Nitriles-buliding-blocks

He, Yu-Cai published the artcileBioproduction of glycolic acid from glycolonitrile with a new bacterial isolate of Alcaligenes sp. ECU0401, Safety of 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, the publication is Applied Biochemistry and Biotechnology (2010), 160(5), 1428-1440, database is CAplus and MEDLINE.

Alcaligenes sp. ECU0401 has been isolated from soil samples with high nitrilase activity against glycolonitrile using the enrichment culture technique. The preferred carbon/nitrogen sources and metal ions were sodium acetate, a composite of peptone and yeast extract, and Cu²⁺, resp. Glycolic acid was obtained in a yield of 96.5% after 14 h of biotransformation from a total of 200 mM glycolonitrile in the mode of sequential addition during the cultivation of Alcaligenes sp. ECU0401 in a 5-L jar fermenter. Fifty micromolars of glycolonitrile could be hydrolyzed in a yield of 94.1% by resting cells after 36 h. The microbial nitrilase system could hydrolyze various nitriles with high activity, and no amidase activity and glycolic acid were observed in hydrolyzing glycolamide. It significantly exhibited high enantioselectivity in the hydrolysis of mandelonitrile and 2-chloromandelonitrile (>99.9% e.e._p). Efficient biocatalyst recycling was achieved as a result of immobilization in glutaraldehyde/polyethylenimine cross-linked carrageenan with immobilized cells exhibiting a biocatalyst productivity of 1,042.2 g glycolic acid per g dry cell weight after 29 batch recycles.

Applied Biochemistry and Biotechnology published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Safety of 2-(2-Chlorophenyl)-2-hydroxyacetonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wang, Mei-Ling published the artcileMizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination, COA of Formula: C10H12F6N4O6PdS2, the publication is Organic Letters (2021), 23(6), 2147-2152, database is CAplus and MEDLINE.

Mizoroki-Heck reaction of unstrained aryl ketone with acrylate/styrene was accomplished via palladium-catalyzed ligand-promoted C-C bond cleavage. Various (hetero)aryl ketones were compatible in the reaction, affording the alkene product in good to excellent yields. Further applications in the late-stage olefination of some drugs, natural products, and fragrance-derived aryl ketones demonstrated the synthetic utility of this protocol. By employing ketone as both the directing group and the leaving group, 1,2-bifunctionalization was achieved via sequential ortho-C-H alkylation/ipso-Heck olefination.

Organic Letters published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C38H74Cl2N2O4, COA of Formula: C10H12F6N4O6PdS2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wang, Ming-Zhong published the artcileDesign, synthesis and antifungal activities of novel pyrrole alkaloid analogs, Application of 2-(Chloromethyl)benzonitrile, the publication is European Journal of Medicinal Chemistry (2011), 46(5), 1463-1472, database is CAplus and MEDLINE.

A series of novel analogs of pyrrole alkaloids were designed and synthesized by a facile method and their structures were characterized by ¹H NMR, ¹³C NMR and high-resolution mass spectrometry (HRMS). The structure of compound I was identified by 2D NMR including heteronuclear multiple-quantum coherence (HMQC), heteronuclear multiple-bond correlation (HMBC) and H-H correlation spectrometry (H-H COSY) spectra. Their antifungal activities against five fungi were evaluated, and the results indicated that some of the title compounds showed moderate fungicidal activities in vitro against Alternaria solani, Cercospora arachidicola, Fusarium omysporum, Gibberella zeae and Physalospora piricola at the dosage of 50 μg mL^-1. Compound I and its dibromo derivative exhibited good activities against P. piricola at low dosage.

European Journal of Medicinal Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C23H28N2O4, Application of 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Shi, Ce published the artcileDiscovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction, HPLC of Formula: 5098-14-6, the publication is ACS Medicinal Chemistry Letters (2012), 3(6), 501-504, database is CAplus and MEDLINE.

Toll-like receptors (TLRs) are key targets in the design of immunomodulating agents for use as vaccine adjuvants and anticancer treatments. The imidazoquinolines, imiquimod and resiquimod, have been shown to activate TLR-7 and -8, which in turn induce cytokine production as part of the innate immune response. Herein, we report the synthesis and discovery of a C7-methoxycarbonyl derivative of imiquimod (5, I) that stimulates cytokine production but is devoid of TLR-7/8 activity. Data are presented that shows that this analog not only induces IL-12p40 and TNF production, similar to that of imiquimod and resiquimod, but greatly enhances the production of IL-1β, a key cytokine involved in the activation of CD4 T cells. It is further demonstrated that TLR-7/8 activation can be recovered by the addition of a C2-alkyl substituent to this newly discovered analog. The results support the existence of an alternative mechanism of action by which imidazoquinolines can stimulate cytokine production

ACS Medicinal Chemistry Letters published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C17H16O2, HPLC of Formula: 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Ninglin published the artcileCobalt-Catalyzed Protodeboronation of Aryl and Vinyl Boronates, Formula: C12H14BNO2, the publication is Journal of Organic Chemistry (2021), 86(2), 1972-1979, database is CAplus and MEDLINE.

An efficient cobalt-based catalytic system for protodeboronation of various aryl and vinyl boronates ArR [R = 5,5-dimethyl-1,3,2-dioxaborinan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl, 1,3,2-dioxaborolan-2-yl, 4-oxo-1,2,3,4-tetrahydro-1,3,2-benzodiazaborinin-2-yl; Ar = 4-chlorophenyl, 4-(9H-carbazol-9-yl)benzen-1-yl, anthracen-2-yl, etc.]/(E/Z)-Ar¹CH=C(R¹)R² (Ar¹ = 4-bromophenyl, 1-benzothiophen-2-yl, pyridin-2-yl, etc.; R¹ = H, Ph, tetramethyl-1,3,2-dioxaborolan-2-yl; R² = Ph, 5,5-dimethyl-1,3,2-dioxaborinan-2-yl, tetramethyl-1,3,2-dioxaborolan-2-yl) is described. The reaction is capable of tolerating a wide range of functional groups. The reaction is also extended to deuterodeboronation with D₂O, which provides a potential protocol for the synthesis of regiospecifically deuterated arenes and olefins R³D [R³ = 4-phenylphenyl, 3-(4-cyanophenyl)prop-1-en-1-yl, 4-(9H-carbazol-9-yl)benzen-1-yl, 2-(4-([6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amino)phenyl)ethenyl, etc.].

Journal of Organic Chemistry published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, Formula: C12H14BNO2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Lei, Zhen-lin published the artcileSynthesis with solvent-free and antifungal activities of 6-ether coumarin derivatives, Application In Synthesis of 612-13-5, the publication is Nongyao (2015), 54(10), 724-726, 743, database is CAplus.

2-Methyl-4-benzenediol was reacted with Et acetoacetate via Pechmann condensation to yield 6-hydroxy-4,7-dimethyl-coumarin, then the coumarin grinded with substituted benzyl chloride without solvent to yield twelve title compounds 4a-4l. The structure of the compounds were confirmed by ¹H NMR and LC-MS. The preliminary bioassay indicated some compounds, such as 4b, 4c and 4e, displayed over 90% antifungal activities against Botryodiplodia theobromae at 100 mg/L.

Nongyao published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Xiang-Yu published the artcileCatalytic MBH reaction of β-substituted nitroalkenes with azodicarboxylates, Name: (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Organic & Biomolecular Chemistry (2013), 11(34), 5722-5726, database is CAplus and MEDLINE.

An unprecedented N-heterocyclic carbene (NHC) catalyzed Morita-Baylis-Hillman (MBH) reaction of β-substituted nitroalkenes and azodicarboxylates has been developed. Both β-aryl and β-alkyl nitroalkenes worked well for the reaction using 5 mol% of NHC catalyst, giving the desired α-hydrazino-α,β-unsaturated nitroalkenes in good to excellent yields. E.g., in presence of NHC catalyst (I) and DMAP, Morita-Baylis-Hillman reaction of (E)-PhCH:CHNO₂ and DEAD gave 91% II.

Organic & Biomolecular Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Name: (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Duong, Hung A. published the artcileCobalt-Catalyzed Cross-Coupling Reactions of Arylboronic Esters and Aryl Halides, Application of 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, the publication is Organometallics (2017), 36(22), 4363-4366, database is CAplus.

An efficient cobalt catalyst system for the Suzuki-Miyaura cross-coupling reaction of arylboronic esters and aryl halides has been identified. In the presence of cobalt(II)/terpyridine catalyst and potassium methoxide, a diverse array of (hetero)biaryls have been prepared in moderate to excellent yields.

Organometallics published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, Application of 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Xiangmin published the artcileOne-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides, Application of 2-(Chloromethyl)benzonitrile, the publication is Organic Letters (2018), 20(7), 1712-1715, database is CAplus and MEDLINE.

A facile, one-pot approach for synthesizing deuterated aldehydes from arylmethyl halides was developed using D₂O as the deuterium source. The efficient process is realized by a sequence of formation, H/D exchange and oxidation of pyridinium salt intermediates. The mild and air-compatible reaction conditions enable efficient synthesis of diverse deuterated aldehydes with high deuterium incorporation.

Organic Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application of 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Yang, Bowen published the artcileDiscovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors, HPLC of Formula: 1036991-35-1, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127749, database is CAplus and MEDLINE.

In an inhouse screening, 1H-pyrrolo[2,3-b]pyridine scaffold was found to have high inhibition on TNIK. Several series of compounds were designed and synthesized, among which some compounds had potent TNIK inhibition with IC₅₀ values lower than 1 nM. Some compounds showed concentration-dependent characteristics of IL-2 inhibition. These results provided new applications of TNIK inhibitors and new prospects of TNIK as a drug target.

Bioorganic & Medicinal Chemistry Letters published new progress about 1036991-35-1. 1036991-35-1 belongs to nitriles-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, and the molecular formula is C14H12N2S, HPLC of Formula: 1036991-35-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts