Tag: 100-200

On February 2, 2006, Nishiyabu, Ryuhei; Anzenbacher, Pavel Jr. published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was 1,3-Indane-Based Chromogenic Calixpyrroles with Push-Pull Chromophores: Synthesis and Anion Sensing. And the article contained the following:

Knoevenagel condensation of 2-formyl-octamethylcalix[4]pyrrole with selected 1,3-indanedione derivatives yields calix[4]pyrrole anion sensors with push-pull chromophores displaying strong intramol. charge transfer. The push-pull feature results in augmented signal output as well as in dramatic changes in anion selectivity exemplified by a 50-fold increase in acetate vs. chloride selectivity compared to the parent calix[4]pyrrole. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to indane chromogenic calixpyrrole push pull chromophore anion sensing, Inorganic Analytical Chemistry: Determinations and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 31, 2017, Deilami, K.; Sayyahi, S. published an article.Name: 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Porous hierarchical magnesium oxide-based heterogeneous catalyst for the Knoevenagel condensation. And the article contained the following:

Herein, an operationally facile and efficient Knoevenagel reaction catalyzed by porous hierarchical MgO/Mg(OH)2 is presented. Condensation of various aldehydes with malononitrile proceeds under mild conditions and gives the target products with high yields. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Name: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to porous hierarchical magnesium oxide catalyst preparation knoevenagel condensation, aryl aldehyde knoevenagel condensation malononitrile magnesium oxide catalyzed, General Organic Chemistry: Synthetic Methods and other aspects.Name: 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dewanji, Abhishek; van Dalsen, Leendert; Rossi-Ashton, James A.; Gasson, Eloise; Crisenza, Giacomo E. M.; Procter, David J. published an article in 2021, the title of the article was A general arene C-H functionalization strategy via electron donor-acceptor complex photoactivation.Formula: C10H7NO2 And the article contains the following content:

The photoactivation of electron donor-acceptor (EDA) complexes has emerged as a sustainable, selective and versatile strategy for the generation of radical species. However, when it comes to aryl radical formation, this strategy remains hamstrung by the electronic properties of the aromatic radical precursors and electron-deficient aryl halide acceptors are required. This has prevented the implementation of a general synthetic platform for aryl radical formation. Our study introduces triarylsulfonium salts as acceptors in photoactive EDA-complexes, used in combination with catalytic amounts of newly-designed amine donors. The sulfonium salt label renders inconsequential the electronic features of the aryl radical precursor and, more importantly, it is installed regioselectively in native aromatic compounds by C-H sulfenylation. Using this general, site-selective aromatic C-H functionalization approach, we have developed metal free protocols for the alkylation and cyanation of arenes, and showcased their application in both the synthesis and the late-stage modification of pharmaceuticals and agrochems. The experimental process involved the reaction of 4-Oxochroman-6-carbonitrile(cas: 138801-92-0).Formula: C10H7NO2

The Article related to arene carbon hydrogen functionalization donor acceptor complex photoactivation, alkylation cyanation triarylsulfonium salt silane intermediate radical mechanism, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C10H7NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 15, 2021, Azad, Iqbal; Khan, Tahmeena; Ahmad, Rumana; Kamal, Azhar; Khan, Abdul Rahman; Nasibullah, Malik published an article.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was A Simplistic Approach for Preparation of Alkylidenemalononitrile Derivatives: Characterization, In silico Studies, Quantum Chemical Evaluation, Molecular Docking, and In vitro Biological Activity Evaluation. And the article contained the following:

A new and efficient green grinding-based catalyst free Knoevenagel condensation of aldehydes/ketones and malononitrile for the rapid preparation of twelve malononitrile I [R1 = H, Cl; R2= H, Cl ] and II [R3 = H, Br; R4 = H, Me, Ph ]was proposed. Characterization of the derivatives was done by 1H NMR, 13C NMR, IR, elemental and mass spectral analyses. Quantum chem. calculations were performed by DFT/B3LYP/6-31G(d,p) method. The exptl. and theor. spectra were found to be in good agreement with each other. Natural bond order (NBO) calculations were also performed to calculate the natural at. charges at at. sites. The present study also involved study of the intramol. charge transfer (ICT) interactions and the non-linear optical (NLO) properties. Critical drug character assessment parameters like metabolic transformation, druglikeness, ADMET (absorption, distribution, metabolism and excretion) and toxicol. analyses of the synthesized malononitrile derivatives were also performed. Mol. docking studies were performed against two target proteins viz. tyrosine-protein kinase (HCK) and ribonucleoside diphosphate reductase (RR). The synthesized malononitrile derivatives were also evaluated for their anticancer activity against the triple neg. breast cancer (TNBC) cell line (MDA-MB-231) while their antibacterial potential was tested against S. aureus and E. coli. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to alkylidenemalononitrile preparation antibacterial antitumor agent enzyme inhibitor mol docking, sar homo lumo stabilization energy mol structure green chem, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chowhan, Bushra; Gupta, Monika; Sharma, Neha published an article in 2019, the title of the article was Designing of Ultrafine PdNPs Immobilized Pyridinic-N Doped Carbon and Evaluation of its Catalytic Potential for Konevenagel Condensation, Synthesis of 4H-pyran Derivatives and Nitroreduction.Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

The desiging of ultrafine Pd-based nanocatalyst containing N-doped carbon structure (Pd@NC) was reported. The material was prepared by direct dehydration at 120 °C followed by mixing and heating with a dopant (ammonium oxalate) at 150 °C in a furnace. The Pd@NC nanocatalyst containing electron-rich pyridinic-N doped carbon structure, was thoroughly characterized by various techniques namely SEM, EDX, TEM, FTIR, ICP-AES, XRD, XPS, TGA and Raman spectroscopy. The utility of the Pd@NC nanocatalyst was explored for base-free Knoevenagel condensation and 4H-pyran derivatives and also in the reduction of nitroarenes under mild and greener conditions. Further, the optical property was explored using photoluminescence spectroscopy and band gap was also calculated The heterogeneous nature and stability of the catalyst facilitated by its ease of separation for long-term performance and recycling studies showed that catalyst was robust and remained active upto six recycling experiments Also, the leaching of metal was confirmed by ICP-AES. The superiority of the catalyst was attributed to the metal support interaction (MSI) between metallic palladium and pyridinic-N doped carbon to acquire excellent catalytic activity and changing the reducing nature of NaBH4 towards nitro functionality. The MSI between pyridinic-N dopant on the carbon structure and PdNPs produces highly active sites for catalytic performance under mild conditions. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to palladium nanoparticle preparation thermal stability, arylidene malononitile preparation, pyran preparation, aniline preparation green chem, General Organic Chemistry: Synthetic Methods and other aspects.Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saidalimu, Ibrayim; Guo, Ming; Tokunaga, Etsuko; Shibata, Norio published an article in 2016, the title of the article was Direct Fluoro-aminosulfenylation of Active Methylenes by Dialkylaminosulfur Trifluorides under Catalyst-Free Conditions.SDS of cas: 2510-01-2 And the article contains the following content:

The direct fluoro-aminosulfenylation of active methylene compounds, e.g., 2-(2,3-dihydro-1H-inden-1-ylidene)malononitrile by diethylaminosulfur trifluoride and its derivatives F3SR (R = dimethylamino, diethylamino, bis(2-methoxyethyl)amino, morpholino) has been disclosed. A variety of α-fluorinated α-sulfenamides with a tetrasubstituted carbon center, e.g., I were synthesized from active methylene compounds under mild reaction conditions. This direct fluoro-aminosulfenylation reaction occurs very smoothly under metal-free and base-free conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to sulfenamide fluoro preparation, active methylene compound dialkylaminosulfur trifluoride fluoro aminosulfenylation, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Poomathi, Nataraj; Perumal, Paramasivan T. published an article in 2016, the title of the article was Cinchona alkaloid and di-tert-butyl dicarbonate-DMAP promoted efficient synthesis of (E)-nitroolefins.Formula: C12H7N3 And the article contains the following content:

Herein, an alternative metal-free protocol for the synthesis of β-nitroolefins from arylidene malononitriles using cinchona alkaloid along with di-tert-Bu dicarbonate-DMAP in high yields with total selectivity is reported. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to nitroolefin preparation cinchona alkaloid catalyst dmap tert butyl dicarbonate, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C12H7N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 15, 2022, Paul, Priya Kumari; Mehta, Raj Kumar; Yadav, Mahendra; Obot, I. B. published an article.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Theoretical, electrochemical and computational inspection for anti-corrosion activity of triazepine derivatives on mild steel in HCl medium. And the article contained the following:

The two triazepine derivatives, 2-amino-9-(1H-indol-3-yl)-4-(4-methoxyphenyl)-7-oxo-1,7-dihydropyrido[1,2-b][1,2,4]triazepine-3,8,10-tricarbonitrile [AITT] and Et 2-amino-8,10-dicyano-9-(2-hydroxy-3-methoxyphenyl)-4-(4-methoxyphenyl)-7-oxo-1,7-dihydropyrido [1,2 -b][1,2,4]triazepine-3-carboxylate [EHTC] were successfully synthesized and demonstrated as corrosion inhibitor for mild steel in 15% HCl medium. Their auspicious inhibiting performance was measured by weight loss measurement and the electrochem. impedance spectroscopic method. The adsorption of inhibitors chem. or phys. on the exposed metal surface is the main key factor behind the protection mechanism. The investigation at an optimum concentration of 200 ppm (303 K) showed the inhibitor AITT and EHTC with 96.88% and 95.56% inhibition efficiency. The functional groups attached to inhibitor AITT encourages the electron d. over the whole mol. and makes it more efficient as a corrosion inhibitor than EHTC. The minimization of cathodic as well as anodic reactions from the potentiodynamic polarization method reveals the inhibitors as mixed-type inhibitors which is also supported by the computed free energy of adsorption values from best fitted Langmuir Adsorption isotherm. The extreme improvement in damaged surface (inhibitor-free medium) was found on the application of inhibitors which is characterized by the surface topog. analyses FESEM and AFM. The elemental anal. of the inhibited metal surface was executed by XPS anal. The computational methods as Monte-Carlo Simulation, DFT and Fukui calculations, were also employed for the justification of outcomes from exptl. methods. All the observations were mutually supported. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to triazepine derivative synthesis mild steel anti corrosion evaluation, Placeholder for records without volume info and other aspects.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 2001, Mishriky, N.; Girgis, A. S.; Asaad, F. M.; Ibrahim, Y. A.; Sobieh, U. I.; Fawzy, N. G. published an article.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Simple synthesis of condensed pyran containing compounds and their antimicrobial properties. And the article contained the following:

Reaction of various fused pyran compounds with formic acid was studied. Thus, refluxing 6-aminopyrano[2,3-c]pyrazole-5-carbonitriles with formic acid afforded the corresponding 3-aryl-3-(5-hydroxy-3-methyl-1H-pyrazole-4-yl)propanoic acids. Reaction of formic acid with 2-amino-4H-1-benzopyran-3-carbonitriles gave quinoline-2,5(1H,6H)-diones. The study was also extended toward spiro compounds possessing pyran residue. The antimicrobial properties of the prepared compounds was screened. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to fused pyran preparation antimicrobial property, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 1, 2018, Yalcin, Ergin; Matkovic, Marija; Jukic, Marijana; Obrovac, Ljubica Glavas; Piantanida, Ivo; Seferoglu, Zeynel published an article.Application of 2510-01-2 The title of the article was Novel fluorene/fluorenone DNA and RNA binders as efficient non-toxic ds-RNA selective fluorescent probes. And the article contained the following:

A series of structurally similar 1-substituted heteroaryl fluorene derivatives were prepared in a simple single step reaction, oxidized to fluorenones and then both, fluorenes and fluorenones, were methylated to enhance the solubility and increase the affinity to DNA/RNA. Interactions of both, fluorene and fluorenone analogs with various ds-DNA, ds-RNA revealed strong ds-DNA/RNA binding, and various thermal stabilization effects. Most intriguingly, some fluorene derivatives showed opposite fluorescence change (increase for ds-RNA and decrease for ds-DNA), which was not previously reported for any fluorene analog. CD experiments along with other methods support ds-DNA minor groove binding and major groove ds-RNA binding. All compounds showed negligible interaction with G-quadruplex DNA. Very low cell cytotoxicity of studied compounds combined with very efficient cellular uptake makes these fluorescent dyes safe for laboratory applications. Moreover, especially compounds which show opposite fluorescence response to ds-DNA and ds-RNA, are promising lead compounds for further studies aimed toward ds-RNA-specific fluorescence markers. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to fluorene fluorenone binding dsdna dsrna fluorescent probe, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts