Nitriles-buliding-blocks

DeSantis, Grace published the artcileAn enzyme library approach to biocatalysis: development of nitrilases for enantioselective production of carboxylic acid derivatives, Related Products of nitriles-buliding-blocks, the publication is Journal of the American Chemical Society (2002), 124(31), 9024-9025, database is CAplus and MEDLINE.

The discovery, from nature, of a large and diverse set of nitrilases is reported. The utility of this nitrilase library for identifying enzymes that catalyze efficient production of valuable hydroxy carboxylic acid derivatives is demonstrated. Unprecedented enantioselectivity and substrate scope are highlighted for 3 newly discovered and distinct nitrilases. For example, a wide array of (R)-mandelic acid derivatives and analogs were produced with high rates, yields, and enantiomeric excesses (95-99% ee). We also have found nitrilases that provide direct access to (S)-phenyllactic acid and other aryllactic acid derivatives, again with high yields and enantioselectivities. Finally, different nitrilases have been discovered that catalyze enantiotopic hydrolysis of 3-hydroxyglutaronitrile to afford either enantiomer of 4-cyano-3-hydroxybutyric acid with high enantiomeric excesses (>95% ee). The 1st enzymes are reported that effect this transformation to furnish the (R)-4-cyano-3-hydroxybutyric acid, which is a precursor to the blockbuster drug Lipitor.

Journal of the American Chemical Society published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhang, Ying published the artcileHierarchical self-assembly of alkynylplatinum(II) bzimpy functionalized metallacage via Pt···Pt and π-π interactions, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Inorganic Chemistry (2018), 57(7), 3516-3520, database is CAplus and MEDLINE.

A new discrete supramol. metallacage functionalized with an alkynylplatinum(II) 2,6-bis(benzimidazole-2′-yl)-pyridine (bzimpy) moiety has been successfully constructed via coordination-driven self-assembly. A study on the hierarchical self-assembly behavior of the obtained metallacage revealed that it displayed a solvent-induced emission switch accompanied by enhancement of the emission intensity as a result of the change in intermol. Pt···Pt and π-π interactions. More interestingly, the metallacage has been found to spontaneously self-assemble into a transparent metallogel at room temperature without a heating-cooling process.

Inorganic Chemistry published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C14H10O4S2, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Zhen published the artcileUse of a Traceless Activating and Directing Group for the Construction of Trifluoromethylpyrazoles: One-Pot Transformation of Nitroolefins and Trifluorodiazoethane, Quality Control of 5153-73-1, the publication is Angewandte Chemie, International Edition (2017), 56(16), 4569-4574, database is CAplus and MEDLINE.

We disclose an efficient one-pot transformation of trifluorodiazoethane and higher perfluorinated homologues with various nitroolefins. This method takes advantage of the nitro group as a traceless activating and directing group (TADG) that is released in the aromatization step to produce 4-substituted 3-perfluoroalkyl pyrazoles with complete regioselectivity [e.g, trans-β-nitrostyrene + CF₃CHN₂ → pyrazole I (89%) in presence of Ag₂O and Na₃PO₄]. The potential of this method is further demonstrated by the synthesis of penthiopyrad. Safety: 2,2,2-trifluorodiazoethane is potentially explosive.

Angewandte Chemie, International Edition published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Quality Control of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Xu, Lu-Feng published the artcileSynthesis of 2-aryloxymethylbenzonitriles from 2-cyanobenzyl chloride, SDS of cas: 612-13-5, the publication is Asian Journal of Chemistry (2012), 24(11), 5329-5331, database is CAplus.

2-[(Aryloxy)methyl]benzonitriles were synthesized from 2-cyanobenzyl chloride and phenols with K₂CO₃ as a base in DMF at 80-110° in good to excellent yields. 2-Cyanobenzyl chloride is a better alternative to the more costly and less atom economical bromo analog or chloro- or bromobenzoate.

Asian Journal of Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C5H5N3S, SDS of cas: 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhou, Wenjun published the artcileSynthesis and characterization of o-cyanostilbenes, Application In Synthesis of 612-13-5, the publication is Huagong Shengchan Yu Jishu (2011), 18(3), 28-31, database is CAplus.

The preparation and characterization of five o-cyanostilbenes from o-cyanobenzyl chloride, tri-Et phosphate, aromatic aldehydes in N,N-DMF via Wittig-Horner reaction with yields ranged from 83.8% to 93.1% were reported. The reported method had the advantages of reliable and high yields, simple operations, cheap and readily available raw materials.

Huagong Shengchan Yu Jishu published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C15H24O2, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Xie, Yan published the artcileSynthesis of 2-(2-Aryl)ethylbenzoic acid, Computed Properties of 612-13-5, the publication is Zhongguo Yiyao Gongye Zazhi (2012), 43(2), 87-89, database is CAplus.

2-(2-Phenylethyl)benzoic acid or 2-(thiophene-2-ylethyl)benzoic acid was synthesized from o-cyanobenzyl chloride via Wittig-Horner reaction with benzaldehyde or 2-thiopene carboxaldehyde, hydrolysis and then hydrogenation, with the overall yield of about 64% or 60%.

Zhongguo Yiyao Gongye Zazhi published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C3H7NO2, Computed Properties of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Miaomiao published the artcileTransition Metal-Free Oxidative Cross-Coupling Reaction of Activated Olefins with N-Alkyl Amides, Category: nitriles-buliding-blocks, the publication is Journal of Organic Chemistry (2021), 86(5), 3989-3998, database is CAplus and MEDLINE.

The K₂S₂O₈-mediated transition metal-free oxidative cross-coupling reaction of activated olefins with N-alkyl amides was developed, and the reaction gave N-allylic amides in moderate to good yield. This reaction protocol was suitable for different kinds of activated olefins.

Journal of Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Yicun published the artcileDesign, synthesis, and pharmacological evaluation of haloperidol derivatives as novel potent calcium channel blockers with vasodilator activity, Quality Control of 612-13-5, the publication is PLoS One (2011), 6(11), e27673, database is CAplus and MEDLINE.

Several haloperidol derivatives with a piperidine scaffold that was decorated at the nitrogen atom with different alkyl, benzyl, or substituted benzyl moieties were synthesized at our laboratory to establish a library of compounds with vasodilator activity. Compounds were screened for vasodilatory activity on isolated thoracic aorta rings from rats, and their quant. structure-activity relationships (QSAR) were examined Based on the result of QSAR, N-4-tert-Bu benzyl haloperidol chloride (16c) was synthesized and showed the most potent vasodilatory activity of all designed compounds 16C dose-dependently inhibited the contraction caused by the influx of extracellular Ca²⁺ in isolated thoracic aorta rings from rats. It concentration-dependently attenuated the calcium channel current and extracellular Ca²⁺ influx, without affecting the intracellular Ca²⁺ mobilization, in vascular smooth muscle cells from rats. 16C, possessing the N-4-tert-Bu benzyl piperidine structure, as a novel calcium antagonist, may be effective as a calcium channel blocker in cardiovascular disease.

PLoS One published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Quality Control of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Qiao, Jin-Bao published the artcileAllylboronates from Vinyl Triflates and α-Chloroboronates by Reductive Nickel Catalysis, Recommanded Product: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)butanenitrile, the publication is Organic Letters (2020), 22(13), 5085-5089, database is CAplus and MEDLINE.

Allylboronates are unique building blocks widely used in organic synthesis, but the construction of cyclic allylboranates remains a challenging subject. The authors demonstrate here a mild and efficient access to this type of compound through the cross-electrophile coupling of vinyl triflates and α-chloroboronates. The reaction proceeded with a good substrate scope and good functional group compatibility. The ready availability of vinyl triflates from ketones, as well as the rich chem. of allylboranates, makes the authors’ method suitable for the divergent modification of biol. active compounds Preliminary mechanistic studies revealed that α-chloroboronates were activated via a radical process.

Organic Letters published new progress about 238088-16-9. 238088-16-9 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Aliphatic cyclic hydrocarbon,Boronic Acids,Boronate Esters, name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)butanenitrile, and the molecular formula is C10H18BNO2, Recommanded Product: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)butanenitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wang, Guan published the artcileDiscovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types, Recommanded Product: 2-(Chloromethyl)benzonitrile, the publication is Journal of Medicinal Chemistry (2020), 63(8), 3976-3995, database is CAplus and MEDLINE.

ERK1 and ERK5 are proposed to have pivotal roles in several types of cancer. Under some circumstance, ERK5 may provide a common bypass route, which rescues proliferation upon abrogation of ERK1 signaling. Thus, we accurately classified the tumor types from The Cancer Genome Atlas (TCGA) based on the expression levels of ERK1 and ERK5. We proposed a novel therapeutic strategy to overcome the above-mentioned compensatory mechanism in specific tumor types by co-targeting both ERK1 and ERK5. On the basis of the idea of overcoming ERK5 compensation mechanism, 22ac (ADTL-EI1712) as the first selective dual-target inhibitor of ERK1 and ERK5 was discovered to have potent antitumor effects in vitro and in vivo. Interestingly, this compound was found to induce regulated cell death accompanied by autophagy in MKN-74 cells. Taken together, our results warrant the potential of this dual-target inhibitor as a new candidate drug that conquers compensatory mechanism in certain tumor types.

Journal of Medicinal Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C6H12O2, Recommanded Product: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts