consisting of 2-5 chem. elements, wherein the chem. elements are independently C, H, O, or F; Z = (un)substituted cyclobutyl, Ph, iso-Pr, or t-butyl; R1 = CN, OMe, CF3, etc.; R2, R3, and R4 independently = H, F, Cl, etc.], and their pharmaceutically acceptable salts, are prepared and disclosed as Kv7 potassium channel activators. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in Kv7.2/7.3 activation assays (data given). The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Name: 3-Chloro-4-nitrobenzonitrile

The Article related to benzoimidazolylamide preparation kv7 potassium channel activator, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Name: 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 12, 2011, Hallman, Jason; Laudeman, Christopher; Liu, Ronggang; Miller, Aaron; Moore, Michael Lee; Dock, Steven; Musso, David; Parrish, Cynthia published a patent.Formula: C7H3ClN2O2 The title of the patent was Benzimidazoles as fatty acid synthase inhibitors and their preparation and use for the treatment of cancer. And the patent contained the following:

The invention relates to benzimidazole derivatives of formula I, which are fatty acid synthase inhibitors and which are useful in the treatment of cancer. Compounds of formula I wherein each R1 is independently halo, C1-6 alkyl, alkoxy, CN, etc.; R2 is (un)substituted aryl and (un)substituted heteroaryl; R3 is amino, alkylamino, dialkylamino, etc.; each R4 is C1-6 alkyl, alkoxy, OH and halo; each Y is independently C and N; n is 0 to 4; m is 0 to 4; provided that at least two Y are C; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their fatty acid synthase inhibitory activity. From the assay, it was determined that compound II exhibited a pIC50 value of 7.26. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Formula: C7H3ClN2O2

The Article related to benzimidazole preparation fatty acid synthase inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Formula: C7H3ClN2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 31, 2008, Efremov, Ivan Viktorovich; Rogers, Bruce Nelsen; Duplantier, Allen Jacob; Zhang, Lei; Zhang, Qian; Maklad, Noha Serour; Evrard, Edelweiss Virginie; Brodney, Michael A. published a patent.Formula: C7H3ClN2O2 The title of the patent was Benzimidazolyl compounds as potentiators of mGluR2 subtype of glutamate receptor and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. Compounds of formula I wherein X1 is CR7; X2 is CR4; X3 is CR6; X4 is (CHR9)0-2; X5 is CH2, CH2CH2; X8 is CR3; R1, R2, R3, R4 and R6 are independently H, halo, CN, OH and derivatives, alkyl, alkenyl, etc.; R7 is H, halo, OH, alkyl, alkoxy, CN and alkyl-CO; R5, R8 and R9 are independently halo, CN, OH and derivatives, CO2H and derivatives, NH2 and derivatives, H, alkyl, alkenyl, etc.; R11, R12, R13 and R14 are independently halo, CN, H, CO2H and derivatives, CONH2 and derivatives, OH and derivatives, NH2 and derivatives, alkyl, etc.; R17 is (un)substituted alkyl, (un)substituted alkenyl, (un)substituted cycloalkyl, and (un)substituted cycloalkenyl; R18 is H, halo and alkyl; R19 are H; R8R19 taken together to form =O; and their pharmaceutically acceptable salts thereof, are claimed. Example compound II•HCl was prepared by reductive alkylation of 4-(2-methoxy-4-trifluoromethylphenyl)piperidine hydrochloride with 1-methyl-1H-benzo[d]imidazole-2-carboxaldehyde. All the invention compounds were evaluated for their ability to potentiate mGluR2. From the assay, it was determined that compound II exhibited EC50 value of < 0.0193 μM. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Formula: C7H3ClN2O2

The Article related to benzimidazolyl compound preparation potentiator mglur2 treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Formula: C7H3ClN2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 1, 2007, Ng, Raymond A.; Guan, Jihua; Alford, Vernon C.; Lanter, James C.; Allan, George F.; Sbriscia, Tifanie; Linton, Olivia; Lundeen, Scott G.; Sui, Zhihua published an article.Recommanded Product: 4,5-Diamino-2-(trifluoromethyl)benzonitrile The title of the article was Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives. And the article contained the following:

The synthesis and in vivo SAR of 5,6-dichloro-benzimidazole derivatives as novel selective androgen receptor antagonists were described. During screening of 2-alkyl benzimidazoles, it was found that a trifluoromethyl group greatly enhances antagonist activity in the prostate. Benzimidazole I was a potent AR antagonist in the rat prostate (ID50 = 0.15 mg/day). The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Recommanded Product: 4,5-Diamino-2-(trifluoromethyl)benzonitrile

The Article related to benzimidazole dichloro derivative preparation androgen receptor antagonist sar, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Recommanded Product: 4,5-Diamino-2-(trifluoromethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts