Tag: 100-200

Turpaev, Kyril; Ermolenko, Mikhail; Cresteil, Thierry; Drapier, Jean Claude published an article in 2011, the title of the article was Benzylidenemalononitrile compounds as activators of cell resistance to oxidative stress and modulators of multiple signaling pathways. A structure-activity relationship study.Reference of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

Benzylidenemalononitrile (BMN) tyrphostins are well known as potent tyrosine kinase inhibitors. Moreover, in recent years it has been recognized that members of the tyrphostin family possess addnl. biol. activities independent of their ability to inhibit protein tyrosine kinases. In this study, we examined the relationship between the structure of 49 BMNs and related compounds, and their capacity to induce heme oxygenase 1 (HO-1) gene expression in U937 human monocytic cells, to activate upstream signaling pathways and to protect cells against menadione-induced oxidative stress. It was found that the electron-withdrawing (NO2, CN, halogen) groups in BMN mols. and double meta-MeO substituents increased the HO-1 gene induction, while the electron-donating groups in ortho/para position (OH, MeO and N-morpholino) significantly decreased it. The magnitude of activation of c-Jun, Nrf2, p38 MAPK, and p70S6K correlated with specific substitution patterns in the BMN structure. BMN-dependent maximal up-regulation of HO-1 required parallel increase in Nrf2 and phospho-c-Jun cellular levels. Liquid chromatog. mass spectrometry (LC-MS) anal. revealed that BMNs can generate conjugates with one or two glutathione equivalent(s). This study supports the hypothesis that BMNs induce the expression of protective genes by alkylating sensitive cysteine residues of regulatory factors. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Reference of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to benzylidene malononitrile resistance oxidative stress signaling structure, Pharmacology: Structure-Activity and other aspects.Reference of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 9, 2003, Moeller, Hinrich; Oberkobusch, Doris; Hoeffkes, Horst published a patent.Related Products of 2510-01-2 The title of the patent was Oxidative hair dyes containing dicyanmethylene indane derivatives, other dyes and color intensifiers. And the patent contained the following:

The invention concerns hair dyes that contain dicyanmethylene indane derivatives and optionally substances selected from the group of (a) primary and secondary aromatic amines, hydroxydes, nitrogen-containing heterocycles; (b) amino acids; (c) 2-9 amino acid-containing oligopeptides; (d) CH-acids; (d) aryl or heteroaryl aldehydes or ketones; (f) quaternary ammonium compounds Thus in a hair dyeing experiment 5 mmol 1,3-bis(dicyanmethylene)-indane, 5 mmol 4-dimethylaminobenzaldehyde were mixed with 5 mmol sodium acetate in 50 mL water at 50°C; pH 9 was set and the solution was used to dye hair; intense blue color was obtained. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Related Products of 2510-01-2

The Article related to oxidative hair dye dicyanmethylene indane derivative, Essential Oils and Cosmetics: Hair Preparations and other aspects.Related Products of 2510-01-2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 11, 2002, Moeller, Hinrich; Oberkobusch, Doris; Hoeffkes, Horst published a patent.Synthetic Route of 2510-01-2 The title of the patent was Oxidative hair dyes containing acridine aldehydes and acridine ketones. And the patent contained the following:

The invention concerns the synthesis of acridine aldehyde and acridine ketone derivatives and their application in oxidative hair dyes. Compounds of the general formula (I) are defined, where R1 = hydrogen atom, C1-4-Alkyl or group of aryls; R2, R3, R4 and a R5, same or different = a hydrogen atom, halogen atom, a C1-C4-Alkyl, C1-C4-Hydroxyalkyl, C1-C4-Alkoxy, C1-C4-Hydroxyalkoxy, hydroxy group, nitro group, sulfo group, amino group, which can be substituted by C1-C4-Alkyl, or a C1-C4-Acyl, whereby two of the groups can form a condensed aromatic ring, whereby the groups of COR1, R2, R3, R4 and R5 to any ring of the cyclic system; X- an anion, in particular halide, sulfonate, like benzene sulfonate, p-Toluene sulfonate, methanesulfonate or trifluoro methanesulfonate, Me sulfate, Et sulfate, perchlorate, sulfate, hydrogensulfate, tetrafluoroborate or tetrachlorozincate, alkanoate, whereby X- is absent if R6 is neg. charged; R6 = hydrogen atom, C1-4-Alkyl, C1-C4-Hydroxyalkyl, C1-C6 carboxyalkyl, C1-C6 sulfoalkyl, C1-4-aralkyl, heteroalkyl, neg. charged oxygen. Thus 9-formyl-10-methylacridinium-p-toluene sulfonate was synthesized from acridine-9-carboxaldehyde and p-toluene sulfonic acid Me ester. The product was used in combination with 3-methyl-p-aminophenol to yield a light brown hair color. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Synthetic Route of 2510-01-2

The Article related to oxidative hair dye acridine aldehyde ketone, Essential Oils and Cosmetics: Hair Preparations and other aspects.Synthetic Route of 2510-01-2

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Nitrile – Wikipedia,
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On November 22, 2001, Moeller, Hinrich; Oberkobusch, Doris; Hoeffkes, Horst published a patent.HPLC of Formula: 2510-01-2 The title of the patent was Hair dyes containing derivatives of nitrosopyridine or nitrosopyrimidine. And the patent contained the following:

The invention concerns hair dyes that contain nitrosopyridine or nitrosopyrimidine derivatives of the general formula (I), groups are defined, and a second dye that contains amino or hydroxy groups; the compositions color hair without the addition of oxidative agents. Thus violet red color was achieved by a composition that included 5 mmol 5-nitroso-2,4,6-triaminopyrimidine; 5 mmol 4-formyl-1-methylquinoline-p-toluene sulfate; 5 mmol piperidine, 1 drop of 20% fatty alkyl ether sulfate; 50 mL water; pH to 9 with sodium hydroxide and hydrochloric acid resp. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).HPLC of Formula: 2510-01-2

The Article related to hair dye nitrosopyridine nitrosopyrimidine, Essential Oils and Cosmetics: Hair Preparations and other aspects.HPLC of Formula: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 24, 2002, Moeller, Hinrich; Meinigke, Bernd published a patent.Application of 2510-01-2 The title of the patent was Hair dye containing nitroxanthene derivatives. And the patent contained the following:

The invention concerns hair dyes that contain nitroxanthene derivatives of the general formula (I); where R1 = H, carboxy-, carboxylato-;, sulfo-, sulfonato-, hydroxy group; R2, R3 = H, halogen, hydroxyl; M = H, alkali, alkali earth atom. The nitroxanthene derivative is preferably C.I. Acid Red 91. The compositions further contain other dyes, surfactants and amino acids. Thus a pinkish red color was achieved by using 5 mmol Acid red 91 and 5 mmol 2,4,5,6-tetraamidopyrimidine x H2SO4 in a pH 6 aqueous medium that further contained 5 mmol sodium acetate, one drop of 20% fatty alkyl ether sulfonate. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to hair dye nitroxanthen derivative acid red, Essential Oils and Cosmetics: Hair Preparations and other aspects.Application of 2510-01-2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 20, 2001, Gross, Wibke; Hoeffkes, Horst; Martin, Hans-Dieter; Moeller, Hinrich; Oberkobusch, Doris published a patent.Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the patent was Hair dyeing compositions containing oxocyclopentenes. And the patent contained the following:

Hair dyes contain oxocyclopentene derivative (I, R1 and R2 = H, or a C1-4 alkyl, R3 and R4 = H, C1-4 alkyl or group of aryls, the remainder of R1 and R2 and/or R3 and R4 can form a ring, and X = C:O, C:S or CH2). Thus, 2,5,5-trimethyl-3-oxocyclopent-1-enecarboxaldehyde (II) was prepared and used in a formulation consisting of II 8, Natrosol 250HR 2.0 and water to 100 g. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to oxacyclopentene hair dye preparation, Essential Oils and Cosmetics: Hair Preparations and other aspects.Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 26, 2001, Moeller, Hinrich; Oberkobusch, Doris; Hoeffkes, Horst published a patent.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the patent was Aromatic aldehydes and ketones with imidazoles as coloring agents for keratin fibers. And the patent contained the following:

Oxidative hair dyes containing aromatic aldehydes and ketones combined with imidazoles and other heterocyclic compounds are disclosed. Aromatic components may include salicylaldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, o-anisaldehyde, etc. Heterocyclic components may include 1,4-dimethylquinolinium salts, 1,2-dimethylquinolinium salts, 1,4-dimethylpyridinium salts, 3-ethyl-2-methylbenzothiazolium salts, etc. These may be combined with rhodanine, barbituric acid, thiobarbituric acid, oxindole, etc. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to oxidative hair dye aromatic ketone, Essential Oils and Cosmetics: Hair Preparations and other aspects.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 20, 2001, Gross, Wibke; Hoeffkes, Horst; Martin, Hans-Dieter; Moeller, Hinrich; Oberkobusch, Doris published a patent.Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the patent was Hair dyeing compositions containing quinoxaline derivatives. And the patent contained the following:

Hair dye compositions contain at least one quinoxaline derivative containing e.g., C1-4 alkenyl, hydroxyalkyl, carboxyalkyl groups, and halo groups. Thus, 1,1,3-trimethylcyclo-2-penten[1,2-b]quinozaline-2-carboxaldehyde (I) was prepared in a seies of steps and formulated into a hair dye formulation containing I 4.4, Natrosol 250HR 2.0 and water to 100.0 g. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to hair dye quinoxaline preparation, Essential Oils and Cosmetics: Hair Preparations and other aspects.Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 10, 2003, Moeller, Hinrich; Hoeffkes, Horst; Oberkobusch, Doris published a patent.SDS of cas: 2510-01-2 The title of the patent was Oxidative hair dyes containing aromatic compounds, other dyes and color intensifiers. And the patent contained the following:

The invention concerns oxidative hair dyes that contain aromatic compounds other dyes and color intensifiers. The components are selected from the group of primary and secondary aromatic amines, hydroxides, nitrogen-containing heterocycles, amino acids, oligopeptides, CH-acids and quaternary ammonium compounds Thus a dye contained(weight/weight%): Texapon NSO 18.00; Dehyton K 11.25; Hydrenol D 7.65; Lorol 1.80; Eumulgin 0.68; propylene carbonate 8.50; N-allylisatine 1.50; N,N-Bis(2’hydroxyethyl)-p-phenylene diamine sulfate 2.95; ascorbic acid 0.10; sodium sulfite 0.10; ammonia (25%) 4.00; water to 100; pH 9.20. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to oxidative hair dye aromatic, Essential Oils and Cosmetics: Hair Preparations and other aspects.SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lv, Yongjun; Guo, Yong; Xu, Jian; Shao, Shijun published an article in 2011, the title of the article was Simple indole-based colorimetric sensors with electron-withdrawing chromophores: Tuning selectivity in anion sensing.Related Products of 75629-62-8 And the article contains the following content:

Three simple colorimetric anion sensors containing anthrone, 1,3-indanedione, and malononitrile as signaling chromophores and an indole binding site were designed and synthesized. The introduction of electron-withdrawing groups can not only provide chromogenic signal output, but also tune the sensitivity and selectivity of indole-based anion sensors by electron push-pull features. Their anion binding and sensing properties were studied in detail by dramatic color changes, UV-visible absorption, and 1H NMR. As results revealed, sensor I showed high selectivity for F- over AcO- and H2PO4- with a distinct change in color due to the deprotonation of indole NH group. The excellent selectivity of I for F- can be attributed to the fitness in the acidity of its NH-group, which is tuned to be able to distinguish the subtle difference in the affinity of F-, AcO-, and H2PO4- to NH proton. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Related Products of 75629-62-8

The Article related to indole based colorimetric sensor electron withdrawing chromophore, fluoride acetate dihydrogen phosphate sensing indole derivative colorimetric, Inorganic Analytical Chemistry: Determinations and other aspects.Related Products of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts