Nitriles-buliding-blocks

On February 28, 2019, Chen, Yiyang; Peng, Zhixing; Tao, Yuhan; Wang, Zaibin; Lu, Ping; Wang, Yanguang published an article.Formula: C12H8N2 The title of the article was Polymorphism-dependent emissions of two phenoxazine derivatives. And the article contained the following:

Two phenoxazine derivatives 1 and 2 were synthesized and their photoluminescent properties were systematically investigated. These two compounds presented crystallization-induced emission (CIE) with polymorphism-dependent emission (PDE). Compound 1 presented two single crystal structures with maximum emission wavelengths of 540 nm and 560 nm, while compound 2 possessed three single crystal structures with maximum emission wavelengths of 516 nm, 547 nm, and 556 nm, resp. Moreover, compound 1 showed reversible mechanochromic luminescence by grinding/heating or solvent fuming processes. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Formula: C12H8N2

The Article related to polymorphism emission phenoxazine derivative, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Formula: C12H8N2

Referemce:
Nitrile – Wikipedia,
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On October 14, 2004, Ando, Kazuo; Kawai, Makoto; Kawamura, Mitsuhiro; Matsumizu, Miyako; Morita, Asato; Sakurada, Isao published a patent.Reference of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of heterocyclic bicyclic compounds as NR2B receptor antagonists. And the patent contained the following:

Title compounds I [R1-2 = H, halo, alkyl, alkoxy, etc.; X = bond, alkylene, etc.; A = bicyclic, aromatic, (un)saturated heterocyclic ring, etc.; B = Ph, heteroaryl, etc.] are prepared For instance, N-[(2-benzyl-1H-indol-5-yl)methyl]-4-hydroxybenzamide (II)is prepared in 2 steps from (2-benzyl-1H-indol-5-yl)carbonitrile. II has Ki = 2 nM for the NR2B receptor. I is useful for the treatment of disease conditions caused by over activation of NMDA NR2B receptor, e.g., pain. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

The Article related to bicyclic benzimidazole benzoxazole quinazoline nr2b receptor antagonist preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 11, 2022, Zhai, Wenqiang; Zhang, Zhimin; Pan, Hao; Wang, Zhe; Guo, Liubin; Zhang, Yuren; Liu, Dongzhou published a patent.Category: nitriles-buliding-blocks The title of the patent was Pyrrolopyridazine compound, and preparation method therefor and use thereof. And the patent contained the following:

The present invention relates to a pyrrolopyridazine compound as represented by a formula I [wherein X = C or N; R1 = H, halo, alkyl, alkenyl, etc.; Y = H, halo, OH, NH2, etc.; R3 = H, halo, alkyl, alkenyl, etc.; L2 = a single bond, CO, alkylene, etc.; Cy2 = cycloalkylene, heterocyclylene, O, etc.; R6 = independently halo, OH, NH2, CN, etc.; L3 = a single bond, O, or alkylene; Cy3 = cycloalkyl, heterocyclyl, aryl, or heteroaryl; R8 = independently H, halo, alkyl, etc.; m = 0-4; p = 0-3; with provisos] or a pharmaceutically acceptable salt thereof, and also relates to a pharmaceutical preparation, a pharmaceutical composition and the use thereof, wherein the compound can be used for the preparation of drugs for treating or preventing related diseases mediated by HPK1. For example, II was prepared in a multi-step synthesis. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Category: nitriles-buliding-blocks

The Article related to pyrrolopyridazine hpk1 treatment cancer human, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
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On October 31, 2003, Elinson, M. N.; Fedukovich, S. K.; Zaimovskaya, T. A.; Vereshchagin, A. N.; Nikishin, G. I. published an article.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Electrocatalytic transformation of malononitrile and cycloalkylidenemalononitriles into spirotricyclic and spirotetracyclic compounds containing cyclopropane and pyrroline fragments. And the article contained the following:

Electrolysis of cycloalkylidenemalononitriles and malononitrile in MeOH in an undivided cell in the presence of the NaBr-NaOMe mediator system gives spirotricyclic compounds containing cyclopropane and pyrroline fragments in 50-77% yields. Spirobicyclic and spirotricyclic tetracyanocyclopropanes undergo electrolysis in alcs. to afford spirotricyclic and spirotetracyclic products containing cyclopropane and pyrroline fragments in 50-93% yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to electrocatalytic spirocyclization malononitrile cycloalkylidenemalononitrile spirotricyclic spirotetracyclic cyclopropane pyrroline, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 17, 2020, Feng, Jiaxu; Chen, Yingying; Qin, Wenhui; Huang, You published an article.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Phosphine-Catalyzed (3 + 2)/(3 + 2) Sequential Annulation of γ-Vinyl Allenoates: Access to Fused Carbocycles. And the article contained the following:

The first (3 + 2)/(3 + 2) sequential annulation of γ-vinyl allenoates with alkylidenemalononitriles enabled by phosphine catalysis has been reported. A broad range of structurally dense tetra- and penta-substituted bicyclic[3,3,0]octene derivatives, containing a quaternary center and three sequential stereogenic center, were synthesized in good to excellent yields. In this approach, three new C-C bonds are formed in one pot, and εC and αC of γ-vinyl allenoate are two electrophilic centers, whereas its γC exhibits nucleophilic reactivity. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to alkylidenemalononitrile vinyl allenoate phosphine catalyst sequential diastereoselective annulation, fused carbocycle one pot preparation, Alicyclic Compounds: Tricyclic Compounds and Higher Analogs, Including Adamantanes, Fullerenes and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 31, 2009, Li, Xiaochuan; Kim, Sung-Hoon; Kun, Jun; Son, Young-A. published an article.Electric Literature of 2510-01-2 The title of the article was Synthesis and Optical Properties of (A)n-π-(Ph)3N Type Dyes. And the article contained the following:

Two new (A)n-π-(Ph)3N type dyes were designed, synthesized and characterized. The optical properties and structures of them were studied, including UV-visible spectroscopy, photo-luminescence spectroscopy. The geometric structures of them were calculated theor. based on the DFT level using BLYP/GGA basis set, the HOMO/LOMO levels were also measured and calculated The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Electric Literature of 2510-01-2

The Article related to dye synthesis optical property, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Optical Properties (Linear) and other aspects.Electric Literature of 2510-01-2

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Nitrile – Wikipedia,
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On December 27, 2018, Du-Cuny, Lei; Xiao, Qitao; Xun, Guoliang; Zheng, Qiangang published a patent.Product Details of 1036991-35-1 The title of the patent was Preparation of substituted 5-cyanoindole compounds for the treatment of lysine (K)-specific demethylase 1A mediated diseases. And the patent contained the following:

A compound of formula I, or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1) – mediated diseases or disorders. Compounds of formula I wherein R1 is substituted C1-6 alkyl, substituted C3-6 cycloalkyl, substituted 7- to 11-membered spirocyclyl, etc.; R2 is H, halo, C1-4 alkyl, C1-4 haloalkyl, etc.; R3 is (un)substituted aminophenyl, (un)substituted aminopyridinyl, (un)substituted indolinyl, etc.; R4 is H, halo and C1-4 alkyl; R5 is H, halo, C1-4 alkyl, C1-4 haloalkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their LSD1 modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 0.010 μM. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Product Details of 1036991-35-1

The Article related to cyanoindole preparation lsd1 modulator, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 1036991-35-1

Referemce:
Nitrile – Wikipedia,
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On December 4, 1997, Mitchell, Glynn; Smith, Stephen Christopher published a patent.Application of 13544-06-4 The title of the patent was Preparation of 1-aminoacetylindolines and analogs as herbicides. And the patent contained the following:

RC(:W1)CR1R2YC(:W2)ZR3 [I; R = (un)substituted indolino; R1,R2 = H or alkyl; R3 = H or (halo)aliphatyl, etc.; W1,W2 = O or S; Y = O or NR4; R4 = H, alkoxy, aliphatyl; Z = NR5 or CR6R7; R5-R7 = H or aliphatyl; R4R5 = CH2CH2, CH:CH, COCO, CH2CO; R6R7 = atoms to complete a carbocyclic ring] were prepared Thus, (EtO2CCH2)2NH was N-acylated by Me3CNCO and the product cyclized to give, after saponification, 2,4-dioxo-3-tert-butylimidazolidine-1-acetic acid which was chloridnated and the product amidated by 6-chloroindoline to give title compound II. Data for biol. activity of I were given. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Application of 13544-06-4

The Article related to aminoacetylindoline preparation herbicide, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 13544-06-4

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Nitrile – Wikipedia,
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On December 31, 2018, Dyachenko, V. D.; Matusov, I. O.; Dyachenko, I. V.; Nenajdenko, V. G. published an article.Reference of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Knoevenagel Reactions of Indole-3-carbaldehyde. Synthesis of 3-Substituted Indole Derivatives. And the article contained the following:

The Knoevenagel condensations of 1H-indole-3-carbaldehyde with various CH acids gave a number of substituted 3-(1H-indol-3-yl)acrylonitriles and acrylamides which were alkylated to afford the corresponding N-alkyl derivatives I [R = CN, CO2(CH2)6CH3, C(O)NHc-Pr; R1 = Me, allyl, Bn, etc.]. The latter were used as Michael acceptors in the synthesis of 4H-pyran, pyridine, 5,6,7,8-tetrahydroquinoline and [1,3]thiazolo[3,2-a]pyridine derivatives containing an indole fragment. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Reference of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indole preparation, nitrile indole knoevenagel condensation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 25, 2018, Cao, Dongdong; Yang, Jianguo; Ying, Anguo; Mo, Hanjie; Chen, Dingben; Chen, Gang published a patent.Category: nitriles-buliding-blocks The title of the patent was Method for preparing trisubstituted 4-aminocarbazole and disubstituted 1-aminodibenzo[b,d]thiophene compound from 3-nitroindole compound or 3-nitrobenzothiophene and 2-(1-arylethylidene)malononitrile. And the patent contained the following:

The title method for preparing trisubstituted 4-aminocarbazole and disubstituted 1-aminodibenzo[b,d]thiophene compound includes adopting 3-nitroindole compound or 3-nitrobenzothiophene and 2-(1-arylethylidene)malononitrile as raw materials, reacting at 50°C for 6-24 h in solvent acetonitrile under the catalysis of triethylamine under the protection of nitrogen gas to obtain the final product. For instance, 1-amino-3-phenyl-2-dibenzothiophenecarbonitrile was prepared from 3-nitro-benzo[b]thiophene and 2-(1-phenylethylidene)-propanedinitrile in 52% yield. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks

The Article related to aminocarbazole aminodibenzothiophene preparation cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts