Tag: 100-200

《A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Kuehl, Nikos; Graf, Dominik; Bock, Josephine; Behnam, Mira A. M.; Leuthold, Mila-Mareen; Klein, Christian D.. Name: 4-Cyanobenzyl bromide The article mentions the following:

Dengue and West Nile virus are rapidly spreading global pathogens for which no specific therapeutic treatments are available. One of the promising targets for drug discovery against dengue and other flaviviruses is the viral serine protease NS2B-NS3. We present the design, synthesis, and in vitro and cellular characterization of a novel chemotype of potent small-mol. non-peptidic dengue protease inhibitors derived from 4-benzyloxyphenylglycine. A newly developed luciferase-based DENV-2 protease reporter system in HeLa cells (DENV2proHeLa) was employed to determine the activity of the compounds in a cellular environment. Specificity and selectivity of the DENV2proHeLa system were confirmed by viral titer reduction assays. The compounds reach low micromolar to upper nanomolar inhibitory potency in cell-based assays, are selective against other serine proteases, and do not show relevant cytotoxicity. An extensive structure-activity relationship study provides a perspective for further drug development against flaviviral infections. In the experiment, the researchers used many compounds, for example, 4-Cyanobenzyl bromide(cas: 17201-43-3Name: 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Name: 4-Cyanobenzyl bromide

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《Hantzsch Ester as a Visible-Light Photoredox Catalyst for Transition-Metal-Free Coupling of Aryl halides and Arylsulfinates》 was published in Chemistry – A European Journal in 2020. These research results belong to Zhu, Da-Liang; Wu, Qi; Li, Hai-Yan; Li, Hong-Xi; Lang, Jian-Ping. Quality Control of 2-Bromobenzonitrile The article mentions the following:

Di-Et 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (HEH) was utilized as a visible-light photoredox catalyst for the cross coupling of aryl halides and aryl sulfinates without transition metal, sacrificial agent and mediator. This method was compatible with various functional groups and provided diaryl sulfones in good to high yields. Mechanistic studies indicated that this reaction underwent the stepwise light irradiation of HE-, single electron transfer (SET) in donor-acceptor complex (DAC) from *HE- to aryl halide, trapping of aryl radical with sulfinate and SET oxidation of sulfone radical anion by HE. to sulfone by the DAC method. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Quality Control of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Quality Control of 2-Bromobenzonitrile

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《Synthesis of Epoxides from Alkyl Bromides and Alcohols with in Situ Generation of Dimethyl Sulfonium Ylide in DMSO Oxidations》 was published in Journal of Organic Chemistry in 2020. These research results belong to Zhang, Zhi-Wei; Li, Hai-Bo; Li, Jin; Wang, Cui-Cui; Feng, Juan; Yang, Yi-Hua; Liu, Shouxin. Recommanded Product: 17201-43-3 The article mentions the following:

Direct conversion of the readily available alkyl bromides and alcs. to value-added epoxides using DMSO (DMSO) under mild reaction conditions has been developed. Benzyl and allyl bromides, and activated and unactivated alcs. all proceeded smoothly to give epoxides in high to excellent yield. Di-Me sulfide, generated by DMSO oxidations, was in situ elaborated to form the substituted di-Me sulfonium ylide species that participates in the Corey-Chaykovsky epoxidation in a domino and one-pot fashion, resp. After reading the article, we found that the author used 4-Cyanobenzyl bromide(cas: 17201-43-3Recommanded Product: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Recommanded Product: 17201-43-3

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《Hypervalent Iodine(III)-Catalysed Enantioselective α-Acetoxylation of Ketones》 was published in Chemistry – A European Journal in 2020. These research results belong to Hokamp, Tobias; Wirth, Thomas. Electric Literature of C9H7NO The article mentions the following:

An enantioselective catalytic synthesis of α-acetoxylated ketones through I(I)/I(III) catalysis using a resorcinol/lactamide-based chiral iodoarene was reported. Catalyst turnover by in-situ generation of the active iodine(III) derivative was achieved by oxidation with mCPBA in the presence of acetic acid. The prior transformation of ketones to easily accessible acetyl enol ethers was beneficial and yields up to 97% with enantioselectivities up to 88% ee were obtained using only low catalyst loadings of only 5 mol % under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Electric Literature of C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Electric Literature of C9H7NO

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In 2019,Organic & Biomolecular Chemistry included an article by Nandi, Jyoti; Leadbeater, Nicholas E.. Name: 4-Bromobenzonitrile. The article was titled 《Visible-light-driven catalytic oxidation of aldehydes and alcohols to nitriles by 4-acetamido-TEMPO using ammonium carbamate as a nitrogen source》. The information in the text is summarized as follows:

A mild and efficient route to prepare nitriles from aldehydes by combining photoredox catalysis with oxoammonium cations was reported. The reaction was performed using ammonium carbamate as the nitrogen source. The practicality of the method was increased by the extension of the dual catalytic system to one-pot two-step conversion of alcs. to nitriles. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzonitrile(cas: 623-00-7Name: 4-Bromobenzonitrile)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Name: 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

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In 2019,Bioorganic & Medicinal Chemistry included an article by Chen, Chen; Nie, Yiming; Xu, Guangsen; Yang, Xinying; Fang, Hao; Hou, Xuben. HPLC of Formula: 17201-43-3. The article was titled 《Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors》. The information in the text is summarized as follows:

Bcl-2 family proteins, which divides into pro-apoptosis proteins and anti-apoptosis proteins, are involved in cell apoptosis progression. As numerous studies illustrated, targeting Bcl-2 family proteins is more and more attractive and practicable to cancer treatment. In this work, we designed and synthesized a series of indomethacin derivatives as new inhibitors for Bcl-2 family proteins. Our results of binding assay to Bcl-2 proteins, MTT assay and apoptotic assay indicated that some compounds had potent binding affinity to Bcl-2/Mcl-1 but not Bcl-xL. Furthermore, compound 8j showed improved anti-proliferative activity than known Bcl-2 inhibitor WL-276. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3HPLC of Formula: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.HPLC of Formula: 17201-43-3

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In 2016,Kong, Weiguang; Li, Bingnan; Xu, Xuezhao; Song, Qiuling published 《Fe-Catalyzed Aerobic Oxidative C-CN Bond Cleavage of Arylacetonitriles Leading to Various Esters》.Journal of Organic Chemistry published the findings.Application In Synthesis of 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

Fe-catalyzed aerobic oxidative esterifications of arylacetonitriles with alcs., tri alkoxsilanes, silicate esters, or borate esters have been developed. The acyl groups which were in situ generated via chemoselective C(CO)-CN bond cleavage were directly used as electrophiles, leading to corresponding aryl esters in good to excellent yields under mol. oxygen when attacked by alcs. or alc. surrogates. Dioxygen serves as both oxidant and reactant in this protocol. The reaction has a very broad substrate scope. Cheap starting materials as well as environmentally benign and inexpensive iron catalyst and ideal oxidant O2 feature this transformation and make it a practical and sustainable protocol to afford esters. The experimental part of the paper was very detailed, including the reaction process of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Application In Synthesis of 2-(3-Bromophenyl)acetonitrile)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Application In Synthesis of 2-(3-Bromophenyl)acetonitrile

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Recommanded Product: 53005-44-0On September 30, 2015 ,《Phytotoxic interference of volatile organic compounds and water extracts of Tinospora tuberculata Beumee on growth of weeds in rice fields》 was published in South African Journal of Botany. The article was written by Aslani, F.; Juraimi, A. S.; Ahmad-Hamdani, M. S.; Alam, M. A.; Hashemi, F. S. Golestan; Omar, D.; Hakim, M. A.. The article contains the following contents:

Tinospora tuberculata Beumee is an aromatic shrub with pharmacol. properties and belongs to the Menispermaceae family. We assessed T. tuberculata for its ability to suppress growth of weeds in rice fields. In seedling bioassays, the rate of seed germination and the radicle and hypocotyl lengths of barnyardgrass, rice and weedy rice seedlings were reduced as the concentration of aqueous water extracts and volatile organic compounds increased compared to the control. In a glasshouse experiment, T. tuberculata leaf powder also exhibited effective reduction in the emergence and growth of weeds in rice fields. Applications at rates of 4 t ha- 1 completely suppressed emergence of barnyardgrass, sprangletop and smallflower umbrella. The chem. compositions of extracts and volatiles were analyzed by GC-MS and HS-SPME-GC-MS. The results showed that 7 of 43 components in the leaf aqueous extract, as compared to 5 of 15 compounds in the stem aqueous extract, are known to be toxic compounds Moreover, eight main volatile organic compounds were identified, which accounted for 97 and 95% of the whole fresh and dry leaf volatiles, resp. We observed qual. and quant. differences in the compounds present in the dry and fresh leaf. Confocal laser scanning microscope images showed that the volatile emissions and aqueous extracts also inhibited the main root diameter, and the number and elongation of root hairs of tested weeds in rice fields. These results suggest that T. tuberculata contains a significant source of plant growth inhibitors. Hence, it can be used as a mulch to suppress weeds in rice fields and for developing new herbicide based on phytotoxic compounds release by this plant. In the experimental materials used by the author, we found 2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0Recommanded Product: 53005-44-0)

2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Recommanded Product: 53005-44-0 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

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《Practical Synthesis of (Z)-α,β-Unsaturated Nitriles via a One-Pot Sequential Hydroformylation/Knoevenagel Reaction》 was written by Jiang, Yanxin; Li, Chao; Tang, Songbai; Tao, Shaokun; Yuan, Maolin; Li, Ruixiang; Chen, Hua; Fu, Haiyan; Zheng, Xueli. Recommanded Product: 31938-07-5This research focused onunsaturated nitrile preparation; olefin alkyne one pot sequential hydroformylation Knoevenagel reaction. The article conveys some information:

Herein, the synthesis of (Z)-α,β-unsaturated nitriles by a sequential hydroformylation/Knoevenagel reaction has been first developed. A variety of crude α-olefins from Fischer-Tropsch synthesis, internal and special olefins, as well as alkynes could be transformed into value-added alkenyl nitriles (39 examples) up to 90% yield. Remarkably, compared with commonly used tedious multistep reactions, the one-pot protocol features cheap and easily available raw materials, excellent chemo-, regio-, and stereoselectivity, very mild reaction conditions, and easy scale-up production The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Recommanded Product: 31938-07-5

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《Nucleophilic Iron Complexes in Proton-Transfer Catalysis: An Iron-Catalyzed Dimroth Cyclocondensation》 was written by Baykal, Aslihan; Zhang, Dihan; Knelles, Jakob; Alt, Isabel T.; Plietker, Bernd. Quality Control of 3-Oxo-3-phenylpropanenitrileThis research focused ontriazole preparation; aryl azide ketone Dimroth cyclocondensation reaction iron catalyst; Dimroth cyclocondensation; cyclocondensation-C−H-amination; homogeneous catalysis; iron; triazoles. The article conveys some information:

The nucleophilic iron complex Bu4N[Fe(CO)3(NO)](TBA[Fe]) is an active catalyst in C-H-amination but also in proton-transfer catalysis. Herein, the successful use of this complex as a proton-transfer catalyst in the cyclocondensation reaction between azides R1N3 (R1 = Ph, 4-nitrophenyl, naphthalen-2-yl, pyridin-3-yl, etc.) and ketones R2C(O)CH2R3 (R2 = Me, 1-methyl-1H-imidazol-2-yl, 1-methyl-1H-1,3-benzodiazol-2-yl, Ph, etc.; R3 = C(O)Me, Ph, thiophen-3-yl, CN, etc.) to the corresponding 1,2,3-triazoles I has been described. Cross-experiments indicate that the proton-transfer catalysis is significantly faster than the nitrene-transfer catalysis, which would lead to the C-H amination product. An example of a successful sequential Dimroth triazole-indoline synthesis to the corresponding triazole-substituted indolines II (R4 = Ph, 1-methyl-1H-imidazol-2-yl) is presented. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Quality Control of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Quality Control of 3-Oxo-3-phenylpropanenitrile

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