Tag: 100-200

In 2015,Chen, Mao; Ichikawa, Saki; Buchwald, Stephen L. published 《Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions》.Angewandte Chemie, International Edition published the findings.Recommanded Product: 31938-07-5 The information in the text is summarized as follows:

A general, rapid, and efficient method for the copper-catalyzed Finkelstein reaction of (hetero)aromatics has been developed using continuous flow to generate a variety of aryl iodides. The described method can tolerate a broad spectrum of functional groups, including N-H and O-H groups. Addnl., in lieu of isolation, the aryl iodide solutions were used in two distinct multistep continuous-flow processes (amidation and Mg-I exchange/nucleophilic addition) to demonstrate the flexibility of this method. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 31938-07-5)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Recommanded Product: 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines》 were Markley, Lowell D.; Tong, Yulan C.; Dulworth, Jacqueline K.; Steward, David L.; Goralski, Christopher T.; Johnston, Howard; Wood, Steven G.; Vinogradoff, Anna P.; Bargar, Thomas M.. And the article was published in Journal of Medicinal Chemistry in 1986. Recommanded Product: 99902-72-4 The author mentioned the following in the article:

Seventy-four title compounds [I; R1 and R2 = e.g. H, 3-, 4-, 5-, or 6-MeSO2, 4-NO2, 2,4-(NO2)2, 4-MeSO2-2-CN, 5-CN, 4-MeO, 4-MeCONH-2-CN, etc.; R3 and R4 = e.g. H, 4-Cl, 3,4-Cl2, 4-COMe, 3,4-(MeO)2, 4-SMe 3-CF3, 4-CN, etc.; and X = CH or N] were prepared, mostly by nucleophilic aromatic substitution reactions of the appropriate phenol with aryl halides with subsequent functional group transformations where necessary, and tested for activity against picornaviruses (rhino- and coxsackie-virus) in vitro; selected I were also tested for protection from coxsackievirus infection in mice. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile  [78940-62-2] demonstrated broad-spectrum antipicornavirus activity; this compound and several of its analogs were also effective antiviral agents in vivo. Some structure-activity relations are discussed.6-Phenoxynicotinonitrile(cas: 99902-72-4Recommanded Product: 99902-72-4) was used in this study.

6-Phenoxynicotinonitrile(cas: 99902-72-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Recommanded Product: 99902-72-4 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Schofield, Joseph; Derdau, Volker; Atzrodt, Jens; Zane, Patricia; Guo, Zuyu; van Horn, Robert; Czepczor, Valerie; Stoltz, Axelle; Pardon, Magalie published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Effect of deuteration on metabolism and clearance of Nerispirdine (HP184) and AVE5638》.Formula: C12H8N2 The author mentioned the following in the article:

Replacing hydrogen with deuterium as a means of altering ADME properties of drug mols. has recently enjoyed a renaissance, such that at least two deuterated chem. entities are currently in clin. development. Although most research in this area aims to increase the metabolic stability, and hence half-life of the active species, experience has shown that prediction of the in vivo behavior of deuterated mols. is difficult and depends on multiple factors including the complexity of the metabolic scheme, the enzymes involved and hence the mechanism of the rate-determining step in the biotransformation. In an effort to elucidate some of these factors we examined the metabolic behavior of two mols. from the Sanofi portfolio in a range of in vitro and in vivo systems. Although some key metabolic reactions of the acetylcholine release stimulator HP184 4 were slowed in vitro and in vivo when deuterium was present at the sites of metabolism, this did not translate to an increase in overall metabolic stability. By contrast, the tryptase inhibitor AVE5638 13 was much more metabolically stable in vitro in its deuterated form than when unlabeled. These results indicate that it could be of value to concentrate efforts in this area to mols. which are metabolised by a major pathway that involves enzymes of the amine oxidase family or other low-capacity enzyme families. In the experiment, the researchers used many compounds, for example, 3-(Pyridin-4-yl)benzonitrile(cas: 4350-55-4Formula: C12H8N2)

3-(Pyridin-4-yl)benzonitrile(cas: 4350-55-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Formula: C12H8N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Angewandte Chemie, International Edition included an article by Li, Xiangdong; Golz, Christopher; Alcarazo, Manuel. Product Details of 614-16-4. The article was titled 《5-(Cyano)dibenzothiophenium Triflate: A Sulfur-Based Reagent for Electrophilic Cyanation and Cyanocyclizations》. The information in the text is summarized as follows:

The synthesis of 5-(cyano)dibenzothiophenium triflate 9 (I.OTf-), prepared by activation of dibenzo[b,d]thiophene-5-oxide with Tf2O and subsequent reaction with TMSCN is reported, and its reactivity as electrophilic cyanation reagent evaluated. The scalable preparation, easy handling and broad substrate scope of the electrophilic cyanation promoted by 9, which includes amines, thiols, silyl enol ethers, alkenes, electron rich (hetero)arenes and polyaromatic hydrocarbons, illustrate the synthetic potential of this reagent. Importantly, Lewis acid activation of the reagent is not required for the transfer process. We addnl. report herein biomimetic cyanocyclization cascade reactions, which are not promoted by typical electrophilic cyanation reagents, demonstrating the superior ability of 9 to trigger challenging transformations. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Product Details of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Product Details of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Bulletin of the Korean Chemical Society included an article by Chia, Poh Wai; Yong, Fu Siong Julius; Mohamad, Habsah; Kan, Su-Yin. Safety of 4-Fluorobenzonitrile. The article was titled 《Cyanation of Anilines to Aryl Nitriles Using tert-Butyl Isocyanide: A Simple and Copper-free Procedure》. The information in the text is summarized as follows:

In this manuscript, a simple and copper-free procedure for the synthesis of aryl nitrile derivatives from anilines is described. Under the improved protocol, the anilines were reacted with tert-Bu isocyanide under a mild reaction condition without the use of solvents and copper catalyst to synthesize benzonitriles. This copper-free Sandmeyer-type reaction could tolerate a range of anilines bearing different functional groups and also can be conducted even without the exclusion of air. In addition, this method has afforded the aryl nitriles I (R1 = H, 4-Cl, 4-Me, 2-F, etc.) in moderate to good yields (52-81%). The obtained results in this study reveal that the tert-Bu isocyanide as a potential cyanide source for the cyanation reaction. In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1Safety of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Safety of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,European Journal of Medicinal Chemistry included an article by Yu, Jia-Ying; Li, Xue-Qiang; Wei, Meng-Xue. Related Products of 17201-43-3. The article was titled 《Synthesis and biological activities of artemisinin-piperazine-dithiocarbamate derivatives》. The information in the text is summarized as follows:

Twelve derivatives of artemisinin-piperazine-dithiocarbamate, I (R = CH2Ph, CH2C6H4Me-4, n-pentyl, CH2CO2CH2Ph, etc.), have been synthesized, and some of them show good in vitro cytotoxic activity. Compound I (R = CH2C6H4CN-4) (II) exhibits the best inhibitory activity against SMMC-7721 cell lines with an IC50 of 0.0025 ± 0.04 μM for 72 h, but the toxicity was lower against LO2 cell lines with an IC50 of 0.18 ± 0.04 μM for 72 h. The results indicate that compound II is more cytotoxic towards cancer cell lines than towards benign cell lines compared with vincristine in vitro. And compound II also has good inhibitory activity against colon, breast and prostate cancer cells. Meanwhile, we have also proposed the six-member ring mechanism of DMSO in catalyzing the esterification of hydroxyl and acyl chloride. Instead of using the hydroxyl, we can obtain the nucleophilic substitution production simply and efficiently without a Lewis acid, which has not been reported previously. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanobenzyl bromide(cas: 17201-43-3Related Products of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Related Products of 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2014,Wu, Guojiao; Deng, Yifan; Wu, Chaoqiang; Zhang, Yan; Wang, Jianbo published 《Synthesis of α-Aryl Esters and Nitriles: Deaminative Coupling of α-Amino-Esters and α-Aminoacetonitriles with Arylboronic Acids》.Angewandte Chemie, International Edition published the findings.Safety of 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

Transition-metal-free synthesis of α-aryl esters and nitriles using arylboronic acids with α-amino esters and α-(amino)acetonitrile derivatives, resp., as starting materials has been developed. The reaction represents a rare case of converting C(sp3)-N bonds (carbon-nitrogen bonds) into C(sp3)-C(sp2) bonds (carbon-carbon bonds). The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. The synthesis of the target compounds was achieved using glycine ester hydrochloride, leucine ester hydrochloride, aspartate ester hydrochloride, alanine ester hydrochloride as starting materials in a reaction with (aryl)boronic acids. The title compounds thus formed included benzeneacetic acid esters, 1-naphthaleneacetic acid ester, benzenepropanoic acid esters, α-phenyl-1H-indole-3-propanoic acid ester, benzenebutanoic acid ester and similar substances. A reaction of (aryl)boronic acids with α-(amino)acetonitrile gave α-(alkyl)benzeneacetonitrile derivatives Nitriles included α-(hexyl)benzeneacetonitrile, α-phenyl-3-thiophenepropanenitrile and similar compounds In addition to this study using 2-(3-Bromophenyl)acetonitrile, there are many other studies that have used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Safety of 2-(3-Bromophenyl)acetonitrile) was used in this study.

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Safety of 2-(3-Bromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2013,Lee, Sunggi; Lee, Hyelee; Tan, Kian L. published 《Meta-Selective C-H Functionalization Using a Nitrile-Based Directing Group and Cleavable Si-Tether》.Journal of the American Chemical Society published the findings.Recommanded Product: 31938-07-5 The information in the text is summarized as follows:

A nitrile-based template that enables meta-selective C-H bond alkenylation of benzylic alcs. was developed. The template is applicable to a range of substituted arenes and tolerates a variety of functional groups. The directing group uses a silicon atom for attachment, allowing for a facile introduction/deprotection strategy increasing the synthetic practicality of this template. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Recommanded Product: 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2010,Christiansen, Elisabeth; Due-Hansen, Maria E.; Ulven, Trond published 《A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists》.Journal of Organic Chemistry published the findings.Formula: C8H6BrN The information in the text is summarized as follows:

A protocol for rapid and efficient Pd/Cu-catalyzed coupling of aryl bromides and iodides to terminal alkynes has been developed with use of 2-(di-tert-butylphosphino)-N-phenylindole (cataCXium PIntB) as ligand in TMEDA and water. The new protocol successfully couples substrates which failed with standard Sonogashira conditions, and enables an efficient general synthetic route to free fatty acid (FFA1) receptor 1 ligands from 3-(4-bromophenyl)propionic acid. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Formula: C8H6BrN)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2006,Stachulski, Andrew V.; Berry, Neil G.; Low, A. C. Lilian; Moores, Shelley L.; Row, Eleanor; Warhurst, David C.; Adagu, Ipemida S.; Rossignol, Jean-Francois published 《Identification of Isoflavone Derivatives as Effective Anticryptosporidial Agents in Vitro and in Vivo》.Journal of Medicinal Chemistry published the findings.Recommanded Product: 31938-07-5 The information in the text is summarized as follows:

The preparation and antiparasitic activity in vitro and in vivo of a series of isoflavone derivatives related to genistein was reported. The prepared analogs retain the 5,7-dihydroxyisoflavone core of genistein. Genistein analogs I (R2 = R3 = H, R4 = NO2, Br; R2 = R4 = H, R3 = NO2, Br), 2-carboethoxyisoflavones I (R2 = CO2Et, R3 = H, R4 = NO2, Br; R2 = CO2Et, R3 = NO2, Br, R4 = H), and the corresponding precursor deoxybenzoins II were all evaluated. Excellent in vitro activity against Cryptosporidium parvum was observed for both classes of isoflavones in cell cultures, and the lead compound RM 6427 I (R2 = CO2Et, R3 = Br, R4 = H), showed high in vivo efficacy against an exptl. infection. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Recommanded Product: 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts