Nitriles-buliding-blocks

On April 12, 2004, Blazej, Sylwia; Kwast, Andrzej; Makosza, Mieczyslaw published an article.Reference of 3-Chloro-4-nitrobenzonitrile The title of the article was cine-Substitution of the nitro group in 2,4-disubstituted nitroarenes with carbanions of aryl alkyl sulfones. And the article contained the following:

Rapid protonation of short lived σH adducts, e.g., I, derived from the nucleophilic addition of aryl alkyl sulfones to 2,4-disubstituted nitrobenzenes, resulted in elimination of nitrous acid giving 1,3,5-trisubstituted benzenes, e.g., II, as products of cine-substitution of the nitro group. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

The Article related to nitrobenzene aryl alkyl sulfone cine substitution, aryl arylalkyl sulfone preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 27, 2021, Shen, Chunli; Sun, Guanglong; Wu, Chengde; Chen, Shuhui published a patent.Reference of 5-Bromo-3-hydroxypicolinonitrile The title of the patent was Bicyclic compound used as selective androgen receptor modulator. And the patent contained the following:

Disclosed are a bicyclic compound used as a non-steroidal selective androgen receptor modulator and the use thereof in the preparation of a drug for treating related diseases which are mediated by an androgen receptor. Specifically, the present invention discloses a compound as shown in formula I or a pharmaceutically acceptable salt thereof. The experimental process involved the reaction of 5-Bromo-3-hydroxypicolinonitrile(cas: 1160936-51-5).Reference of 5-Bromo-3-hydroxypicolinonitrile

The Article related to bicyclic compound preparation androgen receptor modulator treatment disease, Alicyclic Compounds: Bicyclic Compounds, Including Azulenes, Heptalenes, and Pentalenes and other aspects.Reference of 5-Bromo-3-hydroxypicolinonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Yingtian; Dang, Xinxin; He, Yu; Bai, Hudong; Chen, Xuehong; Li, Jun-Long; Fan, Junting; Jiang, Hezhong; Li, Jiahong published an article in 2019, the title of the article was Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile And the article contains the following content:

A straightforward and efficient method was developed for the synthesis of 2-cyanoacrylamides R1R2C:C(CN)CONH2 [R1 = n-Pr, Ph, 4-MeOC6H4, PhCH:CH, 2-furyl, etc., R2 = H; R1 = Ph, R2 = Me, Ph; R1R2 = (CH2)5, o-C6H4CH2CH2, etc.] from 2-methylenemalononitriles R1R2C:C(CN)2 in good to excellent yields through monohydration under mild and simple reaction conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to methylene malononitrile preparation diastereoselective monohydration palladium catalyst, cyano acrylamide preparation, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 31, 1985, Makosza, Mieczyslaw; Wenall, Maria; Golinski, Miroslaw; Kinowski, Andrzej published an article.Application of 13544-06-4 The title of the article was Reactions of organic anions. Part 130. Specific ortho-cyanomethylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen. And the article contained the following:

The reactions of 3-RC6H4NO2 (I, R = MeO, CF3, NO2, MeSO2 halo, cyano) with ClCH2CN (II), PhOCH2CN, and Me2NCS2CH2CN yielded products substituted ortho to the NO2 group. Ortho substitution also resulted in the reactions of II with o- and p-substituted nitrobenzenes. Thus, II and I (R = 2-Cl) in THF containing Me3COK at -10° to -20° gave 10% 2,3-O2N(Cl)C6H3CH2CN. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Application of 13544-06-4

The Article related to cyanomethylation nitroarene regiochem, nucleophile substitution nitroarene regiochem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitro and Nitroso Compounds and other aspects.Application of 13544-06-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 31, 2009, Liang, Jing; Zhang, Meimei; Wei, Xianyong; Zong, Zhimin; Wang, Xiangshan published an article.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was One-step synthesis of fluorene or phenanthrene derivatives via the reaction of arylaldehyde and malononitrile with 2-(1,2-dihydroinden-3-ylidene)malononitrile or 2-(2,3-dihydronaphthalen-4(1H)-ylidene)-malononitrile catalyzed by KF/Al2O3 in ethyl alcohol. And the article contained the following:

A method for the synthesis of the title compounds [i.e., 3-amino-1-(phenyl)-9H-fluorene-2,4-dicarbonitrile derivatives and 3-amino-1-(phenyl)-9,10-dihydro-2,4-phenanthrenedicarbonitrile derivatives] is reported here. A series of fluorene or phenanthrene derivatives was synthesized from aryl aldehyde derivatives, malononitrile and 2-(1,2-dihydro-3-indenylidene)malononitrile or 2-(2,3-dihydro-4-naphthalenylidene)malononitrile catalyzed by KF/Al2O3 at 80° in ethanol. This method has the advantages, such as mild reaction conditions, high yields (72-88%) and easy operation. The structures of the products were characterized by IR, NMR, elemental anal. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to phenanthrene amino phenyl phenanthrenedicarbonitrile preparation, fluorene amino phenyl fluorenedicarbonitrile preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Anthracenes and Phenanthrenes and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 27, 2021, Fu, Jiya; Zhang, Chuanbao; Zhao, Lili; Li, Ran; Deng, Yihang; Yuan, Jinfang; Wang, Yanbo; Zhu, Junyan published a patent.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the patent was Preparation of spiro dihydrofluorene derivatives. And the patent contained the following:

The invention discloses a preparation of spiro dihydrofluorene derivative, which has the advantages of high efficiency, low cost and good application prospect. Spiro dihydrofluorene derivatives are shown in formula I, wherein R1 is selected from: CN or CO2 Me; R2 is selected from substituted Ph, substituted pyridyl, substituted furanyl, substituted thiophene or substituted naphthyl; R3 is selected from one of hydrogen, halogen, alkyl, trifluoromethyl, hydroxyl, alkoxy, nitro, ester, amino, acylamino, alkacyloxy, cyano, aryl, alkenyl, halobenzyloxy, halobenzylamine or halophenoxy; R4 is selected from one of hydrogen, halogen, alkyl, trifluoromethyl, alkoxy, nitro, ester, amino, cyano, aryl, alkenyl, halobenzyloxy, halobenzylamine or halophenoxy. Spiro dihydrofluorene derivatives were prepared via cyclization of 2-benzofuranone derivatives and 1-indene methylene malononitrile. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to spiro dihydrofluorene preparation cyclization, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qin, Wenbing; Lin, Weifeng; Li, Xin; Xiong, Wei; Liu, Guokai published an article in 2020, the title of the article was Difluoromethylation of dicyanoalkylidenes by electrophilic S-(difluoromethyl)sulfonium salt: efficient construction of difluoromethylated all-carbon-substituted centers.HPLC of Formula: 2510-01-2 And the article contains the following content:

An efficient approach for difluoromethylation of dicyanoalkylidenes by electrophilic S-(difluoromethyl)sulfonium salt under organic base was described. A wide range of structurally and functionally diverse dicyanoalkylidenes was readily transferred into corresponding desirable difluoromethylated compounds bearing difluoromethylated all-carbon-substituted centers in good to excellent yields under standard reaction conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).HPLC of Formula: 2510-01-2

The Article related to difluoromethylation dicyanoalkylidene difluoromethyl sulfonium, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.HPLC of Formula: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 7, 2015, Saidalimu, Ibrayim; Tokunaga, Etsuko; Shibata, Norio published an article.Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Carbene-Induced Intra- vs Intermolecular Transfer-Fluoromethylation of Aryl Fluoromethylthio Compounds under Rhodium Catalysis. And the article contained the following:

The intra- vs intermol. transfer-fluoromethylation of aryl fluoromethylthio compounds is proposed. Finely designed ArSCF3 I [X = CF3] nicely releases its trifluoromethyl (CF3) group intermolecularly under rhodium catalysis, whereas a difluoromethylated analog, ArSCF2H I [X = CF2H] shows intramol. reaction. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to carbene induced transfer fluoromethylation aryl fluoromethylthio compound rhodium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 24, 2012, Delisser, Vern; Hedberg, Martin; Jansson, Annette; Raadevik, Andreas; Ryberg, Per; Thiering, Swantje published a patent.Synthetic Route of 34662-29-8 The title of the patent was Process for the manufacturing of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1h-indole-5-carbonitrile 701. And the patent contained the following:

The present invention relates to a new process for the manufacture of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile as a free base and pharmaceutically acceptable salts thereof, particularly the 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate, and to new intermediates prepared in said process suitable for large scale manufacturing of said compound The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Synthetic Route of 34662-29-8

The Article related to preparation morpholin indole citrate, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Synthetic Route of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 30, 2008, Delisser, Vern; Hedberg, Martin; Jansson, Annette; Raadevik, Andreas; Ryberg, Per; Thiering, Swantje published a patent.Category: nitriles-buliding-blocks The title of the patent was Process for preparation of 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile. And the patent contained the following:

The present invention pertains to a process for the preparation of 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile as a free base and pharmaceutically acceptable salts thereof, particularly the citrate salt. For example, Et 2-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]acetate was reacted with 3-fluoro-4-nitrobenzonitrile in THF at -20 °C in presence of lithium tert-butoxide to afford an intermediate, which was treated with Degussa heterogeneous catalyst (platinum and vanadium on active carbon) under hydrogen for selective reduction of nitro group to amino group. The reduction product obtained above was treated with citric acid monohydrate at 60-75 °C for 2 h in Bu acetate, DMF, and iso-propanol, cooled to 5 °C over 10 h, and held overnight at 5 °C to gave 75 % yield of 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile citrate as an orange solid. Advantageously, the new process is suitable for large scale industrial manufacturing The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Category: nitriles-buliding-blocks

The Article related to preparation morpholin indole citrate, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts