Tag: 100-200

Kaloglu, Murat; Slimani, Ichraf; Ozdemir, Namik; Gurbuz, Nevin; Hamdi, Naceur; Ozdemir, Ismail published an article in 2021. The article was titled 《The direct C(sp2)-H functionalization and coupling of aromatic N-heterocycles with (hetero)aryl bromides by [PdX2(imidazolidin-2-ylidene)(Py)] catalysts》, and you may find the article in Journal of Organometallic Chemistry.Category: nitriles-buliding-blocks The information in the text is summarized as follows:

A series of air- and moisture-stable imidazolidin-2-ylidene-based new palladium complexes with the general formula [PdX2(NHC)(Py)] were synthesized (NHC = N-heterocyclic carbene, Py = pyridine, X = Cl or I). The structures of the palladium complexes were characterized by different techniques such as 1H NMR, 13C NMR, FT-IR spectroscopy and elemental anal. The more detailed structural characterization of one of the palladium complex was determined by single-crystal X-ray diffraction study. The catalytic activities of all palladium complexes were tested in the direct arylation of five-membered aromatic N-heterocycles such as 3,5-dimethylisoxazole and 1-methyl-1H-pyrrole-2-carboxaldehyde with (hetero)aryl bromides in presence of 1 mol% catalyst loading at 120°C. Desired products were obtained in moderate to good yields. In addition to this study using 2-Bromobenzonitrile, there are many other studies that have used 2-Bromobenzonitrile(cas: 2042-37-7Category: nitriles-buliding-blocks) was used in this study.

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Niknam, Esmaeil; Panahi, Farhad; Khalafi-Nezhad, Ali published an article in 2021. The article was titled 《Immobilized Pd on a NHC-functionalized metal-organic framework MIL-101(Cr): an efficient heterogeneous catalyst in the Heck and copper-free Sonogashira coupling reactions》, and you may find the article in Journal of Organometallic Chemistry.Safety of 4-Bromobenzonitrile The information in the text is summarized as follows:

A heterogeneous palladium catalyst system based on immobilization of palladium moieties on a N-heterocyclic carbene (NHC) modified metal organic framework (MOF) was developed for the Heck and copper-free Sonogashira coupling reactions. In order to prepare this catalyst system, first, MIL-101(Cr) was functionalized with NHC moieties through a post-synthetic modification (PSM) approach, and then Pd metal was stabilized on the prepared MIL-101(Cr)-NHC substrate. This material was characterized using various microscopic and spectroscopic techniques and then was used as an efficient heterogeneous Pd catalyst system in the Heck and copper-free Sonogashira reactions. Results of the heterogeneity tests showed that the Pd-NHC-MIL-101(Cr) catalyst can efficiently catalyzed these coupling reactions heterogeneously and no remarkable changes observed in the morphol. and structure of MIL-101(Cr) template during the reaction progress. Also, existence of palladium nanoparticles immobilized on the MOF structure affirmed by the TEM and XPS anal. confirmed the oxidation state of Pd. A variety of alkene and alkyne derivatives were synthesized in good to excellent yields using this heterogeneous Pd catalyst system under normal conditions. More importantly Pd-NHC-MIL-101(Cr) catalyst was simply recovered from the reaction medium without remarkable decreasing in its catalytic activities after five times of reusability. The ICP anal. showed the very low Pd and Cr metals leaching, representing high stability and applicability of this catalyst in Pd coupling reactions. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzonitrile(cas: 623-00-7Safety of 4-Bromobenzonitrile)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Safety of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hu, Rong; Tao, Yigao; Zhang, Xiaofeng; Su, Weiping published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《1,2-Aryl Migration Induced by Amide C-N Bond-Formation: Reaction of Alkyl Aryl Ketones with Primary Amines Towards α,α-Diaryl β,γ-Unsaturated γ-Lactams》.COA of Formula: C8H6BrN The article contains the following contents:

Rearrangement reactions incorporated into cascade reactions play an important role in rapidly increasing mol. complexity from readily available starting materials. Reported here is a Cu-catalyzed cascade reaction of α-(hetero)aryl-substituted alkyl (hetero)aryl ketones with primary amines that incorporates an unusual 1,2-aryl migration induced by amide C-N bond formation to produce a class of structurally novel α,α-diaryl β,γ-unsaturated γ-lactams in generally good-to-excellent yields. This cascade reaction has a broad substrate scope with respect to primary amines, allows a wide spectrum of (hetero)aryl groups to smoothly undergo 1,2-migration, and tolerates electronically diverse α-substituents on the (hetero)aryl ring of the ketones. Mechanistically, this 1,2-aryl migration may stem from the intramol. amide C-N bond formation which induces nucleophilic migration of the aryl group from the acyl carbon center to the electrophilic carbon center that is conjugated with the resulting iminium moiety. After reading the article, we found that the author used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5COA of Formula: C8H6BrN)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.COA of Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tang, Shi; Xu, Zhen-Hua; Liu, Ting; Wang, Shuo-Wen; Yu, Jian; Liu, Jian; Hong, Yu; Chen, Shi-Lu; He, Jin; Li, Jin-Heng published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Radical 1,4-Aryl Migration Enabled Remote Cross-Electrophile Coupling of α-Amino-β-Bromo Acid Esters with Aryl Bromides》.Recommanded Product: 2-Bromobenzonitrile The article contains the following contents:

Here an unprecedented, efficient nickel-catalyzed radical relay was reported for the remote cross-electrophile coupling of β-bromo-α-benzylamino acid esters with aryl bromides via 1,4-aryl migration/arylation cascades. β-Bromo-α-benzylamino acid esters were considered as unique mol. scaffolds allowing for aryl migration reactions, which were conceptually novel variants for the radical Truce-Smiles rearrangement. This reaction enabled the formation of two new C(sp3)-C(sp2) bonds using a bench-stable Ni/bipyridine/Zn system featuring a broad substrate scope and excellent diastereoselectivity, which provided an effective platform for the remote aryl group migration and arylation of amino acid esters via redox-neutral C(sp3)-C(sp2) bond cleavage. Mechanistically, this cascade reaction was accomplished by combining two powerful catalytic cycles consisting of a cross-electrophile coupling and radical 1,4-aryl migration through the generation of C(sp3)-centered radical intermediates from the homolysis of C(sp3)-Br bonds and the switching of the transient alkyl radical into a robust α-aminoalkyl radical. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Recommanded Product: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
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Li, Gang; Yang, Liu; Liu, Jian-Jun; Zhang, Wei; Cao, Rui; Wang, Chao; Zhang, Zunting; Xiao, Jianliang; Xue, Dong published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Light-Promoted C-N Coupling of Aryl Halides with Nitroarenes》.Safety of 2-(3-Bromophenyl)acetonitrile The article contains the following contents:

A photochem. C-N coupling of aryl halides with nitroarenes is demonstrated for the first time. Catalyzed by a NiII complex in the absence of any external photosensitizer, readily available nitroarenes undergo coupling with a variety of aryl halides, providing a step-economic extension to the widely used Buchwald-Hartwig C-N coupling reaction. The method tolerates coupling partners with steric-congestion and functional groups sensitive to bases and nucleophiles. Mechanistic studies suggest that the reaction proceeds via the addition of an aryl radical, generated from a NiI/NiIII cycle, to a nitrosoarene intermediate. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Safety of 2-(3-Bromophenyl)acetonitrile)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Safety of 2-(3-Bromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Synthesis of α-Ketoamides from β-Ketonitriles and Primary Amines: A Catalyst-Free Oxidative Decyanation-Amidation Reaction》 were Zhang, Ya-Kai; Wang, Bin. And the article was published in European Journal of Organic Chemistry in 2019. Recommanded Product: 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:

AN oxidative decyanation-amidation of β-ketonitriles and primary amines readily occurs using hydrogen peroxide sodium carbonate adduct (Na2CO3·1.5H2O2), K2CO3, and 1,4-dioxane. This reaction affords α-ketoamides under mild conditions without the need of a catalyst. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Recommanded Product: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Recommanded Product: 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Impregnated copper ferrite on mesoporous graphitic carbon nitride: An efficient and reusable catalyst for promoting ligand-free click synthesis of diverse 1,2,3-triazoles and tetrazoles》 were Khalili, Dariush; Rezaee, Meysam. And the article was published in Applied Organometallic Chemistry in 2019. Computed Properties of C8H6BrN The author mentioned the following in the article:

Synthesis of magnetic CuFe2O4/g-C3N4 hybrids via a facile method and their catalytic performances were evaluated via click chem. was reported. The structural and morphol. characterization of CuFe2O4, g-C3N4, CuFe2O4/g-C3N4 were carried out by different techniques such as X-ray diffraction, high-resolution transmission electron microscopy, field emission SEM, Fourier IR spectroscopy, vibrating sample magnetometry, thermogravimetric anal. and N2 adsorption-desorption anal. (Brunauer-Emmett-Teller surface area). The utilization of magnetic CuFe2O4/g-C3N4 enabled superior performance in the one-pot azide-alkyne cycloaddition reaction in water using alkyl halides and epoxides as azide precursors without the need of any addnl. agents to afford triazoles I [R = cyclohexyl, allyl, Bn, etc.; Ar = Ph, 2-methoxynaphthalenyl] and II [Ar1 = Ph, 2-methoxynaphthalenyl; R1 = H, Ph, 4-ClC6H4; R2 = H, Et, CH2OPh, etc.]. Also 5-substituted 1H-tetrazoles III [Ar2 = Ph, 4-MeC6H4, 2-ClC6H4, etc.] were prepared via [3 + 2] cycloaddition of sodium azide and aryl nitriles by using magnetic CuFe2O4/g-C3N4 nanoparticles. In addition, the catalytic system highly fulfilled the demands of “”green click chem.”” with its convenient conditions, especially easy access to a variety of significant products in low catalyst loading and simple work-up and isolation procedure.4-Cyanobenzyl bromide(cas: 17201-43-3Computed Properties of C8H6BrN) was used in this study.

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Computed Properties of C8H6BrN

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In 2018,Wang, Lei; Tang, Jing; Huber, Andrew D.; Casey, Mary C.; Kirby, Karen A.; Wilson, Daniel J.; Kankanala, Jayakanth; Parniak, Michael A.; Sarafianos, Stefan G.; Wang, Zhengqiang published 《6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H》.European Journal of Medicinal Chemistry published the findings.Application of 31938-07-5 The information in the text is summarized as follows:

Herein the design, synthesis, biochem. and antiviral evaluations of a new 6-biphenylmethyl subtype of the 3-hydroxypyrimidine-2,4-dione (HPD) chemotype is reported. In biochem. assays, analogs of this new subtype potently inhibited RT RNase H in low nanomolar range without inhibiting RT polymerase (pol) or integrase strand transfer (INST) at the highest concentrations tested. In cell-based assays, a few analogs inhibited HIV in low micromolar range without cytotoxicity at concentrations up to 100 μM. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Application of 31938-07-5)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Application of 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2008,Cao, Yu-Qing; Zhang, Zhan; Guo, Yan-Xin published 《A practical one-pot conversion of alcohols into homologous nitriles catalyzed by PEG 400 and sodium iodide》.Organic Chemistry: An Indian Journal published the findings.Related Products of 31938-07-5 The information in the text is summarized as follows:

Alcs. were converted into nitriles by one-pot reactions with trimethylchlorosilane and sodium cyanide catalyzed by PEG400 and sodium iodide in dichloromethane in excellent yields.2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Related Products of 31938-07-5) was used in this study.

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Related Products of 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2002,Imoto, Hiroshi; Imamiya, Eikoh; Momose, Yu; Sugiyama, Yasuo; Kimura, Hiroyuki; Sohda, Takashi published 《Studies on non-thiazolidinedione antidiabetic agents. 1. Discovery of novel oxyiminoacetic acid derivatives》.Chemical & Pharmaceutical Bulletin published the findings.Electric Literature of C8H6BrN The information in the text is summarized as follows:

A novel series of oxyiminoacetic acid derivatives were synthesized in an effort to develop a potent antidiabetic agent, which does not contain the 2,4-thiazolidinedione moiety. These compounds were evaluated for glucose and lipid lowering effects in genetically obese and diabetic KKAy mice. Several of the compounds showed strong antidiabetic activity, including functional potency at peroxisome proliferator-activated receptor (PPAR)-γ. (Z)-2-[4-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino]-2-(4-phenoxyphenyl)acetic acid (25) significantly reduced plasma glucose (33%, p<0.01) and plasma triglyceride levels (43%, p<0.01) even at a dosage of 0.001% in diet. Pharmacokinetic analyses of 25 are also reported. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Electric Literature of C8H6BrN)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Electric Literature of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts