Nitriles-buliding-blocks

Application of 105942-08-3In 2018 ,《Design, synthesis and evaluate of novel dual FGFR1 and HDAC inhibitors bearing an indazole scaffold》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Liu, Jian; Qian, Chengbo; Zhu, Yehua; Cai, Jianguo; He, Yufang; Li, Jie; Wang, Tianlin; Zhu, Haohao; Li, Zhi; Li, Wei; Hu, Lihong. The article conveys some information:

Both histone deacetylase (HDAC) and fibroblast growth factor receptor (FGFR) are important targets for cancer therapy. Although combining dual HDAC pharmacophore with tyrosine kinase inhibitors (TKIs) had achieved a successful progress, dual HDAC/FGFR1 inhibitors haven’t been reported yet. Herein, we designed a series of hybrids bearing 1H-indazol-3-amine and benzohydroxamic acids scaffold with scaffold hopping and mol. hybridization strategies. Among them, compound 7j showed the most potent inhibitory activity against HDAC6 with IC50 of 34 nM and exhibited the great inhibitory activities against a human breast cancer cell line MCF-7 with IC50 of 9 μM in vitro. Meanwhile, the compound also exhibited moderate FGFR1 inhibitory activities. This study provides new tool compounds for further exploration of dual HDAC/FGFR1 inhibition. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application of 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Application of 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Safety of 4-Cyano-3-fluorophenyl 4-butylbenzoateOn June 3, 2015, Rozwadowski, Tomasz; Massalska-Arodz, Maria; Kolek, Lukasz; Grzybowska, Katarzyna; Bak, Andrzej; Chledowska, Krystyna published an article in Crystal Growth & Design. The article was 《Kinetics of Cold Crystallization of 4-Cyano-3-fluorophenyl 4-Butylbenzoate (4CFPB) Glass Forming Liquid Crystal. I. Nonisothermal Process As Studied by Microscopic, Calorimetric, and Dielectric Methods》. The article mentions the following:

For 4-cyano-3-fluorophenyl 4-butylbenzoate (4CFPB), the process of the crystallization of the CrII phase was studied in microscopic (POM), calorimetric (DSC), and dielec. (BDS) nonisothermal experiments with various (0.5-50 K/min) heating of the metastable nematic phase obtained from its glass. Growth of areas of crystal CrII in the microscopic texture of nematic phase during heating allows estimation of degree of crystallinity D(T) vs temperature curves similar to these obtained basing on DSC heat flow curves and for slow heating with help of dielec. relaxation (BDS) method. Two types of CrII crystallization mechanisms seem to be identified: (1) strong ϕ dependence on temperature of full crystallization Tc(ϕ) and half time of crystallization t1/2(ϕ) on slow heating up to 5 K/min points to diffusion-controlled mechanism with the energy barrier 57 kJ/mol, and (2) small effect of faster heating on Tc(ϕ) and t1/2(ϕ) seems to illustrate thermodn. mechanism with energy barrier 180 kJ/mol. The scenario of two mechanisms of CrII crystallization is in agreement with the results of new method proposed by Mo et al., using combination of Avrami and Ozawa equations for description of nonisothermal crystallization In addition to crystallization of CrII of 4CFPB, at higher temperature range CrII-CrI transformation to a stable CrI crystal was digitalized based on microscopic and DCS results for heating at 1 K/min. In the part of experimental materials, we found many familiar compounds, such as 4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5Safety of 4-Cyano-3-fluorophenyl 4-butylbenzoate)

4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Safety of 4-Cyano-3-fluorophenyl 4-butylbenzoate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 1954,Journal of the Chemical Society included an article by Gray, G. W.; Jones, Brynmor. Safety of 5-Amino-1-naphthonitrile. The article was titled 《The preparation of 4- and 5-n-alkoxy-1-naphthoic and 6-and 7-n-alkoxy-2-naphthoic acids》. The information in the text is summarized as follows:

1-Naphthol was alkylated with NaOEt and the n-alkyl bromide or iodide by boiling 8 h. in EtOH. Distillation under reduced pressure gives the following ethers in 65-70% yield (b. p./mm. given): Me 134°/13, Et 152°/17 (m. 5°), Pr 143°/3, Bu 160°/4 (m. 19.5°), pentyl 173°/6 (m. 29.5°), hexyl 166°/4 (m. -3°), heptyl 171°/5, octyl 189°/5, nonyl 185°/4, decyl 212°/4, dodecyl 227°/3, hexadecyl 258°/1 (m. 31°), octadecyl 236°/10-2 (m. 50.5°). The 1-n-alkoxynaphthalenes were brominated with IBr in CHCl3 at 10-20°. The CHCl3 is removed and the 4-Br ethers are distilled under reduced pressure, being obtained in 65-75% yields (b. p./mm. given): Me 159°/4, Et 158°/3 (m. 48.5°), Pr 188°/8 (m. 31°), Bu 199°/5 (m. 25°), pentyl 181°/3 (m. 47.5°), hexyl 206°/5 (m. 45°). 1-n-Alkoxynaphthalenes in CS2 containing AlCl3 are treated with BrCN to form 4-n-alkoxy-1-naphthonitriles (I) in 80% yield (m. p. given): Et 88°, pentyl 60°, hexyl 62°, heptyl 54°, octyl 61°, nonyl 53°, decyl 64°, dodecyl 67°, hexadecyl 69°, octadecyl 71°. 4-n-Alkoxy-1-naphthoic acids are made from 1 g.-atom Mg turnings and 2 g. of the 1-bromonaphthalene in 25 mL. ether by refluxing 5 min. A total of 0.1 mol of the 1-bromonaphthalene in 75 mL. ether is added dropwise in 30 min. and reflux is continued 10 h. The mixture is added to ether saturated with Dry Ice. The excess CO2 is evaporated and the solution stirred with 50 mL. 17% HCl. The ether is removed and the acid washed free of MgCl2. The acids are recrystallized from glacial HOAc in 80-5% yield. Another method of forming the acids is to reflux 0.1 mol of the nitrile with 250 mL. of a solution of MeOH saturated with KOH for 15-25 h. The diluted mixture is acidified, redissolved in NaOH, and reacidified to give the following 1-carboxy analogs of I in 95-7% yields (m. p. given): Me 248°, Et 220°, Pr 203°, Bu 213.5°, pentyl 207°, hexyl 212°, heptyl 189°, octyl 183.5°, nonyl 161°, decyl 174.5°, dodecyl 147.5°, hexadecyl 136°, octadecyl 137.5°. Na 5-aminonaphthalene-1-sulfonate (70 g.) and 14 g. KCN are ground together and dry-distilled in an all-glass retort at 500-600°, the distillate is dissolved in 1.3 l. boiling 0.3N HCl, the solution is cooled and filtered, and the filtrate is neutralized with concentrated NH3 to give 22-6% 5-amino-1-naphthonitrile (II), m. 140°, b2-3 187-93°. II (0.03 mol) is dissolved in 60 mL. glacial HOAc at 80°, 60 mL. 40% H2SO4 is added with stirring, the solution is cooled to 0°, 0.06 mol NaNO2 in 30 mL. H2O is added, the solution is stirred at 0-5° until it clears, urea is used to destroy the excess NO2-, the solution is immediately added dropwise with stirring to a boiling solution of 180 mL. 40% H2SO4 in 30 min. refluxing is continued 1 h., the mixture is cooled, 300 mL. H2O is added, the solution is extracted with ether, the ether is extracted with N NaOH, and the basic extract is acidified to give 67% 5-hydroxy-1-naphthonitrile (III), m. 204-6°. After 8.4 g. III is refluxed with 50 g. KOH in 100 mL. H2O for 4-5 h., acidification gives 90% 5-hydroxy-1-naphthoic acid (IV), m. 238°; acetyl derivative, m. 204-5°. IV is methylated with Me sulfate at 40-50° in basic solution (the ester, which is a byproduct, is removed by refluxing with MeOH-KOH). The product is 5-methoxy-1-naphthoic acid (V), m. 232.5°. The following homologs of V are similarly prepared (alkyl and m. p. given): Et 201°, Pr 189°, Bu 172°, pentyl 143°, hexyl 154°, heptyl 135.5°, octyl 142.5°, nonyl 143°, decyl 137°, dodecyl 125°, hexadecyl 117.5°, octadecyl 122°. 2-Naphthol (1 mol) in 400 mL. glacial HOAc is brominated at room temperature and the resulting 1,6-dibromo-2-naphthol is reduced with mossy Sn at reflux to give 90-100% 6-bromo-2-naphthol (VI), m. 123-7°. The VI is treated with Me sulfate in alkali to give 60-70% 2-bromo-6-methoxynaphthalene (VII), m. 106-7°, b. 189-99°/20 mm. 6-Methoxy-2-naphthoic acid is formed from VII by the method of Fries and Schimmelschmidt (C.A. 20, 1616), m. 206° in 50-5% yield. AcCl treated with VII in the presence of AlCl3 in PhNO2 and distillation gives 5% 2-acetyl-6-methoxynaphthalene (VIII), m. 104-5°, b. 165-70°/3-4 mm. VIII (50 g.) in 350 mL. dioxane, is treated with NaOBr (from 140 g. NaOH, 600 mL. H2O, and 50 mL. Br) dropwise for 30 min. at 35-40° (reaching 50-5° at the end), excess Br is destroyed, 2 l. H2O is added, dioxane and CHBr3 are removed by steam distillation, and the solution is filtered and acidified with concentrated HCl to give 70-5% 6-methoxy-2-naphthoic acid (IX), m. 205-6°. IX (8 g.) is heated 2.5 h. with 35 mL. AcOH, 35 mL. 48% HBr, and 20 mL. glacial HOAc to give 6-hydroxy-2-naphthoic acid (X), m. 250° (Bz derivative, m. 257°; Ac derivative, m. 228°; phenylsulfonyl derivative, m. 228.5°). X was alkylated in 85-90% yield. The following 6-alkoxy analog of X were prepared (alkyl and m. p. given): Me 206°, Et 213°, Pr 208°, Bu 198°, pentyl 179.5°, hexyl 147°, heptyl 163°, octyl 161.5°, nonyl 147.5°, decyl 139°, dodecyl 119°, hexadecyl 107°, octadecyl 114.6°, isopentylnaphthoic acid 194.6°, 3,5,5-trimethylhexyl 170°. 7-Amino-2-naphthonitrile m. 197°. 7-Hydroxy-2-naphthonitrile, m. 186.5°. 7-Hydroxy-2-naphthoicacid m. 269-70°. 7-n-Octyloxy-2-naphthoic acid m. 142.5°, sublimes 170°/2-3 mm. 7-n-Hexadecyloxy-2-naphthoic acid m. 138°. The results came from multiple reactions, including the reaction of 5-Amino-1-naphthonitrile(cas: 72016-73-0Safety of 5-Amino-1-naphthonitrile)

5-Amino-1-naphthonitrile(cas: 72016-73-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Safety of 5-Amino-1-naphthonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kim, Young Ha; Lee, Hyuk; Kim, Yeong Joon; Kim, Bum Tae; Heo, Jung-Nyoung published an article on January 18 ,2008. The article was titled 《Direct One-Pot Synthesis of Phenanthrenes via Suzuki-Miyaura Coupling/Aldol Condensation Cascade Reaction》, and you may find the article in Journal of Organic Chemistry.Related Products of 325141-71-7 The information in the text is summarized as follows:

An efficient cascade reaction was developed where a Suzuki-Miyaura coupling is followed by an aldol condensation, for the construction of phenanthrene derivatives using microwave irradiation For example, the reaction of Me 2-bromophenylacetamide with 2-formylphenylboronic acid in the presence of a palladium catalyst and a base provided a biaryl intermediate, which underwent in situ cyclization to afford the corresponding phenanthrene I in high yield. This methodol. was used to synthesis a fluorescent phenanthrene excimer by bromination of 10-methylphenanthrene Et ester, a product from the previous cascade reaction, followed by lactamization with methylamine. The results came from multiple reactions, including the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile(cas: 325141-71-7Related Products of 325141-71-7)

2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile(cas: 325141-71-7) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Related Products of 325141-71-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2003,Langer, Peter; Anders, Joachim T.; Weisz, Klaus; Jaehnchen, Judith published 《Efficient synthesis of 2-alkylidene-3-iminoindoles, indolo[1,2-b]isoquinolin-5-ones, δ-carbolines, and indirubines by domino and sequential reactions of functionalized nitriles》.Chemistry – A European Journal published the findings.Application of 31938-07-5 The information in the text is summarized as follows:

The sodium hydride mediated cyclization of arylacetonitriles with oxalic acid bis(imidoyl) dichlorides, aza-analogs of oxalyl chloride, afforded functionalized 2-alkylidene-3-iminoindoles with very good regio- and E/Z selectivity. Excellent chemoselectivities were observed for functionalized substrates. Based on these results a domino “”cyclization-lactamization”” reaction of bis(imidoyl) chlorides with Me 2-(cyanomethyl)benzoate was developed. This process allowed a convenient one-pot synthesis of indolo[1,2-b]isoquinolin-5-ones related to tryptanthrin. A new and convenient synthesis of δ-carbolines by intramol. electrocyclization-elimination reactions of 2-alkylidene-3-iminoindoles was developed. It was shown that δ-carbolines selectively bind to triplex or duplex DNA (intercalation). Indirubine analogs were prepared by deprotection and lactonization of functionalized 2-alkylidene-3-iminoindoles. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Application of 31938-07-5)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Application of 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2013,Wu, Hai-Qiu; Yan, Zi-Hong; Chen, Wen-Xue; He, Qiu-Qin; Chen, Fen-Er; De Clercq, Erik; Balzarini, Jan; Daelemans, Dirk; Pannecouque, Christophe published 《Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies》.Bioorganic & Medicinal Chemistry published the findings.SDS of cas: 31938-07-5 The information in the text is summarized as follows:

A series of C6-rigid S-DABO analogs characterized by a substituted benzoyl group at C6 position of the pyrimidine ring has been synthesized and biol. evaluation as NNRTIs against wild-type HIV-1 strain IIIB, double RT mutant (K103N + Y181C) strain RES056 as well as HIV-2 strain ROD in MT-4 cell cultures. Most of the compounds exhibited moderate antiviral activities. Among them, compound 7q displayed the highest anti-HIV-1 activity with an EC50 value of 0.26 μM and a selectivity index (SI) of 541. The preliminary structure-activity relationship (SAR) of these new S-DABOs was investigated, the target RT was confirmed and docking study was performed. After reading the article, we found that the author used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5SDS of cas: 31938-07-5)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.SDS of cas: 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Cellulose (Dordrecht, Netherlands) included an article by Dong, Yahao; Bi, Jiajun; Zhu, Dajian; Meng, Di; Ming, Shujun; Guo, Wen; Chen, Zhen; Liu, Qian; Guo, Lei; Li, Tao. Recommanded Product: 623-00-7. The article was titled 《Functionalized cellulose with multiple binding sites for a palladium complex catalyst: synthesis and catalyst evaluation in Suzuki-Miyaura reactions》. The information in the text is summarized as follows:

Due to their eco-friendly nature, polysaccharides are desirable supporting materials in organic transformations. Nevertheless, as is the case for other supports, polysaccharides have to face the issue of seeking more binding sites via multifunctional structures to capture metal species in the catalyst, which enhance stability and promote catalytic performance in aforementioned process. In this paper, an environmentally-friendly and multifunctional cellulose supported Pd(II)-Schiff base complex is fabricated and applied in the formation of different biaryls under mild ambient conditions. The results of thermal anal. reveal that the composite has high thermal stability. The as-prepared catalyst demonstrates to be a robust and efficient catalyst with more than 90% yields in H2O: EtOH (1:1) at 70° by using 0.30 mol% of catalyst under air towards the coupling of various substituted aryl halides and phenylboronic acids. Moreover, identified by ICP-OES anal., the green Pd(II) catalyst displays higher metal content (1.93%) in comparison with the direct deposition of Pd particles on cellulose (0.93%), and prevents the metal leaching (< 1%) via the coordination interaction of multiple capturing sites (-OH, Schiff base and pyridyl moieties) with palladium. The resultant catalyst is characterized by FT-IR, TGA, XRD, SEM, TEM, XPS, CP/MAS 13C-NMR, and ICP-OES examination Also, this green catalyst is able to be retrieved in five cycles with simple centrifugation. Notably, the authors propose a plausible multifunctional catalyst complex. The present study offers a novel and effective supported catalyst, which broadens the contributions of polysaccharides in green catalysis. The experimental process involved the reaction of 4-Bromobenzonitrile(cas: 623-00-7Recommanded Product: 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Recommanded Product: 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Pyrrolopyrimidine vs. Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase》 were Revuelto, Alejandro; Ruiz-Santaquiteria, Marta; de Lucio, Hector; Gamo, Ana; Carriles, Alejandra A.; Gutierrez, Kilian Jesus; Sanchez-Murcia, Pedro A.; Hermoso, Juan A.; Gago, Federico; Camarasa, Maria-Jose; Jimenez-Ruiz, Antonio; Velazquez, Sonsoles. And the article was published in ACS Infectious Diseases in 2019. Application In Synthesis of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:

Disruption of protein-protein interactions of essential oligomeric enzymes by small mols. represents a significant challenge. We recently reported some linear and cyclic peptides derived from an α-helical region present in the homodimeric interface of Leishmania infantum trypanothione reductase (Li-TryR) that showed potent effects on both dimerization and redox activity of this essential enzyme. Here, we describe our first steps toward the design of nonpeptidic small-mol. Li-TryR dimerization disruptors using a proteomimetic approach. The pyrrolopyrimidine and the 5-6-5 imidazole-phenyl-thiazole α-helix-mimetic scaffolds were suitably decorated with substituents that could mimic three key residues (K, Q, and I) of the linear peptide prototype (PKIIQSVGIS-Nle-K-Nle). Extensive optimization of previously described synthetic methodologies was required. A library of 15 compounds bearing different hydrophobic alkyl and aromatic substituents was synthesized. The imidazole-phenyl-thiazole-based analogs outperformed the pyrrolopyrimidine-based derivatives in both inhibiting the enzyme and killing extracellular and intracellular parasites in cell culture. The most active imidazole-phenyl-thiazole compounds 3e and 3f inhibit Li-TryR and prevent growth of the parasites at low micromolar concentrations similar to those required by the peptide prototype. The intrinsic fluorescence of these compounds inside the parasites visually demonstrates their good permeability in comparison with previous peptide-based Li-TryR dimerization disruptors. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application In Synthesis of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Nickel-Catalyzed Tandem Reaction of Functionalized Arylacetonitriles with Arylboronic Acids in 2-MeTHF: Eco-Friendly Synthesis of Aminoisoquinolines and Isoquinolones》 was published in Chemistry – An Asian Journal in 2020. These research results belong to Zhen, Qianqian; Chen, Lepeng; Qi, Linjun; Hu, Kun; Shao, Yinlin; Li, Renhao; Chen, Jiuxi. Reference of 4-Bromo-2-fluorobenzonitrile The article mentions the following:

The first example of the nickel-catalyzed tandem addition/cyclization of 2-(cyanomethyl)benzonitriles R1-2-(NCCH(R2))C6H3CN (R1 = H, 4-Me, 6-Ph, 5-Br, etc.; R2 = H, Ph, thiophen-3-yl, i-Pr, etc.) with arylboronic acids ArB(OH)2 (Ar = Ph, thiophen-3-yl, benzo[d][1,3]dioxol-5-yl, etc.) in 2-MeTHF has been developed, which provides the facile synthesis of aminoisoquinolines I (R1 = H, 6-Me, 8-Ph, 7-Br, etc.) with good functional group tolerance under mild conditions. This chem. has also been successfully applied to the synthesis of isoquinolones II by the tandem reaction of Me 2-(cyanomethyl)benzoates with arylboronic acids. The use of the bio-based and green solvent 2-MeTHF as the reaction medium makes the synthesis process environmentally benign. The synthetic utility of this chem. is also indicated by the synthesis of biol. active mols. The experimental process involved the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Reference of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Reference of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Synthesis and Characterization of Ultrapure HKUST-1 MOFs as Reusable Heterogeneous Catalysts for the Green Synthesis of Tetrazole Derivatives》 was published in ChemistrySelect in 2020. These research results belong to Kal-Koshvandi, Afsaneh Taheri; Maleki, Ali; Tarlani, Aliakbar; Soroush, Maral Rahim. Recommanded Product: 4-Fluorobenzonitrile The article mentions the following:

An ultrapure HKUST-1 MOFs synthesized through a precised methodol. as a heterogeneous catalyst for a green approach to the synthesis of tetrazole derivatives via two-, three-, and four-component reactions in milder reaction conditions was presented. Various preparation methods to produce HKUST-1 such as microwave irradiation, reflux, hydrothermal technique, and ultrasonication was precisely compared and it was proved that the best result was obtained during the hydrothermal technique. This was the first design, preparation, characterization and application in the present of HKUST-1 MOFs to the synthesis of the biol. and pharmaceutically important tetrazole compounds in green conditions. Moreover, plausible mechanisms of reactions was suggested for the catalytic activity of the presented catalyst. The catalyst was characterized by various techniques such as FT-IR, SEM, EDX, and XRD. Addnl., HKUST-1 was recoverable as well as reusable without any significant loss of its activity, which strongly supports the heterogeneous nature of the catalyyst. This novel catalysis protocol offered several advantages such as eco-friendly conditions, lower reaction time, milder reaction conditions, excellent catalytic activity and an easy separation of the catalyst make it a good heterogeneous system. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts