Nitriles-buliding-blocks

Zatsikha, Yuriy V. published the artcileEnvironmentally Benign Route for Scalable Preparation of 1-Imino-3-thioisoindolines-The Key Building Blocks for the Synthesis of Dithio- and Diamino-β-isoindigo Derivatives, COA of Formula: C8H4N2, the main research area is imino thioisoindoline synthesis; dithio diamino beta isoindigo derivative synthesis.

A one-step, gram-scale protocol for the preparation of 1-imino-3-thioisoindolines and a novel one-pot two-step methodol. of the synthesis of dithio- or diamino-β-isoindigo derivatives starting from phthalonitriles and sodium hydrosulfide in an aprotic dipolar solvent have been developed. It was demonstrated that the electronic properties of the substituent(s) in the phthalonitrile core play a critical role in β-isoindigo synthesis resulting either in the selective formation of dithio- or diamino-β-isoindigo chromophores. The N-acylated 1-imino-3-thioisoindolines can be used for the direct, easily scalable, and chromatog.-free procedure for the preparation of a new class of N,N’-diacylamino-β-isoindigoid compounds Properties of the monomeric as well as J-aggregated forms of dithio- and diamino-β-isoindigo were probed by the absorption and fluorescence spectroscopies. It was demonstrated that the tetracyano-diamino-β-isoindigo 3f can form a J-aggregate that absorbs at 793 nm and fluoresces at 824 nm. This aggregate is stable in N,N-dimethylformamide solution; however, it slowly dissociates in THF or under sonication conditions. D. functional theory (DFT) and time-dependent DFT (TDDFT) calculations were employed to elucidate the electronic structures, spectroscopic properties, and aggregation of new dithio- and diamino-β-isoindigo derivatives

Journal of Organic Chemistry published new progress about Cyclization. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, COA of Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chan, Joseph Y. M. published the artcile[3 + 1] Mixed Cyclization: A Synthetic Route to Prepare Low-Symmetry Phthalocyanines, HPLC of Formula: 91-15-6, the main research area is zinc phthalocyanine nanoparticle preparation; base promoted cyclization trisphthalonitrile metal template.

A novel synthetic strategy for low-symmetry phthalocyanines was developed, which involves the base-promoted cyclization of a preconnected trisphthalonitrile and a free phthalonitrile in the presence of a metal template. By using this [3 + 1] mixed cyclization approach, a series of zinc(II) phthalocyanine derivatives were synthesized in up to 12% yields, including a very rare ABCD-type phthalocyanine and an amphiphilic ABAC-type analog that can self-assemble in aqueous media, forming stable spherical nanoparticles.

Journal of Organic Chemistry published new progress about Cyclization. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Chunyan published the artcileA practical base mediated synthesis of 1,2,4-triazoles enabled by a deamination annulation strategy, Recommanded Product: Picolinonitrile, the main research area is trisubstituted triazole preparation; nitrile hydrazine deamination annulation base mediated.

A rapid and efficient base mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles I [R = i-Pr, Ph, 1-naphthyl, etc.; R1 = n-Bu, Ph, 2-furyl, etc.] was developed using the annulation of nitriles with hydrazines, which could be expanded to a wide range of triazoles in good to excellent yields. Ammonia gas was liberated during the reaction, and halo and hetero functional groups as well as free hydroxyl and amino groups are tolerated in this transformation. A variety of alkyl and aryl-substituted nitriles could be functionalized with aromatic and aliphatic hydrazines employing this procedure. This finding provided a practical and useful strategy for the synthesis of various 15N-labeled 1,2,4-triazole derivatives, and two types of mGlu5 receptor pharmaceuticals could be easily assembled in a one-pot manner.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyclization. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Campaigne, E. published the artcileCyclization of ylidenemalononitriles. VIII. Synthesis of coumarins from o-methoxybenzylidenemalonitriles, Formula: C9H9NO2, the main research area is coumarin; malononitrile benzylidene cyclization; cyclization benzylidenemalononitrile.

The coumarins I (R = H, Cl; R1 = H, 6-,7-,8-MeO) were prepared by direct cyclization of α-cyano-o-methoxycinnamates (II) in H2SO4. Alkoxy groups other than the o-methoxy group involved in lactone formation are not hydrolyzed during the reaction. The 3-cyano group on the resulting coumarin is not hydrated in concentrated H2SO4, but can be converted to the carbamido group in 90% sulfuric acid. In certain cases these conditions do cleave methoxy substituents on the coumarins. The indenones III can be obtained by cyclizing the II with BF3.Et2O.

Journal of Heterocyclic Chemistry published new progress about Cyclization. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Formula: C9H9NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Stefancich, Giorgio published the artcileResearch on nitrogen heterocyclic compounds. XII. Synthesis of 5H-pyrrolo[1,2-b][2]benzazepine derivatives, Application of 2-(2-(Bromomethyl)phenyl)acetonitrile, the main research area is pyrrolobenzazepine; carboxymethylbenzylpyrrole preparation cyclization; chloromethylbenzylpyrrolecarboxaldehyde cyclization.

Several routes to the unknown 5H-pyrrolo[1,2-b][2]benzazepine ring system have been explored. 1-(2-Cyanobenzyl)pyrrole was useful as starting material for 1-(2-carboxymethylbenzyl)pyrrole and 1-(2-chloromethylbenzyl)-2-pyrrolecarboxaldehyde. Polyphosphoric acid-catalyzed intramol. cyclization of the former substance and treatment of the latter compound with KCN led to 11-oxo-10,11-dihydo-5H-pyrrolo[1,2-b][2]benzazepine and to 10-cyano-5H-pyrrolo[1,2-b][2]benzazepine, resp., which were converted to the parent nucleus 5H-pyrrolo[1,2-b][2]benzazepine and its 10,11-dihydro- and 1,2,3,10,11,11a-hexahydro derivatives

Journal of Heterocyclic Chemistry published new progress about Cyclization. 73217-11-5 belongs to class nitriles-buliding-blocks, name is 2-(2-(Bromomethyl)phenyl)acetonitrile, and the molecular formula is C9H8BrN, Application of 2-(2-(Bromomethyl)phenyl)acetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Barrett, Anthony G. M. published the artcileOxazole synthesis with minimal purification: synthesis and application of a ROMPgel Tosmic reagent, Name: 4-(5-Oxazolyl)benzonitrile, the main research area is oxazole preparation ROMPgel Tosmic reagent.

The synthesis of ring opening metathesis, polymer-supported Tosmic reagent I, prepared in 7 steps from 4-bromothiophenol, is described. This reagent was utilized in the conversion of aldehydes to a small library of oxazoles in good yields and purities. Thus, reacting PhCHO with I gave oxazole II in 51% yield and 90% purity.

Organic Letters published new progress about Cyclization. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Name: 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gumrukcu, Selin published the artcileIn-situ synthesis of phthalocyanines on electrospun TiO2 nanofiber by solvothermal process for photocatalytic degradation of methylene blue, Recommanded Product: Phthalonitrile, the main research area is phthalocyanine electrospun titanium dioxide nanofiber methylene blue photocatalytic degradation.

Titanium dioxide/phthalocyanine (TiO2/Pc), TiO2/fluor containing phthalocyanine (TiO2/FPc), and TiO2/fluor containing cobalt phthalocyanine (TiO2/FCoPc) had been successfully fabricated by a simple combination of phthalocyanines obtained by insitu synthesis on the surface of TiO2 nanofibers prepared by electrospinning. SEM micrographs and X-ray diffraction anal. indicated that the phthalocyanines uniformly immobilized on the surface of TiO2 nanofibers. Photocatalytic activity of TiO2, TiO2/Pc, TiO2/FPc, TiO2/FCoPc nanofibers for methylene blue in water was comparatively investigated firstly by ultravioletvisible absorption measurements with time, and kinetic parameters were calculated Results indicated that the obtained TiO2/Pc, TiO2/ FPc and TiO2/FCoPc exhibited high photocatalytic activity for the degradation of methylene blue and TiO2/FCoPc was found the best. It showed similar or higher activities than related studies and can be suggested as a promising candidate for environmental and energy applications.

Turkish Journal of Chemistry published new progress about Calcination. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Watson, Angus A. published the artcilePurine N-oxides. 66. Synthesis of 9-hydroxyadenine, Product Details of C10H11N3O3S, the publication is Journal of Organic Chemistry (1977), 42(9), 1610-12, database is CAplus and MEDLINE.

The synthesis of 9-hydroxyadenine (I, R = H), by a variation of the Shaw purine synthesis, involved the condensation of Et N-(dicyanomethyl)formimidate tosylate with benzyloxyamine to a cyanoimidazole derivative II (R = H), which was then ring-closed to III (R = H) and hydrolyzed to the desired purine derivative This is the 3rd adenine N-oxide isomer available for carcinogenicity testing. Analogously prepared was I (R = Me).

Journal of Organic Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C7H16Cl2Si, Product Details of C10H11N3O3S.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Thanassi, John W. published the artcileReactions of aminomalononitrile with electrophiles, Category: nitriles-buliding-blocks, the publication is Journal of Molecular Evolution (1975), 7(1), 65-73, database is CAplus and MEDLINE.

Aminomalononitrile reacted with electrophiles, aldehydes and CH2:CHCN, under very mild conditions of temperature and pH to produce intermediates which, after acid hydrolysis, yielded amino acids, glycine, DL-erythro- and DL-threo-β-hydroxyaspartic acids, DL-glutamic acid, DL-threonine and allothreonine. The mechanism of their formation and the possible significance of these reactions in prebiotic syntheses are discussed.

Journal of Molecular Evolution published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C6H3FN2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Steiner, Thomas published the artcileThe C-H…O hydrogen bond in (dicyanomethyl)ammonium p-toluenesulfonate, Computed Properties of 5098-14-6, the publication is Acta Crystallographica, Section C: Crystal Structure Communications (2001), C57(6), 775-776, database is CAplus and MEDLINE.

In the title compound, C₃H₄N₃⁺·C₇H₇O₃S^–, the activated C-H group of the cation forms a short but bent C-H…O H bond with a sulfonate O atom of the anion; C…O = 3.075(5) Å and C-H…O = 130°. Crystallog. data are given.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C11H10ClNO, Computed Properties of 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts