Nitriles-buliding-blocks

Liu, Xin-yong published the artcileSynthesis and anti-HIV activity evaluation of novel 2,4-disubstituted 7-methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo-[4,5-e][1,2]thiadiazines, HPLC of Formula: 612-13-5, the publication is Archiv der Pharmazie (Weinheim, Germany) (2008), 341(4), 216-222, database is CAplus and MEDLINE.

A series of novel 2,4-disubstituted 7-methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo[4,5-e] [1,2,4]thiadiazines (PTDs) was synthesized, structurally confirmed by spectral anal., and evaluated for their anti-HIV activities by inhibition of HIV-induced cytopathogenicity in MT-4 cell culture. The results showed that some compounds exhibited inhibitory activity specifically against HIV-2 replication. The most active HIV-2 inhibitor was compound I with an EC₅₀ value of 18.7 μM and SI = 15, which may provide a useful lead for further mol. optimization.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, HPLC of Formula: 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhan, Peng published the artcileSynthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives, Name: 2-(Chloromethyl)benzonitrile, the publication is Drug Discoveries & Therapeutics (2011), 5(6), 279-285, database is CAplus and MEDLINE.

Sixteen 2,4-dibenzyl-substituted 7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazines (PTDs) were prepared by a facile 1-pot reaction starting from 7-methyl-pyrazolo[4,5-e][1,2,4]thiadiazine and two different benzyl halides. The structures of all synthesized compounds were confirmed by ¹H- and ¹³C-NMR, IR spectra (IR) and mass spectra (MS). Anti-HIV activity was evaluated and none of the compounds inhibit HIV replication in human T-lymphocyte (MT-4) cell culture.

Drug Discoveries & Therapeutics published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C9H9ClN2, Name: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kanega, Ryoichi published the artcileDiphenyl Carbonate Synthesis by Homogeneous Pd Electrocatalyst, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Topics in Catalysis (2014), 57(10-13), 995-999, database is CAplus.

Electrochem. carbonylation of phenol with CO to di-Ph carbonate (DPC) using Pd electrocatalyst was studied at P(CO) = 1 atm and room temperature Electrochem. carbonylation was conducted by galvanostatic electrolysis at 1 mA in electrolyte solutions containing phenol, Na phenoxide and MeCN. Electrochem. carbonylation by Pd was promoted by using 1,3-dimesitylimidazol-2-ylidene (IMes) ligand of a N-heterocyclic carbene. The current efficiency of DPC increased >3.4 times using the IMes ligand. The maximum current efficiency of DPC formation was 45%.

Topics in Catalysis published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Sakata, Yoko published the artcileMetallonanobelt: A Kinetically Stable Shape-Persistent Molecular Belt Prepared by Reversible Self-Assembly Processes, Computed Properties of 68569-14-2, the publication is Inorganic Chemistry (2018), 57(24), 15500-15506, database is CAplus and MEDLINE.

A triptycene-based shape-persistent belt-shaped macrocycle, metallonanobelt, was synthesized by the self-assembly of 2,3,6,7-tetraaminotriptycene L and square planar Pd²⁺. The pentamer was selectively formed by the complexation of L with Pd²⁺ in the presence of the pillar[6]arene derivative P6 having triethylene glycol pendant as a template, whereas a mixture of a trimer, tetramer, and pentamer was obtained in the absence of the template. The pentamer was successfully isolated based on the solubility difference between the metallonanobelt and the template. Also the isolated pentamer was remarkably stable in solutions such as acetonitrile or methanol thanks to the relatively inert planar chelate metal complex, [Pd(o-phenylenediamine)₂] unit. Thus, the authors can handle the metallonanobelt almost as a static organic nanobelt that was synthesized covalently.

Inorganic Chemistry published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Computed Properties of 68569-14-2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Biswas, Soumen published the artcileDiastereoselective pot- and atom-economical synthesis of densely-substituted polycyclic 1,2- and 1,2,3-fused indole scaffolds, Application of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Tetrahedron Letters (2019), 60(32), 150921, database is CAplus.

A simple, efficient, one-pot sequential process for the preparation of a family of 8,9-dihydropyrido[1,2-a]indol-6(7H)-one scaffolds I [R¹ = Ph, 2-ClC₆H₄, 2-furyl, etc.; stereo = cis, trans] in acceptable yields was established under mild conditions. The Michael-hemiaminalization-oxidation reaction proceeded between Me 2-(3-formyl-1H-indol-2-yl) acetate and trans-β-aryl/alkyl-substituted acroleins using pyrrolidine-BzOH as an efficient organocatalyst, followed by oxidation of in situ generated of C,N-fused hemiaminal adducts in the presence of PDC at room temperature Excitingly, organobase-catalyzed highly diastereoselective (up to ≤9:1 dr) construction of a series of pharmacol. attractive 1,2,3-fused tetracyclic indole scaffolds with five contiguous chiral centers including an all-carbon stereogenic center II [R² = CO₂Me, Ph, 2-furyl, etc.; R³ = Ph, 4-MeOC₆H₄] was achieved using developed method. Moreover, pyrrolidine-BzOH and PTSA as combined catalytic systems promoted the uninterrupted sequential Michael-cyclization reaction, followed by N-alkylation reaction with carbazole to produce interesting class of 6-(9H-carbazol-9-yl)-6,7,8,9-tetrahydropyrido[1,2-a]indole derivatives III [R³ = Ph, 4-MeOC₆H₄] in a diastereoselective manner.

Tetrahedron Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Application of (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Sun, Minzhi published the artcileFree-Radical-Promoted Alkenylation of C(sp³)-H Bond in Chloroalkane with Cinnamic Acid and β-Nitrostyrene, Formula: C9H6N2O2, the publication is Advanced Synthesis & Catalysis (2020), 362(11), 2195-2199, database is CAplus.

Herein a free-radical alkenylation of the C(sp³)-H bond in 1,2-dichloroethane with cinnamic acid and β-nitrostyrene has been demonstrated. This method not only provides a facile approach to chloroalkylated styrenes, but also would be instructive for halogen-atom directing selective functionalization of inert C(sp³)-H bond.

Advanced Synthesis & Catalysis published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C11H12O4, Formula: C9H6N2O2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Qu, Bingxue published the artcileDesign, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells, Formula: C13H17BN2O2, the publication is European Journal of Medicinal Chemistry (2022), 114257, database is CAplus and MEDLINE.

Multiple myeloma (MM) is a highly malignant hematol. cancer that occurs when an atypical plasma cell develops in the bone marrow and reproduces quickly. Despite varies of new drugs have been developed or under clinic trial, MM is still essentially incurable, while XPO1 inhibition has emerged as a promising therapeutic strategy in the treatment of MM. Using the second-generation XPO1 inhibitor KPT-8602 as the lead compound, structure-based optimization provided D4 with high anti-proliferation efficacy (IC50 = 24 nM in MM.1S). In addition, the treatment with D4 significantly induced MM.1S cell cycle arrested and cell apoptosis, which was confirmed as on-target effect by immunofluorescence microscopy and competitive binding assay. Moreover, D4 displayed good metabolic stability over rat plasma and liver microsomes, as well as good pharmacokinetic profile on SD rat model with high drug exposure and decent bioavailability by oral gavage. All these good properties of D4 pave the way for further drug development and clin. application.

European Journal of Medicinal Chemistry published new progress about 1036991-35-1. 1036991-35-1 belongs to nitriles-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, and the molecular formula is C13H17BN2O2, Formula: C13H17BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chu, Xue-Qiang published the artcileTBAI-Catalyzed/Water-Assisted Double C-S Bond Formations: An Efficient Approach to Sulfides through Metal-Free Three-Component Reactions, Recommanded Product: 2-(Chloromethyl)benzonitrile, the publication is Chemistry – A European Journal (2016), 22(40), 14181-14185, database is CAplus and MEDLINE.

An aqueous catalytic method for double C-S bond formations that involves alc. derivatives, organic halides, and sodium thiosulfate was developed. A diverse range of functionalized sulfides, including pharmaceutical and biol. derivatives, can be obtained in an efficient and eco-friendly manner under air. The mechanistic studies revealed that this tetrabutylammonium-iodide-catalyzed/water-assisted reaction generated a mercaptan species as the key intermediate.

Chemistry – A European Journal published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Recommanded Product: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Corbett, Michael T. published the artcileTrisubstituted 2-Trifluoromethyl Pyrrolidines via Catalytic Asymmetric Michael Addition/Reductive Cyclization, Quality Control of 5153-73-1, the publication is Organic Letters (2014), 16(9), 2362-2365, database is CAplus and MEDLINE.

The stereoselective synthesis of trisubstituted 2-trifluoromethyl pyrrolidines by asym. Michael addition/hydrogenative cyclization is described. The direct organocatalytic addition of 1,1,1-trifluoromethyl ketones to nitroolefins proceeds under mild reaction conditions and low catalyst loadings to provide Michael adducts in high yield with excellent diastereo- and enantioselectivity. Catalytic hydrogenation of the Michael adducts stereoselectively generates 2-trifluoromethylated pyrrolidines bearing three contiguous stereocenters. A stereospecific route to epimeric 2-trifluoromethyl pyrrolidines from a common intermediate is described.

Organic Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Quality Control of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Lan, Feng published the artcileSyntheses and herbicidal activities of novel 1,2,4-triazolinone derivatives, Formula: C8H6ClN, the publication is Gaodeng Xuexiao Huaxue Xuebao (2009), 30(4), 712-715, database is CAplus.

Environmentally benign triazolinone herbicides have a broad application perspective. Several triazolinone compounds such as amicarbazone, sulfentrazone [i.e., N-[2,4-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]phenyl]methanesulfonamide], azafenidin [i.e., 2-[2,4-dichloro-5-(2-propyn-1-yloxy)phenyl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one] and carfentrazone-Et [i.e., α,2-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorobenzenepropanoic acid Et ester] have already been developed as herbicides. In order to search for novel 1,2,4-triazolinone derivatives with high herbicidal activity, 2-(2,4,5-trichlorophenyl)-4-(benzyl)-5-methyl-3H-1,2,4-triazol-3-one derivatives and 2,4-bis(benzyl)-1,2,4-triazol-3-one derivatives were designed and synthesized. Their structures were determined by NMR, MS, elemental anal. The results of preliminary biol. activity tests show that some compounds display excellent herbicidal activity and some display good activity toward promoting cucumber cotyledon root-formation at 1.5 kg/ha.

Gaodeng Xuexiao Huaxue Xuebao published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Formula: C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts