Nitriles-buliding-blocks

Gaspa, Silvia published the artcileMetal-Free Preparation of α-H-Chlorinated Alkylaromatic Hydrocarbons by Sunlight, Related Products of nitriles-buliding-blocks, the publication is ChemistrySelect (2018), 3(27), 7991-7995, database is CAplus.

A metal and additive free process for the synthesis of benzyl chloride and α-chloro alkyl arenes is reported. The proposed methodol. can be carried out by the use of sunlight. The yield and conversion of the obtained benzyl chlorides are very high.

ChemistrySelect published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ueno, Tasuku published the artcileMechanism-Based Molecular Design of Highly Selective Fluorescence Probes for Nitrative Stress, Computed Properties of 26187-28-0, the publication is Journal of the American Chemical Society (2006), 128(33), 10640-10641, database is CAplus and MEDLINE.

Nitrative stress is implicated in various pathogenic processes, including neurodegenerative disorders, but there is no practical fluorescence probe which can monitor the generation of nitrative stress with high selectivity. To design a suitable fluorescence probe, the authors have first focused on the fluorescence quenching mechanism of the nitro group, which has been believed to be a unique quencher of fluorescent dyes. The authors found that nitro group-based fluorescence quenching could be explained in terms of an electron transfer process, from the excited fluorophore to the electron-deficient aromatic nitro moiety. By utilizing this result, the authors succeeded in developing novel fluorogenic probes, NiSPYs, which can selectively monitor the generation of nitrative stress based on aromatic nitration. NiSPYs showed strong fluorescence enhancement upon the reaction with nitrating agents, including peroxynitrite, but showed little or no fluorescence augmentation in the presence of other reactive oxygen species. NiSPYs should be potentially useful as tools to study the role of nitrative stress in various biol. applications.

Journal of the American Chemical Society published new progress about 26187-28-0. 26187-28-0 belongs to nitriles-buliding-blocks, auxiliary class Pyrrole,Nitrile, name is 2,4-Dimethyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C11H14O2, Computed Properties of 26187-28-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Jensen, Rader S. published the artcileSynthesis and catalytic properties of cationic palladium(II) and rhodium(I) complexes bearing diphosphinidinecyclobutene ligands, Application of Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Journal of Organometallic Chemistry (2007), 692(1-3), 286-294, database is CAplus.

Cationic Pd(II) and Rh(I) complexes bearing 1,2-diaryl-3,4-bis[(2,4,6-tri-t-butylphenyl)phosphinidene]cyclobutene ligands (DPCB-Y) were prepared and their structures and catalytic activity were examined (aryl = Ph (DPCB), 4-methoxyphenyl (DPCB-OMe), 4-(trifluoromethyl)phenyl (DPCB-CF₃)). The Pd complexes [Pd(MeCN)₂(DPCB-Y)]X₂ (X = OTf, BF₄, BAr₄ (Ar = 3,5-bis(trifluoromethyl)phenyl)) were prepared by the reactions of DPCB-Y with [Pd(MeCN)₄]X₂, which were generated from Pd(OAc)₂ and HX in MeCN. However, the Rh complexes [Rh(MeCN)₂(DPCB-Y)]OTf were prepared by the treatment of [Rh(μ-Cl)(cyclooctadiene)₂]₂ with DPCB-Y in CH₂Cl₂, followed by treatment with AgOTf in the presence of MeCN. The cationic complexes catalyzed conjugate addition of benzyl carbamate to α,β-unsaturated ketones.

Journal of Organometallic Chemistry published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Application of Tetrakis(acetonitrile)palladium(II) Ditriflate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Alagoz, Dilek published the artcilePurification, immobilization and characterization of (R)-hydroxynitrile lyase from Prunus amygdalus turcomanica seeds and their applicability for synthesis of enantiopure cyanohydrins, SDS of cas: 13312-84-0, the publication is Journal of Molecular Catalysis B: Enzymatic (2014), 40-46, database is CAplus.

A hydroxynitrile lyase (HNL) was purified from wild almond seeds (Prunus amygdalus turcomanica Lincz.) for the first time. Native and subunit mol. masses of the HNL were determined as 100 and 25 kDa, resp. indicating that the enzyme is a homotetramer. The purified enzyme was immobilized onto Eupergit CM and Eupergit C 250 L supports and their lyase and carboligation (synthetic) activities were characterized in terms of optimal pH, temperature and kinetic parameters. While the optimal pH of the free HNL for the lyase activity was 6.0, it was 5.5 for both of the immobilized HNLs. Optimal temperature was determined as 25 °C for all HNL preparations For mandelonitrile cleavage, the apparent K_m – V_max values were 0.38 mM – 197.0 U mg protein^-1 for the free HNL, 1.30 mM – 26.0 U mg protein^-1 for HNL immobilized onto Eupergit CM (HNL-Eup CM) and 0.95 mM – 17.5 U mg protein^-1 for HNL immobilized onto Eupergit C 250 L (HNL-Eup C 250 L), resp. For the carboligation activity, the optimal pH was measured as 4.0 and optimal temperature was determined as 5 °C for all of the HNL preparations For mandelonitrile synthesis, the apparent K_m – V_max values were 14.0 mM – 2.70 U mg protein^-1 for the free HNL, 41.0 mM – 0.49 U mg protein^-1 for HNL-Eup CM and 38.0 mM – 0.54 U mg protein^-1 for HNL-Eup C 250 L, resp. All of the HNL preparations were employed for the synthesis of mandelonitrile, 2-chloromandelonitrile, 3,4-dihydroxymandelonitrile and 2-hydroxy-4-Ph butyronitrile in a biphasic tert-Bu Me ether-citrate buffer (pH 4.0) medium. The results showed that the immobilized HNL preparations were better than the free HNL in the synthesis of abovementioned cyanohydrins except 2-chloromandelonitrile with higher yields and enantiopurities.

Journal of Molecular Catalysis B: Enzymatic published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, SDS of cas: 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Surzur, Jean M. published the artcileRadical addition to unsaturated alcohols. IV. Synthesis of 4-cyano-4-carbethoxytetrahydropyrans by intramolecular radical addition, SDS of cas: 30431-99-3, the publication is Bulletin de la Societe Chimique de France (1970), 3070-5, database is CAplus.

Esters (I) (Y = CN) were cyclized with Bz2O2 in refluxing cyclohexane. After decomposition of the excess peroxide, the products were distilled to sep. cyclohexane and the telomers. The distillate was analyzed by vapor-phase chromatog. I (m = 2, n = 0, R = H,Me) gave 71-88% tetrahydropyran derivative (II). I (m = 2; n = 1; R and R1 = H (or Me) gave 96-98% tetrahydropyran derivatives and no 7-membered heterocyclic O-containing compounds could be detected. I (m = n = 1, R = H and Me, and X = CO2Et, Y = CO2Et and CN) gave only polymerized products. This type of reaction gave substituted tetrahydropyran or tetrahydrofuran derivatives which are often not readily accessible by other methods. However, the presence of the O atom makes it necessary to operate at very high dilutions and to use longer reaction times if polymerization, is to be avoided.

Bulletin de la Societe Chimique de France published new progress about 30431-99-3. 30431-99-3 belongs to nitriles-buliding-blocks, auxiliary class Tetrahydropyran,Nitrile,Ester, name is Ethyl 4-cyanotetrahydro-2H-pyran-4-carboxylate, and the molecular formula is C8H7NO4, SDS of cas: 30431-99-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kita, Yusuke published the artcileRhodium-Catalyzed Alkenylation of Nitriles via Silicon-Assisted C-CN Bond Cleavage, Category: nitriles-buliding-blocks, the publication is Organic Letters (2010), 12(8), 1864-1867, database is CAplus and MEDLINE.

Rhodium-catalyzed Mizoroki-Heck type reaction of nitriles via the cleavage of C-C bonds is described. Orthogonal and iterative functionalizations of arenes were also demonstrated by combining the present and conventional halide-based cross-coupling reactions.

Organic Letters published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kita, Yusuke published the artcileRhodium-catalyzed carbon-cyano bond cleavage reactions using organosilicon reagents, SDS of cas: 214360-44-8, the publication is Yuki Gosei Kagaku Kyokaishi (2010), 68(11), 1112-1122, database is CAplus.

Rh-catalyzed C-cyano bond cleavage reactions using organosilicon reagents are described. When disilane is used as the Si reagent, the C-CN bonds in aryl and alkenyl cyanides are silylated to form the corresponding silylated products along with silyl cyanide. Reductive decyanation of nitriles is achieved when hydrosilane is used as the Si reagent. This catalytic system can be applied to the C(sp³)-CN bonds in simple aliphatic nitriles. In both reactions, the silylrhodium species generated in situ serves as a catalytically active species, cleaving C-CN bonds via an η²-iminoacyl complex. Addition of external electrophiles allowed the Si-assisted cleavage of C-CN bonds to be applied to C-C bond formation reactions. Intramol. arylation of benzonitrile bearing a tethered chlorophenyl group and decyanative Mizoroki-Heck-type alkenylation of nitriles with vinylsilanes have been developed.

Yuki Gosei Kagaku Kyokaishi published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, SDS of cas: 214360-44-8.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Shyshkina, Olena O. published the artcileA novel synthesis and transformations of isothiochroman 2,2-dioxide, Recommanded Product: 2-(Chloromethyl)benzonitrile, the publication is Tetrahedron Letters (2012), 53(33), 4296-4299, database is CAplus.

A convenient synthesis of isothiochromen-4-one 2,2-dioxide was carried out via cyclization of o-cyanobenzyl thioacetate by a Thorpe reaction. The reactions of isothiochromen-4-one 2,2-dioxide with nitrogen-containing nucleophilic reagents have been investigated. X-rays single crystal structures of five compounds are shown.

Tetrahedron Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C7H5I2NO3, Recommanded Product: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Wei published the artcileFacile synthesis of 1,2,4-trisubstituted imidazoles via aerobic copper catalyzed ligand-free [3+2] cycloaddition, Application of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Letters in Organic Chemistry (2014), 11(5), 386-392, database is CAplus.

A simple and facile approach to highly functionalized imidazoles in moderate to good yields was developed. This method involves Cu-catalyzed aerobic [3+2] cycloaddition of amidines with nitro olefins in absence of ligand. Based on observation of the intermediates, possible reaction mechanism different from the same reported approach was proposed.

Letters in Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Application of (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Seck, Pierre published the artcileSynthesis of new selenophene and thiazole analogues of the tacrine series, Application of 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is ARKIVOC (Gainesville, FL, United States) (2012), 431-441, database is CAplus.

New 2-aminoselenophene-3-carbonitriles and 5-amino-1,3-thiazole-4-carbonitriles were prepared and reacted with cycloalkanones to give tetrahydroselenolo[2,3-b]quinolines, cycloalkene-fused selenolo[3,2-e]pyridines, [1,3]thiazolo[5,4-b]quinolines, thiazolo[4,5-e]pyridines, and tetrahydro-[1,3]thiazolo[5,4-b]quinolines.

ARKIVOC (Gainesville, FL, United States) published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C27H39ClN2, Application of 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts